JP2016525562A - 抗感染症化合物 - Google Patents

抗感染症化合物 Download PDF

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Publication number
JP2016525562A
JP2016525562A JP2016530547A JP2016530547A JP2016525562A JP 2016525562 A JP2016525562 A JP 2016525562A JP 2016530547 A JP2016530547 A JP 2016530547A JP 2016530547 A JP2016530547 A JP 2016530547A JP 2016525562 A JP2016525562 A JP 2016525562A
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JP
Japan
Prior art keywords
chloro
ethyl
hydrogen
methyl
occurrence
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Japanese (ja)
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JP2016525562A5 (enExample
Inventor
ジェスン キム，
ジェスン キム，
サンヒ カン，
サンヒ カン，
ミン ジュン ソ，
ミン ジュン ソ，
ムーヨン ソ，
ムーヨン ソ，
ジョンジェ ソ，
ジョンジェ ソ，
スミ リ，
スミ リ，
ジュヘ カン，
ジュヘ カン，
ドンシク パク，
ドンシク パク，
リャン ヨ キム，
リャン ヨ キム，
ケビン ペテ，
ケビン ペテ，
キヨン ナム，
キヨン ナム，
ジョンジュン キム，
ジョンジュン キム，
スヒュン オー，
スヒュン オー，
セヨン リ，
セヨン リ，
ジエ アン，
ジエ アン，
Original Assignee
インスティチュート パスツール コリア
インスティチュート パスツール コリア
キュリエント カンパニー， リミテッド
キュリエント カンパニー， リミテッド
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Application filed by インスティチュート パスツール コリア, インスティチュート パスツール コリア, キュリエント カンパニー， リミテッド, キュリエント カンパニー， リミテッド filed Critical インスティチュート パスツール コリア
Publication of JP2016525562A publication Critical patent/JP2016525562A/ja
Publication of JP2016525562A5 publication Critical patent/JP2016525562A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016530547A 2013-08-02 2014-08-01 抗感染症化合物 Withdrawn JP2016525562A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361861750P 2013-08-02 2013-08-02
US61/861,750 2013-08-02
PCT/EP2014/066614 WO2015014993A2 (en) 2013-08-02 2014-08-01 Anti-infective compounds

Related Child Applications (1)

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JP2018119810A Division JP6757768B2 (ja) 2013-08-02 2018-06-25 抗感染症化合物

Publications (2)

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JP2016525562A true JP2016525562A (ja) 2016-08-25
JP2016525562A5 JP2016525562A5 (enExample) 2017-03-23

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JP2016530547A Withdrawn JP2016525562A (ja) 2013-08-02 2014-08-01 抗感染症化合物
JP2018119810A Active JP6757768B2 (ja) 2013-08-02 2018-06-25 抗感染症化合物
JP2019077088A Pending JP2019131606A (ja) 2013-08-02 2019-04-15 抗感染症化合物

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JP2018119810A Active JP6757768B2 (ja) 2013-08-02 2018-06-25 抗感染症化合物
JP2019077088A Pending JP2019131606A (ja) 2013-08-02 2019-04-15 抗感染症化合物

Country Status (12)

Country Link
US (1) US20160185774A1 (enExample)
EP (1) EP3027615B1 (enExample)
JP (3) JP2016525562A (enExample)
KR (1) KR102292293B1 (enExample)
CN (2) CN109575018A (enExample)
DK (1) DK3027615T3 (enExample)
ES (1) ES2883565T3 (enExample)
HU (1) HUE056198T2 (enExample)
PH (1) PH12016500207A1 (enExample)
RU (1) RU2734760C2 (enExample)
SG (1) SG11201600686QA (enExample)
WO (1) WO2015014993A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020203610A1 (ja) * 2019-03-29 2020-10-08 日本ケミファ株式会社 関節リウマチを治療するためのｔ型カルシウムチャネル阻害剤の使用
JPWO2020203609A1 (enExample) * 2019-03-29 2020-10-08
JP2022550784A (ja) * 2019-09-30 2022-12-05 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ４－キノリノン抗菌化合物
JP2022551823A (ja) * 2019-09-30 2022-12-14 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗菌化合物

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017001660A1 (en) 2015-07-02 2017-01-05 Janssen Sciences Ireland Uc Antibacterial compounds
AU2016324598A1 (en) 2015-09-17 2018-03-15 Marvin J. Miller Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection
JP2019518046A (ja) * 2016-06-16 2019-06-27 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗菌薬としての複素環式化合物
JP2019518050A (ja) * 2016-06-16 2019-06-27 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗菌薬としての複素環式化合物
WO2018158280A1 (en) 2017-03-01 2018-09-07 Janssen Sciences Ireland Uc Combination therapy
US11129816B2 (en) 2017-10-05 2021-09-28 Quretech Bio Ab Ring-fused thiazolino 2-pyridones in combination with a drug against tuberculosis
CN108101828B (zh) * 2018-01-15 2021-05-04 西华师范大学 3-吲哚基甲酰胺类化合物及其制备方法
CN108159049B (zh) * 2018-02-01 2021-01-05 中国科学院广州生物医药与健康研究院 一种吡啶类化合物的新用途
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
TWI861208B (zh) * 2019-09-10 2024-11-11 日商鹽野義製藥股份有限公司 對分枝桿菌感染有用之含苄胺的 5,6-雜芳族化合物
WO2021048342A1 (en) 2019-09-13 2021-03-18 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
KR102381397B1 (ko) * 2020-07-10 2022-03-30 경희대학교 산학협력단 신규 나프토퀴논 유도체 화합물 및 이를 포함하는 항균용 조성물
KR20230157400A (ko) 2021-03-16 2023-11-16 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 항박테리아성 화합물
CA3211592A1 (en) 2021-03-17 2022-09-22 Jerome Emile Georges Guillemont Antibacterial compounds
CN117440958A (zh) * 2021-03-17 2024-01-23 爱尔兰詹森科学公司 抗菌化合物
CN118159543A (zh) 2021-10-28 2024-06-07 爱尔兰詹森科学公司 在治疗细菌感染中使用的咪唑并吡啶酰胺和相关化合物
WO2024089170A1 (en) 2022-10-27 2024-05-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2024223859A1 (en) 2023-04-26 2024-10-31 Janssen Pharmaceutica Nv Antibacterial compounds
WO2025017047A1 (en) 2023-07-18 2025-01-23 Janssen Pharmaceutica Nv Combination products of at least three antibiotics comprising bedaquiline, pretomanid or delamanid, and a cytochrome bc1 inhibitor, and their use in the treatment of mycobacterial infections

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522253A (ja) * 2010-03-18 2013-06-13 インスティチュート・パスツール・コリア 抗感染化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2906250B1 (fr) * 2006-09-22 2008-10-31 Sanofi Aventis Sa Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
US20100298314A1 (en) * 2006-12-20 2010-11-25 Schering Corporation Novel jnk inhibitors
WO2009140101A2 (en) * 2008-05-12 2009-11-19 Boehringer Ingelheim International Gmbh Imidazopyridine compounds useful as mmp-13 inhibitors
EP2496578A4 (en) * 2009-11-05 2013-08-21 Univ Notre Dame Du Lac IMIDAZO [1,2-A] PYRIDINE COMPOUNDS, THEIR SYNTHESIS AND METHODS OF USE THEREOF
US9029389B2 (en) * 2011-04-21 2015-05-12 Institut Pasteur Korea Anti-inflammation compounds
CN103324035B (zh) * 2013-06-20 2015-07-01 深圳市华星光电技术有限公司 掩膜板和阵列基板的制作方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522253A (ja) * 2010-03-18 2013-06-13 インスティチュート・パスツール・コリア 抗感染化合物

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020203610A1 (ja) * 2019-03-29 2020-10-08 日本ケミファ株式会社 関節リウマチを治療するためのｔ型カルシウムチャネル阻害剤の使用
JPWO2020203609A1 (enExample) * 2019-03-29 2020-10-08
WO2020203609A1 (ja) * 2019-03-29 2020-10-08 日本ケミファ株式会社 掻痒を治療するためのｔ型カルシウムチャネル阻害剤の使用
JP2022550784A (ja) * 2019-09-30 2022-12-05 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ４－キノリノン抗菌化合物
JP2022551823A (ja) * 2019-09-30 2022-12-14 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗菌化合物

Also Published As

Publication number Publication date
SG11201600686QA (en) 2016-02-26
RU2016107378A3 (enExample) 2018-03-29
JP2018158941A (ja) 2018-10-11
EP3027615B1 (en) 2021-07-21
RU2016107378A (ru) 2017-09-07
JP2019131606A (ja) 2019-08-08
KR20170082450A (ko) 2017-07-14
DK3027615T3 (da) 2021-10-25
WO2015014993A3 (en) 2015-04-02
PH12016500207A1 (en) 2016-04-25
HUE056198T2 (hu) 2022-02-28
JP6757768B2 (ja) 2020-09-23
EP3027615A2 (en) 2016-06-08
KR102292293B1 (ko) 2021-08-23
ES2883565T3 (es) 2021-12-09
CN109575018A (zh) 2019-04-05
WO2015014993A2 (en) 2015-02-05
CN105745208A (zh) 2016-07-06
RU2734760C2 (ru) 2020-10-23
US20160185774A1 (en) 2016-06-30

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