JP2016523891A5 - - Google Patents

Info

Publication number

JP2016523891A5

JP2016523891A5 JP2016522936A JP2016522936A JP2016523891A5 JP 2016523891 A5 JP2016523891 A5 JP 2016523891A5 JP 2016522936 A JP2016522936 A JP 2016522936A JP 2016522936 A JP2016522936 A JP 2016522936A JP 2016523891 A5 JP2016523891 A5 JP 2016523891A5

Authority

JP

Japan

Prior art keywords

xaa

amino acid

sequence

absent

seq

Prior art date

2014-06-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001413 amino acids Chemical class 0.000 claims description 44
• 125000000539 amino acid group Chemical group 0.000 claims description 40
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 19
• 239000000863 peptide conjugate Substances 0.000 claims description 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 13
• 239000001257 hydrogen Substances 0.000 claims 13
• 150000001875 compounds Chemical class 0.000 claims 11
• 230000021615 conjugation Effects 0.000 claims 10
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 150000002431 hydrogen Chemical class 0.000 claims 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
• 150000002632 lipids Chemical class 0.000 claims 4
• 238000000034 method Methods 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 239000012453 solvate Substances 0.000 claims 3
• 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
• 239000000562 conjugate Substances 0.000 claims 2
• 125000004404 heteroalkyl group Chemical group 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 150000003573 thiols Chemical class 0.000 claims 2
• 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 description 6
• 239000000463 material Substances 0.000 description 6
• 238000006596 Alder-ene reaction Methods 0.000 description 4
• 239000007795 chemical reaction product Substances 0.000 description 4
• OXBLVCZKDOZZOJ-UHFFFAOYSA-N 2,3-Dihydrothiophene Chemical compound C1CC=CS1 OXBLVCZKDOZZOJ-UHFFFAOYSA-N 0.000 description 2
• AEIRHGWZYWCVPX-UHFFFAOYSA-N S1C=CCC1.C(CCCCCCCCCCCCCCC)(=O)OC=C Chemical compound S1C=CCC1.C(CCCCCCCCCCCCCCC)(=O)OC=C AEIRHGWZYWCVPX-UHFFFAOYSA-N 0.000 description 2
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• 229920002554 vinyl polymer Polymers 0.000 description 1