JP2016513644A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016513644A5 JP2016513644A5 JP2016501386A JP2016501386A JP2016513644A5 JP 2016513644 A5 JP2016513644 A5 JP 2016513644A5 JP 2016501386 A JP2016501386 A JP 2016501386A JP 2016501386 A JP2016501386 A JP 2016501386A JP 2016513644 A5 JP2016513644 A5 JP 2016513644A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- pharmaceutical composition
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims description 48
- 239000000427 antigen Substances 0.000 claims description 47
- 102000036639 antigens Human genes 0.000 claims description 47
- 108091007433 antigens Proteins 0.000 claims description 47
- 108010067003 Interleukin-33 Proteins 0.000 claims description 25
- 102000017761 Interleukin-33 Human genes 0.000 claims description 25
- 101000998137 Homo sapiens Interleukin-33 Proteins 0.000 claims description 8
- 102000045906 human IL33 Human genes 0.000 claims description 8
- 238000010494 dissociation reaction Methods 0.000 claims description 7
- 230000005593 dissociations Effects 0.000 claims description 7
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 4
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 4
- 208000027866 inflammatory disease Diseases 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000005557 antagonist Substances 0.000 claims 12
- 239000013566 allergen Substances 0.000 claims 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 208000006673 asthma Diseases 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 230000001404 mediated effect Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
- 230000003993 interaction Effects 0.000 claims 4
- 102100037850 Interferon gamma Human genes 0.000 claims 3
- 108010074328 Interferon-gamma Proteins 0.000 claims 3
- 108090000978 Interleukin-4 Proteins 0.000 claims 3
- 108010002616 Interleukin-5 Proteins 0.000 claims 3
- 206010035664 Pneumonia Diseases 0.000 claims 3
- 238000010171 animal model Methods 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 210000003651 basophil Anatomy 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000035945 sensitivity Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 208000030961 allergic reaction Diseases 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 1
- 229930182837 (R)-adrenaline Natural products 0.000 claims 1
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- -1 bronchodilator Substances 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 230000002327 eosinophilic effect Effects 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 229960005139 epinephrine Drugs 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000000670 ligand binding assay Methods 0.000 claims 1
- 230000002912 lymphogenic effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 238000001525 receptor binding assay Methods 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 claims 1
- 230000002992 thymic effect Effects 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000000872 buffer Substances 0.000 description 5
- 239000012146 running buffer Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 241000282693 Cercopithecidae Species 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 101100476210 Caenorhabditis elegans rnt-1 gene Proteins 0.000 description 2
- 108010093488 His-His-His-His-His-His Proteins 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 238000012575 bio-layer interferometry Methods 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 101000998136 Mus musculus Interleukin-33 Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361778687P | 2013-03-13 | 2013-03-13 | |
| US61/778,687 | 2013-03-13 | ||
| US201361819018P | 2013-05-03 | 2013-05-03 | |
| US61/819,018 | 2013-05-03 | ||
| PCT/US2014/023930 WO2014164959A2 (en) | 2013-03-13 | 2014-03-12 | Anti-il-33 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019018423A Division JP6845876B2 (ja) | 2013-03-13 | 2019-02-05 | 抗ｉｌ−３３抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513644A JP2016513644A (ja) | 2016-05-16 |
| JP2016513644A5 true JP2016513644A5 (https=) | 2017-04-06 |
| JP6479755B2 JP6479755B2 (ja) | 2019-03-06 |
Family
ID=50678269
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501386A Active JP6479755B2 (ja) | 2013-03-13 | 2014-03-12 | 抗ｉｌ−３３抗体及びその使用 |
| JP2019018423A Active JP6845876B2 (ja) | 2013-03-13 | 2019-02-05 | 抗ｉｌ−３３抗体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019018423A Active JP6845876B2 (ja) | 2013-03-13 | 2019-02-05 | 抗ｉｌ−３３抗体及びその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US9453072B2 (https=) |
| EP (3) | EP3683235B1 (https=) |
| JP (2) | JP6479755B2 (https=) |
| KR (1) | KR102103159B1 (https=) |
| CN (1) | CN105051063B (https=) |
| AU (1) | AU2014248839B2 (https=) |
| CA (1) | CA2902172C (https=) |
| CL (2) | CL2015002469A1 (https=) |
| DK (2) | DK2970460T3 (https=) |
| EA (1) | EA031745B1 (https=) |
| ES (2) | ES2804592T3 (https=) |
| FI (1) | FI3683235T3 (https=) |
| HR (2) | HRP20200846T1 (https=) |
| HU (2) | HUE051018T2 (https=) |
| IL (2) | IL240354A0 (https=) |
| JO (1) | JO3532B1 (https=) |
| LT (2) | LT2970460T (https=) |
| MX (2) | MX377712B (https=) |
| MY (3) | MY201923A (https=) |
| PH (1) | PH12015501656B1 (https=) |
| PL (2) | PL3683235T3 (https=) |
| PT (2) | PT3683235T (https=) |
| RS (2) | RS65586B1 (https=) |
| SG (1) | SG11201505745WA (https=) |
| SI (2) | SI3683235T1 (https=) |
| TW (1) | TWI633119B (https=) |
| UY (1) | UY35417A (https=) |
| WO (1) | WO2014164959A2 (https=) |
| ZA (1) | ZA201505376B (https=) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112812184A (zh) | 2011-02-25 | 2021-05-18 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
| CN109517059B (zh) | 2011-06-30 | 2023-03-28 | 中外制药株式会社 | 异源二聚化多肽 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| JP6124800B2 (ja) | 2011-11-30 | 2017-05-10 | 中外製薬株式会社 | 免疫複合体を形成する細胞内への運搬体（キャリア）を含む医薬 |
| AR091069A1 (es) | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
| JP6306588B2 (ja) | 2012-08-21 | 2018-04-04 | サノフィ・バイオテクノロジー | Ｉｌ−４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
| TW202237660A (zh) | 2012-08-24 | 2022-10-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| US10766960B2 (en) | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| WO2014152195A1 (en) | 2013-03-15 | 2014-09-25 | Regeneron Pharmaceuticals, Inc. | Il-33 antagonists and uses thereof |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| BR112016013347B1 (pt) | 2013-12-26 | 2023-12-12 | Mitsubishi Tanabe Pharma Corporation | Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos |
| SG11201605580RA (en) * | 2014-01-10 | 2016-10-28 | Anaptysbio Inc | Antibodies directed against interleukin-33 (il-33) |
| EP3134120B1 (en) | 2014-04-21 | 2024-01-24 | The Children's Hospital of Philadelphia | Compositions and methods for treating cytokine-related disorders |
| NO2785538T3 (https=) | 2014-05-07 | 2018-08-04 | ||
| EP3201227A4 (en) | 2014-09-29 | 2018-04-18 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| TWI705976B (zh) | 2014-11-10 | 2020-10-01 | 美商建南德克公司 | 抗介白素-33抗體及其用途 |
| CN107109494B (zh) * | 2014-11-10 | 2023-10-27 | 豪夫迈·罗氏有限公司 | Il-33介导型疾病的治疗方法和诊断方法 |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| EP3265107B1 (en) | 2015-03-02 | 2024-10-02 | 180 Therapeutics LP | Method of treating a localized fibrotic disorder using a tnf receptor 2 antagonist |
| KR102261618B1 (ko) * | 2015-03-31 | 2021-06-04 | 메디뮨 리미티드 | 신규한 il33 형태, il33의 돌연변이된 형태, 항체, 검정 및 이의 이용 방법 |
| ES2904514T3 (es) * | 2015-04-06 | 2022-04-05 | Meso Scale Technologies Llc | Sistema de alto rendimiento para realizar ensayos mediante el uso de electroquimioluminiscencia que incluye un aparato de agitación de consumibles |
| TW202440904A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（二） |
| EA201890891A1 (ru) * | 2015-10-06 | 2018-09-28 | Ридженерон Фармасьютикалз, Инк. | Биомаркеры, связанные с заболеваниями, опосредованными интерлейкином-33 (ил-33), и их применение |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| SG11201805900YA (en) * | 2016-01-14 | 2018-08-30 | Anaptysbio Inc | Inhibition of allergic reaction using an il-33 inhibitor |
| US12297266B2 (en) | 2016-04-18 | 2025-05-13 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human CD40 and uses thereof |
| KR20180135031A (ko) * | 2016-04-22 | 2018-12-19 | 메디뮨 엘엘씨 | Ilc2의 기능적 소성, 면역성 및 copd |
| KR102460040B1 (ko) | 2016-04-27 | 2022-11-01 | 애브비 인코포레이티드 | 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법 |
| JP2019516362A (ja) | 2016-04-27 | 2019-06-20 | ファイザー・インク | 抗ｉｌ−３３抗体、その組成物、方法および使用 |
| TWI693940B (zh) | 2016-08-05 | 2020-05-21 | 日商中外製藥股份有限公司 | Ｉｌ-８相關疾病之治療用或預防用組成物 |
| WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| MY203971A (en) * | 2016-10-13 | 2024-07-26 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Anti-lag-3 antibodies and compositions |
| JOP20190093A1 (ar) * | 2016-10-28 | 2019-04-25 | Lilly Co Eli | أجسام مضادة لـ il-33 واستخداماتها |
| TWI857389B (zh) * | 2016-12-01 | 2024-10-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| PE20191548A1 (es) | 2017-02-10 | 2019-10-24 | Genentech Inc | Anticuerpos contra triptasa, composiciones de estos y usos de estos |
| CN108456251A (zh) * | 2017-02-21 | 2018-08-28 | 上海君实生物医药科技股份有限公司 | 抗pd-l1抗体及其应用 |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| ES3052989T3 (en) | 2017-04-13 | 2026-01-16 | Regeneron Pharma | Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1 |
| CA3066918A1 (en) | 2017-06-12 | 2018-12-20 | Bluefin Biomedicine, Inc. | Anti-il1rap antibodies and antibody drug conjugates |
| KR102659791B1 (ko) | 2017-07-06 | 2024-04-23 | 리제너론 파마슈티칼스 인코포레이티드 | 당단백질을 만들기 위한 세포 배양 과정 |
| MY199245A (en) | 2017-08-31 | 2023-10-23 | Hyogo College Medicine | Il-33 antagonist-containing therapeutic agent for endometriosis |
| EP3710589A4 (en) | 2017-11-14 | 2021-11-10 | Chugai Seiyaku Kabushiki Kaisha | ANTI-C1S ANTIBODIES AND METHOD OF USING |
| BR112020010615A2 (pt) | 2017-12-22 | 2020-10-27 | Regeneron Pharmaceuticals, Inc. | produto farmacêutico proteico, método e sistema para caracterizar impurezas de produto farmacêutico proteico e de fármaco de baixo peso molecular, método para produzir um anticorpo, anticorpo, e, usos do método e do sistema |
| CN111655722A (zh) | 2018-01-31 | 2020-09-11 | 瑞泽恩制药公司 | 用于表征药物产品杂质的系统和方法 |
| TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| AU2019218128A1 (en) | 2018-02-09 | 2020-09-17 | Genentech, Inc. | Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases |
| MX2020008988A (es) | 2018-02-28 | 2020-09-28 | Regeneron Pharma | Sistemas y metodos para la identificacion de contaminantes virales. |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| US12253490B2 (en) | 2018-03-19 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| CA3089655C (en) | 2018-03-19 | 2026-01-20 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| IL307286B2 (en) * | 2018-04-11 | 2026-03-01 | Regeneron Pharma | Methods and reagents for IL-33 quantification |
| TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| EP3835321A4 (en) | 2018-08-10 | 2022-11-02 | Chugai Seiyaku Kabushiki Kaisha | ANTI-CD137 ANTIGEN-BINDING MOLECULE AND USE THEREOF |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| AU2019333047A1 (en) | 2018-08-30 | 2020-12-03 | Regeneron Pharmaceuticals, Inc. | Methods for characterizing protein complexes |
| ES2942024T3 (es) | 2019-01-16 | 2023-05-29 | Regeneron Pharma | Métodos para caracterizar enlaces disulfuro |
| TW202519263A (zh) | 2019-03-21 | 2025-05-16 | 美商再生元醫藥公司 | 含有抗il-33抗體之穩定調配物 |
| SG11202111255YA (en) * | 2019-05-01 | 2021-11-29 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-33 antagonist |
| EP3969908A1 (en) | 2019-05-13 | 2022-03-23 | Regeneron Pharmaceuticals, Inc. | Improved competitive ligand binding assays |
| MX2021013441A (es) | 2019-05-15 | 2021-12-10 | Chugai Pharmaceutical Co Ltd | Molecula de union a antigenos, composicion farmaceutica y metodo. |
| WO2021011614A1 (en) | 2019-07-16 | 2021-01-21 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| EP4653865A3 (en) | 2019-09-24 | 2026-02-18 | Regeneron Pharmaceuticals, Inc. | Systems and methods for chromatography use and regeneration |
| US11560595B2 (en) | 2019-10-03 | 2023-01-24 | Dasman Diabetes Institute | Method for preventing progression to type II Diabetes |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| IL292443A (en) | 2019-11-04 | 2022-06-01 | Medimmune Ltd | Methods for using IL-33 antagonists |
| AU2020380588A1 (en) | 2019-11-04 | 2022-06-09 | Medimmune Limited | Anti IL-33 therapeutic agent FPR treating renal disorders |
| WO2021108548A1 (en) | 2019-11-25 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous emulsions |
| EP4081544A1 (en) * | 2019-12-23 | 2022-11-02 | Sanofi Biotechnology | Methods for treating or preventing allergic asthma by administering an il-33 antagonist and/or an il-4r antagonist |
| CN113214395A (zh) * | 2020-01-21 | 2021-08-06 | 迈威(上海)生物科技股份有限公司 | 抗st2抗体及其应用 |
| MX2022008973A (es) | 2020-01-21 | 2022-08-11 | Regeneron Pharma | Metodos de desglicosilacion para electroforesis de proteinas glicosiladas. |
| JP2023516497A (ja) | 2020-03-13 | 2023-04-19 | メドイミューン・リミテッド | Ｉｌ３３にリスクアレルを有する対象を治療するための治療方法 |
| AU2021236306A1 (en) | 2020-03-13 | 2022-09-15 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| US20230174637A1 (en) | 2020-04-06 | 2023-06-08 | Medimmune Limited | Treating acute respiratory distress syndrome with il-33 axis binding antagonists |
| CN115398006A (zh) * | 2020-04-13 | 2022-11-25 | 麦登顾问有限责任公司 | 用于治疗covid-19的ace2靶向组合物和方法 |
| KR20230010239A (ko) | 2020-05-11 | 2023-01-18 | 메디뮨 리미티드 | 항-il-33 항체의 제형물 |
| MX2022014243A (es) * | 2020-05-12 | 2022-12-02 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Proteina de union al antigeno st2. |
| KR102789102B1 (ko) * | 2020-08-18 | 2025-03-28 | 성균관대학교산학협력단 | Il-33 항체 또는 이의 항원 결합 단편 |
| AU2021332355A1 (en) | 2020-08-31 | 2023-03-23 | Regeneron Pharmaceuticals, Inc. | Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants |
| CN114249825A (zh) * | 2020-09-25 | 2022-03-29 | 三生国健药业（上海）股份有限公司 | 结合人il-33的抗体、其制备方法和用途 |
| WO2022115588A1 (en) | 2020-11-25 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous membrane emulsification |
| JP2024500409A (ja) | 2020-12-17 | 2024-01-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | タンパク質封入マイクロゲルの作製 |
| KR20230134117A (ko) | 2021-01-20 | 2023-09-20 | 리제너론 파마슈티칼스 인코포레이티드 | 세포 배양물에서 단백질 역가를 개선시키는 방법 |
| IL305156A (en) | 2021-03-03 | 2023-10-01 | Regeneron Pharma | Systems and methods for quantifying and modifying protein viscosity |
| BR112023018665A2 (pt) | 2021-03-26 | 2023-10-03 | Regeneron Pharma | Métodos e sistemas para desenvolvimento de protocolos de mistura |
| EP4348234B1 (en) | 2021-06-01 | 2026-04-08 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| CN113493513B (zh) * | 2021-06-30 | 2022-07-12 | 深圳大学 | 抗人il-33中和性自身抗体及其制备方法和应用 |
| CN113603775B (zh) * | 2021-09-03 | 2022-05-20 | 江苏荃信生物医药股份有限公司 | 抗人白介素-33单克隆抗体及其应用 |
| US20230077710A1 (en) | 2021-09-08 | 2023-03-16 | Regeneron Pharmaceuticals, Inc. | HIGH-THROUGHPUT AND MASS-SPECTROMETRY-BASED METHOD FOR QUANTITATING ANTIBODIES AND OTHER Fc-CONTAINING PROTEINS |
| JP2024531800A (ja) | 2021-09-20 | 2024-08-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗体の不均一性を制御する方法 |
| WO2023059800A2 (en) | 2021-10-07 | 2023-04-13 | Regeneron Pharmaceuticals, Inc. | Systems and methods of ph modeling and control |
| CA3230985A1 (en) | 2021-10-07 | 2023-04-13 | Ross BROWNE | Ph meter calibration and correction |
| CA3236367A1 (en) | 2021-10-26 | 2023-05-04 | Michelle Lafond | Systems and methods for generating laboratory water and distributing laboratory water at different temperatures |
| EP4430072A1 (en) | 2021-11-10 | 2024-09-18 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| US20240117030A1 (en) * | 2022-03-03 | 2024-04-11 | Pfizer Inc. | Multispecific antibodies and uses thereof |
| IL315548A (en) | 2022-03-18 | 2024-11-01 | Regeneron Pharma | Methods and systems for analyzing polypeptide variants |
| TW202402790A (zh) | 2022-03-25 | 2024-01-16 | 英商梅迪繆思有限公司 | 減少呼吸系統感染之方法 |
| WO2024038185A1 (en) | 2022-08-19 | 2024-02-22 | Medimmune Limited | Method of selecting patients for treatment with an il-33 axis antagonist |
| EP4634659A1 (en) | 2022-12-16 | 2025-10-22 | Regeneron Pharmaceuticals, Inc. | Methods and systems for assessing chromatographic column integrity |
| US20240245779A1 (en) | 2023-01-25 | 2024-07-25 | Regeneron Pharmaceuticals, Inc. | Methods of modeling liquid protein composition stability |
| WO2024158961A1 (en) | 2023-01-25 | 2024-08-02 | Regeneron Pharmaceuticals, Inc. | Mass spectrometry-based characterization of antibodies co-expressed in vivo |
| US20240255519A1 (en) | 2023-02-01 | 2024-08-01 | Regeneron Pharmaceuticals, Inc. | Asymmetrical flow field-flow fractionation with mass spectrometry for biomacromolecule analysis |
| US20240280551A1 (en) | 2023-02-22 | 2024-08-22 | Regeneron Pharmaceuticals, Inc. | System suitability parameters and column aging |
| EP4704808A1 (en) | 2023-05-01 | 2026-03-11 | Regeneron Pharmaceuticals, Inc. | Multidose antibody drug products using phenol or benzyl alcohol |
| WO2025048206A1 (ko) | 2023-08-28 | 2025-03-06 | 서울대학교산학협력단 | 세포독성능을 갖는 제2형 선천성 림프구 세포, 이의 제조방법 및 용도 |
| JP7668943B2 (ja) * | 2023-08-30 | 2025-04-25 | ファイザー・インク | 多重特異性抗体およびその使用 |
| TW202528736A (zh) | 2023-09-08 | 2025-07-16 | 美商再生元醫藥公司 | 用於評估層析管柱完整性的方法及系統 |
| WO2025064403A2 (en) | 2023-09-18 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for developing chromatography protocols |
| CN121925272A (zh) | 2023-09-29 | 2026-04-24 | 瑞泽恩制药公司 | 利用受控成核进行冻干 |
| WO2025085594A1 (en) | 2023-10-18 | 2025-04-24 | Regeneron Pharmaceuticals, Inc. | Rapid purification of monoclonal antibody from in-process upstream cell culture material |
| US20250145662A1 (en) | 2023-11-02 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipase activity using stress |
| WO2025120567A1 (en) | 2023-12-07 | 2025-06-12 | Medimmune Limited | Method of treatment of asthma |
| TW202535949A (zh) | 2023-12-20 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 靶向IL-18受體β(IL-18RB)之抗體及相關方法 |
| WO2025166281A1 (en) | 2024-02-01 | 2025-08-07 | Regeneron Pharmaceuticals, Inc. | Platform for charge-detection mass spectrometry analysis of aavs |
| WO2025175164A1 (en) | 2024-02-16 | 2025-08-21 | Regeneron Pharmaceuticals, Inc. | Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods |
| TW202602489A (zh) | 2024-03-15 | 2026-01-16 | 美商再生元醫藥公司 | 作為經穩定的蛋白質調配物之賦形劑的聚山梨醇酯及聚氧乙烯山梨糖醇酐 |
| TW202540173A (zh) | 2024-04-04 | 2025-10-16 | 英商梅迪繆思有限公司 | 治療及選擇對象之方法 |
| WO2025242618A1 (en) | 2024-05-20 | 2025-11-27 | Medimmune Limited | Bronchiectasis treatment |
| WO2025259840A1 (en) | 2024-06-13 | 2025-12-18 | Regeneron Pharmaceuticals, Inc. | Methods and systems for scaled chromatography |
| WO2026025028A1 (en) | 2024-07-26 | 2026-01-29 | Regeneron Pharmaceuticals, Inc. | Methods of making ultra-high concentrated protein formulations using lyophilization |
| WO2026060350A1 (en) | 2024-09-13 | 2026-03-19 | Regeneron Pharmaceuticals, Inc. | Methods of improving photo stability and controlling formation of hmw species in biologic formulations, and biologic formulations produced by the methods |
| WO2026076201A2 (en) | 2024-10-03 | 2026-04-09 | Regeneron Pharmaceuticals, Inc. | Systems and methods for producing therapeutic proteins using single pass tangential flow filtration for in-line concentration and volume reduction of production pools |
| WO2026080597A1 (en) | 2024-10-08 | 2026-04-16 | Regeneron Pharmaceuticals, Inc. | Sustained delivery of biologics and non-aqueous manufacture of same |
| WO2026007411A1 (zh) * | 2025-02-11 | 2026-01-08 | 广州医科大学 | 抗IL1RL1/IL-33/NF-kB抗体和使用其治疗急性髓性白血病的方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US550362A (en) | 1895-11-26 | crosby | ||
| US1000056A (en) | 1910-11-03 | 1911-08-08 | Carlos Van Bergh | Threshing-machine. |
| US1001164A (en) | 1911-06-09 | 1911-08-22 | Arthur W Porter | Cotton-sweep. |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| US5576191A (en) | 1994-06-17 | 1996-11-19 | Immunex Corporation | Cytokine that binds ST2 |
| WO2004056868A2 (en) | 2002-12-19 | 2004-07-08 | Endocube Sas | Nf-hev compositions and methods of use |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
| US7666622B2 (en) | 2005-10-19 | 2010-02-23 | Regeneron Pharmaceuticals, Inc. | Monomeric self-associating fusion polypeptides and therapeutic uses thereof |
| WO2007140205A2 (en) | 2006-05-24 | 2007-12-06 | Biogen Idec Ma Inc. | Methods of treating fibrosis |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| US7560530B1 (en) | 2006-07-20 | 2009-07-14 | Schering Corporation | IL-33 receptor |
| IE20080331A1 (en) | 2007-04-26 | 2009-07-08 | Trinity College Dublin | Products for altering cytokine activity and methods therefor |
| AU2008254704A1 (en) | 2007-05-18 | 2008-11-27 | Medimmune, Llc | IL-33 in inflammatory disease |
| JP2011500748A (ja) | 2007-10-26 | 2011-01-06 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 神経変性障害の治療におけるｃａｓｐａｓｅＩ−依存性サイトカインの阻害剤 |
| WO2011031600A1 (en) | 2009-09-10 | 2011-03-17 | Schering Corporation | Use of il-33 antagonists to treat fibrotic disease |
| US9090694B2 (en) | 2012-04-30 | 2015-07-28 | Janssen Biotech, Inc. | ST2L antibody antagonists |
| AR091069A1 (es) | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| WO2014152195A1 (en) | 2013-03-15 | 2014-09-25 | Regeneron Pharmaceuticals, Inc. | Il-33 antagonists and uses thereof |
| BR112016013347B1 (pt) | 2013-12-26 | 2023-12-12 | Mitsubishi Tanabe Pharma Corporation | Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos |
| SG11201605580RA (en) | 2014-01-10 | 2016-10-28 | Anaptysbio Inc | Antibodies directed against interleukin-33 (il-33) |
-
2014
- 2014-03-09 JO JOP/2014/0080A patent/JO3532B1/ar active
- 2014-03-11 TW TW103108304A patent/TWI633119B/zh active
- 2014-03-12 HU HUE14722008A patent/HUE051018T2/hu unknown
- 2014-03-12 LT LTEP14722008.1T patent/LT2970460T/lt unknown
- 2014-03-12 MX MX2015010599A patent/MX377712B/es active IP Right Grant
- 2014-03-12 RS RS20240631A patent/RS65586B1/sr unknown
- 2014-03-12 ES ES14722008T patent/ES2804592T3/es active Active
- 2014-03-12 KR KR1020157021200A patent/KR102103159B1/ko active Active
- 2014-03-12 PT PT201598711T patent/PT3683235T/pt unknown
- 2014-03-12 PT PT147220081T patent/PT2970460T/pt unknown
- 2014-03-12 ES ES20159871T patent/ES2983609T3/es active Active
- 2014-03-12 MY MYPI2019007720A patent/MY201923A/en unknown
- 2014-03-12 RS RS20200801A patent/RS60503B1/sr unknown
- 2014-03-12 CN CN201480014548.XA patent/CN105051063B/zh active Active
- 2014-03-12 PL PL20159871.1T patent/PL3683235T3/pl unknown
- 2014-03-12 HR HRP20200846TT patent/HRP20200846T1/hr unknown
- 2014-03-12 EA EA201591716A patent/EA031745B1/ru unknown
- 2014-03-12 FI FIEP20159871.1T patent/FI3683235T3/fi active
- 2014-03-12 SI SI201432077T patent/SI3683235T1/sl unknown
- 2014-03-12 PL PL14722008T patent/PL2970460T3/pl unknown
- 2014-03-12 AU AU2014248839A patent/AU2014248839B2/en active Active
- 2014-03-12 LT LTEP20159871.1T patent/LT3683235T/lt unknown
- 2014-03-12 EP EP20159871.1A patent/EP3683235B1/en active Active
- 2014-03-12 SG SG11201505745WA patent/SG11201505745WA/en unknown
- 2014-03-12 CA CA2902172A patent/CA2902172C/en active Active
- 2014-03-12 DK DK14722008.1T patent/DK2970460T3/da active
- 2014-03-12 MY MYPI2022005368A patent/MY209528A/en unknown
- 2014-03-12 SI SI201431574T patent/SI2970460T1/sl unknown
- 2014-03-12 HR HRP20240774TT patent/HRP20240774T1/hr unknown
- 2014-03-12 EP EP14722008.1A patent/EP2970460B1/en active Active
- 2014-03-12 DK DK20159871.1T patent/DK3683235T3/da active
- 2014-03-12 US US14/205,512 patent/US9453072B2/en active Active
- 2014-03-12 MY MYPI2015702406A patent/MY174740A/en unknown
- 2014-03-12 JP JP2016501386A patent/JP6479755B2/ja active Active
- 2014-03-12 HU HUE20159871A patent/HUE067119T2/hu unknown
- 2014-03-12 EP EP24170532.6A patent/EP4403570A3/en active Pending
- 2014-03-12 WO PCT/US2014/023930 patent/WO2014164959A2/en not_active Ceased
- 2014-03-13 UY UY0001035417A patent/UY35417A/es not_active Application Discontinuation
-
2015
- 2015-07-24 ZA ZA2015/05376A patent/ZA201505376B/en unknown
- 2015-07-24 PH PH12015501656A patent/PH12015501656B1/en unknown
- 2015-08-04 IL IL240354A patent/IL240354A0/en unknown
- 2015-08-17 MX MX2020012416A patent/MX2020012416A/es unknown
- 2015-09-04 CL CL2015002469A patent/CL2015002469A1/es unknown
-
2016
- 2016-08-26 US US15/248,348 patent/US10000564B2/en active Active
-
2018
- 2018-01-12 CL CL2018000101A patent/CL2018000101A1/es unknown
- 2018-05-14 US US15/979,187 patent/US10519230B2/en active Active
- 2018-09-13 IL IL261743A patent/IL261743B/en active IP Right Grant
-
2019
- 2019-02-05 JP JP2019018423A patent/JP6845876B2/ja active Active
- 2019-11-18 US US16/687,257 patent/US11104729B2/en active Active
-
2021
- 2021-07-29 US US17/388,322 patent/US12037388B2/en active Active
-
2024
- 2024-06-05 US US18/734,956 patent/US20240425580A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016513644A5 (https=) | ||
| US20230250164A1 (en) | IL-18 Binding Protein (IL-18BP) In Inflammatory Diseases | |
| JP6845876B2 (ja) | 抗ｉｌ−３３抗体及びその使用 | |
| JP6830533B2 (ja) | 抗ｉｌ−３３抗体およびその使用 | |
| JP7778701B2 (ja) | 抗ｓｔ２抗体及びその適用 | |
| CN110167963A (zh) | 治疗发炎病况的方法 | |
| JP2016515130A5 (https=) | ||
| JP2020513404A5 (https=) | ||
| JP2018509153A (ja) | Ｔｓｌｐ結合タンパク質 | |
| CN106211782A (zh) | 抗体‑fynomer缀合物 | |
| JP2016503412A5 (ja) | Ｉｌ−６アンタゴニストおよびその使用 | |
| JP2022023049A (ja) | バイオ医薬組成物 | |
| JP2016029027A (ja) | プロスタグランジンｅ２結合タンパク質およびこの使用 | |
| TWI799417B (zh) | 生物製藥組成物及相關方法 | |
| KR20150074179A (ko) | 리실 옥시다제-유사 2 (loxl2)와 관련된 치료 및 진단 방법 | |
| RU2009120202A (ru) | Способы и композиции для лечения и мониторинга лечения связанных с il-13 расстройств | |
| TW202304980A (zh) | 經修飾的抗ｔｓｌｐ抗體 | |
| KR20200010294A (ko) | 치료용 항-cd40 리간드 항체 | |
| CN104470540B (zh) | 抗-mif抗体和糖皮质激素的联合治疗 | |
| WO2017153426A1 (en) | Tslp binding proteins | |
| JP2021533806A5 (https=) | ||
| JP2018529704A (ja) | アトピー性皮膚炎の治療および／または予防のためのｉｌ−１７ｃの拮抗剤 | |
| JP2022172170A (ja) | 治療抗ＩｇＥ抗体並びにその方法及び組成物 | |
| JPWO2020041537A5 (https=) | ||
| CN116940379A (zh) | 在过敏群体中使用抗IL-13Rα1抗体或其结合片段治疗特应性皮炎 |