BR112013011194B1 - partícula micelar, composição farmacêutica compreendendo a mesma, uso de uma partícula micelar e método de preparação de uma micela - Google Patents

partícula micelar, composição farmacêutica compreendendo a mesma, uso de uma partícula micelar e método de preparação de uma micela Download PDF

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Publication number
BR112013011194B1
BR112013011194B1 BR112013011194-1A BR112013011194A BR112013011194B1 BR 112013011194 B1 BR112013011194 B1 BR 112013011194B1 BR 112013011194 A BR112013011194 A BR 112013011194A BR 112013011194 B1 BR112013011194 B1 BR 112013011194B1
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BR
Brazil
Prior art keywords
proteins
protein
vlps
cells
glycoproteins
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BR112013011194-1A
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English (en)
Portuguese (pt)
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BR112013011194A2 (pt
Inventor
Gale Smith
Ye Liu
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Novavax, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Novavax, Inc filed Critical Novavax, Inc
Publication of BR112013011194A2 publication Critical patent/BR112013011194A2/pt
Publication of BR112013011194B1 publication Critical patent/BR112013011194B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/205Rhabdoviridae, e.g. rabies virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/20011Rhabdoviridae
    • C12N2760/20111Lyssavirus, e.g. rabies virus
    • C12N2760/20134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR112013011194-1A 2010-11-05 2011-11-07 partícula micelar, composição farmacêutica compreendendo a mesma, uso de uma partícula micelar e método de preparação de uma micela BR112013011194B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41076710P 2010-11-05 2010-11-05
US61/410,767 2010-11-05
PCT/US2011/059602 WO2012061815A2 (en) 2010-11-05 2011-11-07 RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs)

Publications (2)

Publication Number Publication Date
BR112013011194A2 BR112013011194A2 (pt) 2017-06-27
BR112013011194B1 true BR112013011194B1 (pt) 2020-12-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013011194-1A BR112013011194B1 (pt) 2010-11-05 2011-11-07 partícula micelar, composição farmacêutica compreendendo a mesma, uso de uma partícula micelar e método de preparação de uma micela

Country Status (22)

Country Link
US (3) US9724405B2 (enExample)
EP (2) EP3246019B1 (enExample)
JP (2) JP6158088B2 (enExample)
KR (1) KR101847908B1 (enExample)
CN (2) CN103282023B (enExample)
AU (1) AU2011323090B2 (enExample)
BR (1) BR112013011194B1 (enExample)
CA (1) CA2817005C (enExample)
CY (1) CY1119284T1 (enExample)
DK (1) DK2635257T3 (enExample)
ES (1) ES2636965T3 (enExample)
HR (1) HRP20171213T1 (enExample)
HU (1) HUE034247T2 (enExample)
LT (1) LT2635257T (enExample)
MX (1) MX354750B (enExample)
PL (1) PL2635257T3 (enExample)
PT (1) PT2635257T (enExample)
RS (1) RS56157B1 (enExample)
SG (1) SG190140A1 (enExample)
SI (1) SI2635257T1 (enExample)
SM (1) SMT201700392T1 (enExample)
WO (1) WO2012061815A2 (enExample)

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EP3246019B1 (en) * 2010-11-05 2021-03-03 Novavax, Inc. Rabies glycoprotein virus-like particles (vlps)
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
ES2665512T3 (es) * 2011-06-13 2018-04-26 Medicago Inc. Producción de partículas pseudovíricas de la rabia en plantas
KR101479668B1 (ko) 2012-07-31 2015-01-12 대한민국 광견병 바이러스 유전자를 발현하는 재조합 아데노바이러스 및 이를 포함하는 광견병의 예방 또는 치료용 백신 조성물
CN103777021B (zh) * 2012-10-18 2016-03-02 辽宁成大生物股份有限公司 狂犬疫苗糖蛋白含量的检测方法
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CN106905434B (zh) * 2017-02-28 2021-01-26 国药中生生物技术研究院有限公司 一种包含蹄蝠肝炎病毒核心蛋白的重组融合蛋白及其制备方法和应用
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JP2020534795A (ja) 2017-07-28 2020-12-03 プレジデント アンド フェローズ オブ ハーバード カレッジ ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物
US11992526B2 (en) * 2017-11-06 2024-05-28 Intervet Inc. Rabies virus vaccine
US12406749B2 (en) 2017-12-15 2025-09-02 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
WO2019183063A1 (en) 2018-03-19 2019-09-26 Novavax, Inc. Multivalent influenza nanoparticle vaccines
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
KR102077772B1 (ko) 2018-11-29 2020-02-17 주식회사 바이오앱 광견병 예방용 백신 조성물 및 이의 제조 방법
KR102211077B1 (ko) * 2019-01-16 2021-02-02 충남대학교 산학협력단 바이러스 유사 입자를 이용한 슈도-타입 광견병 백신
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
CN110007080B (zh) * 2019-04-12 2022-09-23 长春西诺生物科技有限公司 一种狂犬病毒抗体定量检测试剂盒及其制备方法与检测方法
CN109959789B (zh) * 2019-04-12 2022-08-16 长春西诺生物科技有限公司 一种狂犬病毒抗体检测试纸及其制备方法与检测方法
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Also Published As

Publication number Publication date
CA2817005C (en) 2018-09-11
SMT201700392T1 (it) 2017-09-07
JP6195965B2 (ja) 2017-09-13
EP3246019B1 (en) 2021-03-03
ES2636965T3 (es) 2017-10-10
KR101847908B1 (ko) 2018-04-11
WO2012061815A3 (en) 2013-03-14
RU2013125695A (ru) 2014-12-10
EP2635257B1 (en) 2017-07-05
LT2635257T (lt) 2017-09-25
AU2011323090B2 (en) 2015-02-12
KR20130111581A (ko) 2013-10-10
CN109157658A (zh) 2019-01-08
HUE034247T2 (en) 2018-02-28
AU2011323090A1 (en) 2013-04-04
EP2635257A2 (en) 2013-09-11
MX2013005090A (es) 2013-10-25
CN103282023B (zh) 2018-09-21
SG190140A1 (en) 2013-06-28
CN103282023A (zh) 2013-09-04
BR112013011194A2 (pt) 2017-06-27
EP2635257A4 (en) 2014-04-02
JP2017035093A (ja) 2017-02-16
US10086065B2 (en) 2018-10-02
EP3246019A1 (en) 2017-11-22
US9724405B2 (en) 2017-08-08
JP2014500013A (ja) 2014-01-09
WO2012061815A2 (en) 2012-05-10
JP6158088B2 (ja) 2017-07-05
HRP20171213T1 (hr) 2017-10-20
CY1119284T1 (el) 2018-02-14
SI2635257T1 (en) 2018-01-31
MX354750B (es) 2018-03-20
RS56157B1 (sr) 2017-11-30
DK2635257T3 (en) 2017-09-04
PT2635257T (pt) 2017-08-16
PL2635257T3 (pl) 2017-10-31
US20190224307A1 (en) 2019-07-25
US20180021428A1 (en) 2018-01-25
US20140178419A1 (en) 2014-06-26
CA2817005A1 (en) 2012-05-10

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