WO2009044723A1 - インターフェロン療法の効果予測方法及び予測用キット - Google Patents

インターフェロン療法の効果予測方法及び予測用キット Download PDF

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Publication number
WO2009044723A1
WO2009044723A1 PCT/JP2008/067721 JP2008067721W WO2009044723A1 WO 2009044723 A1 WO2009044723 A1 WO 2009044723A1 JP 2008067721 W JP2008067721 W JP 2008067721W WO 2009044723 A1 WO2009044723 A1 WO 2009044723A1
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WO
WIPO (PCT)
Prior art keywords
interferon therapy
prediction
marker substance
effect
kit
Prior art date
Application number
PCT/JP2008/067721
Other languages
English (en)
French (fr)
Inventor
Toshikazu Yoshikawa
Kenichi Mihara
Tsugihisa Yamaguchi
Jun Mukai
Yutaka Takahashi
Taishi Yanohara
Kazuki Yanagida
Yuji Naito
Original Assignee
Biomarker Science Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2008135088A external-priority patent/JP5684969B2/ja
Application filed by Biomarker Science Co., Ltd. filed Critical Biomarker Science Co., Ltd.
Publication of WO2009044723A1 publication Critical patent/WO2009044723A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/555—Interferons [IFN]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

　Ｃ型肝炎ウイルス持続感染者に対するインターフェロン療法の効果を予測できる技術を提供することを課題とする。 　被験者のＣ型肝炎ウイルス持続感染者から採取した体液における特定のマーカー物質の濃度を指標として、当該被験者がインターフェロン療法によって著効（ＳＶＲ）を示す者であるか、インターフェロン療法終了後にＨＣＶが再燃（relapse）する者であるかを予測する。体液の例としては血液が挙げられる。イオン交換体や金属キレート体を固定化した基板等の担体にマーカー物質を捕捉し、質量分析によってマーカー物質の濃度を測定することができる。当該方法を簡便に実施できるキットも提供される。
PCT/JP2008/067721 2007-10-04 2008-09-30 インターフェロン療法の効果予測方法及び予測用キット WO2009044723A1 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007260523 2007-10-04
JP2007-260523 2007-10-04
JP2008-135088 2008-05-23
JP2008135088A JP5684969B2 (ja) 2007-10-04 2008-05-23 インターフェロン療法の効果予測方法及び予測用キット

Publications (1)

Publication Number Publication Date
WO2009044723A1 true WO2009044723A1 (ja) 2009-04-09

Family

ID=40526151

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/067721 WO2009044723A1 (ja) 2007-10-04 2008-09-30 インターフェロン療法の効果予測方法及び予測用キット

Country Status (1)

Country Link
WO (1) WO2009044723A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102375063A (zh) * 2010-08-23 2012-03-14 湖州赛尔迪生物医药科技有限公司 一种常见蛋白质的免疫质谱试剂盒及制备方法
WO2018139608A1 (ja) * 2017-01-27 2018-08-02 株式会社Ａ－Ｃｌｉｐ研究所 感染性疾患または炎症性疾患の予防および／または治療剤
US20220011322A1 (en) * 2015-03-02 2022-01-13 Toray Industries, Inc. Method and kit for the detection of pancreatic dysfunction

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001149076A (ja) * 1999-11-24 2001-06-05 Nichiko Pharmaceutical Co Ltd 慢性ｃ型肝炎患者におけるインターフェロン治療の有効性の判定方法
JP2001238687A (ja) * 1999-12-22 2001-09-04 Otsuka Pharmaceut Co Ltd Ｃ型肝炎ウイルスの遺伝子型の判定方法
JP2003339380A (ja) * 2002-05-24 2003-12-02 Toshiba Corp インターフェロンαレセプター２型遺伝子の多型およびその使用
JP2004298011A (ja) * 2003-03-28 2004-10-28 Toshiba Corp インターフェロンの治療効果を予測するための新規多型マーカー、プライマー、プローブおよびインターフェロンの治療効果を予測する方法
WO2006107078A1 (ja) * 2005-04-05 2006-10-12 Biomarker Science Co., Ltd インターフェロン療法の有効性判定方法および判定用キット
JP2007043985A (ja) * 2005-08-11 2007-02-22 Hiromitsu Kumada Ｃ型肝炎に対するインターフェロン／リバビリン併用療法の有効性の判定方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001149076A (ja) * 1999-11-24 2001-06-05 Nichiko Pharmaceutical Co Ltd 慢性ｃ型肝炎患者におけるインターフェロン治療の有効性の判定方法
JP2001238687A (ja) * 1999-12-22 2001-09-04 Otsuka Pharmaceut Co Ltd Ｃ型肝炎ウイルスの遺伝子型の判定方法
JP2003339380A (ja) * 2002-05-24 2003-12-02 Toshiba Corp インターフェロンαレセプター２型遺伝子の多型およびその使用
JP2004298011A (ja) * 2003-03-28 2004-10-28 Toshiba Corp インターフェロンの治療効果を予測するための新規多型マーカー、プライマー、プローブおよびインターフェロンの治療効果を予測する方法
WO2006107078A1 (ja) * 2005-04-05 2006-10-12 Biomarker Science Co., Ltd インターフェロン療法の有効性判定方法および判定用キット
JP2007043985A (ja) * 2005-08-11 2007-02-22 Hiromitsu Kumada Ｃ型肝炎に対するインターフェロン／リバビリン併用療法の有効性の判定方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
GRUNGREIFF K. ET AL.: "Serum concentrations of sIL-2R, IL-6, TGF-beta1, neopterin, and zinc in Chronic Hepatitis C patients treated with interferon-alpha.", CYTOKINE, vol. 11, no. 12, 1999, pages 1076 - 1080 *
IMAZEKI F.: "C-gata Mansei Kan'en Chiryo Mukorei no Haikei to Taisaku", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 62, no. 7, 28 July 2004 (2004-07-28), pages 540 - 543 *
KARABAY L. ET AL.: "Paradoxical alteration of acute-phase protein levels in patients with chronic hepatitis C treated with IFN-a2b.", INT. IMMUNOL., vol. 16, no. 1, January 2004 (2004-01-01), pages 51 - 54 *
MATSUNAGA T. ET AL.: "Interferon Chiryoji no Kecchu Kayosei Interleukin-2 Receptor Sokutei no Igi (Sainenrei no Yosoku)", ACTA HEPATOLOGICA JAPONICA, vol. 35, no. 8, 25 August 1994 (1994-08-25), pages 643 *
OKANOUE T.: "C-gata Mansei Kan'en no Chiryo", JAPANESE JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 81, no. 9, 20 September 2004 (2004-09-20), pages 1522 - 1525 *
SOARDO G. ET AL.: "Changes in blood lipid composition and response to interferon treatment in Chronic Heoatitis C.", J.INTERFERON CYTOKINE RES., vol. 15, no. 8, August 1995 (1995-08-01), pages 705 - 712 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102375063A (zh) * 2010-08-23 2012-03-14 湖州赛尔迪生物医药科技有限公司 一种常见蛋白质的免疫质谱试剂盒及制备方法
US20220011322A1 (en) * 2015-03-02 2022-01-13 Toray Industries, Inc. Method and kit for the detection of pancreatic dysfunction
US11733250B2 (en) * 2015-03-02 2023-08-22 Toray Industries, Inc. Method and kit for the detection of pancreatic dysfunction
WO2018139608A1 (ja) * 2017-01-27 2018-08-02 株式会社Ａ－Ｃｌｉｐ研究所 感染性疾患または炎症性疾患の予防および／または治療剤
JPWO2018139608A1 (ja) * 2017-01-27 2020-01-09 株式会社Ａ−Ｃｌｉｐ研究所 感染性疾患または炎症性疾患の予防および／または治療剤
JP7126658B2 (ja) 2017-01-27 2022-08-29 株式会社Ａ－Ｃｌｉｐ研究所 感染性疾患または炎症性疾患の予防および／または治療剤

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