JP2016516735A5 - - Google Patents

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JP2016516735A5
JP2016516735A5 JP2016504425A JP2016504425A JP2016516735A5 JP 2016516735 A5 JP2016516735 A5 JP 2016516735A5 JP 2016504425 A JP2016504425 A JP 2016504425A JP 2016504425 A JP2016504425 A JP 2016504425A JP 2016516735 A5 JP2016516735 A5 JP 2016516735A5
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modified clya
clya pore
cys residue
exactly
pore
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JP6592427B2 (ja
JP2016516735A (ja
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JP2016504425A 2013-03-25 2014-03-25 タンパク質および核酸を検出するためのナノ細孔バイオセンサー Active JP6592427B2 (ja)

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Application Number Priority Date Filing Date Title
US201361805068P 2013-03-25 2013-03-25
US61/805,068 2013-03-25
GB1313477.0 2013-07-29
GBGB1313477.0A GB201313477D0 (en) 2013-07-29 2013-07-29 Nanopore biosensors for detection of proteins and nucleic acids
PCT/BE2014/000013 WO2014153625A1 (en) 2013-03-25 2014-03-25 Nanopore biosensors for detection of proteins and nucleic acids

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JP2016516735A JP2016516735A (ja) 2016-06-09
JP2016516735A5 true JP2016516735A5 (cg-RX-API-DMAC7.html) 2017-04-27
JP6592427B2 JP6592427B2 (ja) 2019-10-16

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US (7) US10006905B2 (cg-RX-API-DMAC7.html)
EP (1) EP2978773B1 (cg-RX-API-DMAC7.html)
JP (1) JP6592427B2 (cg-RX-API-DMAC7.html)
CN (1) CN105358567B (cg-RX-API-DMAC7.html)
AU (1) AU2014245783B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015024452B1 (cg-RX-API-DMAC7.html)
CA (1) CA2904202C (cg-RX-API-DMAC7.html)
GB (1) GB201313477D0 (cg-RX-API-DMAC7.html)
WO (1) WO2014153625A1 (cg-RX-API-DMAC7.html)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
CN112646019B (zh) 2012-04-10 2022-08-16 牛津纳米孔科技公开有限公司 突变胞溶素孔
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
AU2015208919B9 (en) 2014-01-22 2021-04-01 Oxford Nanopore Technologies Limited Method for attaching one or more polynucleotide binding proteins to a target polynucleotide
WO2015166275A1 (en) 2014-05-02 2015-11-05 Oxford Nanopore Technologies Limited Mutant pores
KR20250130441A (ko) 2014-09-01 2025-09-01 브이아이비 브이지더블유 돌연변이체 csgg 포어
WO2016055778A1 (en) 2014-10-07 2016-04-14 Oxford Nanopore Technologies Limited Mutant pores
DK3218519T3 (da) 2014-11-11 2020-12-21 Bgi Shenzhen Multipass-sekvensering
GB201502809D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Mutant pore
GB201502810D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Method
US11169138B2 (en) 2015-04-14 2021-11-09 Katholieke Universiteit Leuven Nanopores with internal protein adaptors
JP7237586B2 (ja) * 2015-12-08 2023-03-13 カトリック ユニヴェルシテット ルーヴェン カーユー ルーヴェン リサーチ アンド ディベロップメント 修飾ナノポア、それを含む組成物およびその使用
WO2017149318A1 (en) 2016-03-02 2017-09-08 Oxford Nanopore Technologies Limited Mutant pores
EP4122949B1 (en) 2016-04-06 2024-06-05 Oxford Nanopore Technologies plc Mutant pore
US10351908B2 (en) 2016-04-21 2019-07-16 Roche Sequencing Solutions, Inc. Alpha-hemolysin variants and uses thereof
FR3053119A1 (fr) * 2016-06-24 2017-12-29 Excilone Procede de detection electrique de peptides, proteines et autres macromolecules
GB201612458D0 (en) * 2016-07-14 2016-08-31 Howorka Stefan And Pugh Genevieve Membrane spanning DNA nanopores for molecular transport
WO2018039587A1 (en) * 2016-08-26 2018-03-01 Ohio State Innovation Foundation Phi29 nanochannel for early detection of breast cancer biomarkers
CN119530363A (zh) 2017-02-10 2025-02-28 牛津纳米孔科技公开有限公司 修饰的纳米孔、包含其的组合物及其用途
GB201705764D0 (en) 2017-04-10 2017-05-24 Imp Innovations Ltd Analyte detection method
GB201707122D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Pore
CN117106037B (zh) 2017-06-30 2025-07-25 弗拉芒区生物技术研究所 新颖蛋白孔
EP3655423B1 (en) * 2017-07-17 2023-12-20 President and Fellows of Harvard College Nanopore-matched protein shuttle for molecular characterization
CN110914679B (zh) 2017-07-17 2023-03-07 哈佛大学校董委员会 用于分子表征的纳米孔匹配的蛋白质穿梭物及其数据分析方法
CA3091126A1 (en) * 2018-02-12 2019-08-15 Oxford Nanopore Technologies Ltd. Nanopore assemblies and uses thereof
GB201809207D0 (en) * 2018-06-05 2018-07-25 Univ Oxford Innovation Ltd Molecular electronic device
JP2022500074A (ja) 2018-09-11 2022-01-04 レイクスユニフェルシテイト フローニンゲン 調節可能な孔直径を有する生物学的ナノポアと分析ツールとしてのその使用
US20200326325A1 (en) 2019-04-12 2020-10-15 Lisa Diamond Nanosensor chip with compound nanopores
CN111912892B (zh) * 2019-05-07 2022-03-25 南京大学 气单胞菌溶素纳米孔通道在生物磷酸化及相关酶分析中的应用
CN112708544A (zh) * 2019-10-25 2021-04-27 成都今是科技有限公司 基因测序的测量装置及其测量方法
CN111235224B (zh) * 2020-01-14 2023-06-20 广东工业大学 一种基于磁泳分离的生物分子精确修饰方法及装置
CN112481363B (zh) * 2020-03-09 2024-05-28 南京大学 突变Aerolysin单体在检测RNA碱基序列及RNA修饰方面的应用
WO2021182957A1 (en) 2020-03-11 2021-09-16 Rijksuniversiteit Groningen Engineered plyab nanopores and uses thereof.
WO2021236828A1 (en) * 2020-05-20 2021-11-25 The Board Of Trustees Of The University Of Illinois Methods and compositions for rapid direct detection and differentiation of infectious from noninfectious virus
KR102309424B1 (ko) * 2020-09-28 2021-10-07 한국생명공학연구원 나노포어를 이용한 리보스위치-표적 물질의 스크리닝 방법
GB202107192D0 (en) 2021-05-19 2021-06-30 Oxford Nanopore Tech Ltd Method
GB202118908D0 (en) 2021-12-23 2022-02-09 Oxford Nanopore Tech Ltd Method
GB202118906D0 (en) 2021-12-23 2022-02-09 Oxford Nanopore Tech Ltd Method
CN120435657A (zh) 2022-10-28 2025-08-05 格罗宁根大学 蛋白质的基于纳米孔的分析
GB202216162D0 (en) 2022-10-31 2022-12-14 Oxford Nanopore Tech Plc Method
GB202307486D0 (en) 2023-05-18 2023-07-05 Oxford Nanopore Tech Plc Method
GB202317028D0 (en) 2023-11-06 2023-12-20 Oxford Nanopore Tech Ltd Method

Family Cites Families (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI82266C (fi) 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5777078A (en) 1993-04-28 1998-07-07 Worcester Foundation For Experimental Biology Triggered pore-forming agents
WO1994025616A1 (en) 1993-04-28 1994-11-10 Worcester Foundation For Experimental Biology Cell-targeted lytic pore-forming agents
DE4320201A1 (de) 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US5386373A (en) 1993-08-05 1995-01-31 Pavilion Technologies, Inc. Virtual continuous emission monitoring system with sensor validation
US5561043A (en) 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
US7569341B2 (en) 1994-01-31 2009-08-04 Trustees Of Boston University Nucleic acid directed immobilization arrays and methods of assembly
US6362002B1 (en) 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
JP3891620B2 (ja) 1996-11-14 2007-03-14 株式会社アイシン・コスモス研究所 ヘアピン型構造の核酸プローブ分子、及び該核酸プローブ分子を利用した核酸検出方法
US20020197614A1 (en) 1997-05-16 2002-12-26 Mosaic Technologies, Inc. Electrophoretic analysis of target molecules using adapter molecules
AU8586298A (en) 1997-07-25 1999-02-16 University Of Massachusetts Designed protein pores as components for biosensors
US6087099A (en) 1997-09-08 2000-07-11 Myriad Genetics, Inc. Method for sequencing both strands of a double stranded DNA in a single sequencing reaction
US6127166A (en) 1997-11-03 2000-10-03 Bayley; Hagan Molluscan ligament polypeptides and genes encoding them
JPH11137260A (ja) 1997-11-06 1999-05-25 Soyaku Gijutsu Kenkyusho:Kk 抗インフルエンザウイルス環状ダンベル型rna−dnaキメラ化合物及び抗インフルエンザウイルス剤
US6123819A (en) 1997-11-12 2000-09-26 Protiveris, Inc. Nanoelectrode arrays
DE19826758C1 (de) 1998-06-15 1999-10-21 Soft Gene Gmbh Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte
US6743605B1 (en) 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US7155344B1 (en) 1998-07-27 2006-12-26 Caliper Life Sciences, Inc. Distributed database for analytical instruments
US6150112A (en) 1998-09-18 2000-11-21 Yale University Methods for identifying DNA sequences for use in comparison of DNA samples by their lack of polymorphism using Y shape adaptors
US6267872B1 (en) 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
US6426231B1 (en) 1998-11-18 2002-07-30 The Texas A&M University System Analyte sensing mediated by adapter/carrier molecules
NO986133D0 (no) 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
AU5631200A (en) 1999-06-22 2001-01-09 President And Fellows Of Harvard College Control of solid state dimensional features
AU5668100A (en) 1999-06-29 2001-01-22 University Health Network Peptide conjugates for the stabilization of membrane proteins and interactions with biological membranes
JP2003508054A (ja) 1999-08-31 2003-03-04 ニーデルバイス,ミヒャエル チャンネル形成性タンパク質の製造方法
JP2003532380A (ja) 1999-12-02 2003-11-05 モレキュラー ステージング,インコーポレイテッド 線状自己アニーリングセグメントからの一本鎖環状dnaの産出
AU2001241474A1 (en) 2000-02-11 2001-08-20 The Texas A And M University System Biosensor compositions and methods of use
WO2001062943A1 (en) 2000-02-25 2001-08-30 Invitrogen Corporation Topoisomerase linker-mediated amplification methods
AU2001250912B2 (en) 2000-03-21 2007-01-04 Curagen Corporation VEGF-modulated genes and methods employing them
EP1265914B1 (en) 2000-03-22 2007-12-26 Curagen Corporation Wnt-1 related polypeptides, and nucleic acids encoding the same
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
AU2001289914A1 (en) 2000-09-25 2002-04-02 Sensovation Ag Image sensor device, apparatus and method for optical measurements
AU2002239284A1 (en) 2000-11-27 2002-06-03 The Regents Of The University Of California Methods and devices for characterizing duplex nucleic acid molecules
US20030087232A1 (en) 2001-01-25 2003-05-08 Fred Christians Methods for screening polypeptides
US7807408B2 (en) 2001-03-19 2010-10-05 President & Fellows Of Harvard College Directed evolution of proteins
US6995236B2 (en) 2001-05-08 2006-02-07 Riken Sphingomyelin detecting probe
JP2002355035A (ja) 2001-05-08 2002-12-10 Inst Of Physical & Chemical Res スフィンゴミエリン検出プローブ
US6863833B1 (en) 2001-06-29 2005-03-08 The Board Of Trustees Of The Leland Stanford Junior University Microfabricated apertures for supporting bilayer lipid membranes
AU2002320294B2 (en) 2001-07-03 2009-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mammalian sweet and amino acid heterodimeric taste receptors
MXPA04001719A (es) 2001-08-31 2004-05-31 Gentex Corp Montaje de lampara de vehiculo con disipador termico.
IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
US20030215881A1 (en) 2002-05-10 2003-11-20 Hagan Bayley Stochastic sensing through covalent interactions
EP1606417A2 (en) 2003-03-07 2005-12-21 Rubicon Genomics Inc. In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna
US7704712B2 (en) 2003-03-25 2010-04-27 Stratagene California DNA polymerase fusions and uses thereof
US7163658B2 (en) 2003-04-23 2007-01-16 Rouvain Bension Rapid sequencing of polymers
US7344882B2 (en) 2003-05-12 2008-03-18 Bristol-Myers Squibb Company Polynucleotides encoding variants of the TRP channel family member, LTRPC3
AU2003904237A0 (en) 2003-08-08 2003-08-21 Garvan Institute Of Medical Research Novel translocation assay
US20070122885A1 (en) 2005-08-22 2007-05-31 Fermalogic, Inc. Methods of increasing production of secondary metabolites by manipulating metabolic pathways that include methylmalonyl-coa
WO2005056750A2 (en) 2003-12-11 2005-06-23 Quark Biotech, Inc. Inversion-duplication of nucleic acids and libraries prepared thereby
WO2005076010A2 (en) 2004-02-06 2005-08-18 Council Of Scientific And Industrial Research Computational method for identifying adhesin and adhesin-like proteins of therapeutic potential
JP2005253427A (ja) 2004-03-15 2005-09-22 Aisin Seiki Co Ltd 核酸検出方法及び核酸単離方法
US7238485B2 (en) 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
WO2005124888A1 (en) 2004-06-08 2005-12-29 President And Fellows Of Harvard College Suspended carbon nanotube field effect transistor
EP1784754A4 (en) 2004-08-13 2009-05-27 Harvard College OPTI-NANOPORE DNA READING PLATFORM WITH ULTRAHOLE THROUGHPUT
US20060105461A1 (en) 2004-10-22 2006-05-18 May Tom-Moy Nanopore analysis system
EP1842061A4 (en) 2004-12-21 2009-05-13 Texas A & M Univ Sys HIGH-TEMPERATURE ION CHANNELS AND ION PORES
GB0505971D0 (en) 2005-03-23 2005-04-27 Isis Innovation Delivery of molecules to a lipid bilayer
US7272518B2 (en) 2005-07-01 2007-09-18 Square D Company Automated hierarchy classification in utility monitoring systems
US7877154B2 (en) 2005-09-30 2011-01-25 Fisher-Rosemount Systems, Inc. Method and system for controlling a batch process
KR100730350B1 (ko) 2005-10-17 2007-06-19 삼성전자주식회사 표면처리된 나노포어를 이용한 dna 검출방법 및검출장치
GB0523282D0 (en) 2005-11-15 2005-12-21 Isis Innovation Methods using pores
EP1963530B1 (en) 2005-12-22 2011-07-27 Pacific Biosciences of California, Inc. Active surface coupled polymerases
US7932029B1 (en) 2006-01-04 2011-04-26 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
US7849581B2 (en) 2006-05-05 2010-12-14 University Of Utah Research Foundation Nanopore electrode, nanopore membrane, methods of preparation and surface modification, and use thereof
US20110039776A1 (en) 2006-09-06 2011-02-17 Ashutosh Chilkoti Fusion peptide therapeutic compositions
US7638034B2 (en) 2006-09-21 2009-12-29 Los Alamos National Security, Llc Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions
WO2008045575A2 (en) 2006-10-13 2008-04-17 J. Craig Venter Institute, Inc. Sequencing method
US8594848B2 (en) 2006-11-28 2013-11-26 Lester F. Ludwig Reconfigurable chemical process systems
US20100196203A1 (en) 2007-02-20 2010-08-05 Gurdial Singh Sanghera Formation of Lipid Bilayers
EP2156179B1 (en) 2007-04-04 2021-08-18 The Regents of The University of California Methods for using a nanopore
CN110872587A (zh) * 2007-05-22 2020-03-10 康乃尔研究基金会有限公司 蛋白质在细菌及其衍生小泡表面展示的组合物和方法及其用途
US8158344B2 (en) 2007-06-29 2012-04-17 Duke University Methods and compositions for correlating genetic markers with multiple sclerosis
GB0716005D0 (en) 2007-08-16 2007-09-26 Imp Innovations Ltd Single molecule spectroscopy using nanoporpus membranes
GB0716264D0 (en) 2007-08-21 2007-09-26 Isis Innovation Bilayers
EP3540436B1 (en) 2007-09-12 2023-11-01 President And Fellows Of Harvard College High-resolution molecular sensor
GB2453377A (en) 2007-10-05 2009-04-08 Isis Innovation Transmembrane protein pores and molecular adapters therefore.
WO2009052214A2 (en) 2007-10-15 2009-04-23 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
US8502972B2 (en) 2007-12-31 2013-08-06 Fujirebio Inc. Clusters of microresonators for cavity mode optical sensing
US8231969B2 (en) 2008-03-26 2012-07-31 University Of Utah Research Foundation Asymmetrically functionalized nanoparticles
BRPI0909212A2 (pt) 2008-03-28 2015-08-18 Pacific Biosciences California Composições e método para sequeciamento de ácido nucléico
EP2293921A4 (en) 2008-05-22 2013-05-22 Univ California MEMBRANE PROBLEMS AND MEMBRANES MADE FROM THESE
US8652771B2 (en) 2008-05-28 2014-02-18 University of Souther California Measurement of succinate in urine samples as a biomarker of kidney damage in diabetic subjects
CN102144037A (zh) 2008-07-07 2011-08-03 牛津纳米孔技术有限公司 检测碱基的孔
CN102245760A (zh) 2008-07-07 2011-11-16 牛津纳米孔技术有限公司 酶-孔构建体
CN104710519B (zh) 2008-09-22 2021-05-28 华盛顿大学 Msp纳米微孔和相关方法
US9080211B2 (en) 2008-10-24 2015-07-14 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
GB0820927D0 (en) 2008-11-14 2008-12-24 Isis Innovation Method
SG171421A1 (en) 2008-11-26 2011-07-28 Illumina Inc Methods and systems for analysis of sequencing data
AU2010209508C1 (en) 2009-01-30 2017-10-19 Oxford Nanopore Technologies Limited Hybridization linkers
BRPI1007214A8 (pt) 2009-01-30 2022-12-20 Oxford Nanopore Tech Ltd Adaptador para sequenciar ácidos nucleicos, par de adaptadores, kit, construto de ácido nucleico, e, métodos para preparar um adaptador, um construto de ácido nucleico, e um construto de dequência, e para sequenciar ácido nucleico de fita dupla.
CN102481341B (zh) 2009-02-23 2017-05-17 希托马克斯医疗有限公司 蛋白原及其使用方法
FR2943656A1 (fr) 2009-03-25 2010-10-01 Air Liquide Procede et installation de production d'hydrogene mettant en oeuvre un compresseur thermocinetique
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
CN102405410B (zh) 2009-04-20 2014-06-25 牛津楠路珀尔科技有限公司 脂质双层传感器阵列
EP2507387B1 (en) 2009-12-01 2017-01-25 Oxford Nanopore Technologies Limited Biochemical analysis instrument and method
FR2955773B1 (fr) 2010-02-01 2017-05-26 Commissariat Energie Atomique Complexe moleculaire de ciblage des antigenes vers les cellules presentatrices d'antigene et ses applications pour la vaccination
CN102834527B (zh) 2010-02-23 2015-06-03 华盛顿大学 用纳米孔的分析物测序
WO2011125015A2 (en) 2010-04-05 2011-10-13 Bar-Ilan University Protease-activatable pore-forming polypeptides
EP2622343B1 (en) 2010-10-01 2016-01-20 Oxford Nanopore Technologies Limited Biochemical analysis apparatus using nanopores
CN102116783B (zh) 2010-12-31 2013-05-29 北京普源精电科技有限公司 一种波形显示方法
GB201100516D0 (en) 2011-01-12 2011-02-23 Isis Innovation Method using fluorinated amphiphiles
CN102174554A (zh) 2011-01-24 2011-09-07 内蒙古民族大学 双控双调节原核表达载体系统及其构建方法和用途
BR112013020411B1 (pt) 2011-02-11 2021-09-08 Oxford Nanopore Technologies Limited Monômero de msp mutante, construto, polinucleotídeo, poro, kit e aparelho para caracterizar uma sequência de ácido nucleico alvo, e, método para caracterizar uma sequência de ácido nucleico alvo
JP6480183B2 (ja) 2011-05-27 2019-03-06 オックスフォード ナノポール テクノロジーズ リミテッド 結合方法
US9580480B2 (en) 2011-05-31 2017-02-28 Massachusetts Institute Of Technology Cell-directed synthesis of multifunctional nanopatterns and nanomaterials
CA2843136C (en) 2011-07-25 2020-12-29 Oxford Nanopore Technologies Limited Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
US20160162634A1 (en) 2011-09-23 2016-06-09 Oxford Nanopore Technologies Limited Analysis of a polymer comprising polymer units
CN104039979B (zh) 2011-10-21 2016-08-24 牛津纳米孔技术公司 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法
CN104136631B (zh) 2011-12-29 2017-03-01 牛津纳米孔技术公司 使用xpd解旋酶表征多核苷酸的方法
AU2012360244B2 (en) 2011-12-29 2018-08-23 Oxford Nanopore Technologies Limited Enzyme method
CA2861457A1 (en) 2012-01-20 2013-07-25 Genia Technologies, Inc. Nanopore based molecular detection and sequencing
JP6275052B2 (ja) * 2012-02-15 2018-02-07 オックスフォード ナノポール テクノロジーズ リミテッド アプタマー法
CN112646019B (zh) 2012-04-10 2022-08-16 牛津纳米孔科技公开有限公司 突变胞溶素孔
TWI655213B (zh) 2012-07-13 2019-04-01 目立康股份有限公司 自我組織化肽衍生物的製造方法
CA2879355C (en) 2012-07-19 2021-09-21 Oxford Nanopore Technologies Limited Helicase construct and its use in characterising polynucleotides
EP3741847A1 (en) 2012-07-19 2020-11-25 Oxford Nanopore Technologies Limited Modified helicases
WO2014013259A1 (en) 2012-07-19 2014-01-23 Oxford Nanopore Technologies Limited Ssb method
WO2014064444A1 (en) 2012-10-26 2014-05-01 Oxford Nanopore Technologies Limited Droplet interfaces
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
US20140206842A1 (en) 2013-01-22 2014-07-24 Muhammed Majeed Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceutical
EP2954320B1 (en) 2013-02-07 2018-04-18 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Hybrid nanopores and uses thereof for detection of analytes
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
CN105209634B (zh) 2013-03-08 2020-05-12 牛津纳米孔技术公司 酶停滞方法
EP2970951B1 (en) 2013-03-13 2019-02-20 Illumina, Inc. Methods for nucleic acid sequencing
US10613076B2 (en) 2013-03-14 2020-04-07 The Trustees Of Boston University Optoelectronic control of solid-state nanopores
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
PT3004378T (pt) 2013-05-24 2018-03-06 Illumina Cambridge Ltd Resumo
WO2015051378A1 (en) 2013-10-04 2015-04-09 University Of Washington Through Its Center For Commercialization Systems and methods for nanopore-based analysis of nucleic acids
CN105899678A (zh) 2013-10-18 2016-08-24 牛津纳米孔技术公司 经修饰的酶
GB201406151D0 (en) 2014-04-04 2014-05-21 Oxford Nanopore Tech Ltd Method
DK3074534T3 (da) 2013-11-26 2019-07-29 Illumina Inc Fremgangsmåder til polynukleotidsekventering
US20160326220A1 (en) 2013-12-24 2016-11-10 Vib Vzw Secretion and functional display of chimeric polypeptides
GB201406155D0 (en) 2014-04-04 2014-05-21 Oxford Nanopore Tech Ltd Method
AU2015208919B9 (en) 2014-01-22 2021-04-01 Oxford Nanopore Technologies Limited Method for attaching one or more polynucleotide binding proteins to a target polynucleotide
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
CN106460061B (zh) 2014-04-04 2020-03-06 牛津纳米孔技术公司 在双链核酸分子的两端使用纳米孔和锚分子来表征所述双链核酸的方法
WO2015166275A1 (en) 2014-05-02 2015-11-05 Oxford Nanopore Technologies Limited Mutant pores
FR3023394B1 (fr) 2014-07-02 2017-12-29 Adn Access Data Networks Dispositif permettant de faciliter l'enseignement de la langue amharique et d'en normaliser l'ecriture
KR20250130441A (ko) 2014-09-01 2025-09-01 브이아이비 브이지더블유 돌연변이체 csgg 포어
WO2016055778A1 (en) 2014-10-07 2016-04-14 Oxford Nanopore Technologies Limited Mutant pores
GB201502810D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Method
GB201502809D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Mutant pore
US11169138B2 (en) 2015-04-14 2021-11-09 Katholieke Universiteit Leuven Nanopores with internal protein adaptors
JP7237586B2 (ja) 2015-12-08 2023-03-13 カトリック ユニヴェルシテット ルーヴェン カーユー ルーヴェン リサーチ アンド ディベロップメント 修飾ナノポア、それを含む組成物およびその使用
WO2017149318A1 (en) 2016-03-02 2017-09-08 Oxford Nanopore Technologies Limited Mutant pores
EP4122949B1 (en) 2016-04-06 2024-06-05 Oxford Nanopore Technologies plc Mutant pore
GB201707122D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Pore
CN117106037B (zh) 2017-06-30 2025-07-25 弗拉芒区生物技术研究所 新颖蛋白孔

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