|
JPH085859B2
(ja)
|
1986-07-01 |
1996-01-24 |
日本バイエルアグロケム株式会社 |
新規アルキレンジアミン類
|
|
US5204482A
(en)
|
1988-07-28 |
1993-04-20 |
Hoffman-Laroche Inc. |
Compounds for treating and preventing cognitive diseases and depression and methods of making same
|
|
EP0352581A3
(de)
|
1988-07-28 |
1990-07-04 |
F. Hoffmann-La Roche Ag |
Aethylendiaminmonoamid-Derivate
|
|
US5932737A
(en)
|
1994-12-02 |
1999-08-03 |
Fujisawa Pharmaceutical Co., Ltd. |
Peptide compounds for treatment of no-mediated diseases
|
|
SE9902765D0
(sv)
|
1999-07-21 |
1999-07-21 |
Astra Pharma Prod |
Novel compounds
|
|
CN1331326A
(zh)
*
|
2000-06-30 |
2002-01-16 |
上海博德基因开发有限公司 |
一种新的多肽——人精氨酸甲基转移酶(hrmt)32.12和编码这种多肽的多核苷酸
|
|
US20020090627A1
(en)
|
2000-10-05 |
2002-07-11 |
Rachel Meyers |
27419, a novel human arginine-N-methyl transferase and uses thereof
|
|
DE10149370A1
(de)
|
2001-10-06 |
2003-04-10 |
Merck Patent Gmbh |
Pyrazolderivate
|
|
CN100445276C
(zh)
|
2002-03-13 |
2008-12-24 |
詹森药业有限公司 |
用作组蛋白去乙酰酶抑制剂的磺酰基衍生物
|
|
GB0219961D0
(en)
|
2002-08-28 |
2002-10-02 |
Pfizer Ltd |
Oxytocin inhibitors
|
|
EP1571146A4
(en)
|
2002-12-10 |
2010-09-01 |
Ono Pharmaceutical Co |
NITROGENIC HETEROCYCLIC COMPOUNDS AND THEIR MEDICAL USE
|
|
US7135575B2
(en)
|
2003-03-03 |
2006-11-14 |
Array Biopharma, Inc. |
P38 inhibitors and methods of use thereof
|
|
DE10315572A1
(de)
|
2003-04-05 |
2004-10-14 |
Merck Patent Gmbh |
Substituierte Pyrazole
|
|
GB0309637D0
(en)
|
2003-04-28 |
2003-06-04 |
Cancer Rec Tech Ltd |
Pyrazole compounds
|
|
WO2004098634A2
(en)
|
2003-04-30 |
2004-11-18 |
Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health |
Protein arginine n-methyltransferase 2 (prmt-2)
|
|
US20050032794A1
(en)
|
2003-08-05 |
2005-02-10 |
Padia Janak K. |
Diamine derivatives of quinone and uses thereof
|
|
DE102004008807A1
(de)
|
2004-02-20 |
2005-09-08 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
|
AU2005224091B2
(en)
|
2004-03-15 |
2012-02-02 |
Janssen Pharmaceutica, N.V. |
Novel compounds as opioid receptor modulators
|
|
ES2355923T3
(es)
|
2004-08-26 |
2011-04-01 |
Pfizer, Inc. |
Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa.
|
|
DK1791973T3
(da)
|
2004-08-31 |
2010-01-25 |
Univ North Carolina |
DOT1-histonmethyltransferaser som et target til at identificere terapeutiske midler mod leukæmi
|
|
WO2006033995A2
(en)
|
2004-09-16 |
2006-03-30 |
Valeant Research And Development |
Thiazolidin-4-ones having anti-hepatitis b activity
|
|
JP2008515950A
(ja)
|
2004-10-13 |
2008-05-15 |
バイエル・ヘルスケア・アクチェンゲゼルシャフト |
泌尿器系障害の処置用の冷メントール受容体−1(cmr−1)アンタゴニストとしての4−置換ベンジルオキシ−フェニルメチルアミド誘導体
|
|
WO2006063356A1
(en)
|
2004-12-10 |
2006-06-15 |
Isis Phamaceuticals, Inc. |
Regulation of epigenetic control of gene expression
|
|
US20070060589A1
(en)
|
2004-12-21 |
2007-03-15 |
Purandare Ashok V |
Inhibitors of protein arginine methyl transferases
|
|
MX2007008781A
(es)
|
2005-01-21 |
2007-09-11 |
Astex Therapeutics Ltd |
Compuestos farmaceuticos.
|
|
US20060235037A1
(en)
*
|
2005-04-15 |
2006-10-19 |
Purandare Ashok V |
Heterocyclic inhibitors of protein arginine methyl transferases
|
|
US8063071B2
(en)
|
2007-10-31 |
2011-11-22 |
GlaxoSmithKline, LLC |
Chemical compounds
|
|
ES2336142T3
(es)
|
2005-08-19 |
2010-04-08 |
Aventis Pharmaceuticals Inc. |
Combinacion de un agente hipnotico y un compuesto sustituido, con bis arilo y heteroarilo y aplicacion terapeutica del mismo.
|
|
US8097708B2
(en)
|
2006-02-07 |
2012-01-17 |
Taisho Pharmaceutical Co., Ltd. |
10a-Azalide compound
|
|
US20090306201A1
(en)
|
2006-06-23 |
2009-12-10 |
University Of Medicine And Dentistry Of New Jersey |
Selective inhibitors for transferases
|
|
WO2008001076A1
(en)
|
2006-06-26 |
2008-01-03 |
Ucb Pharma S.A. |
Fused thiazole derivatives as kinase inhibitors
|
|
US20090253673A1
(en)
*
|
2006-07-12 |
2009-10-08 |
Min Ge |
Substituted Pyrazoles as Ghrelin Receptor Antagonists
|
|
JP2010503656A
(ja)
|
2006-09-13 |
2010-02-04 |
アストラゼネカ アクチボラグ |
スピロ−オキサゾリジノン化合物と代謝共役型グルタミン酸受容体ポテンシエーターとしてのその使用
|
|
CL2007002670A1
(es)
|
2006-09-15 |
2008-05-16 |
Celgene Corp Soc Organizada Ba |
Compuestos derivados de n-metilaminometil-isoindolina; composicion farmaceutica; forma de dosificacion, util para tratar o prevenir enfermedades tales como cancer, dolor, trastorno pulmonar, trastorno del snc y aterosclerosis.
|
|
EP2137158A4
(en)
*
|
2007-02-28 |
2012-04-18 |
Methylgene Inc |
LOW-MOLECULAR INHIBITORS OF PROTEINARGININE METHYLTRANSFERASES (PRMTS)
|
|
WO2008128050A2
(en)
|
2007-04-11 |
2008-10-23 |
Osi Pharmaceuticals, Inc. |
Methods for identification of modulators of carm1 methyl transferase activity
|
|
WO2008137834A2
(en)
|
2007-05-04 |
2008-11-13 |
Osi Pharmaceuticals, Inc. |
Crystal structure of smyd3 protein
|
|
WO2009006577A2
(en)
|
2007-07-03 |
2009-01-08 |
The Regents Of The University Of Michigan |
Compositions and methods for inhibiting ezh2
|
|
US8133904B2
(en)
|
2007-09-07 |
2012-03-13 |
Jenrin Discovery, Inc. |
Cannabinoid receptor antagonists/inverse agonists useful for treating obesity
|
|
JPWO2009084695A1
(ja)
|
2007-12-28 |
2011-05-19 |
カルナバイオサイエンス株式会社 |
2−アミノキナゾリン誘導体
|
|
JP2009179616A
(ja)
|
2008-01-31 |
2009-08-13 |
Kowa Co |
3−ナフチルピラゾール化合物
|
|
CA2715835C
(en)
|
2008-02-29 |
2017-03-21 |
Renovis, Inc. |
Amide compounds, compositions and uses thereof
|
|
WO2009126537A1
(en)
|
2008-04-07 |
2009-10-15 |
Syndax Pharmaceuticals, Inc. |
Administration of an inhibitor of hdac and an hmt inhibitor
|
|
WO2010023877A1
(en)
|
2008-08-27 |
2010-03-04 |
Oncotherapy Science, Inc. |
Prmt1 for target genes of cancer therapy and diagnosis
|
|
KR101364869B1
(ko)
|
2008-09-24 |
2014-02-21 |
바스프 에스이 |
무척추 해충을 방제하기 위한 피라졸 화합물
|
|
US8323918B2
(en)
|
2008-12-12 |
2012-12-04 |
University Of South Carolina |
Chloroacetamidine based inhibitors and activity based probes for the protein arginine methytransferases
|
|
US20130345268A1
(en)
|
2009-02-13 |
2013-12-26 |
The Trustees Of Dartmouth College |
Methods and Compositions for the Treatment of RAS Associated Disorders
|
|
WO2010094009A2
(en)
|
2009-02-13 |
2010-08-19 |
Children's Hospital Medical Center |
Methods and compositions for the treatment of ras associated disorders
|
|
EP2221053A1
(de)
|
2009-02-20 |
2010-08-25 |
Albert-Ludwigs-Universität Freiburg |
Pharmazeutische Zusammensetzung enthaltend Hemmstoffe der Proteinmethyltransferase I und deren Verwendung zur Behandlung von Tumorerkrankungen
|
|
WO2010104406A1
(en)
*
|
2009-03-11 |
2010-09-16 |
Auckland Uniservices Limited |
Prodrug forms of kinase inhibitors and their use in therapy
|
|
IN2012DN00352A
(https=)
|
2009-06-16 |
2015-08-21 |
Bikam Pharmaceuticals Inc |
|
|
WO2011011366A2
(en)
|
2009-07-20 |
2011-01-27 |
Constellation Pharmaceuticals |
Agents for stimulating activity of methyl modifying enzymes and methods of use thereof
|
|
WO2011079236A1
(en)
|
2009-12-22 |
2011-06-30 |
The Ohio State University Research Foundation |
Compositions and methods for cancer detection and treatment
|
|
WO2011082098A1
(en)
|
2009-12-30 |
2011-07-07 |
The Rockefeller University |
Lysine and arginine methyltransferase inhibitors for treating cancer
|
|
WO2011096210A1
(en)
|
2010-02-03 |
2011-08-11 |
Oncotherapy Science, Inc. |
Prmt1 and prmt6 for target genes of cancer therapy and diagnosis
|
|
JP2013518560A
(ja)
|
2010-02-03 |
2013-05-23 |
オンコセラピー・サイエンス株式会社 |
がんの治療および診断の標的遺伝子としてのwhsc1およびwhsc1l1
|
|
US20110251216A1
(en)
|
2010-02-19 |
2011-10-13 |
The Regents Of The University Of Michigan |
Compositions and methods for inhibiting ezh2
|
|
WO2012005805A1
(en)
|
2010-05-07 |
2012-01-12 |
Glaxosmithkline Llc |
Azaindazoles
|
|
EA023788B1
(ru)
|
2010-05-07 |
2016-07-29 |
ГЛЭКСОСМИТКЛАЙН ЭлЭлСи |
Производные индола и фармацевтические композиции на их основе
|
|
BR112013005806B1
(pt)
|
2010-09-10 |
2022-05-10 |
Epizyme, Inc |
Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
|
|
WO2012060760A1
(en)
|
2010-11-05 |
2012-05-10 |
Fujirebio Diagnostics Ab |
Molecular marker for cancer
|
|
US20130310379A1
(en)
|
2010-11-19 |
2013-11-21 |
Constellation Pharmaceuticals |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
EP2646020B1
(en)
|
2010-12-01 |
2016-09-21 |
Glaxosmithkline LLC |
Indoles
|
|
WO2012075381A1
(en)
|
2010-12-03 |
2012-06-07 |
Epizyme, Inc. |
Substituted purine and 7 - deazapurine compounds as modulators of epigenetic enzymes
|
|
CA2819734A1
(en)
|
2010-12-03 |
2012-06-07 |
Epizyme, Inc. |
Carbocycle-substituted purine and 7-deazapurine compounds
|
|
EP2646455A4
(en)
|
2010-12-03 |
2014-04-02 |
Epizyme Inc |
Modulators of histone methyltransferase, and methods of use thereof
|
|
US9145438B2
(en)
|
2010-12-03 |
2015-09-29 |
Epizyme, Inc. |
7-deazapurine modulators of histone methyltransferase, and methods of use thereof
|
|
WO2012118812A2
(en)
|
2011-02-28 |
2012-09-07 |
Epizyme, Inc. |
Substituted 6,5-fused bicyclic heteroaryl compounds
|
|
TW201733984A
(zh)
|
2011-04-13 |
2017-10-01 |
雅酶股份有限公司 |
經取代之苯化合物
|
|
JO3363B1
(ar)
|
2011-04-13 |
2019-03-13 |
Epizyme Inc |
مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
|
|
CA2873984A1
(en)
|
2012-05-23 |
2013-11-28 |
Stemergie Biotechnology Sa |
Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof
|
|
EP2891492B1
(en)
|
2012-08-30 |
2022-11-09 |
The University of Tokyo |
Endoparasite control agent
|
|
EP3143994A1
(en)
|
2012-08-30 |
2017-03-22 |
The University of Tokyo |
Endoparasite control agent and use thereof
|
|
US9745291B2
(en)
|
2012-12-21 |
2017-08-29 |
Epizyme, Inc. |
PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
|
|
CA2894126A1
(en)
|
2012-12-21 |
2014-06-26 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|
|
DK2935222T3
(en)
|
2012-12-21 |
2019-01-07 |
Epizyme Inc |
PRMT5 INHIBITORS AND APPLICATIONS THEREOF
|
|
JP2016511744A
(ja)
|
2012-12-21 |
2016-04-21 |
エピザイム,インコーポレイティド |
Prmt5を阻害する方法
|
|
JP2016505597A
(ja)
|
2012-12-21 |
2016-02-25 |
エピザイム,インコーポレイティド |
Prmt5阻害剤およびその使用
|
|
CA2899363A1
(en)
|
2012-12-21 |
2014-06-26 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|
|
WO2014153100A2
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2014153172A1
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
WO2014153214A1
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Arginine methyl transferase inhibtors and uses thereof
|
|
US9120757B2
(en)
|
2013-03-14 |
2015-09-01 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
EP2970137A1
(en)
|
2013-03-14 |
2016-01-20 |
Epizyme, Inc. |
Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
|
|
US9765035B2
(en)
|
2013-03-14 |
2017-09-19 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2014153208A1
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
EP2970135B1
(en)
|
2013-03-14 |
2018-07-18 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
JP2016518336A
(ja)
|
2013-03-14 |
2016-06-23 |
エピザイム,インコーポレイティド |
Prmt1阻害剤としてのピラゾール誘導体およびその使用
|
|
KR102028793B1
(ko)
|
2013-03-14 |
2019-10-07 |
에피자임, 인코포레이티드 |
아르기닌 메틸기 전이효소 억제제 및 이의 용도
|
|
WO2014144455A1
(en)
|
2013-03-15 |
2014-09-18 |
Epizyme, Inc. |
1 -phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
|
|
US9346802B2
(en)
|
2013-03-15 |
2016-05-24 |
Epizyme, Inc. |
CARM1 inhibitors and uses thereof
|
|
CA2903813C
(en)
|
2013-03-15 |
2023-08-29 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
US20170198006A1
(en)
|
2014-06-25 |
2017-07-13 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|
|
US20170210751A1
(en)
|
2014-06-25 |
2017-07-27 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|
|
WO2016022605A1
(en)
|
2014-08-04 |
2016-02-11 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|
|
EP3200588A4
(en)
|
2014-09-17 |
2018-04-25 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
US20170280720A1
(en)
|
2014-09-17 |
2017-10-05 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
EP3194398A4
(en)
|
2014-09-17 |
2018-02-21 |
Epizyme, Inc. |
Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor
|
|
WO2016044576A1
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Salts, co-crystals, amorphous forms, and crystalline forms of an arginine methyltransferase inhibitor
|
|
US20170283440A1
(en)
|
2014-09-17 |
2017-10-05 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
WO2016044604A1
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
WO2016044641A2
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
WO2016044626A1
(en)
|
2014-09-17 |
2016-03-24 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2017136699A1
(en)
|
2016-02-05 |
2017-08-10 |
Epizyme, Inc |
Arginine methyltransferase inhibitors and uses thereof
|
|
US20190083482A1
(en)
|
2017-09-18 |
2019-03-21 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|