CN105358713B - 与克罗恩病相关的tnfsf15和dcr3的变体 - Google Patents

与克罗恩病相关的tnfsf15和dcr3的变体 Download PDF

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CN105358713B
CN105358713B CN201480038133.6A CN201480038133A CN105358713B CN 105358713 B CN105358713 B CN 105358713B CN 201480038133 A CN201480038133 A CN 201480038133A CN 105358713 B CN105358713 B CN 105358713B
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tnfsf15
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dcr3
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CN105358713A (zh
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D·P·麦戈文
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Cedars-Sinai Medical Center
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
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CN201480038133.6A 2013-05-17 2014-05-16 与克罗恩病相关的tnfsf15和dcr3的变体 Active CN105358713B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361824932P 2013-05-17 2013-05-17
US61/824,932 2013-05-17
PCT/US2014/038468 WO2014186750A2 (en) 2013-05-17 2014-05-16 Variants of tnfsf15 and dcr3 associated with crohn's disease

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CN105358713A CN105358713A (zh) 2016-02-24
CN105358713B true CN105358713B (zh) 2020-02-28

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US (4) US20160090629A1 (enExample)
EP (3) EP2997165A4 (enExample)
JP (5) JP6482533B2 (enExample)
KR (4) KR20210107176A (enExample)
CN (1) CN105358713B (enExample)
ES (1) ES2894963T3 (enExample)
WO (1) WO2014186750A2 (enExample)

Families Citing this family (14)

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US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
EP3495389A1 (en) 2011-09-30 2019-06-12 Teva Pharmaceuticals Australia Pty Ltd Antibodies against tl1a and uses thereof
KR20240122922A (ko) 2013-03-27 2024-08-13 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
KR20210107176A (ko) 2013-05-17 2021-08-31 세다르스-신나이 메디칼 센터 크론병과 연관된 tnfsf15와 dcr3의 변이체
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
HK1257443A1 (zh) 2015-08-21 2019-10-18 The Children's Hospital Of Philadelphia 治疗具有dcr3或dcr3网络基因中的遗传变异的患者的自身免疫病症的方法
TWI703158B (zh) 2015-09-18 2020-09-01 美商希佛隆公司 特異性結合tl1a之抗體
CN109462996A (zh) 2016-03-17 2019-03-12 西达-赛奈医疗中心 通过rnaset2诊断炎性肠病的方法
KR20230003433A (ko) * 2016-05-20 2023-01-05 세다르스-신나이 메디칼 센터 유전자에 기반한 염증성 장 질환의 진단
CN121371183A (zh) * 2018-09-07 2026-01-23 费城儿童医院 用于淋巴系统病症的诊断和治疗的组合物和方法
EP3969621A4 (en) 2019-05-14 2023-01-25 Prometheus Biosciences, Inc. TL1A PATIENT SELECTION METHODS, SYSTEMS AND DEVICES
CN122060049A (zh) * 2019-09-13 2026-05-19 协和麒麟株式会社 DcR3变体
IL302791A (en) * 2020-11-13 2023-07-01 Prometheus Biosciences Inc Methods, systems, and kits for treatment of inflammatory diseases targeting tl1a
IL325993A (en) 2023-08-11 2026-03-01 Paragon Therapeutics Inc TL1A binding proteins and methods of use

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WO2009105590A3 (en) * 2008-02-19 2010-01-07 The Children's Hospital Of Philadelphia Identification of pediatric onset inflammatory bowel disease loci and methods of use thereof for the diagnosis and treatment of the same
WO2010118210A1 (en) * 2009-04-08 2010-10-14 Cedars-Sinai Medical Center Methods of predicting complication and surgery in crohn's disease

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AU2012259312A1 (en) * 2011-05-20 2013-12-12 Government Of The United States, As Represented By The Secretary Department Of Health And Human Services Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof
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WO2009105590A3 (en) * 2008-02-19 2010-01-07 The Children's Hospital Of Philadelphia Identification of pediatric onset inflammatory bowel disease loci and methods of use thereof for the diagnosis and treatment of the same
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US12281359B2 (en) 2025-04-22
KR20250130857A (ko) 2025-09-02
WO2014186750A3 (en) 2015-01-08
US20160090629A1 (en) 2016-03-31
ES2894963T3 (es) 2022-02-16
EP3498867A1 (en) 2019-06-19
EP2997165A4 (en) 2017-03-08
CN105358713A (zh) 2016-02-24
JP2025023316A (ja) 2025-02-14
EP3498867B1 (en) 2021-09-29
EP3988673A3 (en) 2022-08-03
US20180230543A1 (en) 2018-08-16
KR20230093538A (ko) 2023-06-27
JP2022111329A (ja) 2022-07-29
EP2997165A2 (en) 2016-03-23
WO2014186750A2 (en) 2014-11-20
KR20160009582A (ko) 2016-01-26
JP2020127437A (ja) 2020-08-27
US20210371931A1 (en) 2021-12-02
JP2018148931A (ja) 2018-09-27
JP6482533B2 (ja) 2019-03-13
ES2894963T8 (es) 2022-02-24
US20250243548A1 (en) 2025-07-31
KR20210107176A (ko) 2021-08-31
EP3988673A2 (en) 2022-04-27
JP2016526875A (ja) 2016-09-08
KR102295125B1 (ko) 2021-08-31

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