JP2019031568A5 - - Google Patents
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- JP2019031568A5 JP2019031568A5 JP2018208158A JP2018208158A JP2019031568A5 JP 2019031568 A5 JP2019031568 A5 JP 2019031568A5 JP 2018208158 A JP2018208158 A JP 2018208158A JP 2018208158 A JP2018208158 A JP 2018208158A JP 2019031568 A5 JP2019031568 A5 JP 2019031568A5
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- Prior art keywords
- composition
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- antibody
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940127121 immunoconjugate Drugs 0.000 claims 9
- 102100035139 Folate receptor alpha Human genes 0.000 claims 7
- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 239000013612 plasmid Substances 0.000 claims 4
- 238000010186 staining Methods 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 230000037396 body weight Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- FUHCFUVCWLZEDQ-UHFFFAOYSA-N 1-(2,5-dioxopyrrolidin-1-yl)oxy-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid Chemical compound O=C1CCC(=O)N1OC(=O)C(S(=O)(=O)O)CCSSC1=CC=CC=N1 FUHCFUVCWLZEDQ-UHFFFAOYSA-N 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 238000003364 immunohistochemistry Methods 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 231100000419 toxicity Toxicity 0.000 claims 2
- 230000001988 toxicity Effects 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 206010061137 Ocular toxicity Diseases 0.000 claims 1
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 claims 1
- 206010044245 Toxic optic neuropathy Diseases 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 231100000327 ocular toxicity Toxicity 0.000 claims 1
- 201000002628 peritoneum cancer Diseases 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361888365P | 2013-10-08 | 2013-10-08 | |
| US201361888337P | 2013-10-08 | 2013-10-08 | |
| US61/888,337 | 2013-10-08 | ||
| US61/888,365 | 2013-10-08 | ||
| US201461948363P | 2014-03-05 | 2014-03-05 | |
| US61/948,363 | 2014-03-05 | ||
| US201462004815P | 2014-05-29 | 2014-05-29 | |
| US62/004,815 | 2014-05-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521270A Division JP6463744B2 (ja) | 2013-10-08 | 2014-10-08 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019156399A Division JP2019218386A (ja) | 2013-10-08 | 2019-08-29 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019031568A JP2019031568A (ja) | 2019-02-28 |
| JP2019031568A5 true JP2019031568A5 (enExample) | 2019-08-08 |
| JP6581279B2 JP6581279B2 (ja) | 2019-09-25 |
Family
ID=52813740
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521270A Active JP6463744B2 (ja) | 2013-10-08 | 2014-10-08 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
| JP2018208158A Active JP6581279B2 (ja) | 2013-10-08 | 2018-11-05 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
| JP2019156399A Withdrawn JP2019218386A (ja) | 2013-10-08 | 2019-08-29 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
| JP2021125147A Active JP7386208B2 (ja) | 2013-10-08 | 2021-07-30 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
| JP2023192883A Pending JP2024016239A (ja) | 2013-10-08 | 2023-11-13 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521270A Active JP6463744B2 (ja) | 2013-10-08 | 2014-10-08 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019156399A Withdrawn JP2019218386A (ja) | 2013-10-08 | 2019-08-29 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
| JP2021125147A Active JP7386208B2 (ja) | 2013-10-08 | 2021-07-30 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
| JP2023192883A Pending JP2024016239A (ja) | 2013-10-08 | 2023-11-13 | 抗ｆｏｌｒ１免疫抱合体投薬レジメン |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US20150132323A1 (enExample) |
| EP (3) | EP4424323A3 (enExample) |
| JP (5) | JP6463744B2 (enExample) |
| KR (7) | KR20240027861A (enExample) |
| CN (1) | CN106164093A (enExample) |
| AU (4) | AU2014331964C1 (enExample) |
| BR (1) | BR112016007479A2 (enExample) |
| CA (1) | CA2926325C (enExample) |
| CY (1) | CY1122449T1 (enExample) |
| DK (2) | DK3055332T3 (enExample) |
| ES (2) | ES2983055T3 (enExample) |
| FI (1) | FI3653228T3 (enExample) |
| HR (2) | HRP20192140T1 (enExample) |
| HU (2) | HUE046696T2 (enExample) |
| IL (4) | IL313730A (enExample) |
| LT (2) | LT3055332T (enExample) |
| MX (2) | MX384973B (enExample) |
| MY (1) | MY174670A (enExample) |
| NZ (2) | NZ757964A (enExample) |
| PL (2) | PL3055332T3 (enExample) |
| PT (2) | PT3653228T (enExample) |
| RS (2) | RS65798B1 (enExample) |
| RU (1) | RU2696579C2 (enExample) |
| SG (3) | SG10201907042PA (enExample) |
| SI (2) | SI3653228T1 (enExample) |
| SM (1) | SMT201900694T1 (enExample) |
| UA (1) | UA119541C2 (enExample) |
| WO (1) | WO2015054400A2 (enExample) |
| ZA (1) | ZA201902009B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201700139T1 (it) | 2010-02-24 | 2017-05-08 | Immunogen Inc | Immunoconiugati contro il recettore 1 del folato e relativi usi |
| CN114441757A (zh) * | 2011-04-01 | 2022-05-06 | 伊缪诺金公司 | 用于增加folr1癌症治疗的功效的方法 |
| MX362514B (es) | 2012-08-31 | 2019-01-22 | Immunogen Inc | Kits y ensayos de diagnostico para la deteccion del receptor 1 de folato. |
| KR20240068778A (ko) * | 2013-05-14 | 2024-05-17 | 이뮤노젠 아이엔씨 | 항-folr1 면역접합체 투약 섭생 |
| SG11201601037YA (en) | 2013-08-30 | 2016-03-30 | Immunogen Inc | Antibodies and assays for detection of folate receptor 1 |
| JP6880006B2 (ja) | 2015-09-17 | 2021-06-02 | イミュノジェン， インコーポレイテッド | 抗ｆｏｌｒ１免疫複合体を含む治療組み合わせ |
| BR112019023909A8 (pt) * | 2017-05-16 | 2023-04-11 | Immunogen Inc | Uso de um imunoconjugado que se liga a folr1, e, uso de um imunoconjugado que se liga a folr1 e pembrolizumab |
| AU2018333945B2 (en) | 2017-09-18 | 2025-06-12 | Sutro Biopharma, Inc. | Anti- folate receptor alpha antibody conjugates and their uses |
| WO2019177854A1 (en) | 2018-03-13 | 2019-09-19 | Phanes Therapeutics, Inc. | Anti-folate receptor 1 antibodies and uses thereof |
| JP7623939B2 (ja) | 2018-07-09 | 2025-01-29 | マルチチュード インコーポレーテッド | 葉酸受容体アルファに特異的な抗体 |
| KR20220004687A (ko) | 2019-04-29 | 2022-01-11 | 이뮤노젠 아이엔씨 | 이중파라토프 fr-알파 항체 및 면역접합체 |
| US20240226312A1 (en) * | 2021-06-04 | 2024-07-11 | Immunogen, Inc. | Treatment of cancer in patients with soluble fr-alpha |
| EP4440625A1 (en) * | 2021-12-01 | 2024-10-09 | Sutro Biopharma, Inc. | Anti-folate receptor conjugate cancer therapy |
| EP4455164A1 (en) * | 2021-12-24 | 2024-10-30 | Bio-Thera Solutions, Ltd. | ANTI-FRalpha ANTIBODY, AND ANTIBODY-DRUG CONJUGATE AND USE THEREOF |
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| US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
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| MX362514B (es) * | 2012-08-31 | 2019-01-22 | Immunogen Inc | Kits y ensayos de diagnostico para la deteccion del receptor 1 de folato. |
| EA032775B1 (ru) * | 2013-04-08 | 2019-07-31 | Берг Ллк | Способы лечения злокачественной опухоли с использованием комбинированной терапии с коферментом q10 |
| KR20240068778A (ko) * | 2013-05-14 | 2024-05-17 | 이뮤노젠 아이엔씨 | 항-folr1 면역접합체 투약 섭생 |
| SG11201601037YA (en) * | 2013-08-30 | 2016-03-30 | Immunogen Inc | Antibodies and assays for detection of folate receptor 1 |
| JP6880006B2 (ja) * | 2015-09-17 | 2021-06-02 | イミュノジェン， インコーポレイテッド | 抗ｆｏｌｒ１免疫複合体を含む治療組み合わせ |
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2014
- 2014-10-08 SG SG10201907042PA patent/SG10201907042PA/en unknown
- 2014-10-08 WO PCT/US2014/059716 patent/WO2015054400A2/en not_active Ceased
- 2014-10-08 MY MYPI2016000551A patent/MY174670A/en unknown
- 2014-10-08 NZ NZ757964A patent/NZ757964A/en unknown
- 2014-10-08 HU HUE14852834A patent/HUE046696T2/hu unknown
- 2014-10-08 KR KR1020247005572A patent/KR20240027861A/ko active Pending
- 2014-10-08 HU HUE19199163A patent/HUE067367T2/hu unknown
- 2014-10-08 UA UAA201604168A patent/UA119541C2/uk unknown
- 2014-10-08 ES ES19199163T patent/ES2983055T3/es active Active
- 2014-10-08 SM SM20190694T patent/SMT201900694T1/it unknown
- 2014-10-08 LT LTEP14852834.2T patent/LT3055332T/lt unknown
- 2014-10-08 ES ES14852834T patent/ES2759426T3/es active Active
- 2014-10-08 LT LTEP19199163.7T patent/LT3653228T/lt unknown
- 2014-10-08 PL PL14852834T patent/PL3055332T3/pl unknown
- 2014-10-08 RS RS20240830A patent/RS65798B1/sr unknown
- 2014-10-08 BR BR112016007479A patent/BR112016007479A2/pt not_active Application Discontinuation
- 2014-10-08 KR KR1020207014364A patent/KR20200058592A/ko not_active Ceased
- 2014-10-08 KR KR1020227033036A patent/KR20220136468A/ko not_active Ceased
- 2014-10-08 DK DK14852834T patent/DK3055332T3/da active
- 2014-10-08 KR KR1020217010200A patent/KR102303874B1/ko active Active
- 2014-10-08 SI SI201432085T patent/SI3653228T1/sl unknown
- 2014-10-08 EP EP24170072.3A patent/EP4424323A3/en not_active Withdrawn
- 2014-10-08 US US14/509,809 patent/US20150132323A1/en active Pending
- 2014-10-08 SI SI201431419T patent/SI3055332T1/sl unknown
- 2014-10-08 PT PT191991637T patent/PT3653228T/pt unknown
- 2014-10-08 SG SG10202102555TA patent/SG10202102555TA/en unknown
- 2014-10-08 RS RS20191523A patent/RS59644B1/sr unknown
- 2014-10-08 FI FIEP19199163.7T patent/FI3653228T3/fi active
- 2014-10-08 SG SG11201602361UA patent/SG11201602361UA/en unknown
- 2014-10-08 EP EP19199163.7A patent/EP3653228B1/en active Active
- 2014-10-08 KR KR1020167012025A patent/KR102115217B1/ko active Active
- 2014-10-08 EP EP14852834.2A patent/EP3055332B1/en active Active
- 2014-10-08 HR HRP20192140TT patent/HRP20192140T1/hr unknown
- 2014-10-08 HR HRP20240917TT patent/HRP20240917T1/hr unknown
- 2014-10-08 CA CA2926325A patent/CA2926325C/en active Active
- 2014-10-08 PL PL19199163.7T patent/PL3653228T3/pl unknown
- 2014-10-08 NZ NZ718766A patent/NZ718766A/en unknown
- 2014-10-08 DK DK19199163.7T patent/DK3653228T3/da active
- 2014-10-08 KR KR1020237034405A patent/KR102639861B1/ko active Active
- 2014-10-08 JP JP2016521270A patent/JP6463744B2/ja active Active
- 2014-10-08 IL IL313730A patent/IL313730A/en unknown
- 2014-10-08 CN CN201480055444.3A patent/CN106164093A/zh active Pending
- 2014-10-08 AU AU2014331964A patent/AU2014331964C1/en active Active
- 2014-10-08 IL IL298044A patent/IL298044B2/en unknown
- 2014-10-08 KR KR1020217029508A patent/KR20210118220A/ko not_active Ceased
- 2014-10-08 RU RU2016114708A patent/RU2696579C2/ru active
- 2014-10-08 MX MX2016004411A patent/MX384973B/es unknown
- 2014-10-08 PT PT148528342T patent/PT3055332T/pt unknown
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2016
- 2016-03-27 IL IL244772A patent/IL244772B/en active IP Right Grant
- 2016-04-06 MX MX2021009222A patent/MX2021009222A/es unknown
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2018
- 2018-11-05 JP JP2018208158A patent/JP6581279B2/ja active Active
- 2018-12-11 AU AU2018278880A patent/AU2018278880A1/en not_active Abandoned
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2019
- 2019-03-24 IL IL265586A patent/IL265586A/en unknown
- 2019-03-28 ZA ZA2019/02009A patent/ZA201902009B/en unknown
- 2019-08-29 JP JP2019156399A patent/JP2019218386A/ja not_active Withdrawn
- 2019-12-02 CY CY20191101260T patent/CY1122449T1/el unknown
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2020
- 2020-11-03 AU AU2020264270A patent/AU2020264270B2/en active Active
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2021
- 2021-01-15 US US17/150,379 patent/US20210155688A1/en not_active Abandoned
- 2021-07-30 JP JP2021125147A patent/JP7386208B2/ja active Active
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2023
- 2023-11-13 JP JP2023192883A patent/JP2024016239A/ja active Pending
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2024
- 2024-03-12 AU AU2024201615A patent/AU2024201615A1/en active Pending
- 2024-04-12 US US18/634,736 patent/US20240368270A1/en active Pending
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