DK1791973T3 - DOT1-histonmethyltransferaser som et target til at identificere terapeutiske midler mod leukæmi - Google Patents
DOT1-histonmethyltransferaser som et target til at identificere terapeutiske midler mod leukæmiInfo
- Publication number
- DK1791973T3 DK1791973T3 DK04782716.7T DK04782716T DK1791973T3 DK 1791973 T3 DK1791973 T3 DK 1791973T3 DK 04782716 T DK04782716 T DK 04782716T DK 1791973 T3 DK1791973 T3 DK 1791973T3
- Authority
- DK
- Denmark
- Prior art keywords
- leukemia
- dot1
- target
- therapeutic agents
- identify therapeutic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2004/028289 WO2006025832A1 (en) | 2004-08-31 | 2004-08-31 | Dot1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
| EP04782716A EP1791973B1 (en) | 2004-08-31 | 2004-08-31 | Dot1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1791973T3 true DK1791973T3 (da) | 2010-01-25 |
Family
ID=36000364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04782716.7T DK1791973T3 (da) | 2004-08-31 | 2004-08-31 | DOT1-histonmethyltransferaser som et target til at identificere terapeutiske midler mod leukæmi |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1791973B1 (da) |
| AT (1) | ATE446387T1 (da) |
| DE (1) | DE602004023766D1 (da) |
| DK (1) | DK1791973T3 (da) |
| ES (1) | ES2335411T3 (da) |
| WO (1) | WO2006025832A1 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006336552B2 (en) | 2006-01-20 | 2012-12-20 | The University Of North Carolina At Chapel Hill | Diagnostic and therapeutic targets for leukemia |
| EP2892536B1 (en) | 2012-09-06 | 2019-12-18 | Epizyme, Inc. | Method of treating leukemia |
| US9133189B2 (en) | 2013-03-14 | 2015-09-15 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970132B1 (en) | 2013-03-14 | 2020-09-23 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2014153208A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970134B1 (en) | 2013-03-14 | 2018-02-28 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| WO2014153172A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US20160031839A1 (en) | 2013-03-14 | 2016-02-04 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9023883B2 (en) | 2013-03-14 | 2015-05-05 | Epizyme, Inc. | PRMT1 inhibitors and uses thereof |
| US9765035B2 (en) | 2013-03-14 | 2017-09-19 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| CA2903264A1 (en) | 2013-03-14 | 2014-11-06 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
| EP3180348A4 (en) * | 2014-08-08 | 2018-02-07 | Baylor College of Medicine | Dot1l inhibitors and uses thereof |
| CN108997480B (zh) * | 2018-07-02 | 2021-07-27 | 中山大学附属第五医院 | 一种具有抑制组蛋白甲基化酶dot1l二甲基化活性的多肽、抑制剂及其设计方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420328A (en) | 1992-09-11 | 1995-05-30 | Affymax Technologies, N.V. | Methods for the synthesis of phosphonate esters |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5525734A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies N.V. | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5817751A (en) | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
| WO2003016497A2 (en) * | 2001-08-17 | 2003-02-27 | Incyte Genomics, Inc. | Molecules for disease detection and treatment |
-
2004
- 2004-08-31 WO PCT/US2004/028289 patent/WO2006025832A1/en active Application Filing
- 2004-08-31 AT AT04782716T patent/ATE446387T1/de not_active IP Right Cessation
- 2004-08-31 DE DE602004023766T patent/DE602004023766D1/de active Active
- 2004-08-31 DK DK04782716.7T patent/DK1791973T3/da active
- 2004-08-31 ES ES04782716T patent/ES2335411T3/es active Active
- 2004-08-31 EP EP04782716A patent/EP1791973B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| EP1791973A4 (en) | 2008-01-23 |
| EP1791973B1 (en) | 2009-10-21 |
| WO2006025832A1 (en) | 2006-03-09 |
| EP1791973A1 (en) | 2007-06-06 |
| ATE446387T1 (de) | 2009-11-15 |
| ES2335411T3 (es) | 2010-03-26 |
| DE602004023766D1 (de) | 2009-12-03 |
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