JP2016534039A5 - - Google Patents

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Publication number
JP2016534039A5
JP2016534039A5 JP2016521270A JP2016521270A JP2016534039A5 JP 2016534039 A5 JP2016534039 A5 JP 2016534039A5 JP 2016521270 A JP2016521270 A JP 2016521270A JP 2016521270 A JP2016521270 A JP 2016521270A JP 2016534039 A5 JP2016534039 A5 JP 2016534039A5
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JP
Japan
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composition
item
cancer
immunoconjugate
seq
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JP2016521270A
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English (en)
Japanese (ja)
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JP2016534039A (ja
JP6463744B2 (ja
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Priority claimed from PCT/US2014/059716 external-priority patent/WO2015054400A2/en
Publication of JP2016534039A publication Critical patent/JP2016534039A/ja
Publication of JP2016534039A5 publication Critical patent/JP2016534039A5/ja
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Publication of JP6463744B2 publication Critical patent/JP6463744B2/ja
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JP2016521270A 2013-10-08 2014-10-08 抗folr1免疫抱合体投薬レジメン Active JP6463744B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361888337P 2013-10-08 2013-10-08
US201361888365P 2013-10-08 2013-10-08
US61/888,365 2013-10-08
US61/888,337 2013-10-08
US201461948363P 2014-03-05 2014-03-05
US61/948,363 2014-03-05
US201462004815P 2014-05-29 2014-05-29
US62/004,815 2014-05-29
PCT/US2014/059716 WO2015054400A2 (en) 2013-10-08 2014-10-08 Anti-folr1 immunoconjugate dosing regimens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018208158A Division JP6581279B2 (ja) 2013-10-08 2018-11-05 抗folr1免疫抱合体投薬レジメン

Publications (3)

Publication Number Publication Date
JP2016534039A JP2016534039A (ja) 2016-11-04
JP2016534039A5 true JP2016534039A5 (enExample) 2017-11-16
JP6463744B2 JP6463744B2 (ja) 2019-02-06

Family

ID=52813740

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2016521270A Active JP6463744B2 (ja) 2013-10-08 2014-10-08 抗folr1免疫抱合体投薬レジメン
JP2018208158A Active JP6581279B2 (ja) 2013-10-08 2018-11-05 抗folr1免疫抱合体投薬レジメン
JP2019156399A Withdrawn JP2019218386A (ja) 2013-10-08 2019-08-29 抗folr1免疫抱合体投薬レジメン
JP2021125147A Active JP7386208B2 (ja) 2013-10-08 2021-07-30 抗folr1免疫抱合体投薬レジメン
JP2023192883A Pending JP2024016239A (ja) 2013-10-08 2023-11-13 抗folr1免疫抱合体投薬レジメン

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2018208158A Active JP6581279B2 (ja) 2013-10-08 2018-11-05 抗folr1免疫抱合体投薬レジメン
JP2019156399A Withdrawn JP2019218386A (ja) 2013-10-08 2019-08-29 抗folr1免疫抱合体投薬レジメン
JP2021125147A Active JP7386208B2 (ja) 2013-10-08 2021-07-30 抗folr1免疫抱合体投薬レジメン
JP2023192883A Pending JP2024016239A (ja) 2013-10-08 2023-11-13 抗folr1免疫抱合体投薬レジメン

Country Status (29)

Country Link
US (3) US20150132323A1 (enExample)
EP (3) EP4424323A3 (enExample)
JP (5) JP6463744B2 (enExample)
KR (7) KR20240027861A (enExample)
CN (1) CN106164093A (enExample)
AU (4) AU2014331964C1 (enExample)
BR (1) BR112016007479A2 (enExample)
CA (1) CA2926325C (enExample)
CY (2) CY1122449T1 (enExample)
DK (2) DK3055332T3 (enExample)
ES (2) ES2759426T3 (enExample)
FI (1) FI3653228T3 (enExample)
HR (2) HRP20240917T1 (enExample)
HU (2) HUE067367T2 (enExample)
IL (4) IL298044B2 (enExample)
LT (2) LT3055332T (enExample)
MX (2) MX384973B (enExample)
MY (1) MY174670A (enExample)
NZ (2) NZ757964A (enExample)
PL (2) PL3653228T3 (enExample)
PT (2) PT3653228T (enExample)
RS (2) RS65798B1 (enExample)
RU (1) RU2696579C2 (enExample)
SG (3) SG11201602361UA (enExample)
SI (2) SI3653228T1 (enExample)
SM (1) SMT201900694T1 (enExample)
UA (1) UA119541C2 (enExample)
WO (1) WO2015054400A2 (enExample)
ZA (1) ZA201902009B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR080301A1 (es) 2010-02-24 2012-03-28 Immunogen Inc Anticuerpos e inmunoconjugados del receptor 1 de folato y sus usos
PL2694106T3 (pl) 2011-04-01 2018-06-29 Immunogen, Inc. Sposoby zwiększania skuteczności terapii przeciwnowotworowej opartej na receptorze folr1
KR20150046316A (ko) 2012-08-31 2015-04-29 이뮤노젠 아이엔씨 엽산 수용체 1의 검출을 위한 진단성 검정 및 키트
CN119185571A (zh) * 2013-05-14 2024-12-27 伊缪诺金公司 抗folr1免疫缀合物给药方案
PT3038650T (pt) 2013-08-30 2021-08-25 Immunogen Inc Anticorpos e ensaios para a deteção do recetor de folato 1
JP6880006B2 (ja) * 2015-09-17 2021-06-02 イミュノジェン, インコーポレイテッド 抗folr1免疫複合体を含む治療組み合わせ
MX2019013753A (es) * 2017-05-16 2020-07-20 Immunogen Inc Combinaciones de inmunoconjugados anti-folr1 y anticuerpo anti-pd-1.
CN111655726B (zh) 2017-09-18 2024-06-21 苏特罗生物制药公司 抗叶酸受体α抗体偶联物和其用途
CN115925952A (zh) 2018-03-13 2023-04-07 东莞凡恩世生物医药有限公司 抗叶酸受体1抗体及其用途
JP7623939B2 (ja) 2018-07-09 2025-01-29 マルチチュード インコーポレーテッド 葉酸受容体アルファに特異的な抗体
CN114222756A (zh) 2019-04-29 2022-03-22 伊缪诺金公司 双互补位FR-α抗体和免疫缀合物
EP4347661A4 (en) * 2021-06-04 2025-06-18 ImmunoGen, Inc. TREATMENT OF CANCER IN PATIENTS WITH SOLUBLE FR-ALPHA
WO2023102077A1 (en) * 2021-12-01 2023-06-08 Sutro Biopharma, Inc. Anti-folate receptor conjugate cancer therapy
CN116333135A (zh) * 2021-12-24 2023-06-27 百奥泰生物制药股份有限公司 抗FRα抗体及其抗体药物偶联物和用途

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896111A (en) 1973-02-20 1975-07-22 Research Corp Ansa macrolides
US4307016A (en) 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
US4256746A (en) 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
JPS55102583A (en) 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
EP0028683A1 (en) 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHO and production thereof
JPS5645485A (en) 1979-09-21 1981-04-25 Takeda Chem Ind Ltd Production of c-15003pnd
WO1982001188A1 (en) 1980-10-08 1982-04-15 Takeda Chemical Industries Ltd 4,5-deoxymaytansinoide compounds and process for preparing same
US4450254A (en) 1980-11-03 1984-05-22 Standard Oil Company Impact improvement of high nitrile resins
US4313946A (en) 1981-01-27 1982-02-02 The United States Of America As Represented By The Secretary Of Agriculture Chemotherapeutically active maytansinoids from Trewia nudiflora
US4315929A (en) 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
US4563304A (en) 1981-02-27 1986-01-07 Pharmacia Fine Chemicals Ab Pyridine compounds modifying proteins, polypeptides or polysaccharides
JPS57192389A (en) 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6100064A (en) 1984-04-06 2000-08-08 Chiron Corporation Secreted viral proteins useful for vaccines and diagnostics
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2113940T3 (es) 1990-12-03 1998-05-16 Genentech Inc Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
PT1696031E (pt) 1991-12-02 2010-06-25 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
CA2076465C (en) 1992-03-25 2002-11-26 Ravi V. J. Chari Cell binding agent conjugates of analogues and derivatives of cc-1065
US6696248B1 (en) 1995-08-18 2004-02-24 Morphosys Ag Protein/(poly)peptide libraries
ATE219517T1 (de) 1995-08-18 2002-07-15 Morphosys Ag Protein-/(poly)peptidbibliotheken
JP2002514193A (ja) * 1996-11-15 2002-05-14 バクスター、インターナショナル、インコーポレイテッド 同種幹細胞移植のためのコンディショニング
ATE482275T1 (de) 1999-07-02 2010-10-15 Morphosys Ag Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US20020151508A1 (en) * 2001-02-09 2002-10-17 Schering Corporation Methods for treating proliferative diseases
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US6716821B2 (en) 2001-12-21 2004-04-06 Immunogen Inc. Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
GB0202319D0 (en) 2002-02-01 2002-03-20 Calex Electronics Ltd Apparatus
WO2004082463A2 (en) * 2003-03-17 2004-09-30 Medical College Of Ohio Folate receptor gene modulation for cancer diagnosis and therapy
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
AU2005279347A1 (en) 2004-08-30 2006-03-09 Lonza Biologics Plc. Affinity- plus ion exchange- chromatography for purifying antibodies
WO2006105141A1 (en) * 2005-03-30 2006-10-05 Purdue Research Foundation Method for cancer prognosis using cellular folate vitamin receptor quantification
US20090162374A1 (en) * 2005-09-14 2009-06-25 Geraghty Daniel E Specific removal of activated immune cells
EP1900752A1 (en) * 2006-09-15 2008-03-19 DOMPE' pha.r.ma s.p.a. Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US8093364B2 (en) 2008-01-18 2012-01-10 Bio-Rad Laboratories, Inc. Enhanced purification of antibodies and antibody fragments by apatite chromatography
WO2009094456A2 (en) * 2008-01-22 2009-07-30 Johns Hopkins University Use of high-dose, post-transplantation oxazaphosphorine drugs for reduction of transplant rejection
EP2281006B1 (en) 2008-04-30 2017-08-02 Immunogen, Inc. Cross-linkers and their uses
RU2487877C2 (ru) 2008-04-30 2013-07-20 Иммьюноджен, Инк. Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры)
EP2378876B1 (en) * 2008-12-19 2018-11-14 Medicis Pharmaceutical Corporation Lower dosage strength imiquimod formulations and short dosing regimens for treating actinic keratosis
CA2775806A1 (en) * 2009-10-21 2011-04-28 Immunogen, Inc. Novel dosing regimen and method of treatment
AR080301A1 (es) * 2010-02-24 2012-03-28 Immunogen Inc Anticuerpos e inmunoconjugados del receptor 1 de folato y sus usos
US8530122B2 (en) 2010-07-30 2013-09-10 Konica Minolta Business Technologies, Inc. Foil transferring face forming toner and image forming method
US20120207771A1 (en) * 2010-11-05 2012-08-16 Morphotek Inc. Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
PL2694106T3 (pl) * 2011-04-01 2018-06-29 Immunogen, Inc. Sposoby zwiększania skuteczności terapii przeciwnowotworowej opartej na receptorze folr1
US20120282282A1 (en) 2011-04-04 2012-11-08 Immunogen, Inc. Methods for Decreasing Ocular Toxicity of Antibody Drug Conjugates
KR20150046316A (ko) * 2012-08-31 2015-04-29 이뮤노젠 아이엔씨 엽산 수용체 1의 검출을 위한 진단성 검정 및 키트
EP2983654B1 (en) * 2013-04-08 2025-11-12 BPGbio, Inc. Treatment of cancer using coenzyme q10 combination therapies
CN119185571A (zh) * 2013-05-14 2024-12-27 伊缪诺金公司 抗folr1免疫缀合物给药方案
PT3038650T (pt) * 2013-08-30 2021-08-25 Immunogen Inc Anticorpos e ensaios para a deteção do recetor de folato 1
JP6880006B2 (ja) * 2015-09-17 2021-06-02 イミュノジェン, インコーポレイテッド 抗folr1免疫複合体を含む治療組み合わせ

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