JP2016531943A5 - - Google Patents
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- JP2016531943A5 JP2016531943A5 JP2016545959A JP2016545959A JP2016531943A5 JP 2016531943 A5 JP2016531943 A5 JP 2016531943A5 JP 2016545959 A JP2016545959 A JP 2016545959A JP 2016545959 A JP2016545959 A JP 2016545959A JP 2016531943 A5 JP2016531943 A5 JP 2016531943A5
- Authority
- JP
- Japan
- Prior art keywords
- kda
- ppm
- silk fibroin
- based protein
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 24
- 108010022355 Fibroins Proteins 0.000 claims 23
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 102000004169 proteins and genes Human genes 0.000 claims 19
- 239000012634 fragment Substances 0.000 claims 18
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 claims 14
- 239000000243 solution Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 239000007864 aqueous solution Substances 0.000 claims 10
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 9
- 108010013296 Sericins Proteins 0.000 claims 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 6
- 239000000284 extract Substances 0.000 claims 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 3
- 229930003268 Vitamin C Natural products 0.000 claims 3
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 3
- 235000019154 vitamin C Nutrition 0.000 claims 3
- 239000011718 vitamin C Substances 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 230000037303 wrinkles Effects 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 230000001332 colony forming effect Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000009499 grossing Methods 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000000774 hypoallergenic effect Effects 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 239000000419 plant extract Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 230000003716 rejuvenation Effects 0.000 claims 1
- 230000036548 skin texture Effects 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000004408 titanium dioxide Substances 0.000 claims 1
- 238000012876 topography Methods 0.000 claims 1
- 239000000341 volatile oil Substances 0.000 claims 1
- 239000011787 zinc oxide Substances 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361884820P | 2013-09-30 | 2013-09-30 | |
| US61/884,820 | 2013-09-30 | ||
| US201462000928P | 2014-05-20 | 2014-05-20 | |
| US62/000,928 | 2014-05-20 | ||
| US201462036450P | 2014-08-12 | 2014-08-12 | |
| US62/036,450 | 2014-08-12 | ||
| US14/503,021 | 2014-09-30 | ||
| PCT/US2014/058462 WO2015048805A1 (en) | 2013-09-30 | 2014-09-30 | Silk potein fragment compositions and articles manufactured therefrom |
| US14/503,076 | 2014-09-30 | ||
| US14/503,021 US9187538B2 (en) | 2013-09-30 | 2014-09-30 | Stable silk protein fragment compositions |
| US14/503,076 US10166177B2 (en) | 2013-09-30 | 2014-09-30 | Silk protein fragment compositions and articles manufactured therefrom |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020156148A Division JP7263298B2 (ja) | 2013-09-30 | 2020-09-17 | 絹タンパク質断片組成物及びそれから製造された物品 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531943A JP2016531943A (ja) | 2016-10-13 |
| JP2016531943A5 true JP2016531943A5 (enExample) | 2017-11-09 |
| JP6775751B2 JP6775751B2 (ja) | 2020-10-28 |
Family
ID=52740380
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016545959A Active JP6775751B2 (ja) | 2013-09-30 | 2014-09-30 | 絹タンパク質断片組成物及びそれから製造された物品 |
| JP2020156148A Active JP7263298B2 (ja) | 2013-09-30 | 2020-09-17 | 絹タンパク質断片組成物及びそれから製造された物品 |
| JP2022085524A Ceased JP7423688B2 (ja) | 2013-09-30 | 2022-05-25 | 絹タンパク質断片組成物及びそれから製造された物品 |
| JP2024005138A Active JP7776545B2 (ja) | 2013-09-30 | 2024-01-17 | 絹タンパク質断片組成物及びそれから製造された物品 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020156148A Active JP7263298B2 (ja) | 2013-09-30 | 2020-09-17 | 絹タンパク質断片組成物及びそれから製造された物品 |
| JP2022085524A Ceased JP7423688B2 (ja) | 2013-09-30 | 2022-05-25 | 絹タンパク質断片組成物及びそれから製造された物品 |
| JP2024005138A Active JP7776545B2 (ja) | 2013-09-30 | 2024-01-17 | 絹タンパク質断片組成物及びそれから製造された物品 |
Country Status (13)
| Country | Link |
|---|---|
| US (18) | US10166177B2 (enExample) |
| EP (2) | EP3052203A4 (enExample) |
| JP (4) | JP6775751B2 (enExample) |
| KR (4) | KR20210153142A (enExample) |
| CN (2) | CN106029176B (enExample) |
| AU (3) | AU2014324412B2 (enExample) |
| BR (1) | BR112016006898A8 (enExample) |
| CA (2) | CA2925820C (enExample) |
| EA (2) | EA036027B1 (enExample) |
| IL (4) | IL300992A (enExample) |
| MX (1) | MX2016003961A (enExample) |
| SG (2) | SG10201907426UA (enExample) |
| WO (1) | WO2015048805A1 (enExample) |
Families Citing this family (39)
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| KR20210153142A (ko) | 2013-09-30 | 2021-12-16 | 실크 테라퓨틱스, 인코퍼레이티드 | 실크 단백질 단편 조성물 및 이로부터 제작된 물품 |
| DK3182985T3 (da) | 2014-08-20 | 2020-04-06 | Silk Tech Ltd | Fibroinafledt proteinsammensætning |
| EA035551B1 (ru) | 2014-12-02 | 2020-07-06 | Силк Терапьютикс, Инк. | Изделие |
| US11260012B2 (en) * | 2015-01-12 | 2022-03-01 | Evolved By Nature, Inc. | Preserved silk protein fragment compositions and articles manufactured therefrom |
| KR102769548B1 (ko) * | 2015-04-29 | 2025-02-17 | 실크 테라퓨틱스, 인코퍼레이티드 | 실크계 보습제 조성물 및 이의 제조방법 |
| CN108135975A (zh) | 2015-07-14 | 2018-06-08 | 丝绸医疗公司 | 丝性能服装和产品及其制备方法 |
| JP2019519596A (ja) | 2016-04-08 | 2019-07-11 | コーネル・ユニバーシティーCornell University | シルク由来タンパク質を使用して創傷治癒を増進する方法 |
| WO2018031973A1 (en) | 2016-08-12 | 2018-02-15 | Silk Technologies, Ltd. | Silk-derived protein for treating inflammation |
| US10857262B2 (en) | 2016-10-31 | 2020-12-08 | Sofregen Medical, Inc. | Compositions comprising low molecular weight silk fibroin fragments and plasticizers |
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| BR112021020715A2 (pt) * | 2019-04-16 | 2021-12-21 | Evolved By Nature Inc | Composições para o cuidado dos cabelos e para tingir os cabelos, produtos pré-xampu, condicionador, líquido, tônico e cosmético, produtos de xampu para os cabelos, de loção para fixação, de loção para modelar com secador, de espuma para modelar, de agente de ondulação permanente, de espuma, de loção e de cera, produtos para enxágue e para o tratamento dos cabelos, produtos em spray, em gel para modelar, em óleo, em creme, em mousse, em gel e em pasta, fragmentos funcionalizados à base de fibroína de seda e seda funcionalizada |
| CA3133743A1 (en) * | 2019-05-13 | 2020-11-19 | E. Aubrey Woodroof | Improved skin substitute adherence, stretchability, and compliance for skin substitutes |
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| WO2021055903A1 (en) * | 2019-09-20 | 2021-03-25 | Evolved By Nature, Inc. | Edible silk and methods of making and using thereof |
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| CN118909068A (zh) * | 2021-02-08 | 2024-11-08 | 复向丝泰医疗科技(苏州)有限公司 | 利用切向流超滤技术制备可控高浓度丝素蛋白溶液的方法 |
| JP2024513726A (ja) * | 2021-03-16 | 2024-03-27 | エボルブド バイ ネイチャー， インコーポレイテッド | 絹でコーティングされた合成繊維 |
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