JP2016534984A - アフィニティークロマトグラフィーのためおよび治療薬の半減期の延長のための化合物 - Google Patents

アフィニティークロマトグラフィーのためおよび治療薬の半減期の延長のための化合物 Download PDF

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Publication number
JP2016534984A
JP2016534984A JP2016519325A JP2016519325A JP2016534984A JP 2016534984 A JP2016534984 A JP 2016534984A JP 2016519325 A JP2016519325 A JP 2016519325A JP 2016519325 A JP2016519325 A JP 2016519325A JP 2016534984 A JP2016534984 A JP 2016534984A
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substituted
unsubstituted
heteroaryl
aryl
alkyl
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Japanese (ja)
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JP2016534984A5 (OSRAM
Inventor
ピーター、クムパルメ
オリバー、ショーン
クリスティーヌ、パトリシア、ドナヒュー
ゴータス、エビンダー
デイビッド、アイ．イスラエル
デイビッド、パオレッラ
レティアン、クアイ
ニナド、ブイ．プラブー
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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Publication of JP2016534984A publication Critical patent/JP2016534984A/ja
Publication of JP2016534984A5 publication Critical patent/JP2016534984A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
JP2016519325A 2013-10-01 2014-10-01 アフィニティークロマトグラフィーのためおよび治療薬の半減期の延長のための化合物 Pending JP2016534984A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361885146P 2013-10-01 2013-10-01
US61/885,146 2013-10-01
US201462025994P 2014-07-17 2014-07-17
US62/025,994 2014-07-17
PCT/IB2014/064998 WO2015049651A1 (en) 2013-10-01 2014-10-01 Compounds for affinity chromatography and for extending the half-life of a therapeutic agent

Publications (2)

Publication Number Publication Date
JP2016534984A true JP2016534984A (ja) 2016-11-10
JP2016534984A5 JP2016534984A5 (OSRAM) 2017-11-16

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JP2016519325A Pending JP2016534984A (ja) 2013-10-01 2014-10-01 アフィニティークロマトグラフィーのためおよび治療薬の半減期の延長のための化合物

Country Status (12)

Country Link
US (2) US9809558B2 (OSRAM)
EP (1) EP3052483B1 (OSRAM)
JP (1) JP2016534984A (OSRAM)
KR (1) KR20160060660A (OSRAM)
CN (1) CN105593222B (OSRAM)
AU (1) AU2014330781B2 (OSRAM)
BR (1) BR112016007371A2 (OSRAM)
CA (1) CA2925862A1 (OSRAM)
ES (1) ES2721098T3 (OSRAM)
RU (1) RU2016117052A (OSRAM)
SG (1) SG11201601870VA (OSRAM)
WO (1) WO2015049651A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018181738A1 (ja) * 2017-03-30 2018-10-04 日立化成株式会社 分離材

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170066839A1 (en) 2015-09-08 2017-03-09 Merck Patent Gmbh Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies
US10697982B2 (en) 2015-09-08 2020-06-30 Merck Patent Gmbh Methods of evaluating quality of a chromatography media which binds anti-A or anti-B antibodies
US10697983B2 (en) 2015-09-08 2020-06-30 Merck Patent Gmbh Methods of evaluating quality of media suitable for removing anti-A or anti-B antibodies
JP7688395B2 (ja) * 2018-11-26 2025-06-04 ノース カロライナ ステイト ユニヴァーシティ 宿主細胞タンパク質の捕捉のためのペプチドリガンド
MX2021007444A (es) 2018-12-21 2021-08-05 Jiangsu Hengrui Medicine Co Proteina biespecifica.
HUE069128T2 (hu) 2019-12-06 2025-02-28 Vertex Pharma Szubsztituált tetrahidrofurán vegyületek mint nátriumcsatornák modulátorai
AU2022284886A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
WO2022266236A1 (en) 2021-06-18 2022-12-22 Aligos Therapeutics, Inc. Methods and compositions for targeting pd-l1
US12428427B2 (en) 2021-12-16 2025-09-30 Aligos Therapeutics, Inc. Methods and compositions for targeting PD-L1

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49112926A (OSRAM) * 1973-02-09 1974-10-28
JPH06340627A (ja) * 1993-04-07 1994-12-13 Otsuka Pharmaceut Co Ltd ピペリジン誘導体を有効成分とする末梢血管拡張剤および新規ピペリジン誘導体
JPH09511492A (ja) * 1994-02-03 1997-11-18 ザ ピコワー インスティテュート フォア メディカル リサーチ アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法
JP2003503390A (ja) * 1999-06-24 2003-01-28 スミスクライン ビーチャム パブリック リミテッド カンパニー アゾリルベンズアミドおよびアナログならびに骨粗鬆症を治療するためのそれらの使用
WO2004012736A1 (en) * 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
JP2005505530A (ja) * 2001-08-17 2005-02-24 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング アミノアルキル置換芳香族二環式化合物、それらの製造方法及び医薬としてのそれらの使用
WO2012017021A2 (en) * 2010-08-03 2012-02-09 Graffinity Pharmaceuticals Gmbh LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY
JP2013508327A (ja) * 2009-10-19 2013-03-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロペンタンカルボキサミド誘導体、このような化合物を含む薬物及びそれらの使用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722896A (en) 1981-01-26 1988-02-02 The Beth Israel Hospital Association Method for affinity purification of hybridoma antibodies
US5849874A (en) 1991-07-12 1998-12-15 Gist-Brocades, N.V. Process for the purification of serum albumin
NZ514403A (en) 1999-12-27 2002-10-25 Japan Tobacco Inc Fused-ring compounds and use thereof as drugs
GB2403222A (en) 2002-04-01 2004-12-29 Utah Ventures Ii L P Tissue-specific endothelial membrane proteins
US7777051B2 (en) 2003-05-13 2010-08-17 Icagen, Inc. Asymmetric benzimidazoles and related compounds as potassium channel modulators
EP2298770A1 (en) 2005-11-03 2011-03-23 ChemBridge Corporation Heterocyclic compounds as TrkA modulators
LT2459220T (lt) 2009-07-31 2020-12-28 Ascendis Pharma A/S Biologiškai suyrantys vandenyje netirpūs hidrogeliai polietilenglikolio pagrindu
WO2012020080A2 (en) 2010-08-12 2012-02-16 Graffinity Pharmaceuticals Gmbh LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY II
US9480751B2 (en) 2011-04-11 2016-11-01 Yeda Research And Development Co. Ltd. Albumin binding probes and drug conjugates thereof
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
EP2752426A1 (en) 2013-01-03 2014-07-09 Covagen AG Human serum albumin binding compounds and fusion proteins thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49112926A (OSRAM) * 1973-02-09 1974-10-28
JPH06340627A (ja) * 1993-04-07 1994-12-13 Otsuka Pharmaceut Co Ltd ピペリジン誘導体を有効成分とする末梢血管拡張剤および新規ピペリジン誘導体
JPH09511492A (ja) * 1994-02-03 1997-11-18 ザ ピコワー インスティテュート フォア メディカル リサーチ アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法
JP2003503390A (ja) * 1999-06-24 2003-01-28 スミスクライン ビーチャム パブリック リミテッド カンパニー アゾリルベンズアミドおよびアナログならびに骨粗鬆症を治療するためのそれらの使用
JP2005505530A (ja) * 2001-08-17 2005-02-24 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング アミノアルキル置換芳香族二環式化合物、それらの製造方法及び医薬としてのそれらの使用
WO2004012736A1 (en) * 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
JP2013508327A (ja) * 2009-10-19 2013-03-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロペンタンカルボキサミド誘導体、このような化合物を含む薬物及びそれらの使用
WO2012017021A2 (en) * 2010-08-03 2012-02-09 Graffinity Pharmaceuticals Gmbh LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ALHAMADSHEH, M. M. ET AL.: "Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity", SCIENCE TRANSLATIONAL MEDICINE, vol. 3(97), JPN6018027287, 2011, pages 1 - 17, ISSN: 0003838793 *
BORESKOV, Y. G. ET AL.: "Synthesis of fluorescent 3'-carbamoyl derivatives of thymidine", BIOORGANICHESKAYA KHIMIYA, vol. 21(10), JPN6018027289, 1995, pages 795 - 801, ISSN: 0003982788 *
CORBAL, C. ET AL.: "Identification of potential cellular targets of aloisine A by affinity chromatography", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, JPN6018027280, 2009, pages 5572 - 5582, ISSN: 0003982785 *
EL-NEZHAWY A O H; EL-NAEM S I; GALAL S A; EL-DIWANI H I; ABDEL SALAM O M E; BAIOMY A R; ET AL: "SYNTHESIS AND ANALGESIC ACTIVITY OF (2,3-DIPHENYL-1H-INDOL-5-YL)PIPERAZIN-1-YL METHANONE DERIVATIVES", PHARMACEUTICAL CHEMISTRY JOURNAL, vol. VOL:43, NR:1, JPN5016010416, 1 January 2009 (2009-01-01), pages 25 - 29, ISSN: 0003982793 *
EMMANUEL K. ET AL.: "New chemical tools for investigating human mitotic kinesin Eg5", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, JPN6018027286, 2007, pages 6474 - 6488, ISSN: 0003838792 *
GOKER, H. ET AL.: "Synthesis and antimicrobial activity of some new 2-phenyl-N-substituted carboxamido-1H-benzimidazole", ARCH. PHARM. MED. CHEM., vol. 334, JPN6018027282, 2001, pages 148 - 152, ISSN: 0003982786 *
HANS FRISCHKORN; ERICH SCHINZEL; ET AL: "NAPHTHYLENDI(HETEROARENE), III. SYNTHESE UND SPEKTROSKOPISCHES VERHALTEN 以下備考", LIEBIGS ANNALEN DER CHEMIE, vol. VOL:1984, NR:6, JPN5016010413, 12 June 1984 (1984-06-12), pages 1129 - 1136, ISSN: 0003982789 *
KUS, C. ET AL.: "Antioxidant and antifungal properties of benzimidazole derivatives", Z. NATURFORSCH., vol. 65c, JPN6018027291, 2010, pages 537 - 542, ISSN: 0003838794 *
MADHURI DASARI; SUNGMUN LEE; JAY SY; DONGIN KIM; SEUNGJUN LEE; MILTON BROWN; MICHAEL DAVIS; ET AL: "HOECHST-IR: AN IMAGING AGENT THAT DETECTS NECROTIC TISSUE IN VIVO BY BINDING EXTRACELLULAR DNA", ORGANIC LETTERS, vol. VOL:12, NR:15, JPN5016010414, 6 August 2010 (2010-08-06), pages 3300 - 3303, ISSN: 0003982790 *
ROB HOEN; EVA MARIA NOVOA; ALBA LPEZ; NOELIA CAMACHO; LAIA CUBELLS; PEDRO VIEIRA; ET AL: "SELECTIVE INHIBITION OF AN APICOPLASTIC AMINOACYL-TRNA SYNTHETASE FROM PLASMODIUM FALCIPARUM", CHEMBIOCHEM, vol. VOL:14, NR:4, JPN5016010415, 4 March 2013 (2013-03-04), pages 499 - 509, ISSN: 0003982792 *
SAGNOU, M. ET AL.: "A Phenylbenzothiazole Conjugate with the Tricarbonyl fac-[M(I)(CO)3]+ (M=Re, 99Tc, 99mTc) Core for I", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, JPN6018027284, 2012, pages 4279 - 4286, ISSN: 0003982787 *
SHINSUKE SANDO; ATSUSHI NARITA; MASAYOSHI HAYAMI; YASUHIRO AOYAMA; ET AL: "TRANSCRIPTION MONITORING USING FUSED RNA WITH A DYE-BINDING LIGHT-UP APTAMER AS A TAG: 以下備考", CHEMICAL COMMUNICATIONS, vol. NR:33, JPN5016010412, 1 January 2008 (2008-01-01), pages 3858, ISSN: 0003982791 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018181738A1 (ja) * 2017-03-30 2018-10-04 日立化成株式会社 分離材
JPWO2018181738A1 (ja) * 2017-03-30 2020-02-13 日立化成株式会社 分離材

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US9809558B2 (en) 2017-11-07
EP3052483A1 (en) 2016-08-10
CA2925862A1 (en) 2015-04-09
AU2014330781A1 (en) 2016-04-07
CN105593222B (zh) 2018-02-09
CN105593222A (zh) 2016-05-18
US9938243B2 (en) 2018-04-10
US20160221962A1 (en) 2016-08-04
WO2015049651A1 (en) 2015-04-09
AU2014330781B2 (en) 2017-05-04
SG11201601870VA (en) 2016-04-28
RU2016117052A3 (OSRAM) 2018-06-27
US20170369448A1 (en) 2017-12-28
RU2016117052A (ru) 2017-11-10
BR112016007371A2 (pt) 2017-08-01
ES2721098T3 (es) 2019-07-26
KR20160060660A (ko) 2016-05-30
EP3052483B1 (en) 2019-02-06

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