JP2016526875A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016526875A5 JP2016526875A5 JP2016514143A JP2016514143A JP2016526875A5 JP 2016526875 A5 JP2016526875 A5 JP 2016526875A5 JP 2016514143 A JP2016514143 A JP 2016514143A JP 2016514143 A JP2016514143 A JP 2016514143A JP 2016526875 A5 JP2016526875 A5 JP 2016526875A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- variant
- subject
- variants
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 52
- 101000830596 Homo sapiens Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 claims description 11
- 101000597785 Homo sapiens Tumor necrosis factor receptor superfamily member 6B Proteins 0.000 claims description 11
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 claims description 11
- 208000011231 Crohn disease Diseases 0.000 claims description 10
- 206010016654 Fibrosis Diseases 0.000 claims description 10
- 230000004761 fibrosis Effects 0.000 claims description 10
- 102100035284 Tumor necrosis factor receptor superfamily member 6B Human genes 0.000 claims description 7
- 238000003556 assay Methods 0.000 claims description 7
- 238000003205 genotyping method Methods 0.000 claims description 5
- 230000001681 protective effect Effects 0.000 claims description 4
- 238000011477 surgical intervention Methods 0.000 claims description 2
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361824932P | 2013-05-17 | 2013-05-17 | |
| US61/824,932 | 2013-05-17 | ||
| PCT/US2014/038468 WO2014186750A2 (en) | 2013-05-17 | 2014-05-16 | Variants of tnfsf15 and dcr3 associated with crohn's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018124311A Division JP2018148931A (ja) | 2013-05-17 | 2018-06-29 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526875A JP2016526875A (ja) | 2016-09-08 |
| JP2016526875A5 true JP2016526875A5 (enExample) | 2017-06-15 |
| JP6482533B2 JP6482533B2 (ja) | 2019-03-13 |
Family
ID=51899024
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514143A Active JP6482533B2 (ja) | 2013-05-17 | 2014-05-16 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2018124311A Withdrawn JP2018148931A (ja) | 2013-05-17 | 2018-06-29 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2020096798A Withdrawn JP2020127437A (ja) | 2013-05-17 | 2020-06-03 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2022093628A Withdrawn JP2022111329A (ja) | 2013-05-17 | 2022-06-09 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2024213907A Pending JP2025023316A (ja) | 2013-05-17 | 2024-12-06 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018124311A Withdrawn JP2018148931A (ja) | 2013-05-17 | 2018-06-29 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2020096798A Withdrawn JP2020127437A (ja) | 2013-05-17 | 2020-06-03 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2022093628A Withdrawn JP2022111329A (ja) | 2013-05-17 | 2022-06-09 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2024213907A Pending JP2025023316A (ja) | 2013-05-17 | 2024-12-06 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20160090629A1 (enExample) |
| EP (3) | EP2997165A4 (enExample) |
| JP (5) | JP6482533B2 (enExample) |
| KR (4) | KR102295125B1 (enExample) |
| CN (1) | CN105358713B (enExample) |
| ES (1) | ES2894963T3 (enExample) |
| WO (1) | WO2014186750A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
| MX2014003689A (es) | 2011-09-30 | 2014-12-05 | Teva Pharmaceuticals Australia Pty Ltd | Anticuerpos contra tl1a y sus usos. |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| CN105358713B (zh) | 2013-05-17 | 2020-02-28 | 雪松-西奈医学中心 | 与克罗恩病相关的tnfsf15和dcr3的变体 |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| CA2994719A1 (en) | 2015-08-21 | 2017-03-02 | The Children's Hospital Of Philadelphia | Methods of treating autoimmune conditions in patients with genetic variations in dcr3 or in a dcr3 network gene |
| TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| KR20180127416A (ko) | 2016-03-17 | 2018-11-28 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| CN109476698B (zh) * | 2016-05-20 | 2023-10-17 | 西达-赛奈医疗中心 | 基于基因的炎性肠病诊断 |
| CN121371183A (zh) | 2018-09-07 | 2026-01-23 | 费城儿童医院 | 用于淋巴系统病症的诊断和治疗的组合物和方法 |
| CN114375339A (zh) | 2019-05-14 | 2022-04-19 | 普罗米修斯生物科学公司 | Tl1a患者选择方法、系统和装置 |
| CN121949515A (zh) * | 2019-09-13 | 2026-05-01 | 协和麒麟株式会社 | DcR3变体 |
| JP2023551602A (ja) * | 2020-11-13 | 2023-12-08 | プロメテウス バイオサイエンシーズ，インク． | Ｔｌ１ａを標的とする炎症性疾患の治療のための方法、システム、およびキット |
| IL325993A (en) | 2023-08-11 | 2026-03-01 | Paragon Therapeutics Inc | TL1A binding proteins and methods of use |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US20090186034A1 (en) * | 2006-12-19 | 2009-07-23 | Genetech, Inc. | Gene expression markers for inflammatory bowel disease |
| US20100190162A1 (en) | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| WO2009052512A2 (en) | 2007-10-19 | 2009-04-23 | Cedars-Sinai Medical Center | Methods of using genetic variants to diagnose and predict inflammatory bowel disease |
| HRP20150684T1 (hr) | 2008-02-19 | 2015-09-11 | The Children's Hospital Of Philadelphia, Abramson Pediatric Research Center, Office of Technology Transfer | Identifikacija specifiäśnih mjesta nastanka - genetski loci - upalne bolesti crijeva kod djece i postupci njihove uporabe u takvoj dijagnozi te njihovo lijeäśenje |
| WO2010118210A1 (en) * | 2009-04-08 | 2010-10-14 | Cedars-Sinai Medical Center | Methods of predicting complication and surgery in crohn's disease |
| NZ595471A (en) * | 2009-04-14 | 2014-01-31 | Nestec Sa | Inflammatory bowel disease prognostics |
| JP5960707B2 (ja) | 2010-10-18 | 2016-08-02 | ネステク ソシエテ アノニム | 抗薬物抗体アイソタイプを決定するための方法 |
| ES2530175T3 (es) | 2011-02-17 | 2015-02-26 | Nestec S.A. | Ensayos para la detección de autoanticuerpos contra fármacos anti-TNF |
| AU2012259312A1 (en) | 2011-05-20 | 2013-12-12 | Government Of The United States, As Represented By The Secretary Department Of Health And Human Services | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof |
| WO2012174338A2 (en) | 2011-06-15 | 2012-12-20 | Glaxosmithkline Llc | Method of selecting therapeutic indications |
| EP2565277A1 (en) | 2011-09-05 | 2013-03-06 | Progenika Biopharma, S.A. | Method for predicting radiographic severity in ankylosing spondylitis |
| EP2769321B1 (en) | 2011-10-21 | 2016-06-01 | Nestec S.A. | Methods for improving inflammatory bowel disease diagnosis |
| CN105358713B (zh) | 2013-05-17 | 2020-02-28 | 雪松-西奈医学中心 | 与克罗恩病相关的tnfsf15和dcr3的变体 |
| CR20180365A (es) | 2015-12-16 | 2018-09-28 | Amgen Inc | PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS |
| KR20180127416A (ko) | 2016-03-17 | 2018-11-28 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
-
2014
- 2014-05-16 CN CN201480038133.6A patent/CN105358713B/zh active Active
- 2014-05-16 KR KR1020157034355A patent/KR102295125B1/ko active Active
- 2014-05-16 EP EP14797214.5A patent/EP2997165A4/en not_active Withdrawn
- 2014-05-16 KR KR1020237020524A patent/KR20230093538A/ko not_active Ceased
- 2014-05-16 EP EP18201967.9A patent/EP3498867B1/en active Active
- 2014-05-16 KR KR1020257028341A patent/KR20250130857A/ko active Pending
- 2014-05-16 ES ES18201967T patent/ES2894963T3/es active Active
- 2014-05-16 KR KR1020217026836A patent/KR20210107176A/ko not_active Ceased
- 2014-05-16 WO PCT/US2014/038468 patent/WO2014186750A2/en not_active Ceased
- 2014-05-16 JP JP2016514143A patent/JP6482533B2/ja active Active
- 2014-05-16 US US14/890,712 patent/US20160090629A1/en not_active Abandoned
- 2014-05-16 EP EP21193676.0A patent/EP3988673A3/en active Pending
-
2018
- 2018-04-05 US US15/946,632 patent/US20180230543A1/en not_active Abandoned
- 2018-06-29 JP JP2018124311A patent/JP2018148931A/ja not_active Withdrawn
-
2020
- 2020-06-03 JP JP2020096798A patent/JP2020127437A/ja not_active Withdrawn
-
2021
- 2021-08-02 US US17/392,098 patent/US12281359B2/en active Active
-
2022
- 2022-06-09 JP JP2022093628A patent/JP2022111329A/ja not_active Withdrawn
-
2024
- 2024-12-06 JP JP2024213907A patent/JP2025023316A/ja active Pending
-
2025
- 2025-03-19 US US19/084,586 patent/US20250243548A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020127437A5 (enExample) | ||
| JP2017522908A5 (enExample) | ||
| JP2018148931A5 (enExample) | ||
| Peyrin-Biroulet et al. | Defining disease severity in inflammatory bowel diseases: current and future directions | |
| JP2021048856A5 (enExample) | ||
| JP2015511121A5 (enExample) | ||
| WO2012080754A3 (en) | Oligonucleotide probe set and methods of microbiota profiling | |
| EP4417706A3 (en) | Method for diagnosis and prognosis of chronic heart failure | |
| Allen et al. | Emergence of the GII-4 Norovirus Sydney2012 strain in England, winter 2012–2013 | |
| Dacheux et al. | Dual combined real-time reverse transcription polymerase chain reaction assay for the diagnosis of lyssavirus infection | |
| Anh et al. | The prevalence and genetic diversity of group A rotaviruses on pig farms in the Mekong Delta region of Vietnam | |
| WO2012174282A3 (en) | Biomarker compositions and methods | |
| JP2015523569A5 (enExample) | ||
| WO2019051257A3 (en) | Methods for treating hepatitis b infections | |
| Misinzo et al. | African swine fever virus, Tanzania, 2010–2012 | |
| ITUB20161187A1 (it) | Sistema e procedimento per l’associazione dei risultati di analisi eseguite su campioni biologici, in particolare campioni biologici sottoposti ad indagini cliniche, con variabili pre-analitiche a cui detti campioni sono esposti. | |
| WO2014186750A3 (en) | Variants of tnfsf15 and dcr3 associated with crohn's disease | |
| WO2015185653A3 (en) | Methods of diagnosing chronic obstructive pulmonary disease (copd) using novel molecular biomarkers | |
| Kaneko et al. | Identification of vaccine-derived rotavirus strains in children with acute gastroenteritis in Japan, 2012-2015 | |
| JP2018046826A5 (enExample) | ||
| JP4418016B2 (ja) | ハウスダストアレルギーの原因となるダニ・カビ類の検出・識別システム | |
| Hirotsu et al. | Household transmission of SARS-CoV-2 R. 1 lineage with spike E484K mutation in Japan | |
| CN105695574A (zh) | 一种石斑鱼肠道微孢子虫早期检测的方法及其应用 | |
| US20190072558A1 (en) | Method of detecting and determining stress in poultry based on expression of hsp70 in growing feathers | |
| de Azevedo et al. | Comparison of serological and molecular tests for diagnosis of caprine arthritis encephalitis and clinical evaluation of mammary glands of infected dairy goats |