JP2016531894A5 - - Google Patents
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- Publication number
- JP2016531894A5 JP2016531894A5 JP2016519955A JP2016519955A JP2016531894A5 JP 2016531894 A5 JP2016531894 A5 JP 2016531894A5 JP 2016519955 A JP2016519955 A JP 2016519955A JP 2016519955 A JP2016519955 A JP 2016519955A JP 2016531894 A5 JP2016531894 A5 JP 2016531894A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- composition according
- pharmaceutical composition
- fungi
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 241000233866 Fungi Species 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 229960003942 amphotericin b Drugs 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000006207 intravenous dosage form Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 238000000844 transformation Methods 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 150000003672 ureas Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019183577A JP7469862B2 (ja) | 2013-10-07 | 2019-10-04 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361887729P | 2013-10-07 | 2013-10-07 | |
| US61/887,729 | 2013-10-07 | ||
| US201462045956P | 2014-09-04 | 2014-09-04 | |
| US62/045,956 | 2014-09-04 | ||
| PCT/US2014/059334 WO2015054148A1 (en) | 2013-10-07 | 2014-10-06 | Amphotericin b derivatives with improved therapeutic index |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019183577A Division JP7469862B2 (ja) | 2013-10-07 | 2019-10-04 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531894A JP2016531894A (ja) | 2016-10-13 |
| JP2016531894A5 true JP2016531894A5 (enExample) | 2017-11-16 |
| JP6600303B2 JP6600303B2 (ja) | 2019-10-30 |
Family
ID=52813555
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519955A Active JP6600303B2 (ja) | 2013-10-07 | 2014-10-06 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
| JP2019183577A Active JP7469862B2 (ja) | 2013-10-07 | 2019-10-04 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019183577A Active JP7469862B2 (ja) | 2013-10-07 | 2019-10-04 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10323057B2 (enExample) |
| EP (1) | EP3055030B1 (enExample) |
| JP (2) | JP6600303B2 (enExample) |
| KR (2) | KR102321482B1 (enExample) |
| CN (2) | CN110407898B (enExample) |
| AU (2) | AU2014332214B2 (enExample) |
| CA (1) | CA2925904C (enExample) |
| DK (1) | DK3055030T3 (enExample) |
| ES (1) | ES2682328T3 (enExample) |
| SG (1) | SG11201602570WA (enExample) |
| WO (1) | WO2015054148A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102321482B1 (ko) | 2013-10-07 | 2021-11-02 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 개선된 치료 지수를 갖는 암포테리신 b 유도체 |
| AU2015272398B2 (en) | 2014-06-12 | 2018-04-26 | Shionogi And Co., Ltd. | Polyene macrolide derivative |
| WO2016112260A1 (en) | 2015-01-08 | 2016-07-14 | The Board Of Trustees Of The University Of Illinois | Concise synthesis of urea derivatives of amphotericin b |
| EP3283171B1 (en) | 2015-04-15 | 2021-05-26 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin b |
| WO2017100171A1 (en) * | 2015-12-08 | 2017-06-15 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| AU2017248394B2 (en) * | 2016-04-08 | 2023-02-23 | The Board Of Trustees Of The University Of Illinois | Small molecule-mediated restoration of airway surface physiology in human cystic fibrosis lung epithelia |
| WO2018106571A1 (en) * | 2016-12-06 | 2018-06-14 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| EP3846823A4 (en) * | 2018-09-07 | 2022-04-20 | The Board of Trustees of the University of Illinois | AMPHOTERICIN B DERIVATIVES HYBRIDS WITH REDUCED TOXICITY |
| CA3149819A1 (en) * | 2019-08-08 | 2021-02-11 | The Board Of Trustees Of The University Of Illinois | Hybrid amphotericin b derivatives with reduced toxicity |
| CN111909226A (zh) * | 2020-08-11 | 2020-11-10 | 深圳市儿童医院 | 一种葡萄糖酸修饰的两性霉素b衍生物及其用途 |
| AU2023238751A1 (en) | 2022-03-21 | 2024-10-31 | Cystetic Medicines, Inc. | Ion channel prosthetic compositions comprising lipid-coated crystals of amphotericin b |
| CA3261962A1 (en) * | 2022-07-08 | 2024-01-11 | The Board Of Trustees Of The University Of Illinois | TRANSFER OF C2 EPIMERIZED SUGARS TO AGLYCONIC AMPHOTEROCIBN B |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0431870A1 (en) * | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Amphotericin B derivatives |
| WO1993016090A1 (en) * | 1992-02-12 | 1993-08-19 | Smithkline Beecham Plc | Amphotericin b derivative |
| AU2006206952B2 (en) | 2005-01-24 | 2011-08-18 | Microbial Chemistry Research Foundation | Anti-penicillin resistant pneumococci agent and novel 16-membered ring macrolide derivative |
| EP1862467A2 (en) | 2005-03-23 | 2007-12-05 | Consejo Superior de Investigaciones Cientificas (CSIC) | Polyene antibiotics, compositions containing said antibiotics, method and micro-organisms used to obtain same and applications thereof |
| EP1987049A1 (en) * | 2006-02-23 | 2008-11-05 | ETH Zürich | Amphotericin derivatives |
| US20070238746A1 (en) | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
| DE102006060008A1 (de) | 2006-12-19 | 2008-06-26 | Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH | Lampe mit verbesserter Quetschungsgeometrie |
| GB0712881D0 (en) * | 2007-07-03 | 2007-08-15 | Biosergen As | Compounds |
| MX365184B (es) | 2010-12-21 | 2019-05-21 | Centro De Investig Y De Estudios Avanzados Del I P N | Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. |
| WO2014165676A1 (en) | 2013-04-03 | 2014-10-09 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| KR102321482B1 (ko) | 2013-10-07 | 2021-11-02 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 개선된 치료 지수를 갖는 암포테리신 b 유도체 |
| EP3283171B1 (en) | 2015-04-15 | 2021-05-26 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin b |
-
2014
- 2014-10-06 KR KR1020167011985A patent/KR102321482B1/ko active Active
- 2014-10-06 EP EP14853012.4A patent/EP3055030B1/en active Active
- 2014-10-06 CN CN201910693627.2A patent/CN110407898B/zh active Active
- 2014-10-06 AU AU2014332214A patent/AU2014332214B2/en active Active
- 2014-10-06 ES ES14853012.4T patent/ES2682328T3/es active Active
- 2014-10-06 SG SG11201602570WA patent/SG11201602570WA/en unknown
- 2014-10-06 WO PCT/US2014/059334 patent/WO2015054148A1/en not_active Ceased
- 2014-10-06 KR KR1020217035284A patent/KR102548341B1/ko active Active
- 2014-10-06 CN CN201480065533.6A patent/CN105848721B/zh active Active
- 2014-10-06 DK DK14853012.4T patent/DK3055030T3/en active
- 2014-10-06 JP JP2016519955A patent/JP6600303B2/ja active Active
- 2014-10-06 US US15/026,520 patent/US10323057B2/en active Active
- 2014-10-06 CA CA2925904A patent/CA2925904C/en active Active
-
2019
- 2019-06-17 US US16/443,728 patent/US11117920B2/en active Active
- 2019-08-02 US US16/530,109 patent/US11028114B2/en active Active
- 2019-10-04 JP JP2019183577A patent/JP7469862B2/ja active Active
- 2019-12-09 AU AU2019279928A patent/AU2019279928B2/en active Active
-
2021
- 2021-09-02 US US17/464,916 patent/US11970512B2/en active Active
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