JP2016536332A5 - - Google Patents
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- JP2016536332A5 JP2016536332A5 JP2016539564A JP2016539564A JP2016536332A5 JP 2016536332 A5 JP2016536332 A5 JP 2016536332A5 JP 2016539564 A JP2016539564 A JP 2016539564A JP 2016539564 A JP2016539564 A JP 2016539564A JP 2016536332 A5 JP2016536332 A5 JP 2016536332A5
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- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- antibody
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13183193 | 2013-09-05 | ||
| EP13183193.5 | 2013-09-05 | ||
| PCT/EP2014/069013 WO2015032932A1 (en) | 2013-09-05 | 2014-09-05 | Il-18 binding protein (il-18bp) in inflammatory diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019210436A Division JP2020055821A (ja) | 2013-09-05 | 2019-11-21 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016536332A JP2016536332A (ja) | 2016-11-24 |
| JP2016536332A5 true JP2016536332A5 (enExample) | 2017-08-10 |
| JP6820743B2 JP6820743B2 (ja) | 2021-01-27 |
Family
ID=49111035
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539564A Active JP6820743B2 (ja) | 2013-09-05 | 2014-09-05 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
| JP2019210436A Pending JP2020055821A (ja) | 2013-09-05 | 2019-11-21 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019210436A Pending JP2020055821A (ja) | 2013-09-05 | 2019-11-21 | 炎症性疾患におけるil−18結合タンパク質(il−18bp) |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10858426B2 (enExample) |
| EP (2) | EP3041864B1 (enExample) |
| JP (2) | JP6820743B2 (enExample) |
| KR (2) | KR102512797B1 (enExample) |
| CN (2) | CN105722858A (enExample) |
| AU (1) | AU2014317035B2 (enExample) |
| CA (1) | CA2922498A1 (enExample) |
| CL (1) | CL2016000506A1 (enExample) |
| CY (1) | CY1124698T1 (enExample) |
| DK (1) | DK3041864T3 (enExample) |
| ES (1) | ES2892923T3 (enExample) |
| HU (1) | HUE055608T2 (enExample) |
| IL (1) | IL244169B (enExample) |
| LT (1) | LT3041864T (enExample) |
| MX (1) | MX385868B (enExample) |
| NZ (1) | NZ717671A (enExample) |
| PH (1) | PH12016500425B1 (enExample) |
| PL (1) | PL3041864T3 (enExample) |
| PT (1) | PT3041864T (enExample) |
| RU (1) | RU2731713C2 (enExample) |
| SG (1) | SG11201601717VA (enExample) |
| SI (1) | SI3041864T1 (enExample) |
| UA (1) | UA125204C2 (enExample) |
| WO (1) | WO2015032932A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2892923T3 (es) | 2013-09-05 | 2022-02-07 | Ab2 Bio Sa | Proteína de unión a IL-18 (IL-18BP) en enfermedades inflamatorias |
| EP3265807A1 (en) | 2015-03-05 | 2018-01-10 | AB2 Bio SA | Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases |
| US20180362660A1 (en) * | 2016-05-09 | 2018-12-20 | Schickwann Tsai | Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes |
| GB201614455D0 (en) * | 2016-08-24 | 2016-10-05 | Univ Oxford Innovation Ltd | Biomarkers |
| DE102016219607B4 (de) * | 2016-10-10 | 2025-04-30 | Siemens Healthineers Ag | Erzeugung einer mit anatomischen Bilddaten korrelierten Ergebniskarte |
| US11629183B2 (en) | 2017-12-29 | 2023-04-18 | University Of Florida Research Foundation, Inc. | Monoclonal antibodies targeting microtubule-binding domain of tau protein and methods of detecting tau protein in vivo |
| TWI679279B (zh) * | 2018-05-09 | 2019-12-11 | 臺中榮民總醫院 | 檢測成人發作型史笛兒氏症之罹病風險及預後之方法 |
| AU2019290099B2 (en) | 2018-06-19 | 2025-12-11 | Shanghaitech University | Human antibodies to human interleukin 18 receptor alpha and beta |
| EP3892300A4 (en) * | 2018-12-03 | 2022-12-14 | Mabprotein Co.,Ltd. | ANTIBODIES RECOGNIZING A NEO-EPITOPE OF ACTIVATED INTERLEUKIN-18 PROTEINS AND ASSOCIATED APPLICATION |
| CN110433289B (zh) * | 2019-09-10 | 2024-12-17 | 中山大学附属口腔医院 | 用于治疗牙周致病菌感染引起的牙周膜细胞功能紊乱与牙槽骨丧失的药物 |
| CA3158323A1 (en) * | 2019-11-04 | 2021-05-14 | Medimmune Limited | Methods of using il-33 antagonists |
| EP4146174A1 (en) * | 2020-05-06 | 2023-03-15 | AB2 Bio SA | Il-18 binding protein (il-18bp) in respiratory diseases |
| GB202007404D0 (en) * | 2020-05-19 | 2020-07-01 | Nasser Syed Muhammad Tahir | Treatment for viral respiratory infections |
| US20230242623A1 (en) * | 2020-07-08 | 2023-08-03 | Georgia Tech Research Corporation | Compositions and methods for the diagnosis and treatment of sars-cov-2 virus infection |
| EP3943097A1 (en) | 2020-07-24 | 2022-01-26 | AB2 Bio SA | Car-t cell therapy |
| KR20220044057A (ko) * | 2020-09-29 | 2022-04-06 | 주식회사 에이프릴바이오 | 인터루킨-18 결합 단백질 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질, 및 이의 용도 |
| JP2023549257A (ja) | 2020-11-18 | 2023-11-22 | ノバルティス アーゲー | Nlrc4-gofインフラマソーム病の処置における使用のための二特異性抗体 |
| EP4371573A4 (en) | 2021-07-13 | 2025-08-20 | National Univ Corporation Tokai National Higher Education And Research System | MEDICINAL COMPOSITION FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE |
| WO2023067348A1 (en) * | 2021-10-21 | 2023-04-27 | Biosirius Ltd | Treatment for virally-induced pneumonia |
| CN114236139A (zh) * | 2021-12-30 | 2022-03-25 | 苏州和锐生物科技有限公司 | 一种TNF-α生物制剂的抗体检测试剂盒、制备方法 |
| US20250179131A1 (en) | 2022-03-04 | 2025-06-05 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) in the treatment of vexas |
| WO2024148232A2 (en) | 2023-01-06 | 2024-07-11 | Alector Llc | Anti-il18 binding protein antibodies and methods of use thereof |
| AU2024206448A1 (en) | 2023-01-06 | 2025-08-21 | Lassen Therapeutics, Inc. | Anti-il-18bp antibodies |
| TW202434634A (zh) * | 2023-02-20 | 2024-09-01 | 大陸商瑞石生物醫藥有限公司 | 抗IL-18Rβ抗體、其抗原結合片段及其醫藥應用 |
| AU2024238511A1 (en) * | 2023-03-21 | 2025-10-02 | Coya Therapeutics, Inc. | Biomarkers of amyotrophic lateral sclerosis and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| KR100234520B1 (ko) | 1991-01-18 | 1999-12-15 | 그레고리 아보트 | 종양괴사인자 매개병 치료용 의약품 조성물 |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
| US5635599A (en) | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
| ES2176342T5 (es) | 1994-10-21 | 2010-02-09 | Innogenetics N.V. | Secuencias del genotipo 7 del virus de la hepatitis c y su utilizacion como agentes profilacticos, terapeuticos y de diagnosticos. |
| US5756662A (en) | 1995-03-14 | 1998-05-26 | Corixa Corporation | Compounds and methods for the detection of T. cruzi infection |
| US7220717B2 (en) | 1997-08-14 | 2007-05-22 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use |
| IL121860A0 (en) | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| EP2338515A3 (en) | 2000-02-10 | 2011-11-16 | Abbott Laboratories | Antibodies that bind human interleukin-18 and methods of making and using |
| RS51737B (sr) * | 2000-02-21 | 2011-10-31 | Laboratoires Serono Sa. | Korišćenje inhibitora il-18 |
| SI1278540T1 (sl) | 2000-05-05 | 2008-10-31 | Edicale Inserm Inst Nat De La | Uporaba inhibitorjev il-18 za zdravljenje in/ali preventivo ateroskleroze |
| US20040198706A1 (en) | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| MXPA03001915A (es) | 2000-08-03 | 2004-09-10 | Therapeutic Human Polyclonals | Produccion de anticuerpos humanizados en animales transgenicos. |
| AU2002224417A1 (en) | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| RS51125B (sr) * | 2001-01-29 | 2010-10-31 | Laboratoires Serono Sa. | Upotreba inhibitora il-18 za lečenje i/ili prevenciju srčanih oboljenja |
| ES2334773T3 (es) * | 2001-05-16 | 2010-03-16 | Yeda Research And Development Co. Ltd. | Uso de inhibidores de il-18 para el tratamiento o prevencion de la sepsis. |
| CN1305529C (zh) | 2001-05-25 | 2007-03-21 | 阿雷斯贸易股份有限公司 | Il-18抑制剂在治疗或预防中枢神经系统损伤中的应用 |
| GB0300531D0 (en) | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
| EP1622939B1 (en) * | 2003-05-13 | 2012-03-14 | Merck Serono SA | Active variants of the il-18 binding protein and medical uses thereof |
| US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| AU2011224023C1 (en) | 2003-11-12 | 2013-08-29 | Abbvie Inc. | IL-18 binding proteins |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| WO2005087249A1 (ja) | 2004-03-11 | 2005-09-22 | Kurume University | プロテアーゼ阻害剤及び疾患の予防又は治療剤 |
| EP1773403B1 (en) | 2004-07-09 | 2018-04-25 | The University of North Carolina At Chapel Hill | Alphavirus-based adjuvants |
| NZ552837A (en) | 2004-08-20 | 2009-09-25 | Smithkline Beecham Corp | Use of human IL-18 polypeptide for treating mucositis and diabetic ulcers |
| JP5199073B2 (ja) | 2005-06-03 | 2013-05-15 | アレス トレーディング ソシエテ アノニム | 組換えil−18結合タンパク質の生産 |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US7910318B2 (en) | 2005-09-15 | 2011-03-22 | The Royal Institution For The Advancement Of Learning/Mcgill University | Methods of diagnosing ovarian cancer and kits therefor |
| WO2008091588A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| EP2164517A4 (en) | 2007-05-29 | 2011-03-09 | Univ Yale | INHIBITION OF IL-18 AND PROTEIN KINASE R IN THE TREATMENT OF OBSTRUCTIVE CHRONIC BRONCHOPNEUMOPATHY |
| JP2014508511A (ja) | 2010-12-20 | 2014-04-10 | メドイミューン・リミテッド | 抗il−18抗体およびそれらの使用 |
| JOP20200308A1 (ar) * | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
| ES2892923T3 (es) | 2013-09-05 | 2022-02-07 | Ab2 Bio Sa | Proteína de unión a IL-18 (IL-18BP) en enfermedades inflamatorias |
| EP3265807A1 (en) * | 2015-03-05 | 2018-01-10 | AB2 Bio SA | Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases |
-
2014
- 2014-09-05 ES ES14759210T patent/ES2892923T3/es active Active
- 2014-09-05 LT LTEPPCT/EP2014/069013T patent/LT3041864T/lt unknown
- 2014-09-05 RU RU2016112596A patent/RU2731713C2/ru active
- 2014-09-05 JP JP2016539564A patent/JP6820743B2/ja active Active
- 2014-09-05 CN CN201480060413.7A patent/CN105722858A/zh active Pending
- 2014-09-05 KR KR1020217034984A patent/KR102512797B1/ko active Active
- 2014-09-05 AU AU2014317035A patent/AU2014317035B2/en active Active
- 2014-09-05 DK DK14759210.9T patent/DK3041864T3/da active
- 2014-09-05 EP EP14759210.9A patent/EP3041864B1/en active Active
- 2014-09-05 PL PL14759210T patent/PL3041864T3/pl unknown
- 2014-09-05 WO PCT/EP2014/069013 patent/WO2015032932A1/en not_active Ceased
- 2014-09-05 EP EP21181013.0A patent/EP3978526A1/en active Pending
- 2014-09-05 CA CA2922498A patent/CA2922498A1/en active Pending
- 2014-09-05 PH PH1/2016/500425A patent/PH12016500425B1/en unknown
- 2014-09-05 CN CN202210945119.0A patent/CN115925928A/zh active Pending
- 2014-09-05 HU HUE14759210A patent/HUE055608T2/hu unknown
- 2014-09-05 SG SG11201601717VA patent/SG11201601717VA/en unknown
- 2014-09-05 MX MX2016002719A patent/MX385868B/es unknown
- 2014-09-05 KR KR1020167008846A patent/KR102321172B1/ko active Active
- 2014-09-05 NZ NZ717671A patent/NZ717671A/en unknown
- 2014-09-05 PT PT14759210T patent/PT3041864T/pt unknown
- 2014-09-05 SI SI201431879T patent/SI3041864T1/sl unknown
- 2014-09-05 UA UAA201603367A patent/UA125204C2/uk unknown
- 2014-09-05 US US14/916,917 patent/US10858426B2/en active Active
-
2016
- 2016-02-17 IL IL244169A patent/IL244169B/en active IP Right Grant
- 2016-03-04 CL CL2016000506A patent/CL2016000506A1/es unknown
-
2019
- 2019-11-21 JP JP2019210436A patent/JP2020055821A/ja active Pending
-
2020
- 2020-05-26 US US16/883,735 patent/US11530263B2/en active Active
-
2021
- 2021-09-16 CY CY20211100816T patent/CY1124698T1/el unknown
-
2022
- 2022-11-14 US US18/054,936 patent/US20230250164A1/en active Pending
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