JP2016518448A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016518448A5 JP2016518448A5 JP2016514017A JP2016514017A JP2016518448A5 JP 2016518448 A5 JP2016518448 A5 JP 2016518448A5 JP 2016514017 A JP2016514017 A JP 2016514017A JP 2016514017 A JP2016514017 A JP 2016514017A JP 2016518448 A5 JP2016518448 A5 JP 2016518448A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- membered saturated
- alkyl
- compound
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 11
- 229920006395 saturated elastomer Polymers 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 206010015150 Erythema Diseases 0.000 claims 4
- 150000001721 carbon Chemical group 0.000 claims 4
- 231100000321 erythema Toxicity 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 206010012442 Dermatitis contact Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010020649 Hyperkeratosis Diseases 0.000 claims 2
- 208000001126 Keratosis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 206010012455 Dermatitis exfoliative Diseases 0.000 claims 1
- 206010053177 Epidermolysis Diseases 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 102000000344 Sirtuin 1 Human genes 0.000 claims 1
- 108010041191 Sirtuin 1 Proteins 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 208000002029 allergic contact dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000004526 exfoliative dermatitis Diseases 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000001875 irritant dermatitis Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822758P | 2013-05-13 | 2013-05-13 | |
| US61/822,758 | 2013-05-13 | ||
| PCT/US2014/037767 WO2014186313A1 (en) | 2013-05-13 | 2014-05-13 | Substituted bridged urea analogs as sirtuin modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518448A JP2016518448A (ja) | 2016-06-23 |
| JP2016518448A5 true JP2016518448A5 (https=) | 2017-06-29 |
| JP6376707B2 JP6376707B2 (ja) | 2018-08-22 |
Family
ID=53264426
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514017A Expired - Fee Related JP6376707B2 (ja) | 2013-05-13 | 2014-05-13 | サーチュイン調節剤としての置換架橋尿素類似体 |
| JP2017526877A Expired - Fee Related JP6833686B2 (ja) | 2013-05-13 | 2015-11-19 | サーチュイン調節剤としての置換架橋尿素類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526877A Expired - Fee Related JP6833686B2 (ja) | 2013-05-13 | 2015-11-19 | サーチュイン調節剤としての置換架橋尿素類似体 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US9765075B2 (https=) |
| EP (2) | EP2997029B1 (https=) |
| JP (2) | JP6376707B2 (https=) |
| KR (2) | KR20160006215A (https=) |
| CN (2) | CN105392788B (https=) |
| AU (3) | AU2014265671B2 (https=) |
| BR (2) | BR112015028613A2 (https=) |
| CA (2) | CA2912683A1 (https=) |
| ES (1) | ES2718550T3 (https=) |
| RU (2) | RU2015153061A (https=) |
| WO (1) | WO2014186313A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6272833B2 (ja) * | 2013-04-04 | 2018-01-31 | 武田薬品工業株式会社 | 複素環化合物 |
| CN105392788B (zh) | 2013-05-13 | 2018-10-23 | 葛兰素史密斯克莱有限责任公司 | 用作沉默调节蛋白调节剂的取代的桥连脲类似物 |
| JP2016079173A (ja) * | 2014-10-15 | 2016-05-16 | 日本合成化学工業株式会社 | 新規ピリジン系化合物、それを用いたアニオン硬化性化合物用硬化剤、硬化性組成物及び硬化物 |
| PE20171257A1 (es) * | 2014-11-19 | 2017-08-28 | Glaxosmithkline Intellectual Property (No 2) Ltd | Analogos de urea unidos sustituidos como moduladores de sirtuina |
| WO2016095088A1 (en) * | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
| WO2016095089A1 (en) | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
| US10364245B2 (en) | 2017-06-07 | 2019-07-30 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
| AU2018321845B2 (en) * | 2017-08-21 | 2023-03-16 | Microbiotix, Inc. | Metabolically stable N-acylaminooxadiazoles useful as antibacterial agents |
| JP7156207B2 (ja) * | 2019-08-07 | 2022-10-19 | 株式会社島津製作所 | 糖ペプチド解析装置 |
| CN112759593A (zh) * | 2019-11-01 | 2021-05-07 | 北京伯汇生物技术有限公司 | 桥环并醛基吡啶衍生物及其应用 |
| CN112094362B (zh) * | 2020-09-29 | 2022-04-12 | 四川大学华西医院 | 烟酰胺核糖或单核苷酸类似物-大分子载体轭合物及制法和应用 |
| CN112645805A (zh) * | 2020-12-23 | 2021-04-13 | 北京理工大学 | 一种由温勒伯酰胺制备均苯三甲醛的方法 |
| CN115518062B (zh) * | 2022-09-02 | 2024-03-22 | 成都大学 | Phellopterin在制备用于治疗STAT信号通路介导的相关疾病药物中的用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DE4424484A1 (de) | 1994-07-12 | 1996-01-18 | Bayer Ag | Azofarbstoffe, deren Herstellung und Verwendung |
| US8466144B2 (en) * | 2004-07-16 | 2013-06-18 | Proteosys Ag | Muscarinic antagonists with parp and sir modulating activity as cytoprotective agents |
| EP1850840A2 (en) * | 2005-01-13 | 2007-11-07 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
| WO2006094210A2 (en) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Tetrahydroquinoxalinone sirtuin modulators |
| WO2006094248A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Aryl-substituted cyclic sirtuin modulators |
| EP2805719A1 (en) | 2005-03-30 | 2014-11-26 | Glaxosmithkline LLC | Nicotinamide riboside and analogues thereof |
| EP2099445B1 (en) | 2006-09-04 | 2010-11-17 | University Court of The University of Dundee | P53 activating benzoyl urea and benzoyl thiourea compounds |
| CA2709514A1 (en) * | 2007-12-21 | 2009-07-02 | Astrazeneca Ab | Bicyclic derivatives for use in the treatment of androgen receptor associated conditions |
| ES2586459T3 (es) * | 2008-05-01 | 2016-10-14 | Glaxosmithkline Llc | Quinolinas y análogos relacionados como moduladores de sirtuina |
| MX2011003373A (es) | 2008-09-29 | 2011-06-09 | Sirtris Pharmaceuticals Inc | Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina. |
| RU2011121655A (ru) * | 2008-10-29 | 2012-12-10 | Сертрис Фармасьютикалз, Инк. | Производные пиридина, бициклические производные пиридина и родственные аналоги в качестве модуляторов сиртуина |
| BRPI0922435A2 (pt) * | 2008-12-19 | 2018-09-11 | Sirtris Pharmaceuticals Inc | "composto de tiazolopiridina moduladores de sirtuina, composição farmacêutica compreendendo o mesmo e seu uso." |
| MX2012004995A (es) * | 2009-10-29 | 2012-10-03 | Sirtris Pharmaceuticals Inc | Piridinas biciclicas y analogos como moduladores de sirtuina. |
| RU2014120180A (ru) * | 2011-10-20 | 2015-11-27 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Замещенные бициклические аза-гетероциклы и аналоги в качестве модуляторов сиртуина |
| WO2016081692A2 (en) | 2014-11-19 | 2016-05-26 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
| CN105392788B (zh) | 2013-05-13 | 2018-10-23 | 葛兰素史密斯克莱有限责任公司 | 用作沉默调节蛋白调节剂的取代的桥连脲类似物 |
-
2014
- 2014-05-13 CN CN201480040001.7A patent/CN105392788B/zh not_active Expired - Fee Related
- 2014-05-13 CA CA2912683A patent/CA2912683A1/en not_active Abandoned
- 2014-05-13 AU AU2014265671A patent/AU2014265671B2/en not_active Ceased
- 2014-05-13 ES ES14798509T patent/ES2718550T3/es active Active
- 2014-05-13 KR KR1020157034916A patent/KR20160006215A/ko not_active Ceased
- 2014-05-13 WO PCT/US2014/037767 patent/WO2014186313A1/en not_active Ceased
- 2014-05-13 BR BR112015028613A patent/BR112015028613A2/pt not_active Application Discontinuation
- 2014-05-13 RU RU2015153061A patent/RU2015153061A/ru unknown
- 2014-05-13 JP JP2016514017A patent/JP6376707B2/ja not_active Expired - Fee Related
- 2014-05-13 US US14/891,158 patent/US9765075B2/en not_active Expired - Fee Related
- 2014-05-13 EP EP14798509.7A patent/EP2997029B1/en active Active
- 2014-11-19 US US14/547,861 patent/US9834558B2/en not_active Expired - Fee Related
-
2015
- 2015-11-19 JP JP2017526877A patent/JP6833686B2/ja not_active Expired - Fee Related
- 2015-11-19 RU RU2017120859A patent/RU2017120859A/ru unknown
- 2015-11-19 US US15/528,195 patent/US10590135B2/en active Active
- 2015-11-19 CA CA2975291A patent/CA2975291A1/en not_active Abandoned
- 2015-11-19 BR BR112017010592A patent/BR112017010592A2/pt not_active Application Discontinuation
- 2015-11-19 EP EP15861618.5A patent/EP3221312A4/en not_active Withdrawn
- 2015-11-19 CN CN201580074601.XA patent/CN107207496A/zh active Pending
- 2015-11-19 AU AU2015349912A patent/AU2015349912A1/en not_active Abandoned
- 2015-11-19 KR KR1020177016322A patent/KR20170084274A/ko not_active Withdrawn
-
2017
- 2017-06-20 AU AU2017204176A patent/AU2017204176B2/en not_active Ceased
- 2017-08-04 US US15/669,301 patent/US20180044338A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016518448A5 (https=) | ||
| MX375970B (es) | Compuestos de triazolopirimidina y usos de los mismos. | |
| MX392440B (es) | Inhibidores de tirosina quinasa de bazo (syk). | |
| MX383051B (es) | Compuestos que inhiben eif4a y métodos relacionados a los mismos. | |
| PE20181093A1 (es) | Compuestos heterociclicos y usos de los mismos | |
| MX383686B (es) | Derivados de piridazina 1,4-disustituida, y su uso para el tratamiento de afecciones relacionadas con la deficiencia de smn. | |
| MX2014015501A (es) | Carboxamidas heterociclicas fungicidas. | |
| AR096238A1 (es) | Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo | |
| JP2016526024A5 (https=) | ||
| MX377552B (es) | Proceso para preparar un compuesto antiviral de formula i. | |
| MX375261B (es) | Compuestos aromaticos sustituidos para el tratamiento de la fibrosis pulmonar, la fibrosis hepatica, la fibrosis de la piel y la fibrosis cardiaca. | |
| CU20150014A7 (es) | Análogos de piridazina 1,4-disustituida y métodos para el tratamiento de condiciones relacionadas con la deficiencia de smn | |
| TR201904455T4 (tr) | Nükleer taşıma modülatörleri olarak 1,2,4-triazoller ve bunların kullanımları. | |
| MX2015003594A (es) | Agente terapeutico o profilactico para sindrome de lisis tumoral. | |
| EA201592255A1 (ru) | Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания | |
| RU2020123900A (ru) | Новые соединения, ингибирующие mtor | |
| CU20150084A7 (es) | Derivados del ácido 4-((1,1) bisfenil -4-il)-3-(3-fosfonopropanamido)butanoico,activo como inhibidores de nep(endopeptidasa neutral) | |
| CA2920410C (en) | Thienopiperidine derivative and use thereof | |
| RU2020123899A (ru) | Новые соединения, ингибирующие mtor | |
| PE20181274A1 (es) | Compuestos utiles para inhibir ror-gamma-t | |
| PH12015502717B1 (en) | Anti-fibrogenic compounds, methods and uses thereof | |
| PE20131327A1 (es) | Forma cristalina delta de la sal de arginina de perindoprilo, su procedimiento de preparacion, y las composiciones farmaceuticas que la contienen | |
| MX388141B (es) | EL USO DE DERIVADOS DE ÁCIDOS GRASOS POLINSATURADOS PARA REDUCIR apoC-III. | |
| AR091402A1 (es) | Profarmacos de acido fosforadimico | |
| AR090959A1 (es) | Analogos de hexadepsipeptidos como compuestos anticancerigenos |