JP2023534292A5 - - Google Patents
Info
- Publication number
- JP2023534292A5 JP2023534292A5 JP2023503070A JP2023503070A JP2023534292A5 JP 2023534292 A5 JP2023534292 A5 JP 2023534292A5 JP 2023503070 A JP2023503070 A JP 2023503070A JP 2023503070 A JP2023503070 A JP 2023503070A JP 2023534292 A5 JP2023534292 A5 JP 2023534292A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- cancer
- immune complex
- showed
- jimt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2020-0088005 | 2020-07-16 | ||
| KR20200088005 | 2020-07-16 | ||
| KR10-2021-0060721 | 2021-05-11 | ||
| KR1020210060721A KR102349925B1 (ko) | 2020-07-16 | 2021-05-11 | Fl118 약물을 포함하는 화합물 및 이를 이용한 면역접합체 |
| PCT/KR2021/009204 WO2022015110A1 (ko) | 2020-07-16 | 2021-07-16 | Fl118 약물이 산 민감성 링커에 연결된 접합체 및 이를 이용한 면역접합체 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023534292A JP2023534292A (ja) | 2023-08-08 |
| JP2023534292A5 true JP2023534292A5 (enExample) | 2023-09-28 |
| JP7660186B2 JP7660186B2 (ja) | 2025-04-10 |
Family
ID=79339522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023503070A Active JP7660186B2 (ja) | 2020-07-16 | 2021-07-16 | Ｆｌ１１８薬物が酸感受性リンカーに結合された複合体及びそれを用いた免疫複合体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230270867A1 (enExample) |
| EP (1) | EP4183418A4 (enExample) |
| JP (1) | JP7660186B2 (enExample) |
| KR (3) | KR102349925B1 (enExample) |
| CN (1) | CN116075321A (enExample) |
| AU (1) | AU2021308834A1 (enExample) |
| CA (1) | CA3189462A1 (enExample) |
| WO (1) | WO2022015110A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230155992A (ko) * | 2022-05-04 | 2023-11-13 | 주식회사 피노바이오 | Ddx5 단백질에 결합하는 캄토테신계 약물이 산 민감성 링커에 연결된 접합체 및 이를 이용한 면역접합체 |
| EP4538276A1 (en) * | 2022-07-11 | 2025-04-16 | Pinotbio, Inc. | Ddx5 protein-binding camptothecin derivatives and prodrugs thereof |
| JP2025529237A (ja) | 2022-08-30 | 2025-09-04 | ピノットバイオ インコーポレイテッド | カンプトセシン系薬物が抗原結合親和性の低い抗体にリンカーを介して連結された抗体薬物複合体 |
| WO2024199337A1 (en) * | 2023-03-28 | 2024-10-03 | Hansoh Bio Llc | Ligand-cytotoxicity drug conjugates and pharmaceutical uses thereof |
| US20250312469A1 (en) * | 2024-02-06 | 2025-10-09 | Canget Biotekpharma | FL118 COMPLEXES FOR TARGETING DDX5, UbE2T or USP2a |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2632264B1 (en) * | 2010-10-29 | 2019-10-02 | Health Research, Inc. | Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy |
| US10206918B2 (en) * | 2012-12-13 | 2019-02-19 | Immunomedics, Inc. | Efficacy of anti-HLA-DR antiboddy drug conjugate IMMU-140 (hL243-CL2A-SN-38) in HLA-DR positive cancers |
| CN107753954A (zh) * | 2012-12-13 | 2018-03-06 | 免疫医疗公司 | 功效改进且毒性降低的抗体与sn‑38的免疫缀合物的剂量 |
| WO2015012904A2 (en) * | 2012-12-13 | 2015-01-29 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| AU2014293670B2 (en) * | 2013-07-23 | 2019-08-01 | Immunomedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
| IL310627B2 (en) * | 2014-01-31 | 2026-04-01 | Daiichi Sankyo Co Ltd | Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof |
| CN106715443A (zh) * | 2014-03-26 | 2017-05-24 | 坎格特生物技术制药有限责任公司 | Fl118母核化学结构平台产生用于治疗人类疾病的fl118衍生物的用途 |
| TWI851577B (zh) * | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
-
2021
- 2021-05-11 KR KR1020210060721A patent/KR102349925B1/ko active Active
- 2021-07-16 JP JP2023503070A patent/JP7660186B2/ja active Active
- 2021-07-16 EP EP21841752.5A patent/EP4183418A4/en active Pending
- 2021-07-16 AU AU2021308834A patent/AU2021308834A1/en not_active Abandoned
- 2021-07-16 WO PCT/KR2021/009204 patent/WO2022015110A1/ko not_active Ceased
- 2021-07-16 KR KR1020210093769A patent/KR20220009916A/ko not_active Ceased
- 2021-07-16 CN CN202180062303.4A patent/CN116075321A/zh active Pending
- 2021-07-16 CA CA3189462A patent/CA3189462A1/en active Pending
- 2021-07-16 US US18/016,331 patent/US20230270867A1/en active Pending
- 2021-10-15 KR KR1020210137595A patent/KR102857180B1/ko active Active