JP2016515130A5 - - Google Patents
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- JP2016515130A5 JP2016515130A5 JP2016502323A JP2016502323A JP2016515130A5 JP 2016515130 A5 JP2016515130 A5 JP 2016515130A5 JP 2016502323 A JP2016502323 A JP 2016502323A JP 2016502323 A JP2016502323 A JP 2016502323A JP 2016515130 A5 JP2016515130 A5 JP 2016515130A5
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- Prior art keywords
- antagonist
- measured
- surface plasmon
- plasmon resonance
- resonance assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010067003 Interleukin-33 Proteins 0.000 claims 55
- 102000017761 Interleukin-33 Human genes 0.000 claims 55
- 239000005557 antagonist Substances 0.000 claims 39
- 238000003556 assay Methods 0.000 claims 24
- 238000010494 dissociation reaction Methods 0.000 claims 23
- 230000005593 dissociations Effects 0.000 claims 23
- 208000027866 inflammatory disease Diseases 0.000 claims 22
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 102100036706 Interleukin-1 receptor-like 1 Human genes 0.000 claims 7
- 208000006673 asthma Diseases 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 102100039880 Interleukin-1 receptor accessory protein Human genes 0.000 claims 5
- 101710180389 Interleukin-1 receptor accessory protein Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 241000282693 Cercopithecidae Species 0.000 claims 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 206010020751 Hypersensitivity Diseases 0.000 claims 4
- 101000998136 Mus musculus Interleukin-33 Proteins 0.000 claims 4
- 239000013566 allergen Substances 0.000 claims 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 101000998137 Homo sapiens Interleukin-33 Proteins 0.000 claims 3
- 208000030961 allergic reaction Diseases 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 102000045906 human IL33 Human genes 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 2
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 230000036783 anaphylactic response Effects 0.000 claims 2
- 208000003455 anaphylaxis Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 1
- 229930182837 (R)-adrenaline Natural products 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- -1 bronchodilator Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 230000002327 eosinophilic effect Effects 0.000 claims 1
- 229960005139 epinephrine Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000670 ligand binding assay Methods 0.000 claims 1
- 230000002912 lymphogenic effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000014232 psoriasis 12 Diseases 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 239000000779 smoke Substances 0.000 claims 1
- 230000002992 thymic effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361787121P | 2013-03-15 | 2013-03-15 | |
| US61/787,121 | 2013-03-15 | ||
| US201361819029P | 2013-05-03 | 2013-05-03 | |
| US61/819,029 | 2013-05-03 | ||
| US201361913417P | 2013-12-09 | 2013-12-09 | |
| US61/913,417 | 2013-12-09 | ||
| PCT/US2014/027058 WO2014152195A1 (en) | 2013-03-15 | 2014-03-14 | Il-33 antagonists and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515130A JP2016515130A (ja) | 2016-05-26 |
| JP2016515130A5 true JP2016515130A5 (https=) | 2017-03-30 |
| JP6404314B2 JP6404314B2 (ja) | 2018-10-10 |
Family
ID=50513479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502323A Active JP6404314B2 (ja) | 2013-03-15 | 2014-03-14 | Ｉｌ−３３拮抗薬とその使用法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9637535B2 (https=) |
| EP (1) | EP2968454B1 (https=) |
| JP (1) | JP6404314B2 (https=) |
| KR (1) | KR20150127591A (https=) |
| CN (1) | CN105007929B (https=) |
| AU (1) | AU2014240101B2 (https=) |
| CA (1) | CA2904377C (https=) |
| EA (1) | EA034834B1 (https=) |
| IL (1) | IL240393B (https=) |
| MX (1) | MX364591B (https=) |
| WO (1) | WO2014152195A1 (https=) |
Families Citing this family (87)
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| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| WO2014152195A1 (en) | 2013-03-15 | 2014-09-25 | Regeneron Pharmaceuticals, Inc. | Il-33 antagonists and uses thereof |
| EA034666B1 (ru) * | 2013-09-13 | 2020-03-04 | Бейджин Свитзерланд Гмбх | Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела |
| BR112016013347B1 (pt) | 2013-12-26 | 2023-12-12 | Mitsubishi Tanabe Pharma Corporation | Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos |
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| JP2011500748A (ja) | 2007-10-26 | 2011-01-06 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 神経変性障害の治療におけるｃａｓｐａｓｅＩ−依存性サイトカインの阻害剤 |
| EP2631302A3 (en) * | 2008-03-31 | 2014-01-08 | Genentech, Inc. | Compositions and methods for treating and diagnosing asthma |
| WO2011031600A1 (en) | 2009-09-10 | 2011-03-17 | Schering Corporation | Use of il-33 antagonists to treat fibrotic disease |
| US9090694B2 (en) | 2012-04-30 | 2015-07-28 | Janssen Biotech, Inc. | ST2L antibody antagonists |
| AR091069A1 (es) | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| WO2014152195A1 (en) | 2013-03-15 | 2014-09-25 | Regeneron Pharmaceuticals, Inc. | Il-33 antagonists and uses thereof |
| BR112016013347B1 (pt) | 2013-12-26 | 2023-12-12 | Mitsubishi Tanabe Pharma Corporation | Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos |
| SG11201605580RA (en) | 2014-01-10 | 2016-10-28 | Anaptysbio Inc | Antibodies directed against interleukin-33 (il-33) |
-
2014
- 2014-03-14 WO PCT/US2014/027058 patent/WO2014152195A1/en not_active Ceased
- 2014-03-14 US US14/210,599 patent/US9637535B2/en active Active
- 2014-03-14 CA CA2904377A patent/CA2904377C/en active Active
- 2014-03-14 MX MX2015011408A patent/MX364591B/es active IP Right Grant
- 2014-03-14 JP JP2016502323A patent/JP6404314B2/ja active Active
- 2014-03-14 KR KR1020157022680A patent/KR20150127591A/ko not_active Abandoned
- 2014-03-14 AU AU2014240101A patent/AU2014240101B2/en active Active
- 2014-03-14 EP EP14718264.6A patent/EP2968454B1/en active Active
- 2014-03-14 EA EA201591331A patent/EA034834B1/ru not_active IP Right Cessation
- 2014-03-14 CN CN201480013599.0A patent/CN105007929B/zh not_active Expired - Fee Related
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2015
- 2015-08-06 IL IL240393A patent/IL240393B/en active IP Right Grant
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2017
- 2017-03-20 US US15/463,910 patent/US10011647B2/en active Active
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2018
- 2018-05-29 US US15/991,763 patent/US10774128B2/en active Active
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