JP2016523932A5 - - Google Patents
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- JP2016523932A5 JP2016523932A5 JP2016524383A JP2016524383A JP2016523932A5 JP 2016523932 A5 JP2016523932 A5 JP 2016523932A5 JP 2016524383 A JP2016524383 A JP 2016524383A JP 2016524383 A JP2016524383 A JP 2016524383A JP 2016523932 A5 JP2016523932 A5 JP 2016523932A5
- Authority
- JP
- Japan
- Prior art keywords
- less
- pharmaceutically acceptable
- acceptable salt
- salt
- pharmaceutically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361842856P | 2013-07-03 | 2013-07-03 | |
US61/842,856 | 2013-07-03 | ||
US201361879070P | 2013-09-17 | 2013-09-17 | |
US61/879,070 | 2013-09-17 | ||
US201361904843P | 2013-11-15 | 2013-11-15 | |
US61/904,843 | 2013-11-15 | ||
US201461975171P | 2014-04-04 | 2014-04-04 | |
US61/975,171 | 2014-04-04 | ||
PCT/US2014/045479 WO2015003166A1 (en) | 2013-07-03 | 2014-07-03 | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018161950A Division JP6655684B2 (ja) | 2013-07-03 | 2018-08-30 | 置換されたベンゾフラニル及びベンゾオキサゾリル化合物並びにその使用 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016523932A JP2016523932A (ja) | 2016-08-12 |
JP2016523932A5 true JP2016523932A5 (ja) | 2017-09-28 |
JP6397010B2 JP6397010B2 (ja) | 2018-09-26 |
Family
ID=51213064
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016524383A Active JP6397010B2 (ja) | 2013-07-03 | 2014-07-03 | 置換されたベンゾフラニル及びベンゾオキサゾリル化合物並びにその使用 |
JP2018161950A Active JP6655684B2 (ja) | 2013-07-03 | 2018-08-30 | 置換されたベンゾフラニル及びベンゾオキサゾリル化合物並びにその使用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018161950A Active JP6655684B2 (ja) | 2013-07-03 | 2018-08-30 | 置換されたベンゾフラニル及びベンゾオキサゾリル化合物並びにその使用 |
Country Status (19)
Country | Link |
---|---|
US (4) | US9856241B2 (ja) |
EP (1) | EP3016946B1 (ja) |
JP (2) | JP6397010B2 (ja) |
KR (2) | KR102325247B1 (ja) |
CN (2) | CN108440515B (ja) |
AU (2) | AU2014285019C1 (ja) |
BR (1) | BR112015032921B1 (ja) |
CA (1) | CA2917315C (ja) |
DK (1) | DK3016946T3 (ja) |
EA (1) | EA201690153A1 (ja) |
ES (1) | ES2935035T3 (ja) |
FI (1) | FI3016946T3 (ja) |
HK (1) | HK1223937A1 (ja) |
IL (1) | IL243216B (ja) |
MX (1) | MX367618B (ja) |
SG (1) | SG11201510339UA (ja) |
UA (1) | UA120592C2 (ja) |
WO (1) | WO2015003166A1 (ja) |
ZA (1) | ZA201509245B (ja) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9938258B2 (en) | 2012-11-29 | 2018-04-10 | Karyopharm Therapeutics Inc. | Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof |
US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
CN108440515B (zh) | 2013-07-03 | 2022-05-03 | 卡尔约药物治疗公司 | 取代的苯并呋喃基和苯并噁唑基化合物及其用途 |
WO2015042414A1 (en) | 2013-09-20 | 2015-03-26 | Karyopharm Therapeutics Inc. | Multicyclic compounds and methods of using same |
JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
JO3556B1 (ar) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
WO2016100515A1 (en) * | 2014-12-16 | 2016-06-23 | Karyopharm Therapeutics Inc. | Cyclic compounds and uses thereof |
BR112017021869A2 (pt) | 2015-04-10 | 2018-12-11 | Araxes Pharma Llc | compostos quinazolina substituídos e métodos de uso dos mesmos |
EP3283462B1 (en) | 2015-04-15 | 2020-12-02 | Araxes Pharma LLC | Fused-tricyclic inhibitors of kras and methods of use thereof |
US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
US20180244660A1 (en) | 2015-08-17 | 2018-08-30 | Karyopharm Therapeutics Inc. | Cyclopropylderivatives and their use as kinase inhibitors |
EP3337796A1 (en) * | 2015-08-17 | 2018-06-27 | Karyopharm Therapeutics, Inc. | 3-(pyridin-3-yl)-acrylamide and n-(pyridin-3-yl)-acrylamide derivatives and their use as pak or nampt modulators |
MX2018001979A (es) * | 2015-08-18 | 2019-04-25 | Karyopharm Therapeutics Inc | (s,e) -3- (6-aminopiridin-3-il) -n- ( (5- (4- (3-fluoruro-3 metilpirrolidin-1-carbonil) fenil) -7- (4 fluorofenil) benzofuran-2-il)metil)acrilamida para el tratamiento del cancer. |
CN105153156B (zh) * | 2015-09-22 | 2017-07-28 | 徐峰 | 一种4‑苯基‑2,7‑萘啶‑1(2h)‑酮的制备方法 |
WO2017058768A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
WO2017058807A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10689356B2 (en) | 2015-09-28 | 2020-06-23 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
EP3356354A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
CN108779097A (zh) | 2015-11-16 | 2018-11-09 | 亚瑞克西斯制药公司 | 包含取代的杂环基的2-取代的喹唑啉化合物及其使用方法 |
WO2017117406A1 (en) * | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof |
WO2017117447A1 (en) * | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
CN110036010A (zh) | 2016-09-29 | 2019-07-19 | 亚瑞克西斯制药公司 | Kras g12c突变蛋白的抑制剂 |
JP2019534260A (ja) | 2016-10-07 | 2019-11-28 | アラクセス ファーマ エルエルシー | Rasの阻害剤としての複素環式化合物およびその使用方法 |
TW201829402A (zh) * | 2016-12-23 | 2018-08-16 | 美商提薩羅有限公司 | 群落刺激因子1受體 (csf-1r)之小分子抑制劑及其用途 |
EP3573971A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
EP3573967A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused hetero-hetero bicyclic compounds and methods of use thereof |
CN107056727B (zh) * | 2017-03-29 | 2020-12-11 | 温州医科大学 | 一种2-芳基-5-芳硒基-1,3,4-噁二唑化合物及制备方法 |
US20180282282A1 (en) | 2017-03-30 | 2018-10-04 | Genentech, Inc. | Isoquinolines as inhibitors of hpk1 |
EP3630745A2 (en) | 2017-05-25 | 2020-04-08 | Araxes Pharma LLC | Covalent inhibitors of kras |
EP3630746A1 (en) | 2017-05-25 | 2020-04-08 | Araxes Pharma LLC | Compounds and methods of use thereof for treatment of cancer |
WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
JP7317309B2 (ja) * | 2019-01-31 | 2023-07-31 | 一般社団法人健康免疫研究機構 | オートファジー性細胞死誘導剤 |
CN114507215A (zh) * | 2020-11-14 | 2022-05-17 | 成都海博为药业有限公司 | 一种作为pak4激酶抑制剂的化合物及其制备方法和应用 |
WO2023137353A1 (en) * | 2022-01-14 | 2023-07-20 | Ventyx Biosciences, Inc. | 15-pgdh inhibitors |
WO2024120442A1 (en) * | 2022-12-07 | 2024-06-13 | Convergen (Suzhou) Pharmaceutical Co., Ltd. | Pak4 protein degraders, pharmaceutical compositions, and therapeutic applications |
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US5229386A (en) | 1989-01-05 | 1993-07-20 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
WO1995009159A1 (en) | 1993-09-28 | 1995-04-06 | Otsuka Pharmaceutical Company, Limited | Quinoxaline derivative as antidiabetic agent |
GB9525262D0 (en) * | 1995-12-11 | 1996-02-07 | Bayer Ag | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
CN1152032A (zh) * | 1995-12-14 | 1997-06-18 | 高翔铎 | 皮江法炼镁中工作真空度高速获得的方法 |
DE19624668A1 (de) | 1996-06-20 | 1998-02-19 | Klinge Co Chem Pharm Fab | Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden |
DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
US6258800B1 (en) * | 1998-04-15 | 2001-07-10 | Warner-Lambert Company | Prodrugs of benzofuranylethyl carbamate NK1 antagonists |
DE19818044A1 (de) | 1998-04-22 | 1999-10-28 | Klinge Co Chem Pharm Fab | Verwendung von Vitamin-PP-Verbindungen |
EP1169031A1 (en) * | 1999-04-09 | 2002-01-09 | British Biotech Pharmaceuticals Limited | Antimicrobial agents |
DE60216097T2 (de) | 2001-07-19 | 2007-06-28 | Pfizer Italia S.R.L. | Phenylacetamido-thiazole verbindungen, verfahren zu ihren herstellung und ihre anwendung als antitumor mittel |
EP1348434A1 (en) | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Use of pyridyl amides as inhibitors of angiogenesis |
US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
US7078419B2 (en) | 2003-03-10 | 2006-07-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
WO2004106317A1 (ja) * | 2003-05-29 | 2004-12-09 | The New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
CA2534678A1 (en) * | 2003-08-07 | 2005-02-17 | Bayer Pharmaceuticals Corporation | Benzofuran derivatives useful for treating hyper-proliferative disorders |
GB2427405A (en) * | 2004-04-07 | 2006-12-27 | Pharmacyclics Inc | Novel hydroxamates as therapeutic agents |
TW200616613A (en) | 2004-10-05 | 2006-06-01 | Shionogi & Co | Biaryl derivatives |
WO2006054793A1 (ja) * | 2004-11-19 | 2006-05-26 | The New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
JP2008534664A (ja) | 2005-04-06 | 2008-08-28 | アストラゼネカ アクチボラグ | 置換複素環およびchk1、pdk1及びpak阻害剤としてのそれらの使用 |
AR055916A1 (es) | 2005-04-22 | 2007-09-12 | Wyeth Corp | Derivados de dihidrobenzofurano, usos de los mismos en la preparacion de un medicamento y composicion farmaceutica |
US20080020413A1 (en) | 2006-03-29 | 2008-01-24 | Columbia University | Crystalline visfatin and methods therefor |
WO2008026018A1 (en) | 2006-09-01 | 2008-03-06 | Topotarget Switzerland Sa | New method for the treatment of inflammatory diseases |
EP2003118A1 (de) * | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Zimtsäurederivate als Modulatoren des EP2-Rezeptors |
WO2009072004A2 (en) | 2007-09-26 | 2009-06-11 | Gemin X Pharmaceuticals Canada, Inc. | Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
US8173677B2 (en) | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
EP2098231A1 (en) | 2008-03-05 | 2009-09-09 | Topotarget Switzerland SA | Use of NAD formation inhibitors for the treatment of ischemia-reperfusion injury |
FR2943669B1 (fr) | 2009-03-24 | 2011-05-06 | Sanofi Aventis | Derives de nicotinamide,leur preparation et leur application en therapeutique |
US8552032B2 (en) * | 2009-12-18 | 2013-10-08 | Janssen Pharmaceutica Nv | Bicyclic derivatives useful as inhibitors of DPP-1 |
EP2542086A4 (en) | 2010-03-01 | 2013-09-04 | Myrexis Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
US20130317027A1 (en) | 2010-03-01 | 2013-11-28 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
BR112013028281A2 (pt) | 2011-05-04 | 2017-01-10 | Forma Tm Llc | compostos e composições para inibição de nampt |
WO2012177782A1 (en) | 2011-06-20 | 2012-12-27 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
WO2013082150A1 (en) | 2011-11-30 | 2013-06-06 | The Curators Of The University Of Missouri | Small molecule inhibitors of nicotinamide phosphoribosyltransferase (nampt) |
WO2014074715A1 (en) | 2012-11-07 | 2014-05-15 | Genentech, Inc. | Cyclopropyl amide derivatives |
US9938258B2 (en) * | 2012-11-29 | 2018-04-10 | Karyopharm Therapeutics Inc. | Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof |
WO2014111871A1 (en) | 2013-01-17 | 2014-07-24 | Aurigene Discovery Technologies Limited | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
CN108440515B (zh) | 2013-07-03 | 2022-05-03 | 卡尔约药物治疗公司 | 取代的苯并呋喃基和苯并噁唑基化合物及其用途 |
WO2015042414A1 (en) | 2013-09-20 | 2015-03-26 | Karyopharm Therapeutics Inc. | Multicyclic compounds and methods of using same |
CN105579449A (zh) | 2013-10-09 | 2016-05-11 | 伊莱利利公司 | 新的用作nampt抑制剂的吡啶基氧基乙酰基四氢异喹啉化合物 |
WO2016100515A1 (en) | 2014-12-16 | 2016-06-23 | Karyopharm Therapeutics Inc. | Cyclic compounds and uses thereof |
US20180244660A1 (en) | 2015-08-17 | 2018-08-30 | Karyopharm Therapeutics Inc. | Cyclopropylderivatives and their use as kinase inhibitors |
EP3337796A1 (en) | 2015-08-17 | 2018-06-27 | Karyopharm Therapeutics, Inc. | 3-(pyridin-3-yl)-acrylamide and n-(pyridin-3-yl)-acrylamide derivatives and their use as pak or nampt modulators |
MX2018001979A (es) | 2015-08-18 | 2019-04-25 | Karyopharm Therapeutics Inc | (s,e) -3- (6-aminopiridin-3-il) -n- ( (5- (4- (3-fluoruro-3 metilpirrolidin-1-carbonil) fenil) -7- (4 fluorofenil) benzofuran-2-il)metil)acrilamida para el tratamiento del cancer. |
WO2017117406A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof |
WO2017117447A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
-
2014
- 2014-07-03 CN CN201810340027.3A patent/CN108440515B/zh active Active
- 2014-07-03 EP EP14742127.5A patent/EP3016946B1/en active Active
- 2014-07-03 DK DK14742127.5T patent/DK3016946T3/da active
- 2014-07-03 UA UAA201600841A patent/UA120592C2/uk unknown
- 2014-07-03 US US14/902,202 patent/US9856241B2/en active Active
- 2014-07-03 AU AU2014285019A patent/AU2014285019C1/en active Active
- 2014-07-03 BR BR112015032921-7A patent/BR112015032921B1/pt active IP Right Grant
- 2014-07-03 FI FIEP14742127.5T patent/FI3016946T3/fi active
- 2014-07-03 CN CN201480046884.2A patent/CN105492437B/zh active Active
- 2014-07-03 ES ES14742127T patent/ES2935035T3/es active Active
- 2014-07-03 JP JP2016524383A patent/JP6397010B2/ja active Active
- 2014-07-03 KR KR1020167002276A patent/KR102325247B1/ko active IP Right Grant
- 2014-07-03 CA CA2917315A patent/CA2917315C/en active Active
- 2014-07-03 MX MX2015018048A patent/MX367618B/es active IP Right Grant
- 2014-07-03 KR KR1020217036148A patent/KR102581373B1/ko active IP Right Grant
- 2014-07-03 EA EA201690153A patent/EA201690153A1/ru unknown
- 2014-07-03 SG SG11201510339UA patent/SG11201510339UA/en unknown
- 2014-07-03 WO PCT/US2014/045479 patent/WO2015003166A1/en active Application Filing
-
2015
- 2015-12-17 IL IL243216A patent/IL243216B/en active IP Right Grant
- 2015-12-18 ZA ZA2015/09245A patent/ZA201509245B/en unknown
-
2016
- 2016-10-25 HK HK16112275.3A patent/HK1223937A1/zh unknown
-
2017
- 2017-12-04 US US15/831,111 patent/US10399963B2/en active Active
-
2018
- 2018-08-30 JP JP2018161950A patent/JP6655684B2/ja active Active
-
2019
- 2019-03-11 AU AU2019201642A patent/AU2019201642B2/en active Active
- 2019-07-10 US US16/507,927 patent/US11008309B2/en active Active
-
2021
- 2021-03-18 US US17/205,797 patent/US20210403459A1/en active Pending
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