JP2016524964A5 - - Google Patents
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- Publication number
- JP2016524964A5 JP2016524964A5 JP2016526468A JP2016526468A JP2016524964A5 JP 2016524964 A5 JP2016524964 A5 JP 2016524964A5 JP 2016526468 A JP2016526468 A JP 2016526468A JP 2016526468 A JP2016526468 A JP 2016526468A JP 2016524964 A5 JP2016524964 A5 JP 2016524964A5
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- hydroxyapatite
- bone
- biomimetic
- composite material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 15
- 239000002131 composite material Substances 0.000 claims 14
- 102000008186 Collagen Human genes 0.000 claims 11
- 108010035532 Collagen Proteins 0.000 claims 11
- 230000003592 biomimetic effect Effects 0.000 claims 11
- 229920001436 collagen Polymers 0.000 claims 11
- 238000000034 method Methods 0.000 claims 9
- 210000000988 bone and bone Anatomy 0.000 claims 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 6
- 239000000835 fiber Substances 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 4
- 238000000978 circular dichroism spectroscopy Methods 0.000 claims 4
- 239000007943 implant Substances 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 239000002159 nanocrystal Substances 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 230000010478 bone regeneration Effects 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims 2
- 102000013373 fibrillar collagen Human genes 0.000 claims 2
- 108060002894 fibrillar collagen Proteins 0.000 claims 2
- 238000010191 image analysis Methods 0.000 claims 2
- 230000011164 ossification Effects 0.000 claims 2
- 239000008055 phosphate buffer solution Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 238000001878 scanning electron micrograph Methods 0.000 claims 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims 1
- IGBSGKOLQRKFIU-UHFFFAOYSA-N O.O.O.O.O.[Ca] Chemical compound O.O.O.O.O.[Ca] IGBSGKOLQRKFIU-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000000316 bone substitute Substances 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims 1
- 229940038472 dicalcium phosphate Drugs 0.000 claims 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13003647.8 | 2013-07-19 | ||
| EP13003647.8A EP2826495A1 (en) | 2013-07-19 | 2013-07-19 | Biomimetic collagen-hydroxyapatite composite material |
| PCT/EP2014/001966 WO2015007393A1 (en) | 2013-07-19 | 2014-07-18 | Biomimetic collagen-hydroxyapatite composite material |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016524964A JP2016524964A (ja) | 2016-08-22 |
| JP2016524964A5 true JP2016524964A5 (cg-RX-API-DMAC7.html) | 2017-08-03 |
| JP6478993B2 JP6478993B2 (ja) | 2019-03-06 |
Family
ID=48856485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016526468A Expired - Fee Related JP6478993B2 (ja) | 2013-07-19 | 2014-07-18 | バイオミメティックなコラーゲン−ヒドロキシアパタイト複合材料 |
Country Status (16)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10238507B2 (en) | 2015-01-12 | 2019-03-26 | Surgentec, Llc | Bone graft delivery system and method for using same |
| WO2016179089A1 (en) | 2015-05-01 | 2016-11-10 | Rensselaer Polytechnic Institute | Biomimetic nano-composite scaffold for enhanced bone healing and fracture repair |
| DE202016103296U1 (de) | 2016-06-09 | 2017-09-18 | Michael Gahlert | Knochenersatzmaterial aus Zirkondioxidkeramik |
| DE102016110622A1 (de) | 2016-06-09 | 2017-12-14 | Michael Gahlert | Knochenersatzmaterial aus Zirkondioxidkeramik |
| CN111465418B (zh) | 2017-12-14 | 2021-07-09 | 盖斯特里希医药公司 | 骨替代材料 |
| TWI783093B (zh) * | 2017-12-14 | 2022-11-11 | 瑞士商蓋茲特利製藥公司 | 骨替代材料及其製備及應用 |
| KR102274968B1 (ko) * | 2017-12-14 | 2021-07-09 | 가이스틀리히 파마 아게 | 건조 임플란트 조성물 및 주사가능한 수성 임플란트 제형 |
| US10687828B2 (en) | 2018-04-13 | 2020-06-23 | Surgentec, Llc | Bone graft delivery system and method for using same |
| US11116647B2 (en) | 2018-04-13 | 2021-09-14 | Surgentec, Llc | Bone graft delivery system and method for using same |
| EP3695856A1 (en) * | 2019-02-13 | 2020-08-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Biomaterials comprising a scaffold containing a mineral compound, and uses thereof as bone substitutes |
| WO2020249714A1 (en) * | 2019-06-14 | 2020-12-17 | Geistlich Pharma Ag | Collagen matrix or granulate blend of bone substitute material |
| CN114761048B (zh) * | 2019-06-14 | 2023-05-02 | 盖斯特里希医药公司 | 骨替代材料的胶原基质或颗粒共混物 |
| FR3101773B1 (fr) | 2019-10-10 | 2023-04-21 | Regeska | Procede de mineralisation d’une membrane de biopolymere |
| CN114209880B (zh) * | 2021-11-25 | 2022-11-08 | 浙江大学 | 一种有序矿化多肽的生物复合材料的制备方法及其产品和应用 |
| CN114732957B (zh) * | 2022-03-16 | 2022-12-23 | 武汉理工大学 | 一种具有预应力的矿化肌腱复合材料及其制备方法与应用 |
| CN114890400B (zh) * | 2022-06-15 | 2023-12-01 | 杭州彗搏科技有限公司 | 纳米晶体羟基磷灰石骨修复颗粒、制备方法及应用 |
| CN116271232B (zh) * | 2022-09-06 | 2025-11-07 | 浙江大学 | 一种基于原位矿化类骨羟基磷灰石的复合凝胶的合成方法及其产品和应用 |
| CN119857939B (zh) * | 2025-03-05 | 2025-10-03 | 中南大学 | 一种种植体表面处理技术 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8813033D0 (en) | 1988-06-02 | 1988-07-06 | Geistlich Soehne Ag | Chemical compound |
| US5231169A (en) | 1990-10-17 | 1993-07-27 | Norian Corporation | Mineralized collagen |
| US5532217A (en) | 1992-04-24 | 1996-07-02 | Silver; Frederick H. | Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone |
| US6201039B1 (en) | 1993-09-21 | 2001-03-13 | The Penn State Research Foundation | Bone substitute composition comprising hydroxyapatite and a method of production therefor |
| GB9400163D0 (en) | 1994-01-06 | 1994-03-02 | Geistlich Soehne Ag | Membrane |
| JP2754348B2 (ja) * | 1994-10-20 | 1998-05-20 | バイオマップ有限会社 | アパタイト被覆基材とその製造法 |
| GB9503492D0 (en) | 1995-02-22 | 1995-04-12 | Ed Geistlich S Hne A G F R Che | Chemical product |
| US6395036B1 (en) | 1998-04-06 | 2002-05-28 | Isis Innovation Limited | Composite material and methods of making the same |
| US7514249B2 (en) | 2002-04-18 | 2009-04-07 | The University Of Florida Research Foundation, Inc. | Biomimetic organic/inorganic composites |
| US20090216336A1 (en) * | 2004-11-23 | 2009-08-27 | Marco Springer | Bioresorbable, mineralised material for filling osseous defects |
| ITMI20050343A1 (it) * | 2005-03-04 | 2006-09-05 | Fin Ceramica Faenza S R L | Sostituto cartilagineo e osteocindrale comprendente una struttura multistrato e relativo impiego |
| EP1909859B1 (en) * | 2005-07-21 | 2017-09-06 | aap Biomaterials GmbH | Method for producing hydroxyapatite particles, in particular subnanodisperse hydroxyapatite particles in a matrix |
| US8491924B2 (en) * | 2006-04-13 | 2013-07-23 | Case Western Reserve University | Biomaterial implants |
| FR2933303B1 (fr) * | 2008-06-30 | 2010-12-03 | Univ Paris Curie | Substitut osseux,et procede pour sa preparation. |
| RU2529802C2 (ru) * | 2009-06-23 | 2014-09-27 | Гайстлих Фарма Аг | Материал заменителя костной ткани |
| DE102011052416A1 (de) * | 2010-08-04 | 2012-02-09 | Technische Universität Dresden | Wachstumsinhibierter Hydroxylapatit, Verfahren zu dessen Herstellung und Verwendung |
| KR101599245B1 (ko) * | 2010-12-22 | 2016-03-03 | 가이스틀리히 파마 아게 | 골 대체 물질 |
-
2013
- 2013-07-19 EP EP13003647.8A patent/EP2826495A1/en not_active Withdrawn
-
2014
- 2014-07-18 JP JP2016526468A patent/JP6478993B2/ja not_active Expired - Fee Related
- 2014-07-18 AU AU2014292503A patent/AU2014292503B2/en not_active Ceased
- 2014-07-18 SG SG11201600364VA patent/SG11201600364VA/en unknown
- 2014-07-18 WO PCT/EP2014/001966 patent/WO2015007393A1/en not_active Ceased
- 2014-07-18 HU HUE14741205A patent/HUE031178T2/en unknown
- 2014-07-18 CN CN201480039113.0A patent/CN105358189B/zh not_active Expired - Fee Related
- 2014-07-18 US US14/903,394 patent/US10029028B2/en active Active
- 2014-07-18 CA CA2917997A patent/CA2917997C/en active Active
- 2014-07-18 DK DK14741205.0T patent/DK3021883T3/en active
- 2014-07-18 BR BR112016001093-0A patent/BR112016001093B1/pt not_active IP Right Cessation
- 2014-07-18 PT PT147412050T patent/PT3021883T/pt unknown
- 2014-07-18 EP EP14741205.0A patent/EP3021883B1/en active Active
- 2014-07-18 KR KR1020167001407A patent/KR101944163B1/ko not_active Expired - Fee Related
- 2014-07-18 ES ES14741205.0T patent/ES2611202T3/es active Active
- 2014-07-18 RU RU2016105556A patent/RU2662326C2/ru active
- 2014-07-18 PL PL14741205T patent/PL3021883T3/pl unknown
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