JP2016536332A5 - - Google Patents
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- JP2016536332A5 JP2016536332A5 JP2016539564A JP2016539564A JP2016536332A5 JP 2016536332 A5 JP2016536332 A5 JP 2016536332A5 JP 2016539564 A JP2016539564 A JP 2016539564A JP 2016539564 A JP2016539564 A JP 2016539564A JP 2016536332 A5 JP2016536332 A5 JP 2016536332A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- antibody
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13183193 | 2013-09-05 | ||
| EP13183193.5 | 2013-09-05 | ||
| PCT/EP2014/069013 WO2015032932A1 (en) | 2013-09-05 | 2014-09-05 | Il-18 binding protein (il-18bp) in inflammatory diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019210436A Division JP2020055821A (ja) | 2013-09-05 | 2019-11-21 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016536332A JP2016536332A (ja) | 2016-11-24 |
| JP2016536332A5 true JP2016536332A5 (enExample) | 2017-08-10 |
| JP6820743B2 JP6820743B2 (ja) | 2021-01-27 |
Family
ID=49111035
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539564A Active JP6820743B2 (ja) | 2013-09-05 | 2014-09-05 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
| JP2019210436A Pending JP2020055821A (ja) | 2013-09-05 | 2019-11-21 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019210436A Pending JP2020055821A (ja) | 2013-09-05 | 2019-11-21 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10858426B2 (enExample) |
| EP (2) | EP3041864B1 (enExample) |
| JP (2) | JP6820743B2 (enExample) |
| KR (2) | KR102321172B1 (enExample) |
| CN (2) | CN105722858A (enExample) |
| AU (1) | AU2014317035B2 (enExample) |
| CL (1) | CL2016000506A1 (enExample) |
| CY (1) | CY1124698T1 (enExample) |
| DK (1) | DK3041864T3 (enExample) |
| ES (1) | ES2892923T3 (enExample) |
| HU (1) | HUE055608T2 (enExample) |
| IL (1) | IL244169B (enExample) |
| LT (1) | LT3041864T (enExample) |
| MX (1) | MX385868B (enExample) |
| NZ (1) | NZ717671A (enExample) |
| PH (1) | PH12016500425B1 (enExample) |
| PL (1) | PL3041864T3 (enExample) |
| PT (1) | PT3041864T (enExample) |
| RU (1) | RU2731713C2 (enExample) |
| SG (1) | SG11201601717VA (enExample) |
| SI (1) | SI3041864T1 (enExample) |
| UA (1) | UA125204C2 (enExample) |
| WO (1) | WO2015032932A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015032932A1 (en) | 2013-09-05 | 2015-03-12 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) in inflammatory diseases |
| CN107660150B (zh) * | 2015-03-05 | 2023-10-24 | Ab2生物股份有限公司 | Il-18结合蛋白(il-18bp)和抗体在炎性疾病中 |
| US20180362660A1 (en) * | 2016-05-09 | 2018-12-20 | Schickwann Tsai | Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes |
| GB201614455D0 (en) | 2016-08-24 | 2016-10-05 | Univ Oxford Innovation Ltd | Biomarkers |
| DE102016219607B4 (de) * | 2016-10-10 | 2025-04-30 | Siemens Healthineers Ag | Erzeugung einer mit anatomischen Bilddaten korrelierten Ergebniskarte |
| WO2019133799A1 (en) * | 2017-12-29 | 2019-07-04 | University Of Florida Research Foundation | Monoclonal antibodies targeting microtubule-binding domain of tau protein |
| TWI679279B (zh) * | 2018-05-09 | 2019-12-11 | 臺中榮民總醫院 | 檢測成人發作型史笛兒氏症之罹病風險及預後之方法 |
| CA3104362A1 (en) | 2018-06-19 | 2019-12-26 | Shanghaitech University | Human antibodies to human interleukin 18 receptor alpha and beta |
| US12269874B2 (en) | 2018-12-03 | 2025-04-08 | mAbProtein Co., Ltd. | Antibody that recognizes neoepitope of activated interleukin-18 proteins and application thereof |
| CN110433289B (zh) * | 2019-09-10 | 2024-12-17 | 中山大学附属口腔医院 | 用于治疗牙周致病菌感染引起的牙周膜细胞功能紊乱与牙槽骨丧失的药物 |
| JP7843701B2 (ja) * | 2019-11-04 | 2026-04-10 | メディミューン リミテッド | Il-33アンタゴニストの使用方法 |
| BR112022020256A2 (pt) | 2020-04-09 | 2023-01-03 | Aprilbio Co Ltd | anticorpo monoclonal ou um fragmento de ligação ao antígeno do mesmo, ácido nucleico, vetor de expressão, célula, composição, uso da composição e uso do anticorpo monoclonal ou fragmento de ligação ao antígeno do mesmo |
| EP4146174A1 (en) * | 2020-05-06 | 2023-03-15 | AB2 Bio SA | Il-18 binding protein (il-18bp) in respiratory diseases |
| GB202007404D0 (en) * | 2020-05-19 | 2020-07-01 | Nasser Syed Muhammad Tahir | Treatment for viral respiratory infections |
| EP4178614A4 (en) * | 2020-07-08 | 2024-10-30 | Georgia Tech Research Corporation | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF SARS-COV-2 VIRUS INFECTIONS |
| EP3943097A1 (en) | 2020-07-24 | 2022-01-26 | AB2 Bio SA | Car-t cell therapy |
| KR20220044057A (ko) * | 2020-09-29 | 2022-04-06 | 주식회사 에이프릴바이오 | 인터루킨-18 결합 단백질 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질, 및 이의 용도 |
| CA3201637A1 (en) | 2020-11-18 | 2022-05-27 | Novartis Ag | Bispecific antibodies for use in treatment of nlrc4-gof inflammasomapathy |
| US20240027460A1 (en) * | 2020-11-20 | 2024-01-25 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Immunomodulatory clinical biomarker profiles and uses thereof |
| JP7880582B2 (ja) | 2021-07-13 | 2026-06-26 | 国立大学法人東海国立大学機構 | 炎症性腸疾患を治療するための医薬組成物 |
| WO2023067348A1 (en) * | 2021-10-21 | 2023-04-27 | Biosirius Ltd | Treatment for virally-induced pneumonia |
| CN114236139A (zh) * | 2021-12-30 | 2022-03-25 | 苏州和锐生物科技有限公司 | 一种TNF-α生物制剂的抗体检测试剂盒、制备方法 |
| EP4486367A1 (en) | 2022-03-04 | 2025-01-08 | AB2 Bio SA | Il-18 binding protein (il-18bp) in the treatment of vexas |
| JP2026503002A (ja) | 2023-01-06 | 2026-01-27 | アレクトル エルエルシー | 抗il18結合タンパク質抗体及びその使用方法 |
| EP4646433A1 (en) | 2023-01-06 | 2025-11-12 | Lassen Therapeutics, Inc. | Anti-il-18bp antibodies |
| TW202434634A (zh) * | 2023-02-20 | 2024-09-01 | 大陸商瑞石生物醫藥有限公司 | 抗IL-18Rβ抗體、其抗原結合片段及其醫藥應用 |
| AU2024238511A1 (en) * | 2023-03-21 | 2025-10-02 | Coya Therapeutics, Inc. | Biomarkers of amyotrophic lateral sclerosis and uses thereof |
| WO2025253161A1 (en) * | 2024-06-05 | 2025-12-11 | Aprilbio Co., Ltd. | Methods for treating liver diseases using recombinant fusion proteins comprising interleukin-18-binding protein and antigen binding fragment to serum albumin |
| WO2026038145A1 (en) | 2024-08-13 | 2026-02-19 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) and methods of using same |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| GEP20002142B (en) | 1991-01-18 | 2000-06-25 | Amgen Inc | Method for Treatment and Prevention of TNF Mediated Diseases |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
| US5635599A (en) | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
| DE69526973T3 (de) | 1994-10-21 | 2010-01-07 | Innogenetics N.V. | Sequenzen von hepatitis-c-virus genotype 7, und deren verwendung als vorbeugende, therapeutische und diagnostische mittel |
| US5756662A (en) | 1995-03-14 | 1998-05-26 | Corixa Corporation | Compounds and methods for the detection of T. cruzi infection |
| IL121860A0 (en) | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| US7220717B2 (en) | 1997-08-14 | 2007-05-22 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use |
| SK12942002A3 (sk) | 2000-02-10 | 2003-05-02 | Abbott Laboratories | Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia |
| RS51737B (sr) * | 2000-02-21 | 2011-10-31 | Laboratoires Serono Sa. | Korišćenje inhibitora il-18 |
| CA2407895C (en) | 2000-05-05 | 2012-12-18 | Applied Research Systems Ars Holding N.V. | Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis |
| US20040198706A1 (en) | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| IL154751A0 (en) | 2000-08-03 | 2003-10-31 | Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals | |
| WO2002032374A2 (en) | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| IL157024A0 (en) | 2001-01-29 | 2004-02-08 | Applied Research Systems | Il-18 inhibitors in heart disease |
| BR0210904A (pt) * | 2001-05-16 | 2005-08-16 | Yeda Res & Dev | Uso de inibidores de il-18 para o tratamento ou prevenção de sepse |
| US7655616B2 (en) | 2001-05-25 | 2010-02-02 | Ares Trading S.A. | Use of IL-18 inhibitors for treating head injuries |
| GB0300531D0 (en) | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
| AU2004238524B2 (en) * | 2003-05-13 | 2011-06-23 | Merck Serono Sa | Active variants of the IL-18 binding protein and medical uses thereof |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| AU2011224023C1 (en) | 2003-11-12 | 2013-08-29 | Abbvie Inc. | IL-18 binding proteins |
| US20050100965A1 (en) * | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| JP4160615B2 (ja) | 2004-03-11 | 2008-10-01 | レドックス・バイオサイエンス株式会社 | プロテアーゼ阻害剤 |
| AU2005327198B2 (en) | 2004-07-09 | 2011-03-31 | University Of North Carolina At Chapel Hill | Viral adjuvants |
| ATE526057T1 (de) * | 2004-08-20 | 2011-10-15 | Glaxosmithkline Llc | Wundheilung durch verabreichung von menschlichem il-18 |
| CA2609060C (en) * | 2005-06-03 | 2014-07-15 | Urs Weber | Production of recombinant il-18 binding protein |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| WO2007030949A2 (en) | 2005-09-15 | 2007-03-22 | Val-Chum, S.E.C. | Methods of diagnosing ovarian cancer and kits therefor |
| EP2112923A1 (en) | 2007-01-22 | 2009-11-04 | Targacept Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| WO2008150431A1 (en) | 2007-05-29 | 2008-12-11 | Yale University | Il- 18 and protein kinase r inhibition for the treatment of copd |
| BR112013015508B1 (pt) * | 2010-12-20 | 2022-04-05 | Medimmune Limited | Molécula de anticorpo para il-18 humana, domínio vh isolado e domínio vl isolado, composição, uso de uma molécula de anticorpo ou do domínio vh isolado e do domínio vl isolado, molécula de ácido nucleico isolada, célula hospedeira procariótica recombinante, método para produzir um anticorpo, e método in vitro para medir il-18 em uma amostra de um indivíduo |
| US9376489B2 (en) * | 2012-09-07 | 2016-06-28 | Novartis Ag | IL-18 binding molecules |
| WO2015032932A1 (en) | 2013-09-05 | 2015-03-12 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) in inflammatory diseases |
| CN107660150B (zh) * | 2015-03-05 | 2023-10-24 | Ab2生物股份有限公司 | Il-18结合蛋白(il-18bp)和抗体在炎性疾病中 |
-
2014
- 2014-09-05 WO PCT/EP2014/069013 patent/WO2015032932A1/en not_active Ceased
- 2014-09-05 SG SG11201601717VA patent/SG11201601717VA/en unknown
- 2014-09-05 HU HUE14759210A patent/HUE055608T2/hu unknown
- 2014-09-05 KR KR1020167008846A patent/KR102321172B1/ko active Active
- 2014-09-05 DK DK14759210.9T patent/DK3041864T3/da active
- 2014-09-05 AU AU2014317035A patent/AU2014317035B2/en active Active
- 2014-09-05 EP EP14759210.9A patent/EP3041864B1/en active Active
- 2014-09-05 LT LTEPPCT/EP2014/069013T patent/LT3041864T/lt unknown
- 2014-09-05 NZ NZ717671A patent/NZ717671A/en unknown
- 2014-09-05 JP JP2016539564A patent/JP6820743B2/ja active Active
- 2014-09-05 PT PT14759210T patent/PT3041864T/pt unknown
- 2014-09-05 CN CN201480060413.7A patent/CN105722858A/zh active Pending
- 2014-09-05 CN CN202210945119.0A patent/CN115925928A/zh active Pending
- 2014-09-05 MX MX2016002719A patent/MX385868B/es unknown
- 2014-09-05 US US14/916,917 patent/US10858426B2/en active Active
- 2014-09-05 ES ES14759210T patent/ES2892923T3/es active Active
- 2014-09-05 KR KR1020217034984A patent/KR102512797B1/ko active Active
- 2014-09-05 EP EP21181013.0A patent/EP3978526A1/en active Pending
- 2014-09-05 PH PH1/2016/500425A patent/PH12016500425B1/en unknown
- 2014-09-05 UA UAA201603367A patent/UA125204C2/uk unknown
- 2014-09-05 SI SI201431879T patent/SI3041864T1/sl unknown
- 2014-09-05 RU RU2016112596A patent/RU2731713C2/ru active
- 2014-09-05 PL PL14759210T patent/PL3041864T3/pl unknown
-
2016
- 2016-02-17 IL IL244169A patent/IL244169B/en active IP Right Grant
- 2016-03-04 CL CL2016000506A patent/CL2016000506A1/es unknown
-
2019
- 2019-11-21 JP JP2019210436A patent/JP2020055821A/ja active Pending
-
2020
- 2020-05-26 US US16/883,735 patent/US11530263B2/en active Active
-
2021
- 2021-09-16 CY CY20211100816T patent/CY1124698T1/el unknown
-
2022
- 2022-11-14 US US18/054,936 patent/US20230250164A1/en active Pending
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