JP2016520293A5 - - Google Patents
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- JP2016520293A5 JP2016520293A5 JP2016503570A JP2016503570A JP2016520293A5 JP 2016520293 A5 JP2016520293 A5 JP 2016520293A5 JP 2016503570 A JP2016503570 A JP 2016503570A JP 2016503570 A JP2016503570 A JP 2016503570A JP 2016520293 A5 JP2016520293 A5 JP 2016520293A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- cell
- oxyethylene
- nucleic acid
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000523 sample Substances 0.000 claims description 52
- 239000000203 mixture Substances 0.000 claims description 43
- 102000039446 nucleic acids Human genes 0.000 claims description 40
- 108020004707 nucleic acids Proteins 0.000 claims description 40
- 150000007523 nucleic acids Chemical class 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 39
- 239000012472 biological sample Substances 0.000 claims description 30
- -1 poly (oxyethylene) Polymers 0.000 claims description 28
- 229920000642 polymer Polymers 0.000 claims description 24
- 230000000087 stabilizing effect Effects 0.000 claims description 16
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 14
- 230000006641 stabilisation Effects 0.000 claims description 14
- 238000011105 stabilization Methods 0.000 claims description 14
- 239000000654 additive Substances 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 12
- 239000001301 oxygen Substances 0.000 claims description 12
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 10
- 230000000996 additive effect Effects 0.000 claims description 10
- 239000003146 anticoagulant agent Substances 0.000 claims description 10
- 229940127219 anticoagulant drug Drugs 0.000 claims description 10
- 229940123169 Caspase inhibitor Drugs 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 6
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
- 125000004429 atom Chemical group 0.000 claims description 6
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 125000003748 selenium group Chemical group *[Se]* 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 239000011593 sulfur Substances 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 4
- 239000002738 chelating agent Substances 0.000 claims description 4
- 238000011109 contamination Methods 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 238000002955 isolation Methods 0.000 claims description 4
- 231100000614 poison Toxicity 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000003440 toxic substance Substances 0.000 claims description 4
- 229940088872 Apoptosis inhibitor Drugs 0.000 claims description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 229930040373 Paraformaldehyde Natural products 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 239000000158 apoptosis inhibitor Substances 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 230000006037 cell lysis Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000010367 cloning Methods 0.000 claims description 2
- 230000009089 cytolysis Effects 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 2
- MBHINSULENHCMF-UHFFFAOYSA-N n,n-dimethylpropanamide Chemical compound CCC(=O)N(C)C MBHINSULENHCMF-UHFFFAOYSA-N 0.000 claims description 2
- 229940127255 pan-caspase inhibitor Drugs 0.000 claims description 2
- 229920002866 paraformaldehyde Polymers 0.000 claims description 2
- 238000010839 reverse transcription Methods 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 238000005057 refrigeration Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13159834.4 | 2013-03-18 | ||
| EP13159834 | 2013-03-18 | ||
| EP13180086 | 2013-08-12 | ||
| EP13180086.4 | 2013-08-12 | ||
| PCT/EP2014/000724 WO2014146780A1 (en) | 2013-03-18 | 2014-03-18 | Stabilization and isolation of extracellular nucleic acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520293A JP2016520293A (ja) | 2016-07-14 |
| JP2016520293A5 true JP2016520293A5 (enExample) | 2017-02-16 |
| JP6407248B2 JP6407248B2 (ja) | 2018-10-17 |
Family
ID=50434155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503572A Pending JP2016518827A (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
| JP2016503570A Active JP6407248B2 (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503572A Pending JP2016518827A (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10144952B2 (enExample) |
| EP (2) | EP2976425B1 (enExample) |
| JP (2) | JP2016518827A (enExample) |
| CN (2) | CN105164258B (enExample) |
| WO (2) | WO2014146780A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| ES2574956T3 (es) | 2011-09-26 | 2016-06-23 | Preanalytix Gmbh | Estabilización y aislamiento de ácidos nucleicos extracelulares |
| AU2012314514B2 (en) | 2011-09-26 | 2018-03-15 | Qiagen Gmbh | Stabilisation and isolation of extracellular nucleic acids |
| US20150225712A1 (en) * | 2012-08-21 | 2015-08-13 | Qiagen Gmbh | Method for isolating nucleic acids from a formaldehyde releaser stabilized sample |
| CA2884915C (en) | 2012-09-25 | 2022-05-17 | Qiagen Gmbh | Stabilisation of biological samples |
| CA2886389A1 (en) | 2012-09-28 | 2014-04-03 | Cepheid | Methods for dna and rna extraction from fixed paraffin-embedded tissue samples |
| WO2014146780A1 (en) | 2013-03-18 | 2014-09-25 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| EP3447141B1 (en) * | 2013-03-18 | 2020-08-05 | PreAnalytiX GmbH | Stabilisation of biological samples |
| US20160374330A1 (en) | 2014-03-18 | 2016-12-29 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| EP3325647B1 (en) * | 2015-07-24 | 2020-02-19 | Cepheid | Compositions and methods for dna and rna extraction from tissue samples |
| CA3005694A1 (en) * | 2015-11-20 | 2017-05-26 | Qiagen Gmbh | Method of preparing sterilized compositions for stabilization of extracellular nucleic acids |
| EP4043475B1 (en) * | 2016-03-31 | 2023-09-20 | Berkeley Lights, Inc. | Nucleic acid stabilization reagent, kits, and methods of use thereof |
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| EP4477751A1 (en) | 2023-06-16 | 2024-12-18 | QIAGEN GmbH | Body fluid stabilization and processing |
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| US20160374330A1 (en) | 2014-03-18 | 2016-12-29 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| CN106796219B (zh) | 2014-08-07 | 2022-05-27 | 通用医疗公司 | 全血样品的稳定化 |
-
2014
- 2014-03-18 WO PCT/EP2014/000724 patent/WO2014146780A1/en not_active Ceased
- 2014-03-18 CN CN201480021235.7A patent/CN105164258B/zh active Active
- 2014-03-18 EP EP14714932.2A patent/EP2976425B1/en active Active
- 2014-03-18 US US14/777,878 patent/US10144952B2/en active Active
- 2014-03-18 US US14/777,882 patent/US20160281133A1/en not_active Abandoned
- 2014-03-18 WO PCT/EP2014/000726 patent/WO2014146782A1/en not_active Ceased
- 2014-03-18 JP JP2016503572A patent/JP2016518827A/ja active Pending
- 2014-03-18 JP JP2016503570A patent/JP6407248B2/ja active Active
- 2014-03-18 CN CN201480021291.0A patent/CN105121643A/zh active Pending
- 2014-03-18 EP EP14714933.0A patent/EP2976426A1/en not_active Withdrawn
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