JP2016531120A5 - - Google Patents

Info

Publication number

JP2016531120A5

JP2016531120A5 JP2016531920A JP2016531920A JP2016531120A5 JP 2016531120 A5 JP2016531120 A5 JP 2016531120A5 JP 2016531920 A JP2016531920 A JP 2016531920A JP 2016531920 A JP2016531920 A JP 2016531920A JP 2016531120 A5 JP2016531120 A5 JP 2016531120A5

Authority

JP

Japan

Prior art keywords

human

cancer

medicament

ala

composition according

Prior art date

2014-07-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 206010028980 Neoplasm Diseases 0.000 claims 16
• 201000011510 cancer Diseases 0.000 claims 16
• 239000003814 drug Substances 0.000 claims 15
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 12
• 230000001093 anti-cancer Effects 0.000 claims 12
• 230000002265 prevention Effects 0.000 claims 9
• 210000004443 dendritic cell Anatomy 0.000 claims 8
• 210000000822 natural killer cell Anatomy 0.000 claims 8
• 238000004519 manufacturing process Methods 0.000 claims 7
• NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 6
• 239000002246 antineoplastic agent Substances 0.000 claims 6
• 229960000575 trastuzumab Drugs 0.000 claims 5
• 206010006187 Breast cancer Diseases 0.000 claims 4
• 208000026310 Breast neoplasm Diseases 0.000 claims 4
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 3
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 3
• 229930012538 Paclitaxel Natural products 0.000 claims 3
• 229940009456 adriamycin Drugs 0.000 claims 3
• 235000004279 alanine Nutrition 0.000 claims 3
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 3
• 229960001467 bortezomib Drugs 0.000 claims 3
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 3
• 229960004316 cisplatin Drugs 0.000 claims 3
• 229960004397 cyclophosphamide Drugs 0.000 claims 3
• 229960003668 docetaxel Drugs 0.000 claims 3
• 229960004679 doxorubicin Drugs 0.000 claims 3
• 210000002443 helper t lymphocyte Anatomy 0.000 claims 3
• 229960001592 paclitaxel Drugs 0.000 claims 3
• 229960002087 pertuzumab Drugs 0.000 claims 3
• 229940121896 radiopharmaceutical Drugs 0.000 claims 3
• 239000012217 radiopharmaceutical Substances 0.000 claims 3
• 230000002799 radiopharmaceutical effect Effects 0.000 claims 3
• 238000001959 radiotherapy Methods 0.000 claims 3
• 229960001603 tamoxifen Drugs 0.000 claims 3
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
• -1 trastuzumab Chemical compound 0.000 claims 3
• GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 3
• 229960002066 vinorelbine Drugs 0.000 claims 3
• ORQXBVXKBGUSBA-UHFFFAOYSA-N 2-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)C(N)CC1CCCCC1 ORQXBVXKBGUSBA-UHFFFAOYSA-N 0.000 claims 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
• 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
• 229940044683 chemotherapy drug Drugs 0.000 claims 2
• 201000005202 lung cancer Diseases 0.000 claims 2
• 208000020816 lung neoplasm Diseases 0.000 claims 2
• 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
• BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 claims 1
• 241000024188 Andala Species 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1