JP2016512563A5 - - Google Patents
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- Publication number
- JP2016512563A5 JP2016512563A5 JP2016501988A JP2016501988A JP2016512563A5 JP 2016512563 A5 JP2016512563 A5 JP 2016512563A5 JP 2016501988 A JP2016501988 A JP 2016501988A JP 2016501988 A JP2016501988 A JP 2016501988A JP 2016512563 A5 JP2016512563 A5 JP 2016512563A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- anticancer agent
- dihydrochloride
- butanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 10
- 239000002246 antineoplastic agent Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- BRADBAOVPACOQQ-UHFFFAOYSA-N hydron;methyl 1-benzyl-4-oxopiperidine-3-carboxylate;chloride Chemical compound Cl.C1CC(=O)C(C(=O)OC)CN1CC1=CC=CC=C1 BRADBAOVPACOQQ-UHFFFAOYSA-N 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- PHTILULPLFUXPS-UHFFFAOYSA-N methyl 1-benzyl-4-oxopiperidine-3-carboxylate Chemical compound C1CC(=O)C(C(=O)OC)CN1CC1=CC=CC=C1 PHTILULPLFUXPS-UHFFFAOYSA-N 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361779828P | 2013-03-13 | 2013-03-13 | |
| US61/779,828 | 2013-03-13 | ||
| US201361904718P | 2013-11-15 | 2013-11-15 | |
| US61/904,718 | 2013-11-15 | ||
| PCT/US2014/025885 WO2014160130A1 (en) | 2013-03-13 | 2014-03-13 | Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018119005A Division JP2018184411A (ja) | 2013-03-13 | 2018-06-22 | 癌に対する薬剤併用療法のための化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512563A JP2016512563A (ja) | 2016-04-28 |
| JP2016512563A5 true JP2016512563A5 (enExample) | 2017-04-13 |
| JP6446025B2 JP6446025B2 (ja) | 2018-12-26 |
Family
ID=51527915
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501988A Active JP6446025B2 (ja) | 2013-03-13 | 2014-03-13 | 癌に対する薬剤併用療法のための化合物 |
| JP2018119005A Pending JP2018184411A (ja) | 2013-03-13 | 2018-06-22 | 癌に対する薬剤併用療法のための化合物 |
| JP2020114024A Pending JP2020172510A (ja) | 2013-03-13 | 2020-07-01 | 癌に対する薬剤併用療法のための化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018119005A Pending JP2018184411A (ja) | 2013-03-13 | 2018-06-22 | 癌に対する薬剤併用療法のための化合物 |
| JP2020114024A Pending JP2020172510A (ja) | 2013-03-13 | 2020-07-01 | 癌に対する薬剤併用療法のための化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9265765B2 (enExample) |
| EP (2) | EP2968294B1 (enExample) |
| JP (3) | JP6446025B2 (enExample) |
| KR (2) | KR20220123335A (enExample) |
| CN (2) | CN119954807A (enExample) |
| AU (3) | AU2014244117B2 (enExample) |
| BR (1) | BR112015023256A2 (enExample) |
| CA (2) | CA2905037C (enExample) |
| CY (1) | CY1121735T1 (enExample) |
| DK (1) | DK2968294T3 (enExample) |
| EA (1) | EA037937B1 (enExample) |
| ES (1) | ES2734568T3 (enExample) |
| HR (1) | HRP20191181T1 (enExample) |
| HU (1) | HUE044238T2 (enExample) |
| IL (2) | IL241452B (enExample) |
| LT (1) | LT2968294T (enExample) |
| ME (1) | ME03470B (enExample) |
| MX (2) | MX2015012636A (enExample) |
| NZ (2) | NZ751509A (enExample) |
| PL (1) | PL2968294T3 (enExample) |
| PT (1) | PT2968294T (enExample) |
| RS (1) | RS59013B1 (enExample) |
| SG (2) | SG11201507247WA (enExample) |
| SI (1) | SI2968294T1 (enExample) |
| SM (1) | SMT201900384T1 (enExample) |
| WO (1) | WO2014160130A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2701708T (pt) | 2011-04-29 | 2020-05-08 | Penn State Res Found | Indução de gene trail de moléculas pequenas através de células tumorais e normais como uma terapia anticancro |
| HUE044238T2 (hu) | 2013-03-13 | 2019-10-28 | Oncoceutics Inc | 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-hexahidroimidazo[l,2-a]pirido[4,3-d]pirimidin-5(3h)-on rák kezelésénél történõ alkalmazásra |
| US9376437B2 (en) | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| SMT201700530T1 (it) | 2013-03-14 | 2018-01-11 | Bristol Myers Squibb Co | Combinazione di agonista di dr5 e antagonista anti-pd-1 e metodi d'uso |
| KR20250006309A (ko) * | 2013-11-15 | 2025-01-10 | 온코슈틱스 인코포레이티드 | 7-벤질-4-(2-메틸벤질)-2,4,6,7,8,9-헥사하이드로이미다조[1,2-a]피리도[3,4-e]피리미딘-5(1H)-온,이의 염 및 이의 용도 |
| ES3040431T3 (en) | 2014-03-12 | 2025-10-31 | Yeda Res & Dev | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| SMT202400497T1 (it) * | 2014-03-31 | 2025-01-14 | Scripps Research Inst | Farmacoforo per induzione di trail |
| CN113149985B (zh) | 2015-01-30 | 2025-01-28 | 昂克希尔迪克斯有限公司 | 六氢咪唑并吡啶并嘧啶酮、其类似物和盐、及其治疗用途 |
| CN104860948B (zh) | 2015-05-15 | 2017-09-26 | 南京盖特医药技术有限公司 | 咪唑并嘧啶酮类化合物及其制备方法和应用 |
| JP6630742B2 (ja) * | 2015-08-17 | 2020-01-15 | クラ オンコロジー， インコーポレイテッド | ファルネシルトランスフェラーゼ阻害剤を用いて癌患者を治療する方法 |
| KR20170037260A (ko) | 2015-09-25 | 2017-04-04 | 현대자동차주식회사 | 차량용 배터리 시스템 및 그 제어 방법 |
| RS66519B1 (sr) | 2016-01-29 | 2025-03-31 | Oncoceutics Inc | Modulacija g protein-spregnutog receptora (gpcr) pomoću imipridona |
| JOP20170053B1 (ar) | 2016-03-02 | 2021-08-17 | Eisai Randd Man Co Ltd | مترافقات جسم مضاد وعقار أساسها إيريبولين وطرق استخدامها |
| KR20170110520A (ko) * | 2016-03-23 | 2017-10-11 | 고려대학교 산학협력단 | mTOR 억제제 및 N-아세틸시스테인을 포함하는 간섬유화 억제용 조성물 |
| CA3058492A1 (en) * | 2016-04-06 | 2017-10-12 | Noxopharm Limited | Radiotherapy improvements |
| JP2019513828A (ja) | 2016-04-06 | 2019-05-30 | ノクソファーム リミティド | 改善された薬物動態を有するイソフラボノイド組成物 |
| US11091483B2 (en) * | 2016-08-12 | 2021-08-17 | Madera Therapeutics, LLC | Protein kinase regulators |
| EP3534885B1 (en) | 2016-11-03 | 2021-01-20 | Kura Oncology, Inc. | Farnesyltransferase inhibitors for use in treating cancer |
| US11576912B2 (en) | 2017-01-04 | 2023-02-14 | The Board Of Trustees Of The Leland Stanford Junior University | Target genes in MYC-driven neoplasia |
| MX393780B (es) | 2017-01-17 | 2025-03-24 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos |
| US10172862B2 (en) * | 2017-01-30 | 2019-01-08 | Oncoceutics, Inc. | Imipridones for gliomas |
| IT201800004082A1 (it) * | 2018-03-29 | 2019-09-29 | Berlin Chemie Ag | Composizioni farmaceutiche antitumorali per terapia combinata |
| US20200046703A1 (en) * | 2018-08-09 | 2020-02-13 | Asymmetric Therapeutics, Llc | Compositions and methods for treatment of the side-effects associated with administration of therapeutic agents |
| US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
| WO2020147842A1 (zh) * | 2019-01-18 | 2020-07-23 | 南京明德新药研发有限公司 | 吡啶并嘧啶类化合物在制备治疗鼻咽癌药物中的应用 |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| MY209389A (en) * | 2019-11-28 | 2025-07-07 | Inxmed Nanjing Co Ltd | Use of bi853520 in cancer treatment |
| AU2021206684B2 (en) | 2020-01-10 | 2024-01-18 | Immuneering Corporation | MEK inhibitors and therapeutic uses thereof |
| AU2021247415A1 (en) | 2020-03-30 | 2022-09-29 | Noxopharm Limited | Methods for the treatment of inflammation associated with infection |
| CN117599041B (zh) * | 2024-01-22 | 2024-05-03 | 中国人民解放军军事科学院军事医学研究院 | 去氢雌马酚及其衍生物作为新型辐射防护剂和细胞保护剂的医药用途 |
| EP4684834A1 (de) | 2024-07-26 | 2026-01-28 | BRIU GmbH | Kristallformen onkologisch wirksamer imipridone und verfahren zu deren herstellung |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2150062A1 (de) * | 1971-10-07 | 1973-04-12 | Boehringer Sohn Ingelheim | Imidazo- eckige klammer auf 1,2-a eckige klammer zu -pyrido- eckige klammer auf 4,3-d eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung |
| US4642345A (en) | 1980-08-14 | 1987-02-10 | Mead Johnson & Company | 6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones |
| US7635690B2 (en) | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
| AU2003217961B2 (en) | 2002-03-08 | 2008-02-28 | Signal Pharmaceuticals, Llc | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| NZ595313A (en) | 2005-02-18 | 2013-03-28 | Abraxis Bioscience Llc | The Use Of Nanoparticles Comprising Rapamycin Or Taxane In The Treatment Of Proliferative Diseases |
| US20080221135A1 (en) | 2005-05-13 | 2008-09-11 | Bristol-Myers Squibb Company | Combination therapy |
| US20110287001A1 (en) * | 2008-09-22 | 2011-11-24 | Tetralogic Pharmaceuticals | Method of treatment |
| US20120128732A1 (en) | 2008-12-11 | 2012-05-24 | Vuong Trieu | Combinations and modes of administration of therapeutic agents and combination therapy |
| US9724337B2 (en) | 2009-04-21 | 2017-08-08 | University Of Kentucky Research Foundation | AG-205 for the treatment of breast cancer |
| DE102010014426A1 (de) * | 2010-04-01 | 2011-10-06 | Bayer Schering Pharma Aktiengesellschaft | Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren |
| PT2701708T (pt) * | 2011-04-29 | 2020-05-08 | Penn State Res Found | Indução de gene trail de moléculas pequenas através de células tumorais e normais como uma terapia anticancro |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| HUE044238T2 (hu) | 2013-03-13 | 2019-10-28 | Oncoceutics Inc | 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-hexahidroimidazo[l,2-a]pirido[4,3-d]pirimidin-5(3h)-on rák kezelésénél történõ alkalmazásra |
| SMT202400497T1 (it) | 2014-03-31 | 2025-01-14 | Scripps Research Inst | Farmacoforo per induzione di trail |
-
2014
- 2014-03-13 HU HUE14775569 patent/HUE044238T2/hu unknown
- 2014-03-13 RS RS20190874A patent/RS59013B1/sr unknown
- 2014-03-13 ME MEP-2019-197A patent/ME03470B/me unknown
- 2014-03-13 CA CA2905037A patent/CA2905037C/en active Active
- 2014-03-13 SM SM20190384T patent/SMT201900384T1/it unknown
- 2014-03-13 WO PCT/US2014/025885 patent/WO2014160130A1/en not_active Ceased
- 2014-03-13 NZ NZ751509A patent/NZ751509A/en active IP Right Revival
- 2014-03-13 SG SG11201507247WA patent/SG11201507247WA/en unknown
- 2014-03-13 HR HRP20191181TT patent/HRP20191181T1/hr unknown
- 2014-03-13 ES ES14775569T patent/ES2734568T3/es active Active
- 2014-03-13 KR KR1020227029471A patent/KR20220123335A/ko not_active Ceased
- 2014-03-13 US US14/208,657 patent/US9265765B2/en active Active
- 2014-03-13 SG SG10201808496VA patent/SG10201808496VA/en unknown
- 2014-03-13 EP EP14775569.8A patent/EP2968294B1/en active Active
- 2014-03-13 EP EP19171477.3A patent/EP3572083A1/en not_active Withdrawn
- 2014-03-13 KR KR1020157028393A patent/KR102438135B1/ko active Active
- 2014-03-13 SI SI201431257T patent/SI2968294T1/sl unknown
- 2014-03-13 AU AU2014244117A patent/AU2014244117B2/en not_active Ceased
- 2014-03-13 CN CN202510107155.3A patent/CN119954807A/zh active Pending
- 2014-03-13 BR BR112015023256A patent/BR112015023256A2/pt not_active Application Discontinuation
- 2014-03-13 EA EA201591715A patent/EA037937B1/ru unknown
- 2014-03-13 MX MX2015012636A patent/MX2015012636A/es active IP Right Grant
- 2014-03-13 JP JP2016501988A patent/JP6446025B2/ja active Active
- 2014-03-13 PL PL14775569T patent/PL2968294T3/pl unknown
- 2014-03-13 NZ NZ711948A patent/NZ711948A/en unknown
- 2014-03-13 DK DK14775569.8T patent/DK2968294T3/da active
- 2014-03-13 LT LTEP14775569.8T patent/LT2968294T/lt unknown
- 2014-03-13 PT PT14775569T patent/PT2968294T/pt unknown
- 2014-03-13 CA CA3204801A patent/CA3204801A1/en active Pending
- 2014-03-13 CN CN201480022856.7A patent/CN105530937A/zh active Pending
-
2015
- 2015-09-10 IL IL241452A patent/IL241452B/en active IP Right Grant
- 2015-09-11 MX MX2019013643A patent/MX2019013643A/es unknown
-
2018
- 2018-06-22 JP JP2018119005A patent/JP2018184411A/ja active Pending
-
2019
- 2019-03-19 AU AU2019201896A patent/AU2019201896A1/en not_active Abandoned
- 2019-07-01 CY CY20191100687T patent/CY1121735T1/el unknown
-
2020
- 2020-06-23 IL IL275623A patent/IL275623A/en unknown
- 2020-07-01 JP JP2020114024A patent/JP2020172510A/ja active Pending
- 2020-09-14 AU AU2020233606A patent/AU2020233606A1/en not_active Abandoned
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