MX343863B - Conjunto de sondas de oligonucleotido y metodos para perfilado de microbiotica. - Google Patents
Conjunto de sondas de oligonucleotido y metodos para perfilado de microbiotica.Info
- Publication number
- MX343863B MX343863B MX2013006669A MX2013006669A MX343863B MX 343863 B MX343863 B MX 343863B MX 2013006669 A MX2013006669 A MX 2013006669A MX 2013006669 A MX2013006669 A MX 2013006669A MX 343863 B MX343863 B MX 343863B
- Authority
- MX
- Mexico
- Prior art keywords
- seq
- nucleotide sequence
- oligonucleotide
- hybridising
- under conditions
- Prior art date
Links
- 108020005187 Oligonucleotide Probes Proteins 0.000 title abstract 4
- 239000002751 oligonucleotide probe Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 241000736262 Microbiota Species 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 8
- 125000003729 nucleotide group Chemical group 0.000 abstract 8
- 108091034117 Oligonucleotide Proteins 0.000 abstract 6
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un conjunto de sondas de oligonucleótido, caracterizado porque comprende: (a) un oligonucleótido que consiste de (ai) una secuencia de nucleótidos que se selecciona (SEC ID NO: 1), opcionalmente con hasta tres bases sustituidas y (SEC ID NO: 27), opcionalmente hasta con tres bases sustituidas, y (aii) 0 a 5 nucleótidos además de (ai) en donde el oligonucleótido (a) es capaz de hibridizar con la SEC ID NO: 27 o SEC ID NO: 1, respectivamente, bajo condiciones de alta severidad; (b) un oligonucleótido que consiste de (bi) una secuencia de nucleótidos que se selecciona de (SEC ID NO: 2), opcionalmente con hasta tres bases sustituidas y (SEC IC NO: 28), opcionalmente hasta con tres bases sustituidas, y (bii) 0 a 5 nucleótidos además de (bi) en donde el oligonucleótido (b) es capaz de hibridizar la SEX ID NO: 28 O SEC ID NO: 2, respectivamente, bajo condiciones de alta severidad; un oligonucleótido que consiste de (ci) una secuencia de nucleótidos que se selecciona de (SEC ID NO: 3),opcionalmente con hasta tres bases sustituidas, y (SEC ID NO: 29); opcionalmente hasta con tres bases sustituidas, y (cii) 0 a 5 nucleótidos además de (ci) en donde el oligonucleótido (c) es capaz de hibridizar a SEC ID NO: 29 o SEC ID NO: 3, respectivamente, bajo condiciones de alta severidad; (d) un oligonucleótido que consiste de (di) una secuencia de nucleótidos que se selecciona de (SEC ID NO; 4), opcionalmente con hasta tres bases sustituidas y (SEC ID NO: 30), opcionalmente hasta con tres bases sustituidas, y (dii) 0 a 5 nucleótidos además de (di) en donde el oligonucleótido (d) es capaz de hibridizar con la SEC ID NO: 30 o SEC ID NO: 4, respectivamente, bajo condiciones de alta severidad; y ( e) uno o más oligonucleótidos que consisten de (ei) una secuencia de nucleótidos que se selecciona de las mencionadas como las SEC ID NOS: 5 A 8 Y 31 a 34 en la tabla 1, opcionalmente hasta con tres bases sustituidas, y (eii) 0 a 5 nucleótidos además de (ei), en donde el oligonucleótido ( e) es capaz de hibridizar con la secuencia de nucleótidos complementaria a las SEC ID NOS: 5 A 8 y 31 a 34, respectivamente, bajo condiciones de alta severidad; y opcionalmente (f) uno o más oligonucleótidos que consisten de (fi) una secuencia de nucleótidos que se selecciona de las mencionadas como las SEC ID NOS: 9 a 26 y 35 a 52 en la tabla 2 y en la tabla 3, opcionalmente hasta con tres bases sustituidas, y (fii) 0 a 5 nucleótidos además de (fi), en donde el oligonucleótido (f) es capaz de hibridizar con la secuencia de nucleótidos complementaria a las SEC ID NOS: 9 a 26 y 35 a 52, respectivamente, bajo condiciones de alta severidad.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1021399.9A GB201021399D0 (en) | 2010-12-16 | 2010-12-16 | Oligonucleotide probe set and methods of microbiota profiling |
| PCT/GB2011/052509 WO2012080754A2 (en) | 2010-12-16 | 2011-12-16 | Oligonucleotide probe set and methods of microbiota profiling |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013006669A MX2013006669A (es) | 2013-11-04 |
| MX343863B true MX343863B (es) | 2016-11-25 |
Family
ID=43567352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013006669A MX343863B (es) | 2010-12-16 | 2011-12-16 | Conjunto de sondas de oligonucleotido y metodos para perfilado de microbiotica. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9243297B2 (es) |
| EP (1) | EP2652145B1 (es) |
| AU (1) | AU2011342983B2 (es) |
| BR (1) | BR112013015082A2 (es) |
| CA (1) | CA2821884C (es) |
| DK (1) | DK2652145T3 (es) |
| ES (1) | ES2573133T3 (es) |
| GB (1) | GB201021399D0 (es) |
| MX (1) | MX343863B (es) |
| NZ (1) | NZ612010A (es) |
| PL (1) | PL2652145T3 (es) |
| RU (1) | RU2605913C2 (es) |
| WO (1) | WO2012080754A2 (es) |
| ZA (1) | ZA201304546B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201021399D0 (en) | 2010-12-16 | 2011-01-26 | Genetic Analysis As | Oligonucleotide probe set and methods of microbiota profiling |
| US20150211053A1 (en) * | 2012-08-01 | 2015-07-30 | Bgi-Shenzhen | Biomarkers for diabetes and usages thereof |
| US11003041B2 (en) * | 2014-06-30 | 2021-05-11 | View, Inc. | Power management for electrochromic window networks |
| WO2016014822A1 (en) * | 2014-07-25 | 2016-01-28 | Ge Healthcare Uk Limited | Screening and monitoring the progression of type 2 diabetes by the molecular identification of gut flora using fta as a faecal collection device |
| GB201505364D0 (en) * | 2015-03-27 | 2015-05-13 | Genetic Analysis As | Method for determining gastrointestinal tract dysbiosis |
| CN105199948A (zh) * | 2015-09-29 | 2015-12-30 | 窦晓鸣 | 大肠杆菌的快速检验试剂盒及检测方法 |
| RU2601132C1 (ru) * | 2015-11-27 | 2016-10-27 | федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" (МФТИ) | Набор синтетических олигонуклеотидов для диагностики болезни крона и неспецифического язвенного колита путем выявления маркерных участков бактериальной днк методом полимеразной цепной реакции |
| JP7655693B2 (ja) | 2016-05-23 | 2025-04-02 | カリフォルニア インスティチュート オブ テクノロジー | 神経変性障害を治療するための腸内微生物叢の制御 |
| RU2630669C1 (ru) * | 2016-07-21 | 2017-09-11 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор") | Способ определения метилирования сайтов PuCGPy регуляторных областей генов-онкомаркеров колоректального рака методом GLAD-ПЦР-анализа и набор олигонуклеотидных праймеров и флуоресцентно-меченых зондов для осуществления указанного способа |
| GB201617519D0 (en) | 2016-10-14 | 2016-11-30 | Genetic Analysis As | A companion diagnostic method for use in the treatment of irritable bowel syndrome with dietary interventions or faecal microbiota transplant |
| EA032051B1 (ru) * | 2017-03-22 | 2019-03-29 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | Способ идентификации в микробиомах и отдельных бактериальных геномах композиции бактериальных генов, участвующих в синтезе и метаболизме различных нейроактивных соединений |
| EP3607096A1 (en) * | 2017-04-03 | 2020-02-12 | Bio-Me AS | Microorganism detection methods |
| US11147792B2 (en) | 2017-05-15 | 2021-10-19 | Axial Therapeutics, Inc. | Inhibitors of microbially induced amyloid |
| WO2018209398A1 (en) * | 2017-05-17 | 2018-11-22 | Microbio Pty Ltd | Biomarkers and uses thereof |
| AU2018253466B2 (en) | 2017-07-17 | 2019-03-28 | smartDNA Pty Ltd | Method of diagnosing a dysbiosis |
| US20210317508A1 (en) * | 2017-08-01 | 2021-10-14 | Axial Therapeutics, Inc. | Methods and apparatus for determining risk of autism spectrum disorder |
| GB201712459D0 (en) | 2017-08-02 | 2017-09-13 | Norges Miljø-Og Biovitenskapelige Univ | Treatment or prevention of gastrointestinal dysbiosis |
| RU2702229C1 (ru) * | 2018-08-09 | 2019-10-07 | федеральное государственное бюджетное образовательное учреждение высшего образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ лечения атопического дерматита у детей пробиотическими препаратами с учетом результатов микробиологического исследования кала |
| GB201817889D0 (en) | 2018-11-01 | 2018-12-19 | Bio Me As | Microorganism detection methods |
| TR201818373A2 (tr) * | 2018-12-03 | 2020-06-22 | T C Erciyes Ueniversitesi | Bağirsak mi̇krobi̇yomundan alzhei̇mer hastaliğinin teşhi̇si̇ i̇çi̇n mi̇ni̇mal bi̇yobeli̇rteçler ve i̇lgi̇li̇ yeni̇ nesi̇l di̇zi̇leme ki̇ti̇ |
| US20220259332A1 (en) * | 2019-07-19 | 2022-08-18 | Washington University | Particle-based method for defining a gut microbiota in humans or other animal species |
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| GB201021399D0 (en) | 2010-12-16 | 2011-01-26 | Genetic Analysis As | Oligonucleotide probe set and methods of microbiota profiling |
-
2010
- 2010-12-16 GB GBGB1021399.9A patent/GB201021399D0/en not_active Ceased
-
2011
- 2011-12-16 NZ NZ612010A patent/NZ612010A/en not_active IP Right Cessation
- 2011-12-16 EP EP11804757.0A patent/EP2652145B1/en active Active
- 2011-12-16 RU RU2013132761/10A patent/RU2605913C2/ru active
- 2011-12-16 MX MX2013006669A patent/MX343863B/es active IP Right Grant
- 2011-12-16 CA CA2821884A patent/CA2821884C/en active Active
- 2011-12-16 BR BR112013015082A patent/BR112013015082A2/pt not_active IP Right Cessation
- 2011-12-16 WO PCT/GB2011/052509 patent/WO2012080754A2/en not_active Ceased
- 2011-12-16 PL PL11804757.0T patent/PL2652145T3/pl unknown
- 2011-12-16 DK DK11804757.0T patent/DK2652145T3/en active
- 2011-12-16 ES ES11804757.0T patent/ES2573133T3/es active Active
- 2011-12-16 AU AU2011342983A patent/AU2011342983B2/en active Active
-
2013
- 2013-06-17 US US13/919,056 patent/US9243297B2/en active Active
- 2013-06-20 ZA ZA2013/04546A patent/ZA201304546B/en unknown
-
2015
- 2015-11-18 US US14/944,289 patent/US9909191B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201304546B (en) | 2014-03-26 |
| DK2652145T3 (en) | 2016-06-13 |
| NZ612010A (en) | 2015-05-29 |
| AU2011342983B2 (en) | 2017-03-30 |
| CA2821884A1 (en) | 2012-06-21 |
| BR112013015082A2 (pt) | 2019-09-17 |
| WO2012080754A2 (en) | 2012-06-21 |
| US20130303397A1 (en) | 2013-11-14 |
| US20160068891A1 (en) | 2016-03-10 |
| US9909191B2 (en) | 2018-03-06 |
| CA2821884C (en) | 2022-07-05 |
| AU2011342983A1 (en) | 2013-07-04 |
| PL2652145T3 (pl) | 2016-09-30 |
| RU2013132761A (ru) | 2015-01-27 |
| RU2605913C2 (ru) | 2016-12-27 |
| EP2652145A2 (en) | 2013-10-23 |
| MX2013006669A (es) | 2013-11-04 |
| EP2652145B1 (en) | 2016-03-09 |
| US9243297B2 (en) | 2016-01-26 |
| GB201021399D0 (en) | 2011-01-26 |
| ES2573133T3 (es) | 2016-06-06 |
| WO2012080754A3 (en) | 2013-06-20 |
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