KR102548341B1 - 개선된 치료 지수를 갖는 암포테리신 b 유도체 - Google Patents

개선된 치료 지수를 갖는 암포테리신 b 유도체 Download PDF

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KR102548341B1
KR102548341B1 KR1020217035284A KR20217035284A KR102548341B1 KR 102548341 B1 KR102548341 B1 KR 102548341B1 KR 1020217035284 A KR1020217035284 A KR 1020217035284A KR 20217035284 A KR20217035284 A KR 20217035284A KR 102548341 B1 KR102548341 B1 KR 102548341B1
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synthesis
compound
derivatives
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KR20210132248A (ko
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마틴 디. 버크
스티븐 데이비스
브리스 이. 우노
저스틴 스트루블
이안 데일리
케이틀린 씨. 그레이
데이비드 엠. 냅
푸린 왕
나가르주나 팔리암
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더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020217035284A 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체 Active KR102548341B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361887729P 2013-10-07 2013-10-07
US61/887,729 2013-10-07
US201462045956P 2014-09-04 2014-09-04
US62/045,956 2014-09-04
PCT/US2014/059334 WO2015054148A1 (en) 2013-10-07 2014-10-06 Amphotericin b derivatives with improved therapeutic index
KR1020167011985A KR102321482B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체

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KR1020167011985A Division KR102321482B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체

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KR20210132248A KR20210132248A (ko) 2021-11-03
KR102548341B1 true KR102548341B1 (ko) 2023-06-26

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KR1020217035284A Active KR102548341B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체
KR1020167011985A Active KR102321482B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체

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US (4) US10323057B2 (enExample)
EP (1) EP3055030B1 (enExample)
JP (2) JP6600303B2 (enExample)
KR (2) KR102548341B1 (enExample)
CN (2) CN110407898B (enExample)
AU (2) AU2014332214B2 (enExample)
CA (1) CA2925904C (enExample)
DK (1) DK3055030T3 (enExample)
ES (1) ES2682328T3 (enExample)
SG (1) SG11201602570WA (enExample)
WO (1) WO2015054148A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102548341B1 (ko) 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
MX378786B (es) 2014-06-12 2025-03-11 Shionogi & Co Derivado de macrólido de polieno.
JP6726192B2 (ja) 2015-01-08 2020-07-22 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ アムホテリシンｂの尿素誘導体の簡便な合成法
PT3283171T (pt) 2015-04-15 2021-07-14 Sfunga Therapeutics Inc Derivados de anfotericina b
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
ES2983639T3 (es) 2016-04-08 2024-10-24 The Board Of Trustees Of The Univ Illinois Restauración mediada por moléculas pequeñas de la fisiología de la superficie de las vías respiratorias en epitelios pulmonares humanos de fibrosis quística
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
CN113056274A (zh) * 2018-09-07 2021-06-29 伊利诺伊大学评议会 具有降低的毒性的杂化两性霉素b衍生物
EP4009984A4 (en) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY
AU2021325676A1 (en) 2020-08-10 2023-03-30 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin B
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
IL315719A (en) 2022-03-21 2024-11-01 Univ Illinois Prosthetic assemblies of ion channels containing lipid-coated amphotericin B crystals
US20260009062A1 (en) * 2022-07-08 2026-01-08 The Board Of Trustees Of The University Of Illinois Transfer of c2'-epimerized sugars to the amphotericin b aglycone

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20070238746A1 (en) 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline

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EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
WO1993016090A1 (en) * 1992-02-12 1993-08-19 Smithkline Beecham Plc Amphotericin b derivative
JP5129485B2 (ja) 2005-01-24 2013-01-30 公益財団法人微生物化学研究会 抗ペニシリン耐性肺炎球菌剤及び新規１６員環マクロライド誘導体
WO2006100330A2 (es) 2005-03-23 2006-09-28 Consejo Superior De Investigaciones Cientificas Antibióticos polienos, composiciones que los contengan, procedimiento y microorganismos para su obtención y sus aplicaciones
US20090186838A1 (en) * 2006-02-23 2009-07-23 Eidgenössische Technische Hochschule Zürich Amphotericin Derivatives
DE102006060008A1 (de) 2006-12-19 2008-06-26 Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH Lampe mit verbesserter Quetschungsgeometrie
GB0712881D0 (en) * 2007-07-03 2007-08-15 Biosergen As Compounds
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2014165676A1 (en) 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
KR102548341B1 (ko) 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
PT3283171T (pt) 2015-04-15 2021-07-14 Sfunga Therapeutics Inc Derivados de anfotericina b

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US20070238746A1 (en) 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline

Non-Patent Citations (4)

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A.N.Tevyashova et al., Antimicrobial Agents and Chemotherapy, 2013, Vol.57, No.8, 3815-3822쪽
B. Byrne et al., 'Biosynthesis of Deoxyamphotericins and Deoxyamphoteronolides by Engineered Strains of Streptomyces nodosus', Chemistry & Biology, 2003, Vol. 10, 1215-1224쪽*
D.M.GEISER, "Antifungal design: The toxicity-resistance yin-yang", NATURE CHEMICAL BIOLOGY, 2015, vol.11, no.7, pp.453-454
S.A.DAVIS et al., "C3-OH of Amphotericin B Plays an Important Role in Ion Conductance", J. of the American Chem. Soc., 2015, vol.137, no.48, pp.15102-15104

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Publication number Publication date
US10323057B2 (en) 2019-06-18
SG11201602570WA (en) 2016-04-28
NZ719529A (en) 2021-06-25
JP6600303B2 (ja) 2019-10-30
AU2019279928A1 (en) 2020-01-16
EP3055030B1 (en) 2018-05-02
AU2019279928B2 (en) 2020-07-23
AU2014332214A1 (en) 2016-05-19
EP3055030A1 (en) 2016-08-17
KR102321482B1 (ko) 2021-11-02
JP2016531894A (ja) 2016-10-13
JP7469862B2 (ja) 2024-04-17
KR20210132248A (ko) 2021-11-03
US11117920B2 (en) 2021-09-14
KR20160068861A (ko) 2016-06-15
JP2020019804A (ja) 2020-02-06
AU2014332214B2 (en) 2019-10-03
US20190345187A1 (en) 2019-11-14
US20160215012A1 (en) 2016-07-28
CA2925904A1 (en) 2015-04-16
CN110407898A (zh) 2019-11-05
DK3055030T3 (en) 2018-08-13
WO2015054148A1 (en) 2015-04-16
US11970512B2 (en) 2024-04-30
NZ757647A (en) 2021-06-25
ES2682328T3 (es) 2018-09-20
US20200002368A1 (en) 2020-01-02
CA2925904C (en) 2021-11-23
CN105848721A (zh) 2016-08-10
EP3055030A4 (en) 2017-03-15
CN105848721B (zh) 2019-08-23
CN110407898B (zh) 2023-12-01
US11028114B2 (en) 2021-06-08
US20220056066A1 (en) 2022-02-24

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