JP2016519078A5 - - Google Patents
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- JP2016519078A5 JP2016519078A5 JP2016502796A JP2016502796A JP2016519078A5 JP 2016519078 A5 JP2016519078 A5 JP 2016519078A5 JP 2016502796 A JP2016502796 A JP 2016502796A JP 2016502796 A JP2016502796 A JP 2016502796A JP 2016519078 A5 JP2016519078 A5 JP 2016519078A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- ring
- compound according
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 CC(*1)NNNC1N Chemical compound CC(*1)NNNC1N 0.000 description 1
- RFRKXBHBPOTRTP-LJQANCHMSA-N Cc1n[o]c(C)c1-c1nc(-c2cc(OC[C@@H](CNC)O)ccc2Cl)nc(N(C2)Cc3c2cccn3)c1C Chemical compound Cc1n[o]c(C)c1-c1nc(-c2cc(OC[C@@H](CNC)O)ccc2Cl)nc(N(C2)Cc3c2cccn3)c1C RFRKXBHBPOTRTP-LJQANCHMSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794442P | 2013-03-15 | 2013-03-15 | |
| US61/794,442 | 2013-03-15 | ||
| US201461937333P | 2014-02-07 | 2014-02-07 | |
| US61/937,333 | 2014-02-07 | ||
| PCT/US2014/028463 WO2014144169A1 (en) | 2013-03-15 | 2014-03-14 | Carm1 inhibitors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018071070A Division JP2018118994A (ja) | 2013-03-15 | 2018-04-02 | Ｃａｒｍ１阻害剤およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016519078A JP2016519078A (ja) | 2016-06-30 |
| JP2016519078A5 true JP2016519078A5 (https=) | 2017-02-02 |
Family
ID=50687649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502796A Pending JP2016519078A (ja) | 2013-03-15 | 2014-03-14 | Ｃａｒｍ１阻害剤およびその使用 |
| JP2018071070A Pending JP2018118994A (ja) | 2013-03-15 | 2018-04-02 | Ｃａｒｍ１阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018071070A Pending JP2018118994A (ja) | 2013-03-15 | 2018-04-02 | Ｃａｒｍ１阻害剤およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9738651B2 (https=) |
| EP (1) | EP2970219B1 (https=) |
| JP (2) | JP2016519078A (https=) |
| KR (1) | KR20160003647A (https=) |
| CN (1) | CN105228997B (https=) |
| AU (2) | AU2014227775B2 (https=) |
| BR (1) | BR112015022787A2 (https=) |
| CA (1) | CA2903813C (https=) |
| EA (1) | EA201591532A1 (https=) |
| IL (1) | IL241370A0 (https=) |
| MX (1) | MX2015012803A (https=) |
| SG (1) | SG11201507070XA (https=) |
| WO (1) | WO2014144169A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3255041A1 (en) * | 2011-09-02 | 2017-12-13 | Purdue Pharma L.P. | Pyrimidines as sodium channel blockers |
| CA2899363A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US9745291B2 (en) | 2012-12-21 | 2017-08-29 | Epizyme, Inc. | PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| CA2894126A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| JP2016505597A (ja) | 2012-12-21 | 2016-02-25 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| DK2935222T3 (en) | 2012-12-21 | 2019-01-07 | Epizyme Inc | PRMT5 INHIBITORS AND APPLICATIONS THEREOF |
| WO2014153208A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970135B1 (en) | 2013-03-14 | 2018-07-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| WO2014153214A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyl transferase inhibtors and uses thereof |
| KR102028793B1 (ko) | 2013-03-14 | 2019-10-07 | 에피자임, 인코포레이티드 | 아르기닌 메틸기 전이효소 억제제 및 이의 용도 |
| US9765035B2 (en) | 2013-03-14 | 2017-09-19 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970137A1 (en) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
| WO2014153172A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2014144455A1 (en) | 2013-03-15 | 2014-09-18 | Epizyme, Inc. | 1 -phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
| CA2903813C (en) | 2013-03-15 | 2023-08-29 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| WO2016022605A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2016044604A1 (en) * | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| EP3194398A4 (en) * | 2014-09-17 | 2018-02-21 | Epizyme, Inc. | Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| WO2017007756A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
| JP7187037B2 (ja) * | 2016-09-07 | 2022-12-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ｐ－タウを減少させ、認知機能を改善させるアロステリック副腎皮質刺激ホルモン放出因子受容体１（ＣＲＦＲ１）アンタゴニスト |
| US11160823B2 (en) | 2016-11-07 | 2021-11-02 | University Of Massachusetts | Therapeutic targets for facioscapulohumeral muscular dystrophy |
| HUE057849T2 (hu) | 2017-01-11 | 2022-06-28 | Alkermes Inc | Hiszton deacetiláz biciklusos gátlói |
| WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| JP7327802B2 (ja) | 2017-01-26 | 2023-08-16 | アラクセス ファーマ エルエルシー | 縮合ヘテロ－ヘテロ二環式化合物およびその使用方法 |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
| US10745385B2 (en) | 2017-05-25 | 2020-08-18 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
| LT3664802T (lt) | 2017-08-07 | 2022-06-27 | Alkermes, Inc. | Bicikliniai histonų deacetilazės inhibitoriai |
| MX2021000887A (es) * | 2018-08-01 | 2021-03-31 | Araxes Pharma Llc | Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer. |
| CN112007032B (zh) * | 2020-09-16 | 2021-10-22 | 厦门大学 | 化合物在制备小分子抑制剂或治疗癌症的药物中的应用及小分子抑制剂和治疗癌症的药物 |
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| PL195600B1 (pl) * | 1998-05-15 | 2007-10-31 | Astrazeneca Ab | Pochodne benzamidowe, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku do leczenia stanów medycznych powstających za pośrednictwem cytokin |
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| CA2894126A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US9745291B2 (en) | 2012-12-21 | 2017-08-29 | Epizyme, Inc. | PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| DK2935222T3 (en) | 2012-12-21 | 2019-01-07 | Epizyme Inc | PRMT5 INHIBITORS AND APPLICATIONS THEREOF |
| CA2899363A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| JP2016511744A (ja) * | 2012-12-21 | 2016-04-21 | エピザイム，インコーポレイティド | Ｐｒｍｔ５を阻害する方法 |
| JP2016505597A (ja) | 2012-12-21 | 2016-02-25 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
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| US9765035B2 (en) | 2013-03-14 | 2017-09-19 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| KR102028793B1 (ko) | 2013-03-14 | 2019-10-07 | 에피자임, 인코포레이티드 | 아르기닌 메틸기 전이효소 억제제 및 이의 용도 |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2014153172A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| WO2014153214A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyl transferase inhibtors and uses thereof |
| EP2970135B1 (en) | 2013-03-14 | 2018-07-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| EP2970137A1 (en) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
| JP2016518336A (ja) | 2013-03-14 | 2016-06-23 | エピザイム，インコーポレイティド | Ｐｒｍｔ１阻害剤としてのピラゾール誘導体およびその使用 |
| WO2014153100A2 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2014153208A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9346802B2 (en) * | 2013-03-15 | 2016-05-24 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
| CA2903813C (en) | 2013-03-15 | 2023-08-29 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| WO2014144455A1 (en) | 2013-03-15 | 2014-09-18 | Epizyme, Inc. | 1 -phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
| US20170198006A1 (en) | 2014-06-25 | 2017-07-13 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US20170210751A1 (en) | 2014-06-25 | 2017-07-27 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2016022605A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| EP3194398A4 (en) | 2014-09-17 | 2018-02-21 | Epizyme, Inc. | Salts, co-crystals, amorphous forms, and crystalline forms of a co-activator-associated arginine methyltransferase 1 (carm1) inhibitor |
| CN107073136A (zh) | 2014-09-17 | 2017-08-18 | 健泰科生物技术公司 | 吡咯并苯并二氮杂卓及其抗体二硫化物偶联物 |
| WO2016044626A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2016044576A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Salts, co-crystals, amorphous forms, and crystalline forms of an arginine methyltransferase inhibitor |
| US20170283440A1 (en) | 2014-09-17 | 2017-10-05 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| WO2016044641A2 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| EP3200588A4 (en) | 2014-09-17 | 2018-04-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US20170280720A1 (en) | 2014-09-17 | 2017-10-05 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2016044604A1 (en) | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| WO2017136699A1 (en) | 2016-02-05 | 2017-08-10 | Epizyme, Inc | Arginine methyltransferase inhibitors and uses thereof |
| CN109715790A (zh) | 2016-07-25 | 2019-05-03 | 埃皮兹姆公司 | Crebbp相关的癌症疗法 |
| US20190083482A1 (en) | 2017-09-18 | 2019-03-21 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
-
2014
- 2014-03-14 CA CA2903813A patent/CA2903813C/en active Active
- 2014-03-14 CN CN201480020614.4A patent/CN105228997B/zh not_active Expired - Fee Related
- 2014-03-14 AU AU2014227775A patent/AU2014227775B2/en not_active Ceased
- 2014-03-14 SG SG11201507070XA patent/SG11201507070XA/en unknown
- 2014-03-14 BR BR112015022787A patent/BR112015022787A2/pt not_active IP Right Cessation
- 2014-03-14 JP JP2016502796A patent/JP2016519078A/ja active Pending
- 2014-03-14 MX MX2015012803A patent/MX2015012803A/es unknown
- 2014-03-14 EA EA201591532A patent/EA201591532A1/ru unknown
- 2014-03-14 US US14/775,766 patent/US9738651B2/en not_active Expired - Fee Related
- 2014-03-14 WO PCT/US2014/028463 patent/WO2014144169A1/en not_active Ceased
- 2014-03-14 EP EP14723190.6A patent/EP2970219B1/en active Active
- 2014-03-14 KR KR1020157029125A patent/KR20160003647A/ko not_active Withdrawn
-
2015
- 2015-09-09 IL IL241370A patent/IL241370A0/en active IP Right Grant
-
2017
- 2017-07-13 US US15/648,701 patent/US9856267B2/en not_active Expired - Fee Related
- 2017-12-08 US US15/835,758 patent/US10118931B2/en active Active
-
2018
- 2018-04-02 JP JP2018071070A patent/JP2018118994A/ja active Pending
- 2018-07-31 AU AU2018211214A patent/AU2018211214A1/en not_active Abandoned
- 2018-10-02 US US16/149,519 patent/US10633389B2/en active Active
-
2020
- 2020-03-18 US US16/822,478 patent/US11834455B2/en active Active
-
2022
- 2022-11-23 US US18/058,549 patent/US20230416263A1/en not_active Abandoned
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