JP2016516729A5 - - Google Patents
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- JP2016516729A5 JP2016516729A5 JP2016503393A JP2016503393A JP2016516729A5 JP 2016516729 A5 JP2016516729 A5 JP 2016516729A5 JP 2016503393 A JP2016503393 A JP 2016503393A JP 2016503393 A JP2016503393 A JP 2016503393A JP 2016516729 A5 JP2016516729 A5 JP 2016516729A5
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- 238000000034 method Methods 0.000 claims 48
- 239000002105 nanoparticle Substances 0.000 claims 27
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 14
- 239000003446 ligand Substances 0.000 claims 9
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- 101000781681 Protobothrops flavoviridis Disintegrin triflavin Proteins 0.000 claims 6
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- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims 2
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- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims 1
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- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 1
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- CFODQUSMSYDHBS-UHFFFAOYSA-N octreotate Chemical compound O=C1NC(CC=2C=CC=CC=2)C(=O)NC(CC=2[C]3C=CC=CC3=NC=2)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(C(=O)NC(C(O)C)C(O)=O)CSSCC1NC(=O)C(N)CC1=CC=CC=C1 CFODQUSMSYDHBS-UHFFFAOYSA-N 0.000 claims 1
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
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- WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794414P | 2013-03-15 | 2013-03-15 | |
| US61/794,414 | 2013-03-15 | ||
| US14/215,879 | 2014-03-17 | ||
| PCT/US2014/030401 WO2014145606A1 (en) | 2013-03-15 | 2014-03-17 | Multimodal silica-based nanoparticles |
| US14/215,879 US9999694B2 (en) | 2009-07-02 | 2014-03-17 | Multimodal silica-based nanoparticles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516729A JP2016516729A (ja) | 2016-06-09 |
| JP2016516729A5 true JP2016516729A5 (enExample) | 2017-03-23 |
| JP6412918B2 JP6412918B2 (ja) | 2018-10-24 |
Family
ID=51538041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503393A Active JP6412918B2 (ja) | 2013-03-15 | 2014-03-17 | マルチモーダルシリカ系ナノ粒子 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US9999694B2 (enExample) |
| EP (1) | EP2968621B1 (enExample) |
| JP (1) | JP6412918B2 (enExample) |
| CN (1) | CN105307687A (enExample) |
| AU (1) | AU2014232907B2 (enExample) |
| CA (1) | CA2900363C (enExample) |
| RU (1) | RU2015132626A (enExample) |
| WO (1) | WO2014145606A1 (enExample) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12161734B2 (en) | 2009-07-02 | 2024-12-10 | Sloan-Kettering Institute For Cancer Research | Multimodal silica-based nanoparticles |
| EP3499233A3 (en) | 2009-07-02 | 2019-09-18 | Sloan-Kettering Institute for Cancer Research | Fluorescent silica-based nanoparticles |
| CA2846629C (en) | 2011-08-25 | 2023-08-01 | University Of Central Florida Research Foundation, Inc. | Methods and compositions comprising a c-terminal bax peptide |
| CN105307687A (zh) | 2013-03-15 | 2016-02-03 | 索隆-基特林癌症研究协会 | 多模态的基于二氧化硅的纳米粒子 |
| CN106455979A (zh) | 2013-12-31 | 2017-02-22 | 纪念斯隆-凯特琳癌症中心 | 用于荧光源实时多通道成像的系统、方法和设备 |
| US10111963B2 (en) | 2014-05-29 | 2018-10-30 | Memorial Sloan Kettering Cancer Center | Nanoparticle drug conjugates |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| WO2016010826A1 (en) | 2014-07-18 | 2016-01-21 | University Of Central Florida Research Foundation, Inc. | Methods and compositions comprising a ct20 peptide |
| WO2016049210A1 (en) * | 2014-09-24 | 2016-03-31 | Indiana University Research And Technology Corporation | Artificial antigen-presenting cells and methods for producing and using the same |
| KR20230042391A (ko) | 2014-10-03 | 2023-03-28 | 나노틱스 엘엘씨 | 가용성 생물분자의 생물학적 활성을 억제하기 위한 조성물 및 방법 |
| US9968688B2 (en) | 2014-11-12 | 2018-05-15 | Verily Life Sciences Llc | Shielded targeting agents, methods, and in vivo diagnostic system |
| KR20170094268A (ko) | 2014-12-15 | 2017-08-17 | 메모리얼 슬로안-케터링 캔서 센터 | 향상된 신경-결합 선택성을 갖는 고리형 펩티드, 상기 고리형 펩티드와 결합된 나노입자, 및 실시간 생체내 신경 조직 영상화를 위한 이들의 용도 |
| WO2016134474A1 (en) * | 2015-02-25 | 2016-09-01 | London Health Sciences Centre Research Inc. | Automated segmentation of histological sections for vasculature quantification |
| BR112017020689A2 (en) * | 2015-04-07 | 2018-06-26 | Memorial Sloan-Kettering Cancer Center | nanoparticulate immunoconjugates |
| WO2016176462A1 (en) * | 2015-04-28 | 2016-11-03 | University Of Central Florida Foundation, Inc. | Methods and compositions for theranostic nanoparticles |
| US10209242B2 (en) | 2015-05-21 | 2019-02-19 | Emit Imaging, Inc. | Fluorescence histo-tomography (FHT) systems and methods |
| US10736972B2 (en) | 2015-05-29 | 2020-08-11 | Memorial Sloan Kettering Cancer Center | Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis |
| JP6975131B2 (ja) * | 2015-07-23 | 2021-12-01 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | ボリュームイメージの対話型平面スライスからの内視鏡誘導 |
| WO2017040671A1 (en) * | 2015-08-31 | 2017-03-09 | Invicro, Llc | Fluorescence histo-tomography (fht) systems and methods |
| EP3165153A1 (en) | 2015-11-05 | 2017-05-10 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | System for fluorescence aided surgery |
| BR112018010205A2 (pt) * | 2015-11-20 | 2018-11-21 | Cristal Delivery B V | nanopartículas com direcionamento ativo |
| KR20180093961A (ko) | 2015-12-15 | 2018-08-22 | 메모리얼 슬로안-케터링 캔서 센터 | 조직 구별, 예를 들어, 수술 중 시각화를 위한 영상화 시스템 및 방법 |
| WO2017117464A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| US20180369422A1 (en) * | 2015-12-31 | 2018-12-27 | City Of Hope | Nanoparticles for cancer detection |
| WO2017176762A1 (en) | 2016-04-06 | 2017-10-12 | Nanotics, Llc | Particles comprising subparticles or nucleic acid scaffolds |
| KR20190003630A (ko) * | 2016-04-29 | 2019-01-09 | 메모리얼 슬로안 케터링 캔서 센터 | 악성 뇌 종양에서의 표적화된 입자 침투, 분포, 및 반응을 위한 조성물 및 방법 |
| CN109475279A (zh) * | 2016-07-07 | 2019-03-15 | 纪念斯隆凯特琳癌症中心 | 用于颗粒驱动的、基于知识的且预测性癌症放射基因组学的成像系统和方法 |
| CA3040257A1 (en) | 2016-07-14 | 2018-01-18 | University Of Central Florida Research Foundation, Inc. | Bi-dota complex-loaded dendritic polymer nanoparticles |
| WO2018035519A1 (en) * | 2016-08-19 | 2018-02-22 | Amrita Vishwa Vidyapeetham | Compositions and methods for autoimmune disease treatment |
| JP6793290B2 (ja) * | 2016-09-30 | 2020-12-02 | 学校法人甲南学園 | 被験物質の皮膚感作性の評価方法、及び樹脂固定ペプチド |
| WO2018102372A1 (en) | 2016-11-30 | 2018-06-07 | Memorial Sloan Kettering Cancer Center | Inhibitor-functionalized ultrasmall nanoparticles and methods thereof |
| US11306187B2 (en) * | 2017-02-21 | 2022-04-19 | Research & Business Foundation Sungkyunkwan University | Polymer-iron oxide nano-complex, uses thereof and preparation method thereof |
| CN110891613B (zh) * | 2017-04-07 | 2022-08-26 | 观点医疗有限公司 | 多模式成像标记物 |
| US12397067B2 (en) * | 2017-04-10 | 2025-08-26 | Cornell University | Sulfur- or heavy atom-containing nanoparticles, methods of making same, and uses thereof |
| WO2018213851A1 (en) | 2017-05-19 | 2018-11-22 | Cornell University | Functionalized nanoparticles and methods of making and using same |
| EP3634500B1 (en) * | 2017-05-25 | 2023-10-25 | Memorial Sloan-Kettering Cancer Center | Ultrasmall nanoparticles labeled with zirconium-89 and methods thereof |
| WO2018237253A1 (en) | 2017-06-23 | 2018-12-27 | Memorial Sloan Kettering Cancer Center | Method of imaging in vivo tissues using nanoparticles comprising a reference dye and a sensor dye. |
| CN107589085B (zh) * | 2017-08-16 | 2020-03-31 | 广西师范大学 | 一种用适配体调控纳米二氧化硅活性-吸收光谱测定Hg2+的方法 |
| CN107607502B (zh) * | 2017-08-30 | 2019-10-01 | 江苏大学 | 一种利用多色荧光碳点同时且可视化检测多种抗生素的方法及多种抗生素的荧光检测指示卡 |
| WO2019059379A1 (ja) * | 2017-09-21 | 2019-03-28 | 国立大学法人北海道大学 | 生体検査装置及び生体検査方法 |
| WO2019113004A1 (en) | 2017-12-04 | 2019-06-13 | Memorial Sloan Kettering Cancer Center | Methods of cancer treatment via regulated ferroptosis |
| JP7296589B2 (ja) * | 2017-12-05 | 2023-06-23 | Jsr株式会社 | 親水化色素含有粒子、色素含有粒子、親水化色素含有粒子の製造方法および生体内を観察する方法 |
| WO2019142913A1 (ja) * | 2018-01-18 | 2019-07-25 | 国立大学法人東京大学 | ３次元組織内のグルコース濃度マッピングのための蛍光マイクロ粒子 |
| BR112020017872A2 (pt) | 2018-03-02 | 2020-12-22 | Kodiak Sciences Inc. | Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos |
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