JP2017035093A5 - - Google Patents
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- Publication number
- JP2017035093A5 JP2017035093A5 JP2016188777A JP2016188777A JP2017035093A5 JP 2017035093 A5 JP2017035093 A5 JP 2017035093A5 JP 2016188777 A JP2016188777 A JP 2016188777A JP 2016188777 A JP2016188777 A JP 2016188777A JP 2017035093 A5 JP2017035093 A5 JP 2017035093A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- micelle
- micelles
- antibody
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 13
- 239000000693 micelle Substances 0.000 claims 8
- 241000711798 Rabies lyssavirus Species 0.000 claims 7
- 108091006027 G proteins Proteins 0.000 claims 6
- 102000030782 GTP binding Human genes 0.000 claims 6
- 108091000058 GTP-Binding Proteins 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000000890 antigenic effect Effects 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000266847 Mephitidae Species 0.000 claims 1
- 241000282330 Procyon lotor Species 0.000 claims 1
- 101900083372 Rabies virus Glycoprotein Proteins 0.000 claims 1
- 241000282485 Vulpes vulpes Species 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41076710P | 2010-11-05 | 2010-11-05 | |
| US61/410,767 | 2010-11-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537909A Division JP6158088B2 (ja) | 2010-11-05 | 2011-11-07 | 狂犬病糖タンパク質ウイルス様粒子（ｖｌｐ） |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017035093A JP2017035093A (ja) | 2017-02-16 |
| JP2017035093A5 true JP2017035093A5 (enExample) | 2017-07-13 |
| JP6195965B2 JP6195965B2 (ja) | 2017-09-13 |
Family
ID=46025156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537909A Active JP6158088B2 (ja) | 2010-11-05 | 2011-11-07 | 狂犬病糖タンパク質ウイルス様粒子（ｖｌｐ） |
| JP2016188777A Active JP6195965B2 (ja) | 2010-11-05 | 2016-09-27 | 狂犬病糖タンパク質ウイルス様粒子（ｖｌｐ） |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537909A Active JP6158088B2 (ja) | 2010-11-05 | 2011-11-07 | 狂犬病糖タンパク質ウイルス様粒子（ｖｌｐ） |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US9724405B2 (enExample) |
| EP (2) | EP2635257B1 (enExample) |
| JP (2) | JP6158088B2 (enExample) |
| KR (1) | KR101847908B1 (enExample) |
| CN (2) | CN109157658A (enExample) |
| AU (1) | AU2011323090B2 (enExample) |
| BR (1) | BR112013011194B1 (enExample) |
| CA (1) | CA2817005C (enExample) |
| CY (1) | CY1119284T1 (enExample) |
| DK (1) | DK2635257T3 (enExample) |
| ES (1) | ES2636965T3 (enExample) |
| HR (1) | HRP20171213T1 (enExample) |
| HU (1) | HUE034247T2 (enExample) |
| LT (1) | LT2635257T (enExample) |
| MX (1) | MX354750B (enExample) |
| PL (1) | PL2635257T3 (enExample) |
| PT (1) | PT2635257T (enExample) |
| RS (1) | RS56157B1 (enExample) |
| SG (1) | SG190140A1 (enExample) |
| SI (1) | SI2635257T1 (enExample) |
| SM (1) | SMT201700392T1 (enExample) |
| WO (1) | WO2012061815A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| PT2610345E (pt) | 2007-11-27 | 2016-01-11 | Medicago Inc | Partículas semelhantes ao vírus (vlps) da gripe recombinantes produzidas em plantas transgénicas que expressam hemaglutinina |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| WO2010077717A1 (en) | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Modified rsv f proteins and methods of their use |
| ES2662778T3 (es) | 2009-09-22 | 2018-04-09 | Medicago Inc. | Método de preparación de proteínas derivadas de plantas |
| RS56157B1 (sr) * | 2010-11-05 | 2017-11-30 | Novavax Inc | Glikoproteinske čestice nalik virusu (vlp) besnila |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| ES2665512T3 (es) * | 2011-06-13 | 2018-04-26 | Medicago Inc. | Producción de partículas pseudovíricas de la rabia en plantas |
| KR101479668B1 (ko) | 2012-07-31 | 2015-01-12 | 대한민국 | 광견병 바이러스 유전자를 발현하는 재조합 아데노바이러스 및 이를 포함하는 광견병의 예방 또는 치료용 백신 조성물 |
| CN103777021B (zh) * | 2012-10-18 | 2016-03-02 | 辽宁成大生物股份有限公司 | 狂犬疫苗糖蛋白含量的检测方法 |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| CA2956224A1 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| MX2018002728A (es) * | 2015-09-03 | 2018-09-05 | Novavax Inc | Composiciones de vacuna que tienen estabilidad e inmunogenicidad mejoradas. |
| CN106905434B (zh) * | 2017-02-28 | 2021-01-26 | 国药中生生物技术研究院有限公司 | 一种包含蹄蝠肝炎病毒核心蛋白的重组融合蛋白及其制备方法和应用 |
| EP3420076B1 (en) * | 2017-03-06 | 2024-02-21 | Guangzhou Realbenefitspot Pharmaceutical Co., Ltd. | Methods of producing and characterizing virus vaccine and virus vaccine composition |
| EP4382183A3 (en) * | 2017-03-06 | 2024-08-21 | Guangzhou Realbenefitspot Pharmaceutical Co., Ltd. | Methods of producing and characterizing virus vaccine and virus vaccine composition |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CN111148509A (zh) | 2017-07-24 | 2020-05-12 | 诺瓦瓦克斯股份有限公司 | 治疗呼吸系统疾病的方法和组合物 |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| JP7472019B2 (ja) * | 2017-11-06 | 2024-04-22 | インターベット インターナショナル ベー． フェー． | 狂犬病ウイルスワクチン |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| IL277274B2 (en) | 2018-03-19 | 2024-02-01 | Novavax Inc | Multifunctional nanoparticle vaccines for influenza |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| KR102077772B1 (ko) | 2018-11-29 | 2020-02-17 | 주식회사 바이오앱 | 광견병 예방용 백신 조성물 및 이의 제조 방법 |
| KR102211077B1 (ko) * | 2019-01-16 | 2021-02-02 | 충남대학교 산학협력단 | 바이러스 유사 입자를 이용한 슈도-타입 광견병 백신 |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| MX2021011426A (es) | 2019-03-19 | 2022-03-11 | Broad Inst Inc | Metodos y composiciones para editar secuencias de nucleótidos. |
| CN110007080B (zh) * | 2019-04-12 | 2022-09-23 | 长春西诺生物科技有限公司 | 一种狂犬病毒抗体定量检测试剂盒及其制备方法与检测方法 |
| CN109959789B (zh) * | 2019-04-12 | 2022-08-16 | 长春西诺生物科技有限公司 | 一种狂犬病毒抗体检测试纸及其制备方法与检测方法 |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2023064931A1 (en) * | 2021-10-15 | 2023-04-20 | La Jolla Institute For Immunology | Engineered rabies virus glycoprotein, compositions, and methods of use thereof |
| CN114272367B (zh) * | 2021-12-03 | 2023-07-07 | 华东理工大学 | 一种口服狂犬病病毒样颗粒疫苗及其制备方法 |
| KR102566969B1 (ko) | 2021-12-14 | 2023-08-16 | 안희철 | 근거리 통신 과정에서 충전 가능한 모바일 단말 |
| CN117867029B (zh) * | 2023-12-29 | 2024-12-20 | 复百澳(苏州)生物医药科技有限公司 | 一种狂犬亚型假病毒的制备方法及应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0237686A1 (en) * | 1986-03-18 | 1987-09-23 | Institut Pasteur | DNA sequences derived from the rabies virus genome |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US5667782A (en) * | 1992-07-16 | 1997-09-16 | Oxford University | Multiple particulate antigen delivery system |
| US6387373B1 (en) | 1993-01-15 | 2002-05-14 | Novavax, Inc. | Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants |
| US5629021A (en) | 1995-01-31 | 1997-05-13 | Novavax, Inc. | Micellar nanoparticles |
| US6589533B1 (en) * | 1997-09-18 | 2003-07-08 | Research Development Foundation | Genetically-engineered alphaviruses, flaviviruses, and bunyaviruses with modified envelope transmembrane glycoproteins and altered host-range phenotype |
| US6673601B1 (en) * | 1999-04-15 | 2004-01-06 | Institut Pasteur | Chimeric lyssavirus nucleic acids and polypeptides |
| AUPR011700A0 (en) * | 2000-09-14 | 2000-10-05 | Austin Research Institute, The | Composition comprising immunogenic virus sized particles (VSP) |
| ATE424815T1 (de) * | 2001-12-03 | 2009-03-15 | Dor Biopharma Inc | Stabilisierte umkehr-mizellen-zusammensetzungen und ihre verwendung |
| US7211378B2 (en) * | 2002-01-31 | 2007-05-01 | Wisconsin Alumni Research Foundation | Filovirus vectors and noninfectious filovirus-based particles |
| WO2003068933A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
| US8592197B2 (en) * | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| US9216212B2 (en) * | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| KR20080094910A (ko) * | 2006-01-17 | 2008-10-27 | 디나벡크 가부시키가이샤 | 신규 단백질 발현계 |
| US8153115B2 (en) * | 2006-06-15 | 2012-04-10 | Ben-Gurion University Of The Negev Research And Development Authority | Virus-like particles for treatment of viral infections |
| WO2008005777A2 (en) | 2006-06-30 | 2008-01-10 | Novavax, Inc. | Methods of enhancing protein incorporation into virus like particles |
| US8980281B2 (en) * | 2006-09-05 | 2015-03-17 | Academia Sinica | High-yield transgenic mammalian expression system for generating virus-like particles |
| TW200907058A (en) * | 2007-05-30 | 2009-02-16 | Wyeth Corp | Raccoon poxvirus expressing rabies glycoproteins |
| EP2175882A4 (en) * | 2007-07-19 | 2011-11-30 | Novavax Inc | VARICELLA ZOSTER VIRUS VIRUS LIKE PARTICLES (VLP) AND ANTIGENE |
| KR100961280B1 (ko) * | 2008-05-21 | 2010-06-03 | 한국생명공학연구원 | 형광특성이 향상된 풀러렌-실리카 나노입자, 이의 제조방법및 이의 용도 |
| WO2009153801A1 (en) * | 2008-06-17 | 2009-12-23 | Manpreet Kaur | Dna vaccine based on glycoprotein gene of rabies virus conjugated to lamp-1 signal sequence at the c-terminus and an adjuvant; and method of its preparation thereof |
| US9296790B2 (en) | 2008-10-03 | 2016-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for protein delivery |
| WO2010077717A1 (en) | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Modified rsv f proteins and methods of their use |
| RS56157B1 (sr) | 2010-11-05 | 2017-11-30 | Novavax Inc | Glikoproteinske čestice nalik virusu (vlp) besnila |
-
2011
- 2011-11-07 RS RS20170786A patent/RS56157B1/sr unknown
- 2011-11-07 PT PT118389428T patent/PT2635257T/pt unknown
- 2011-11-07 KR KR1020137014262A patent/KR101847908B1/ko active Active
- 2011-11-07 ES ES11838942.8T patent/ES2636965T3/es active Active
- 2011-11-07 US US13/883,745 patent/US9724405B2/en active Active
- 2011-11-07 JP JP2013537909A patent/JP6158088B2/ja active Active
- 2011-11-07 HR HRP20171213TT patent/HRP20171213T1/hr unknown
- 2011-11-07 WO PCT/US2011/059602 patent/WO2012061815A2/en not_active Ceased
- 2011-11-07 CN CN201810963479.7A patent/CN109157658A/zh active Pending
- 2011-11-07 DK DK11838942.8T patent/DK2635257T3/en active
- 2011-11-07 PL PL11838942T patent/PL2635257T3/pl unknown
- 2011-11-07 CA CA2817005A patent/CA2817005C/en active Active
- 2011-11-07 EP EP11838942.8A patent/EP2635257B1/en active Active
- 2011-11-07 HU HUE11838942A patent/HUE034247T2/en unknown
- 2011-11-07 SM SM20170392T patent/SMT201700392T1/it unknown
- 2011-11-07 LT LTEP11838942.8T patent/LT2635257T/lt unknown
- 2011-11-07 EP EP17179212.0A patent/EP3246019B1/en active Active
- 2011-11-07 BR BR112013011194-1A patent/BR112013011194B1/pt active IP Right Grant
- 2011-11-07 AU AU2011323090A patent/AU2011323090B2/en active Active
- 2011-11-07 CN CN201180064287.9A patent/CN103282023B/zh active Active
- 2011-11-07 MX MX2013005090A patent/MX354750B/es active IP Right Grant
- 2011-11-07 SI SI201131258T patent/SI2635257T1/en unknown
- 2011-11-07 SG SG2013034178A patent/SG190140A1/en unknown
-
2016
- 2016-09-27 JP JP2016188777A patent/JP6195965B2/ja active Active
-
2017
- 2017-06-30 US US15/638,955 patent/US10086065B2/en active Active
- 2017-08-11 CY CY20171100873T patent/CY1119284T1/el unknown
-
2018
- 2018-08-30 US US16/116,990 patent/US20190224307A1/en not_active Abandoned
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