JP2016518838A - 活性医薬成分としてのヌクレオシドアナログの生体触媒生成 - Google Patents

活性医薬成分としてのヌクレオシドアナログの生体触媒生成 Download PDF

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JP2016518838A
JP2016518838A JP2016511045A JP2016511045A JP2016518838A JP 2016518838 A JP2016518838 A JP 2016518838A JP 2016511045 A JP2016511045 A JP 2016511045A JP 2016511045 A JP2016511045 A JP 2016511045A JP 2016518838 A JP2016518838 A JP 2016518838A
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seq
hydrogen
nucleotide sequence
optionally substituted
ndt
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JP2016518838A5 (enExample
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ギラベルト，マルタ パスクアル
ギラベルト，マルタ パスクアル
トーマス，ビクター マニュエル デロンセレ
トーマス，ビクター マニュエル デロンセレ
アレバロ，ラファエル モンティーラ
アレバロ，ラファエル モンティーラ
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プラズミア バイオテック，エス．エル．
プラズミア バイオテック，エス．エル．
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Publication of JP2016518838A publication Critical patent/JP2016518838A/ja
Publication of JP2016518838A5 publication Critical patent/JP2016518838A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/385—Pyrimidine nucleosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
JP2016511045A 2013-04-29 2014-04-29 活性医薬成分としてのヌクレオシドアナログの生体触媒生成 Pending JP2016518838A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361817064P 2013-04-29 2013-04-29
US61/817,064 2013-04-29
PCT/EP2014/058761 WO2014177585A2 (en) 2013-04-29 2014-04-29 Biocatalytic production of nucleoside analogues as active pharmaceutical ingredients

Publications (2)

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JP2016518838A true JP2016518838A (ja) 2016-06-30
JP2016518838A5 JP2016518838A5 (enExample) 2017-06-15

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JP2016511045A Pending JP2016518838A (ja) 2013-04-29 2014-04-29 活性医薬成分としてのヌクレオシドアナログの生体触媒生成

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Country Link
US (1) US10184142B2 (enExample)
EP (1) EP2992107B1 (enExample)
JP (1) JP2016518838A (enExample)
KR (1) KR20160030876A (enExample)
CA (1) CA2905306A1 (enExample)
WO (1) WO2014177585A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2937420A1 (en) * 2014-04-23 2015-10-28 Synbias Pharma AG Method for the synthesis of clofarabine
JP2016198075A (ja) * 2015-04-14 2016-12-01 プラズミア バイオテック，エス．エル． シトシンヌクレオシドアナログの酵素産生
CN106191172A (zh) * 2015-05-06 2016-12-07 普拉斯米亚生物技术有限公司 胞嘧啶核苷类似物的酶法制备
EP3115461A1 (en) * 2015-07-07 2017-01-11 Synbias Pharma AG Method for the synthesis of pentostatin
BR112018002399A2 (pt) 2015-08-06 2018-09-25 Chimerix, Inc. nucleosídeos de pirrolopirimidina e análogos dos mesmos, úteis como agentes antivirais
EP3684771B1 (en) 2017-09-21 2024-11-27 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7h-pyrrolo(2,3-d)pyrimidine-5-carboxamide and uses thereof
CN115109814B (zh) * 2022-08-26 2022-11-29 常熟药明康德新药开发有限公司 一种制备2’-脱氧-2’-氟-β-D-阿拉伯糖腺苷类似物的方法
CN116064703A (zh) * 2022-10-21 2023-05-05 凯莱英生命科学技术(天津)有限公司 酶催化合成含有保护基的核苷的方法及组合物
CN115725535B (zh) * 2022-11-30 2023-06-06 杭州珲益生物科技有限公司 一种n-脱氧核糖转移酶及其在脱氧核苷制备中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5549395A (en) * 1978-10-02 1980-04-09 Sloan Kettering Inst Cancer 55substituted 11*2**deoxyy2**substitutedd betaaddarabinofuranosyl*pyrimidinenucleoside

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020048930A (ko) 1999-08-20 2002-06-24 로셰 디아그노스틱스 게엠베하 데옥시리보뉴클레오시드의 효소적 합성
US7892838B2 (en) * 2003-03-28 2011-02-22 Institut Pasteur Method for the in vivo modification of the synthesis activity of a metabolite by means of the modification of a gene the activity of which is not the original activity
EP2917341B1 (en) * 2012-11-08 2017-09-27 Centre National de la Recherche Scientifique (CNRS) New phosphodeoxyribosyltransferase mutant enzymes and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5549395A (en) * 1978-10-02 1980-04-09 Sloan Kettering Inst Cancer 55substituted 11*2**deoxyy2**substitutedd betaaddarabinofuranosyl*pyrimidinenucleoside

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ACTA NATURAE, vol. 2, no. 2, JPN6018021615, 2010, pages 36 - 58, ISSN: 0003960664 *
APPL. MICROBIOL. BIOTECHNOL., vol. 97, JPN6018021619, 2013, pages 3773 - 3785, ISSN: 0003960665 *
J. DAIRY SCI., vol. 76, no. 8, JPN6018021617, 1993, pages 2366 - 2379, ISSN: 0003960666 *

Also Published As

Publication number Publication date
CA2905306A1 (en) 2014-11-06
EP2992107B1 (en) 2019-12-11
WO2014177585A2 (en) 2014-11-06
WO2014177585A3 (en) 2015-01-22
US20160076070A1 (en) 2016-03-17
US10184142B2 (en) 2019-01-22
EP2992107A2 (en) 2016-03-09
KR20160030876A (ko) 2016-03-21

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