JP2019524884A5 - - Google Patents
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- JP2019524884A5 JP2019524884A5 JP2019529463A JP2019529463A JP2019524884A5 JP 2019524884 A5 JP2019524884 A5 JP 2019524884A5 JP 2019529463 A JP2019529463 A JP 2019529463A JP 2019529463 A JP2019529463 A JP 2019529463A JP 2019524884 A5 JP2019524884 A5 JP 2019524884A5
- Authority
- JP
- Japan
- Prior art keywords
- pla2r
- cells
- seq
- epitope
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 19
- 102100029392 Secretory phospholipase A2 receptor Human genes 0.000 claims 11
- 101710122046 Secretory phospholipase A2 receptor Proteins 0.000 claims 11
- 206010018372 Glomerulonephritis membranous Diseases 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 201000008350 membranous glomerulonephritis Diseases 0.000 claims 8
- 231100000855 membranous nephropathy Toxicity 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 239000013068 control sample Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 238000003127 radioimmunoassay Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022076451A JP7411718B2 (ja) | 2016-08-12 | 2022-05-06 | 自己免疫疾患の診断、予防、および／または治療 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374382P | 2016-08-12 | 2016-08-12 | |
| US62/374,382 | 2016-08-12 | ||
| PCT/US2017/046626 WO2018031947A1 (en) | 2016-08-12 | 2017-08-11 | Diagnosis, prevention, and/or treatment of autoimmune diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022076451A Division JP7411718B2 (ja) | 2016-08-12 | 2022-05-06 | 自己免疫疾患の診断、予防、および／または治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524884A JP2019524884A (ja) | 2019-09-05 |
| JP2019524884A5 true JP2019524884A5 (enExample) | 2020-09-03 |
| JP7303107B2 JP7303107B2 (ja) | 2023-07-04 |
Family
ID=61163324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529463A Active JP7303107B2 (ja) | 2016-08-12 | 2017-08-11 | 自己免疫疾患の診断、予防、および／または治療 |
| JP2022076451A Active JP7411718B2 (ja) | 2016-08-12 | 2022-05-06 | 自己免疫疾患の診断、予防、および／または治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022076451A Active JP7411718B2 (ja) | 2016-08-12 | 2022-05-06 | 自己免疫疾患の診断、予防、および／または治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11266717B2 (enExample) |
| EP (2) | EP3497452B1 (enExample) |
| JP (2) | JP7303107B2 (enExample) |
| CN (1) | CN109891245B (enExample) |
| ES (1) | ES3014985T3 (enExample) |
| WO (1) | WO2018031947A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7303107B2 (ja) * | 2016-08-12 | 2023-07-04 | イムノワーク，リミテッド ライアビリティ カンパニー | 自己免疫疾患の診断、予防、および／または治療 |
| EP3813885A4 (en) * | 2018-05-02 | 2022-01-12 | The Trustees of The University of Pennsylvania | Compositions and methods of phospholipase a2 receptor chimeric autoantibody receptor t cells |
| US12203933B2 (en) | 2018-08-15 | 2025-01-21 | Mayo Foundation For Medical Education And Research | Methods and materials for identifying and treating membranous nephropathy |
| EP4010704A1 (en) | 2019-08-06 | 2022-06-15 | Euroimmun Medizinische Labordiagnostika AG | An improved autoantibody detection assay |
| EP4117702A4 (en) * | 2020-03-06 | 2024-03-13 | Mayo Foundation for Medical Education and Research | Methods and materials for identifying and treating membranous nephropathy |
| CN112111015B (zh) * | 2020-09-24 | 2021-12-07 | 苏州携创生物技术有限公司 | PLA2R、C1q、THSD7A融合蛋白及其构建方法、应用 |
| CN112557670A (zh) * | 2020-12-07 | 2021-03-26 | 东南大学 | 一种基于尿液外泌体pla2r检测imn的方法、试剂盒及其应用 |
| BR102021022687A2 (pt) | 2020-12-11 | 2022-06-28 | Euroimmun Medizinische Labordiagnostika Ag | Método e reagentes para diagnosticar nefropatia membranosa |
| WO2023015239A1 (en) * | 2021-08-05 | 2023-02-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor cells expressing extended phospholipase a2 receptor fragments |
| CN114588881B (zh) * | 2022-03-07 | 2023-07-18 | 大连理工大学 | 免疫吸附剂及其制备方法 |
| EP4496815A1 (en) * | 2022-03-23 | 2025-01-29 | Bodhi Bio LLC | Compositions and methods for antigen-specific therapy |
| CN116082517B (zh) * | 2022-05-26 | 2025-08-22 | 成都地奥制药集团有限公司 | 融合蛋白及其用途 |
| WO2024147113A1 (en) * | 2023-01-05 | 2024-07-11 | Glycoera Ag | Glycoengineered polypeptides targeting anti-podocyte autoantibodies and uses thereof |
| CN115951047A (zh) * | 2023-02-10 | 2023-04-11 | 大连大学 | 自身免疫性水疱病PBMCs直接免疫荧光诊断试剂盒 |
| WO2024231929A1 (en) * | 2023-05-08 | 2024-11-14 | Canopy Immuno-Therapeutics Ltd. | Ig-like fusion proteins for treating membranous nephropathy |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0365087B1 (en) | 1988-10-21 | 1992-07-22 | Akzo N.V. | Immunotoxins for the treatment or prophylaxis of auto-immune diseases |
| JPH07278196A (ja) * | 1994-04-05 | 1995-10-24 | Shionogi & Co Ltd | ヒトｉ型ホスホリパーゼａ２レセプター |
| CA2417885A1 (en) | 2000-08-01 | 2002-02-07 | The University Of Kansas | Cell internalized peptide-drug conjugates |
| CA2629306A1 (en) * | 2005-11-23 | 2007-05-31 | Genentech, Inc. | Methods and compositions related to b cell assays |
| EP2145684A3 (en) * | 2008-07-14 | 2013-06-26 | Samsung Electronics Co., Ltd. | Microfluidic device, sample analyzing method using the same, and dilution ration measuring method |
| EP2313778B1 (en) * | 2008-07-18 | 2015-01-28 | Boston Medical Center Corporation | Diagnostics for membranous nephropathy |
| WO2012145112A2 (en) | 2011-04-18 | 2012-10-26 | Immunogen, Inc. | Novel maytansinoid derivatives with sulfoxide linker |
| US11340224B2 (en) | 2011-05-04 | 2022-05-24 | Cellular Technology Limited | Whole brain lysate antigen-specific memory B cell and antibody assays in multiple sclerosis |
| JP6208228B2 (ja) | 2012-06-21 | 2017-10-04 | ミラゲン セラピューティクス， インコーポレイテッド | ロックド核酸モチーフを含むオリゴヌクレオチドベースの阻害剤 |
| EP3027652A1 (en) | 2013-07-09 | 2016-06-08 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Anti-pla2r antibody and uses thereof |
| GB201410108D0 (en) | 2014-06-06 | 2014-07-23 | Univ Manchester | Peptides, and methods and apparatus utilising same |
| CN104849452A (zh) * | 2015-05-14 | 2015-08-19 | 深圳市伯劳特生物制品有限公司 | 一种pla2r抗体定量检测试纸条及制作、检测方法 |
| CN105510575A (zh) | 2015-12-04 | 2016-04-20 | 深圳市伯劳特生物制品有限公司 | 抗磷脂酶A2受体抗体IgG试剂盒及检测方法 |
| JP7303107B2 (ja) * | 2016-08-12 | 2023-07-04 | イムノワーク，リミテッド ライアビリティ カンパニー | 自己免疫疾患の診断、予防、および／または治療 |
-
2017
- 2017-08-11 JP JP2019529463A patent/JP7303107B2/ja active Active
- 2017-08-11 CN CN201780062647.9A patent/CN109891245B/zh active Active
- 2017-08-11 EP EP17840379.6A patent/EP3497452B1/en active Active
- 2017-08-11 ES ES17840379T patent/ES3014985T3/es active Active
- 2017-08-11 WO PCT/US2017/046626 patent/WO2018031947A1/en not_active Ceased
- 2017-08-11 EP EP25158624.4A patent/EP4644899A2/en active Pending
- 2017-08-11 US US16/324,870 patent/US11266717B2/en active Active
-
2022
- 2022-03-07 US US17/688,811 patent/US20220193188A1/en active Pending
- 2022-05-06 JP JP2022076451A patent/JP7411718B2/ja active Active
-
2024
- 2024-04-10 US US18/631,559 patent/US20240252590A1/en active Pending
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