JP2014510080A5 - - Google Patents

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Publication number
JP2014510080A5
JP2014510080A5 JP2013557924A JP2013557924A JP2014510080A5 JP 2014510080 A5 JP2014510080 A5 JP 2014510080A5 JP 2013557924 A JP2013557924 A JP 2013557924A JP 2013557924 A JP2013557924 A JP 2013557924A JP 2014510080 A5 JP2014510080 A5 JP 2014510080A5
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JP
Japan
Prior art keywords
amino
edc
group
linker
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013557924A
Other languages
English (en)
Japanese (ja)
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JP2014510080A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/028585 external-priority patent/WO2012122514A1/en
Publication of JP2014510080A publication Critical patent/JP2014510080A/ja
Publication of JP2014510080A5 publication Critical patent/JP2014510080A5/ja
Pending legal-status Critical Current

Links

JP2013557924A 2011-03-09 2012-03-09 細胞外標的化薬物複合体 Pending JP2014510080A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161450795P 2011-03-09 2011-03-09
US61/450,795 2011-03-09
US201161500756P 2011-06-24 2011-06-24
US61/500,756 2011-06-24
US201161507882P 2011-07-14 2011-07-14
US61/507,882 2011-07-14
US201161551287P 2011-10-25 2011-10-25
US61/551,287 2011-10-25
PCT/US2012/028585 WO2012122514A1 (en) 2011-03-09 2012-03-09 Extracellular targeted drug conjugates

Publications (2)

Publication Number Publication Date
JP2014510080A JP2014510080A (ja) 2014-04-24
JP2014510080A5 true JP2014510080A5 (enExample) 2015-06-25

Family

ID=46798582

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013557924A Pending JP2014510080A (ja) 2011-03-09 2012-03-09 細胞外標的化薬物複合体

Country Status (4)

Country Link
US (1) US20140079722A1 (enExample)
EP (1) EP2683737A4 (enExample)
JP (1) JP2014510080A (enExample)
WO (1) WO2012122514A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102572149B1 (ko) * 2013-10-11 2023-08-30 아사나 바이오사이언시스 엘엘씨 단백질-폴리머-약물 접합체
US11299528B2 (en) 2014-03-11 2022-04-12 D&D Pharmatech Inc. Long acting TRAIL receptor agonists for treatment of autoimmune diseases
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
HK1246653A1 (zh) 2014-11-17 2018-09-14 Context Biopharma Inc. 奥那司酮延长释放组合物和方法
US20190008983A1 (en) 2015-07-31 2019-01-10 James R. Prudent Extracellular drug conjugates targeting cd20
US10308676B2 (en) 2015-09-25 2019-06-04 Context Biopharma Inc. Methods of making onapristone intermediates
EP3389632A4 (en) 2015-12-15 2019-11-06 Context Biopharma Inc. AMORPHIC ONAPRISTON COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
US11007251B2 (en) 2015-12-17 2021-05-18 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
AU2017248264B2 (en) 2016-04-07 2020-01-30 The Johns Hopkins University Compositions and methods for treating pancreatitis and pain with death receptor agonists
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
US11767353B2 (en) 2020-06-05 2023-09-26 Theraly Fibrosis, Inc. Trail compositions with reduced immunogenicity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9019553D0 (en) * 1990-09-07 1990-10-24 Unilever Plc Specific binding agents
EP1789090A2 (en) * 2004-09-02 2007-05-30 Bionaut Pharmaceuticals, Inc. Combinatorial chemotherapy treatment using na+/k+-atpase inhibitors
US20060088522A1 (en) * 2004-09-10 2006-04-27 Wyeth Humanized anti-5T4 antibodies and anti-5T4/calicheamicin conjugates
EP1921137A4 (en) * 2005-06-21 2011-01-26 Med & Biological Lab Co Ltd ANTIBODIES WITH INHIBITOR EFFECT ON THE FORMATION OF AMYLOID FIBRILLES
EP2129399A1 (en) * 2007-03-28 2009-12-09 Novartis Ag Fxdy5 modulators for treating, diagnosing, and detecting cancer
RU2487877C2 (ru) * 2008-04-30 2013-07-20 Иммьюноджен, Инк. Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры)
US8361973B2 (en) * 2008-08-07 2013-01-29 Centrose, Llc Glycoside compounds and pharmaceutical compositions thereof
JP2012500815A (ja) * 2008-08-29 2012-01-12 シムフォゲン・アクティーゼルスカブ 抗ｃｄ５抗体
JP2013504585A (ja) * 2009-09-09 2013-02-07 セントローズ， エルエルシー 細胞外標的化薬物複合体

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