JP2016513681A - ロイコトリエンａ４加水分解酵素の阻害剤 - Google Patents

ロイコトリエンａ４加水分解酵素の阻害剤 Download PDF

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JP2016513681A
JP2016513681A JP2016502333A JP2016502333A JP2016513681A JP 2016513681 A JP2016513681 A JP 2016513681A JP 2016502333 A JP2016502333 A JP 2016502333A JP 2016502333 A JP2016502333 A JP 2016502333A JP 2016513681 A JP2016513681 A JP 2016513681A
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ギルフォード，ウィリアム
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セルタクシス，インコーポレイテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
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  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
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  • Hematology (AREA)
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  • Psychology (AREA)
  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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JP2016502333A 2013-03-14 2014-03-14 ロイコトリエンａ４加水分解酵素の阻害剤 Pending JP2016513681A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361781181P 2013-03-14 2013-03-14
US61/781,181 2013-03-14
PCT/US2014/027097 WO2014152229A2 (en) 2013-03-14 2014-03-14 Inhibitors of leukotriene a4 hydrolase

Publications (2)

Publication Number Publication Date
JP2016513681A true JP2016513681A (ja) 2016-05-16
JP2016513681A5 JP2016513681A5 (enExample) 2017-04-13

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US (2) US9856249B2 (enExample)
EP (1) EP2968264A4 (enExample)
JP (1) JP2016513681A (enExample)
KR (1) KR20150127245A (enExample)
AU (2) AU2014240042C1 (enExample)
BR (1) BR112015022226A2 (enExample)
CA (1) CA2906035A1 (enExample)
MX (1) MX2015011677A (enExample)
RU (1) RU2696559C2 (enExample)
WO (1) WO2014152229A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2017131156A1 (ja) * 2016-01-29 2018-11-22 東レ株式会社 環状アミン誘導体及びその医薬用途
JP2020511409A (ja) * 2016-12-09 2020-04-16 セルタクシス，インコーポレイテッド ロイコトリエンａ４ヒドロラーゼの阻害剤

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EP1976828B1 (en) 2005-12-29 2016-12-21 Celtaxsys, Inc. Diamine derivatives as inhibitors of leukotriene a4 hydrolase
AU2012239888B9 (en) 2011-04-06 2017-10-12 Alzeca Biosciences, LLC Lipid-based nanoparticles
JP6130401B2 (ja) 2012-01-20 2017-05-17 アンナプラガダ，アナンス 医学画像を客観的に特徴付けるための方法および組成物
ES2864862T3 (es) 2013-03-12 2021-10-14 Celltaxis Llc Métodos de inhibición de la leucotrieno A4 hidrolasa
MX2015011678A (es) 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
CA2906086A1 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
MX2015011677A (es) * 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
KR102409017B1 (ko) * 2014-10-08 2022-06-16 텍사스 칠드런스 하스피탈 리포좀을 이용한 아밀로이드 플라크의 mri 영상화
EP3551611A1 (en) 2016-12-09 2019-10-16 Celtaxsys Inc. Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase
US10898484B2 (en) 2018-05-31 2021-01-26 Celltaxis, Llc Method of reducing pulmonary exacerbations in respiratory disease patients
CN116157404B (zh) 2020-08-14 2025-10-14 诺华股份有限公司 杂芳基取代的螺哌啶基衍生物及其药物用途

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