JP2016518827A5 - - Google Patents
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- JP2016518827A5 JP2016518827A5 JP2016503572A JP2016503572A JP2016518827A5 JP 2016518827 A5 JP2016518827 A5 JP 2016518827A5 JP 2016503572 A JP2016503572 A JP 2016503572A JP 2016503572 A JP2016503572 A JP 2016503572A JP 2016518827 A5 JP2016518827 A5 JP 2016518827A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- cell
- collection container
- oxyethylene
- biological sample
- Prior art date
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- 239000000203 mixture Substances 0.000 claims description 36
- 210000004027 cell Anatomy 0.000 claims description 35
- 239000012472 biological sample Substances 0.000 claims description 25
- -1 poly (oxyethylene) Polymers 0.000 claims description 24
- 229920000642 polymer Polymers 0.000 claims description 24
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims description 20
- 150000001875 compounds Chemical class 0.000 claims description 18
- 229940123169 Caspase inhibitor Drugs 0.000 claims description 14
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 10
- 239000003146 anticoagulant agent Substances 0.000 claims description 10
- 229940127219 anticoagulant drug Drugs 0.000 claims description 10
- 239000000523 sample Substances 0.000 claims description 10
- 229940088872 Apoptosis inhibitor Drugs 0.000 claims description 8
- 239000000654 additive Substances 0.000 claims description 8
- 230000000996 additive effect Effects 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 239000000158 apoptosis inhibitor Substances 0.000 claims description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- 239000002738 chelating agent Substances 0.000 claims description 6
- MBHINSULENHCMF-UHFFFAOYSA-N n,n-dimethylpropanamide Chemical compound CCC(=O)N(C)C MBHINSULENHCMF-UHFFFAOYSA-N 0.000 claims description 6
- 230000000087 stabilizing effect Effects 0.000 claims description 6
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 4
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 4
- 238000011109 contamination Methods 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 125000003748 selenium group Chemical group *[Se]* 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- 239000003440 toxic substance Substances 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- OOBJCYKITXPCNS-REWPJTCUSA-N (3s)-5-(2,6-difluorophenoxy)-3-[[(2s)-3-methyl-2-(quinoline-2-carbonylamino)butanoyl]amino]-4-oxopentanoic acid Chemical group O=C([C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)C=1N=C2C=CC=CC2=CC=1)C(C)C)COC1=C(F)C=CC=C1F OOBJCYKITXPCNS-REWPJTCUSA-N 0.000 claims description 3
- 229940127255 pan-caspase inhibitor Drugs 0.000 claims description 3
- 206010003445 Ascites Diseases 0.000 claims description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 2
- SUAKHGWARZSWIH-UHFFFAOYSA-N N,N‐diethylformamide Chemical compound CCN(CC)C=O SUAKHGWARZSWIH-UHFFFAOYSA-N 0.000 claims description 2
- 229930040373 Paraformaldehyde Natural products 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 206010048629 Wound secretion Diseases 0.000 claims description 2
- MIFGOLAMNLSLGH-QOKNQOGYSA-N Z-Val-Ala-Asp(OMe)-CH2F Chemical compound COC(=O)C[C@@H](C(=O)CF)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1 MIFGOLAMNLSLGH-QOKNQOGYSA-N 0.000 claims description 2
- 210000004381 amniotic fluid Anatomy 0.000 claims description 2
- 210000003103 bodily secretion Anatomy 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 230000006037 cell lysis Effects 0.000 claims description 2
- 210000003756 cervix mucus Anatomy 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000003431 cross linking reagent Substances 0.000 claims description 2
- 239000012228 culture supernatant Substances 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 230000029142 excretion Effects 0.000 claims description 2
- 210000003608 fece Anatomy 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 210000004880 lymph fluid Anatomy 0.000 claims description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- AJFDBNQQDYLMJN-UHFFFAOYSA-N n,n-diethylacetamide Chemical compound CCN(CC)C(C)=O AJFDBNQQDYLMJN-UHFFFAOYSA-N 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 229920002866 paraformaldehyde Polymers 0.000 claims description 2
- 231100000614 poison Toxicity 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 210000000582 semen Anatomy 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims 1
- 0 C**N(*)C(*C)=* Chemical compound C**N(*)C(*C)=* 0.000 description 4
- 238000005057 refrigeration Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13159834.4 | 2013-03-18 | ||
| EP13159834 | 2013-03-18 | ||
| EP13180086 | 2013-08-12 | ||
| EP13180086.4 | 2013-08-12 | ||
| PCT/EP2014/000726 WO2014146782A1 (en) | 2013-03-18 | 2014-03-18 | Stabilization and isolation of extracellular nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016518827A JP2016518827A (ja) | 2016-06-30 |
| JP2016518827A5 true JP2016518827A5 (enExample) | 2017-02-16 |
Family
ID=50434155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503572A Pending JP2016518827A (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
| JP2016503570A Active JP6407248B2 (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503570A Active JP6407248B2 (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10144952B2 (enExample) |
| EP (2) | EP2976425B1 (enExample) |
| JP (2) | JP2016518827A (enExample) |
| CN (2) | CN105164258B (enExample) |
| WO (2) | WO2014146780A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| ES2574956T3 (es) | 2011-09-26 | 2016-06-23 | Preanalytix Gmbh | Estabilización y aislamiento de ácidos nucleicos extracelulares |
| AU2012314514B2 (en) | 2011-09-26 | 2018-03-15 | Qiagen Gmbh | Stabilisation and isolation of extracellular nucleic acids |
| US20150225712A1 (en) * | 2012-08-21 | 2015-08-13 | Qiagen Gmbh | Method for isolating nucleic acids from a formaldehyde releaser stabilized sample |
| CA2884915C (en) | 2012-09-25 | 2022-05-17 | Qiagen Gmbh | Stabilisation of biological samples |
| CA2886389A1 (en) | 2012-09-28 | 2014-04-03 | Cepheid | Methods for dna and rna extraction from fixed paraffin-embedded tissue samples |
| WO2014146780A1 (en) | 2013-03-18 | 2014-09-25 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| EP3447141B1 (en) * | 2013-03-18 | 2020-08-05 | PreAnalytiX GmbH | Stabilisation of biological samples |
| US20160374330A1 (en) | 2014-03-18 | 2016-12-29 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| EP3325647B1 (en) * | 2015-07-24 | 2020-02-19 | Cepheid | Compositions and methods for dna and rna extraction from tissue samples |
| CA3005694A1 (en) * | 2015-11-20 | 2017-05-26 | Qiagen Gmbh | Method of preparing sterilized compositions for stabilization of extracellular nucleic acids |
| EP4043475B1 (en) * | 2016-03-31 | 2023-09-20 | Berkeley Lights, Inc. | Nucleic acid stabilization reagent, kits, and methods of use thereof |
| CA3025569A1 (en) | 2016-05-27 | 2017-11-30 | Norgen Biotek Corp. | Preservation of cell-free nucleic acids in biological samples |
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| US11591638B2 (en) * | 2017-08-02 | 2023-02-28 | Sarstedt Ag & Co. Kg | Process and composition for the stabilization of cell-free nucleic acids and cells |
| EP3905881A1 (en) * | 2019-01-04 | 2021-11-10 | QIAGEN GmbH | Urine stabilization |
| CA3148731A1 (en) | 2019-09-24 | 2021-04-01 | Qiagen Gmbh | Multimodal analysis of stabilized cell-containing bodily fluid samples |
| US20230203586A1 (en) * | 2020-05-29 | 2023-06-29 | The Rockefeller University | Method and system for rna isolation from self-collected and small volume samples |
| JP7635480B2 (ja) * | 2020-11-27 | 2025-02-26 | 大王製紙株式会社 | Ｒｆｉｄタグ、採血管、及びアンテナ |
| EP4263383A4 (en) | 2020-12-17 | 2024-10-23 | Nephrosant, Inc. | KITS FOR STABILIZATION OF URINE SAMPLES |
| CN118632688A (zh) | 2021-11-19 | 2024-09-10 | 布朗卡布努斯有限公司 | 一种包含包装在药物递送载体中的治疗活性剂的组合物 |
| WO2024070504A1 (ja) * | 2022-09-29 | 2024-04-04 | 積水メディカル株式会社 | 血液保存用組成物及び血液採取容器 |
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| EP4477751A1 (en) | 2023-06-16 | 2024-12-18 | QIAGEN GmbH | Body fluid stabilization and processing |
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2014
- 2014-03-18 WO PCT/EP2014/000724 patent/WO2014146780A1/en not_active Ceased
- 2014-03-18 CN CN201480021235.7A patent/CN105164258B/zh active Active
- 2014-03-18 EP EP14714932.2A patent/EP2976425B1/en active Active
- 2014-03-18 US US14/777,878 patent/US10144952B2/en active Active
- 2014-03-18 US US14/777,882 patent/US20160281133A1/en not_active Abandoned
- 2014-03-18 WO PCT/EP2014/000726 patent/WO2014146782A1/en not_active Ceased
- 2014-03-18 JP JP2016503572A patent/JP2016518827A/ja active Pending
- 2014-03-18 JP JP2016503570A patent/JP6407248B2/ja active Active
- 2014-03-18 CN CN201480021291.0A patent/CN105121643A/zh active Pending
- 2014-03-18 EP EP14714933.0A patent/EP2976426A1/en not_active Withdrawn
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