SI2635257T1 - RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs) - Google Patents
RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs) Download PDFInfo
- Publication number
- SI2635257T1 SI2635257T1 SI201131258T SI201131258T SI2635257T1 SI 2635257 T1 SI2635257 T1 SI 2635257T1 SI 201131258 T SI201131258 T SI 201131258T SI 201131258 T SI201131258 T SI 201131258T SI 2635257 T1 SI2635257 T1 SI 2635257T1
- Authority
- SI
- Slovenia
- Prior art keywords
- protein
- micelles
- rabies virus
- host
- antibodies
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 2
- 101900083372 Rabies virus Glycoprotein Proteins 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 14
- 241000711798 Rabies lyssavirus Species 0.000 claims abstract 10
- 239000000203 mixture Substances 0.000 claims abstract 7
- 108091006027 G proteins Proteins 0.000 claims abstract 4
- 102000030782 GTP binding Human genes 0.000 claims abstract 4
- 108091000058 GTP-Binding Proteins 0.000 claims abstract 4
- 102000003886 Glycoproteins Human genes 0.000 claims abstract 3
- 108090000288 Glycoproteins Proteins 0.000 claims abstract 3
- 229960005486 vaccine Drugs 0.000 claims abstract 3
- 239000000693 micelle Substances 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000000890 antigenic effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000288673 Chiroptera Species 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000282341 Mustela putorius furo Species 0.000 claims 1
- 241000282330 Procyon lotor Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
- 206010037742 Rabies Diseases 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/205—Rhabdoviridae, e.g. rabies virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41076710P | 2010-11-05 | 2010-11-05 | |
| EP11838942.8A EP2635257B1 (en) | 2010-11-05 | 2011-11-07 | RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs) |
| PCT/US2011/059602 WO2012061815A2 (en) | 2010-11-05 | 2011-11-07 | RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2635257T1 true SI2635257T1 (en) | 2018-01-31 |
Family
ID=46025156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131258T SI2635257T1 (en) | 2010-11-05 | 2011-11-07 | RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs) |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US9724405B2 (enExample) |
| EP (2) | EP3246019B1 (enExample) |
| JP (2) | JP6158088B2 (enExample) |
| KR (1) | KR101847908B1 (enExample) |
| CN (2) | CN109157658A (enExample) |
| AU (1) | AU2011323090B2 (enExample) |
| BR (1) | BR112013011194B1 (enExample) |
| CA (1) | CA2817005C (enExample) |
| CY (1) | CY1119284T1 (enExample) |
| DK (1) | DK2635257T3 (enExample) |
| ES (1) | ES2636965T3 (enExample) |
| HR (1) | HRP20171213T1 (enExample) |
| HU (1) | HUE034247T2 (enExample) |
| LT (1) | LT2635257T (enExample) |
| MX (1) | MX354750B (enExample) |
| PL (1) | PL2635257T3 (enExample) |
| PT (1) | PT2635257T (enExample) |
| RS (1) | RS56157B1 (enExample) |
| SG (1) | SG190140A1 (enExample) |
| SI (1) | SI2635257T1 (enExample) |
| SM (1) | SMT201700392T1 (enExample) |
| WO (1) | WO2012061815A2 (enExample) |
Families Citing this family (39)
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| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| NZ587108A (en) | 2007-11-27 | 2013-04-26 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| KR101691574B1 (ko) | 2008-12-09 | 2017-01-02 | 노바백스, 인코포레이티드 | 변형 ｒｓｖ ｆ 단백질 및 이들의 사용 방법 |
| SG178918A1 (en) | 2009-09-22 | 2012-04-27 | Medicago Inc | Method of preparing plant-derived vlps |
| CA2817005C (en) | 2010-11-05 | 2018-09-11 | Novavax Inc. | Rabies glycoprotein virus-like particles (vlps) |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| US20140227322A1 (en) * | 2011-06-13 | 2014-08-14 | Medicago Inc. | Rabies virus like particle production in plants |
| KR101479668B1 (ko) | 2012-07-31 | 2015-01-12 | 대한민국 | 광견병 바이러스 유전자를 발현하는 재조합 아데노바이러스 및 이를 포함하는 광견병의 예방 또는 치료용 백신 조성물 |
| CN103777021B (zh) * | 2012-10-18 | 2016-03-02 | 辽宁成大生物股份有限公司 | 狂犬疫苗糖蛋白含量的检测方法 |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| IL257800B2 (en) | 2015-09-03 | 2023-11-01 | Novavax Inc | Immune compositions with improved stability and immunogenicity |
| CN106905434B (zh) * | 2017-02-28 | 2021-01-26 | 国药中生生物技术研究院有限公司 | 一种包含蹄蝠肝炎病毒核心蛋白的重组融合蛋白及其制备方法和应用 |
| EP3420076B1 (en) * | 2017-03-06 | 2024-02-21 | Guangzhou Realbenefitspot Pharmaceutical Co., Ltd. | Methods of producing and characterizing virus vaccine and virus vaccine composition |
| EP4382183A3 (en) | 2017-03-06 | 2024-08-21 | Guangzhou Realbenefitspot Pharmaceutical Co., Ltd. | Methods of producing and characterizing virus vaccine and virus vaccine composition |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| US12083228B2 (en) | 2017-07-24 | 2024-09-10 | Novavax, Inc. | Methods and compositions for treating respiratory disease |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| CN118490817A (zh) * | 2017-11-06 | 2024-08-16 | 英特维特国际股份有限公司 | 狂犬病毒疫苗 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| AU2019238171B2 (en) | 2018-03-19 | 2026-01-08 | Novavax, Inc. | Multivalent influenza nanoparticle vaccines |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| KR102077772B1 (ko) | 2018-11-29 | 2020-02-17 | 주식회사 바이오앱 | 광견병 예방용 백신 조성물 및 이의 제조 방법 |
| KR102211077B1 (ko) * | 2019-01-16 | 2021-02-02 | 충남대학교 산학협력단 | 바이러스 유사 입자를 이용한 슈도-타입 광견병 백신 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP3942043A2 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| CN109959789B (zh) * | 2019-04-12 | 2022-08-16 | 长春西诺生物科技有限公司 | 一种狂犬病毒抗体检测试纸及其制备方法与检测方法 |
| CN110007080B (zh) * | 2019-04-12 | 2022-09-23 | 长春西诺生物科技有限公司 | 一种狂犬病毒抗体定量检测试剂盒及其制备方法与检测方法 |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2023064931A1 (en) * | 2021-10-15 | 2023-04-20 | La Jolla Institute For Immunology | Engineered rabies virus glycoprotein, compositions, and methods of use thereof |
| CN114272367B (zh) * | 2021-12-03 | 2023-07-07 | 华东理工大学 | 一种口服狂犬病病毒样颗粒疫苗及其制备方法 |
| KR102566969B1 (ko) | 2021-12-14 | 2023-08-16 | 안희철 | 근거리 통신 과정에서 충전 가능한 모바일 단말 |
| CN117867029B (zh) * | 2023-12-29 | 2024-12-20 | 复百澳(苏州)生物医药科技有限公司 | 一种狂犬亚型假病毒的制备方法及应用 |
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| US6673601B1 (en) * | 1999-04-15 | 2004-01-06 | Institut Pasteur | Chimeric lyssavirus nucleic acids and polypeptides |
| AUPR011700A0 (en) * | 2000-09-14 | 2000-10-05 | Austin Research Institute, The | Composition comprising immunogenic virus sized particles (VSP) |
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| US8153115B2 (en) * | 2006-06-15 | 2012-04-10 | Ben-Gurion University Of The Negev Research And Development Authority | Virus-like particles for treatment of viral infections |
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| US8980281B2 (en) | 2006-09-05 | 2015-03-17 | Academia Sinica | High-yield transgenic mammalian expression system for generating virus-like particles |
| TW200907058A (en) * | 2007-05-30 | 2009-02-16 | Wyeth Corp | Raccoon poxvirus expressing rabies glycoproteins |
| CA2729011A1 (en) * | 2007-07-19 | 2009-01-22 | Novavax, Inc. | Varicella zoster virus-virus like particles (vlps) and antigens |
| KR100961280B1 (ko) * | 2008-05-21 | 2010-06-03 | 한국생명공학연구원 | 형광특성이 향상된 풀러렌-실리카 나노입자, 이의 제조방법및 이의 용도 |
| WO2009153801A1 (en) | 2008-06-17 | 2009-12-23 | Manpreet Kaur | Dna vaccine based on glycoprotein gene of rabies virus conjugated to lamp-1 signal sequence at the c-terminus and an adjuvant; and method of its preparation thereof |
| US9296790B2 (en) | 2008-10-03 | 2016-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for protein delivery |
| KR101691574B1 (ko) * | 2008-12-09 | 2017-01-02 | 노바백스, 인코포레이티드 | 변형 ｒｓｖ ｆ 단백질 및 이들의 사용 방법 |
| CA2817005C (en) | 2010-11-05 | 2018-09-11 | Novavax Inc. | Rabies glycoprotein virus-like particles (vlps) |
-
2011
- 2011-11-07 CA CA2817005A patent/CA2817005C/en active Active
- 2011-11-07 CN CN201810963479.7A patent/CN109157658A/zh active Pending
- 2011-11-07 HU HUE11838942A patent/HUE034247T2/en unknown
- 2011-11-07 LT LTEP11838942.8T patent/LT2635257T/lt unknown
- 2011-11-07 SG SG2013034178A patent/SG190140A1/en unknown
- 2011-11-07 KR KR1020137014262A patent/KR101847908B1/ko active Active
- 2011-11-07 JP JP2013537909A patent/JP6158088B2/ja active Active
- 2011-11-07 HR HRP20171213TT patent/HRP20171213T1/hr unknown
- 2011-11-07 BR BR112013011194-1A patent/BR112013011194B1/pt active IP Right Grant
- 2011-11-07 EP EP17179212.0A patent/EP3246019B1/en active Active
- 2011-11-07 SI SI201131258T patent/SI2635257T1/en unknown
- 2011-11-07 EP EP11838942.8A patent/EP2635257B1/en active Active
- 2011-11-07 ES ES11838942.8T patent/ES2636965T3/es active Active
- 2011-11-07 DK DK11838942.8T patent/DK2635257T3/en active
- 2011-11-07 PL PL11838942T patent/PL2635257T3/pl unknown
- 2011-11-07 US US13/883,745 patent/US9724405B2/en active Active
- 2011-11-07 SM SM20170392T patent/SMT201700392T1/it unknown
- 2011-11-07 MX MX2013005090A patent/MX354750B/es active IP Right Grant
- 2011-11-07 PT PT118389428T patent/PT2635257T/pt unknown
- 2011-11-07 AU AU2011323090A patent/AU2011323090B2/en active Active
- 2011-11-07 CN CN201180064287.9A patent/CN103282023B/zh active Active
- 2011-11-07 RS RS20170786A patent/RS56157B1/sr unknown
- 2011-11-07 WO PCT/US2011/059602 patent/WO2012061815A2/en not_active Ceased
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2016
- 2016-09-27 JP JP2016188777A patent/JP6195965B2/ja active Active
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2017
- 2017-06-30 US US15/638,955 patent/US10086065B2/en active Active
- 2017-08-11 CY CY20171100873T patent/CY1119284T1/el unknown
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2018
- 2018-08-30 US US16/116,990 patent/US20190224307A1/en not_active Abandoned
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