JP2009204612A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009204612A5 JP2009204612A5 JP2009043650A JP2009043650A JP2009204612A5 JP 2009204612 A5 JP2009204612 A5 JP 2009204612A5 JP 2009043650 A JP2009043650 A JP 2009043650A JP 2009043650 A JP2009043650 A JP 2009043650A JP 2009204612 A5 JP2009204612 A5 JP 2009204612A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- protease inhibitor
- biological fluid
- aebsf
- sampled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 14
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 9
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 9
- 239000013060 biological fluid Substances 0.000 claims 7
- MGSKVZWGBWPBTF-UHFFFAOYSA-N aebsf Chemical group NCCC1=CC=C(S(F)(=O)=O)C=C1 MGSKVZWGBWPBTF-UHFFFAOYSA-N 0.000 claims 5
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 claims 3
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 claims 3
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 claims 3
- 108010052968 leupeptin Proteins 0.000 claims 3
- 239000002738 chelating agent Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- OBTWBSRJZRCYQV-UHFFFAOYSA-N sulfuryl difluoride Chemical compound FS(F)(=O)=O OBTWBSRJZRCYQV-UHFFFAOYSA-N 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/038,355 US9482677B2 (en) | 2008-02-27 | 2008-02-27 | Method, composition and device for sampling natriuretic peptides in a biological fluid |
| US12/038,355 | 2008-02-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009204612A JP2009204612A (ja) | 2009-09-10 |
| JP2009204612A5 true JP2009204612A5 (enExample) | 2012-04-12 |
| JP5734547B2 JP5734547B2 (ja) | 2015-06-17 |
Family
ID=40671134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009043650A Expired - Fee Related JP5734547B2 (ja) | 2008-02-27 | 2009-02-26 | 生物学的液体中のナトリウム利尿ペプチドのサンプリングのための方法、組成物、および装置 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9482677B2 (enExample) |
| EP (1) | EP2098866B1 (enExample) |
| JP (1) | JP5734547B2 (enExample) |
| CA (1) | CA2656485A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9482677B2 (en) | 2008-02-27 | 2016-11-01 | Scios Inc. | Method, composition and device for sampling natriuretic peptides in a biological fluid |
| NO2491401T3 (enExample) * | 2009-10-21 | 2018-11-03 | ||
| BR112014003787A2 (pt) * | 2011-08-23 | 2020-10-27 | Synapse B.V. | inibidores termoestáveis de ativação do sistema de coagulação sanguínea por contato com superfícies estranhas |
| EP2757151B1 (en) * | 2011-09-13 | 2017-08-30 | Olympus Corporation | Method for inhibiting protease in biological sample containing pancreatic juice component |
| EP2866029B1 (en) | 2012-06-22 | 2017-05-03 | Olympus Corporation | Method for preparing sample containing pancreatic juice component, and kit for storing biological sample containing pancreatic juice component at room temperature |
| EP2972391A1 (en) * | 2013-03-15 | 2016-01-20 | Molecular BioProducts, Inc. | Methods to assess enzyme activity using mass spectrometric immunoassay |
| JP6907188B2 (ja) | 2015-08-13 | 2021-07-21 | ダイアックス コーポレーション | 接触系活性化の評価のためのプロテアーゼ阻害剤を含む真空採血管 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3092465A (en) | 1960-03-25 | 1963-06-04 | Miles Lab | Diagnostic test device for blood sugar |
| DE1598153C3 (de) | 1966-11-22 | 1973-11-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Diagnostisches Mittel zum Nach weis der Inhaltsstoffe von Korperflus sigkeiten |
| US3783672A (en) * | 1972-02-23 | 1974-01-08 | A Morgolenko | High-speed machines for shaping metals which employ the energy of high-pressure gas |
| DE3029579C2 (de) | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| US4816224A (en) | 1980-08-05 | 1989-03-28 | Boehringer Mannheim Gmbh | Device for separating plasma or serum from whole blood and analyzing the same |
| US5135719A (en) | 1986-10-29 | 1992-08-04 | Biotrack, Inc. | Blood separation device comprising a filter and a capillary flow pathway exiting the filter |
| US4820737A (en) | 1987-02-17 | 1989-04-11 | University Of Iowa Research Foundation | Lacrimal secretion stimulant (lss) |
| CA1339210C (en) * | 1988-05-31 | 1997-08-05 | John Lewicki | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
| GB9211686D0 (en) * | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| WO1996037777A1 (en) * | 1995-05-23 | 1996-11-28 | Nelson Randall W | Mass spectrometric immunoassay |
| PT914344E (pt) * | 1996-03-04 | 2005-10-31 | Scios Inc | Ensaio e reagentes para a quantificacao de hbnp |
| DE19628236A1 (de) | 1996-07-12 | 1998-01-15 | Boehringer Mannheim Gmbh | Reagenz zur Erhöhung der Serinproteasen-Inhibitionsspezifität |
| US6102872A (en) * | 1997-11-03 | 2000-08-15 | Pacific Biometrics, Inc. | Glucose detector and method |
| CA2321560C (en) | 1998-03-13 | 2007-05-22 | Johns Hopkins University School Of Medicine | The use of a protein tyrosine inhibitor such as genistein in the treatment of diabetic retinopathy or ocular inflammation |
| US6806075B1 (en) * | 1998-06-05 | 2004-10-19 | Schering Ag | Corin, a serine protease |
| GB9827348D0 (en) | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| US6407211B1 (en) | 1999-12-17 | 2002-06-18 | Mayo Foundation For Medical Education And Research | Chimeric natriuretic peptides |
| CA2434699A1 (en) | 2001-01-17 | 2002-10-17 | Randall W. Nelson | An integrated high throughput system for the analysis of biomolecules |
| WO2003097237A2 (en) | 2002-05-13 | 2003-11-27 | Becton, Dickinson, And Company | Protease inhibitor sample collection system |
| CA2430889A1 (en) | 2002-06-19 | 2003-12-19 | Bayer Corporation | Stabilization of brain natriuretic peptide (bnp) in blood samples, methods and compositions related thereto |
| US7341838B2 (en) * | 2003-04-17 | 2008-03-11 | Biosite Incorporated | Polypeptides related to natriuretic peptides and methods of their identification and use |
| ATE517124T1 (de) | 2003-05-12 | 2011-08-15 | Hoffmann La Roche | Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet |
| US7083163B2 (en) * | 2003-09-19 | 2006-08-01 | Tenneco Automotive Operating Company Inc. | Booster with spring to adapt air spring pressure for load dependent shock absorber |
| DE10355731A1 (de) * | 2003-11-28 | 2005-06-30 | Roche Diagnostics Gmbh | Analytischer Sandwichtest zur Bestimmung von NT-proBNP |
| US20060183681A1 (en) * | 2005-02-14 | 2006-08-17 | Bio-Rad Laboratories, Inc. | Stabilized compositions containing natriuretic peptides |
| WO2007041645A2 (en) | 2005-10-03 | 2007-04-12 | Scios Inc. | Oxidized human bnp |
| US9482677B2 (en) | 2008-02-27 | 2016-11-01 | Scios Inc. | Method, composition and device for sampling natriuretic peptides in a biological fluid |
-
2008
- 2008-02-27 US US12/038,355 patent/US9482677B2/en active Active
-
2009
- 2009-02-26 EP EP09250526.2A patent/EP2098866B1/en active Active
- 2009-02-26 JP JP2009043650A patent/JP5734547B2/ja not_active Expired - Fee Related
- 2009-02-27 CA CA002656485A patent/CA2656485A1/en not_active Abandoned
-
2016
- 2016-09-19 US US15/269,423 patent/US10641781B2/en active Active
-
2020
- 2020-01-24 US US16/752,360 patent/US11105819B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009204612A5 (enExample) | ||
| ZA201001950B (en) | Microfluidic device and method for fluid clotti ng timer determination | |
| DE602005016527D1 (de) | Verfahren zur schnelldiagnose von zielen in menschlichen körperflüssigkeiten | |
| SA521421271B1 (ar) | تركيبة وطريقة لثبات الأحماض النووية في عينات بيولوجية | |
| AU2013207599A1 (en) | Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof | |
| CO6640223A2 (es) | Sistemas y dispositivos para análisis de muestras | |
| SG169968A1 (en) | Adhesive composition for use in an immunosensor | |
| WO2008021290A8 (en) | Organ-specific proteins and methods of their use | |
| WO2011100458A3 (en) | Methods for fractionating and processing microparticles from biological samples and using them for biomarker discovery | |
| NZ710986A (en) | Method and system for operating a cip pre-flush step using fluorometric measurements of soil content | |
| WO2009041577A1 (ja) | 尿中タンパク質定量用の尿前処理剤、尿前処理方法、及び尿中タンパク質定量方法。 | |
| WO2012096480A3 (en) | Diagnostic cartridge and control method for diagnostic cartridge | |
| PL1797379T3 (pl) | Krioaparat i sposób jego eksploatacji | |
| WO2008107724A3 (en) | Stabilisation of biological cell markers | |
| WO2020023906A3 (en) | Polymer-based biospecimen collection devices and uses thereof | |
| WO2007009092A3 (en) | Method for improved accuracy of blood testing | |
| RU2009128762A (ru) | Способ и набор для иммуноферментного определения функциональной активности компонента с3 комплемента человека | |
| WO2012028967A3 (en) | Method for cryopreservation of human spermatozoa free from seminal plasma using a fast and simple aseptic vitrification-devitrification process; portable kit for carrying out the method; and use of the same for treatment of disorders related to reproductive failures | |
| WO2009111485A3 (en) | Infection mediated foam dissolution rate measurement | |
| BRPI0514542A (pt) | método para determinar a concentração de substáncias analisadas em amostras por mediação direta de enzimas | |
| WO2009004189A9 (fr) | Méthode de mesure de l'activité plasmine des microparticules présentes dans un échantillon de fluide biologique et utilisation | |
| AR058510A1 (es) | Procedimiento de diagnostico de enfermedades hepaticas y de muestreo de moleculas para el tratamiento de estas enfermedades | |
| WO2009044723A1 (ja) | インターフェロン療法の効果予測方法及び予測用キット | |
| WO2016193181A8 (en) | Biosensors, kits and assays for measuring metalloproteinase and serine protease activities | |
| ITRM20030556A1 (it) | Metodo per la determinazione quantitativa e semiquantitativa di l-fenilalanina, l-tirosina, l-3,4-diidrossifenilalanina e dei loro corrispondenti chetoacidi nei fluidi biologici e relativo kit diagnostico. |