JP2016520637A5 - - Google Patents

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Publication number
JP2016520637A5
JP2016520637A5 JP2016517275A JP2016517275A JP2016520637A5 JP 2016520637 A5 JP2016520637 A5 JP 2016520637A5 JP 2016517275 A JP2016517275 A JP 2016517275A JP 2016517275 A JP2016517275 A JP 2016517275A JP 2016520637 A5 JP2016520637 A5 JP 2016520637A5
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JP
Japan
Prior art keywords
methyl
methoxy
imidazol
trifluoroethoxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2016517275A
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English (en)
Japanese (ja)
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JP2016520637A (ja
JP6368777B2 (ja
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Priority claimed from PCT/EP2014/061503 external-priority patent/WO2014195323A1/en
Publication of JP2016520637A publication Critical patent/JP2016520637A/ja
Publication of JP2016520637A5 publication Critical patent/JP2016520637A5/ja
Application granted granted Critical
Publication of JP6368777B2 publication Critical patent/JP6368777B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2016517275A 2013-06-04 2014-06-03 ピリミジン化合物およびガンマセクレターゼモジュレーターとしてのその使用 Expired - Fee Related JP6368777B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1350685-2 2013-06-04
SE1350685 2013-06-04
PCT/EP2014/061503 WO2014195323A1 (en) 2013-06-04 2014-06-03 Pyrimidine compounds and their use as gamma secretase modulators

Publications (3)

Publication Number Publication Date
JP2016520637A JP2016520637A (ja) 2016-07-14
JP2016520637A5 true JP2016520637A5 (cg-RX-API-DMAC7.html) 2017-06-01
JP6368777B2 JP6368777B2 (ja) 2018-08-01

Family

ID=50877325

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016517275A Expired - Fee Related JP6368777B2 (ja) 2013-06-04 2014-06-03 ピリミジン化合物およびガンマセクレターゼモジュレーターとしてのその使用

Country Status (9)

Country Link
US (1) US9439904B2 (cg-RX-API-DMAC7.html)
EP (1) EP3004079B1 (cg-RX-API-DMAC7.html)
JP (1) JP6368777B2 (cg-RX-API-DMAC7.html)
CN (1) CN105263923B (cg-RX-API-DMAC7.html)
DK (1) DK3004079T3 (cg-RX-API-DMAC7.html)
ES (1) ES2665421T3 (cg-RX-API-DMAC7.html)
NO (1) NO3004079T3 (cg-RX-API-DMAC7.html)
PL (1) PL3004079T3 (cg-RX-API-DMAC7.html)
WO (1) WO2014195323A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109415369B (zh) * 2016-07-08 2021-12-07 豪夫迈·罗氏有限公司 稠合嘧啶衍生物
CN108191776A (zh) * 2018-01-22 2018-06-22 无锡富泽药业有限公司 一种尿嘧啶的绿色生产工艺
US12297244B2 (en) 2019-06-05 2025-05-13 Rensselaer Polytechnic Institute Systems and methods for inhibiting γ-secretase production of amyloid-β peptides
WO2020247707A1 (en) * 2019-06-05 2020-12-10 Chunyu Wang SYSTEMS AND METHOD FOR INHIBITING γ-SECRETASE PRODUCTION OF AMYLOID-β PEPTIDES
CN110372603A (zh) * 2019-06-24 2019-10-25 南京普锐达医药科技有限公司 一种2-氯-5-氟-6-乙基嘧啶的合成方法
CN113149977A (zh) 2020-01-22 2021-07-23 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途
WO2022204299A1 (en) 2021-03-23 2022-09-29 Halia Therapeutics, Inc. Pyrimidine derivatives useful as lrrk2 kinase inhibitors

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EP1126843A4 (en) * 1998-10-29 2005-06-15 Bristol Myers Squibb Co AMINO-CELL DERIVATIVE COMPOUNDS INHIBITORS OF ENZYME IMPDH
ITMI20030312A1 (it) 2003-02-21 2004-08-22 Chiesi Farma Spa Derivati di acidi 2-fenil-2-alchil-acetici per il trattamento della malattia di alzheimer.
DE602004026597D1 (de) 2003-08-07 2010-05-27 Merck Sharp & Dohme Behandlung von alzheimer-krankheit und verwandten zuständen
EP1708997B1 (en) 2003-12-03 2009-10-21 Merck and Co., Inc. 1-alkyl-3-thio-substituted indole-2-alkynoic acids useful for the treatment for alzheimer's disease and related conditions
KR100966749B1 (ko) * 2004-05-26 2010-06-30 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 화합물
JP5191391B2 (ja) * 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
WO2007125364A1 (en) 2006-04-26 2007-11-08 Merck Sharp & Dohme Limited Piperidines and related compounds for treatment of alzheimer’s disease
EP2019093A4 (en) 2006-05-19 2011-02-23 Eisai R&D Man Co Ltd CINEMA ACID AMID DERIVATIVE FROM THE UREA TYPE
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
US8183276B2 (en) 2007-02-08 2012-05-22 Christian Fischer Therapeutic agents
WO2008100412A1 (en) 2007-02-12 2008-08-21 Merck & Co., Inc. Piperidine derivatives
JP2010518064A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション Ａｄおよび関連状態の治療のためのピペラジン誘導体
WO2008156580A1 (en) 2007-06-13 2008-12-24 Merck & Co., Inc. Triazole derivatives for treating alzheimer's disease and related conditions
EP2185522A1 (en) 2007-08-06 2010-05-19 Schering Corporation Gamma secretase modulators
BRPI0906799A2 (pt) 2008-01-11 2015-07-14 Hoffmann La Roche Moduladores para amiloide beta
KR101247840B1 (ko) 2008-02-22 2013-03-26 에프. 호프만-라 로슈 아게 아밀로이드 베타 조절제
MX2011003246A (es) * 2008-10-09 2011-04-21 Hoffmann La Roche Moduladores de beta amiloide.
EP2367826A4 (en) * 2008-11-06 2012-07-04 Astrazeneca Ab MODULATORS OF THE PROTEIN -AMYLOID
KR101293421B1 (ko) 2008-11-10 2013-08-05 에프. 호프만-라 로슈 아게 헤테로사이클릭 감마 분비효소 조절제
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
UY32622A (es) 2009-05-12 2010-12-31 Astrazeneca Ab Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)
AP2011006034A0 (en) 2009-07-15 2011-12-31 Janssen Pharmaceuticals Inc Substituted triazole and imidazole derivatives as gamma secretase modulators.
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
MX2012008260A (es) 2010-01-15 2012-08-17 Janssen Pharmaceuticals Inc Novedosos derivados de triazol sustituidos como moduladores de la gamma secretasa.
US20110190269A1 (en) 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
TW201206946A (en) 2010-07-15 2012-02-16 Bristol Myers Squibb Co Compounds for the reduction of beta-amyloid production

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