JP2016512207A5 - - Google Patents
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- Publication number
- JP2016512207A5 JP2016512207A5 JP2015561958A JP2015561958A JP2016512207A5 JP 2016512207 A5 JP2016512207 A5 JP 2016512207A5 JP 2015561958 A JP2015561958 A JP 2015561958A JP 2015561958 A JP2015561958 A JP 2015561958A JP 2016512207 A5 JP2016512207 A5 JP 2016512207A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxybutyrate
- skin
- composition
- ketone body
- ketone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002576 ketones Chemical class 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 15
- 230000000699 topical effect Effects 0.000 claims description 15
- AOWPVIWVMWUSBD-RNFRBKRXSA-N [(3r)-3-hydroxybutyl] (3r)-3-hydroxybutanoate Chemical compound C[C@@H](O)CCOC(=O)C[C@@H](C)O AOWPVIWVMWUSBD-RNFRBKRXSA-N 0.000 claims description 11
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 claims description 5
- 230000015556 catabolic process Effects 0.000 claims description 5
- 238000006731 degradation reaction Methods 0.000 claims description 5
- 230000006866 deterioration Effects 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 claims description 3
- 230000003712 anti-aging effect Effects 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- -1 triolide Chemical compound 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 125000002339 acetoacetyl group Chemical group O=C([*])C([H])([H])C(=O)C([H])([H])[H] 0.000 claims description 2
- 230000002411 adverse Effects 0.000 claims description 2
- 230000032683 aging Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000003860 topical agent Substances 0.000 claims description 2
- 239000012071 phase Substances 0.000 claims 6
- YAIPYRLKGQPJCG-AENDTGMFSA-N butane-1,1-diol (3R)-3-hydroxybutanoic acid Chemical compound CCCC(O)O.C[C@@H](O)CC(O)=O YAIPYRLKGQPJCG-AENDTGMFSA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 239000008346 aqueous phase Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 22
- WHBMMWSBFZVSSR-GSVOUGTGSA-N (R)-3-hydroxybutyric acid Chemical group C[C@@H](O)CC(O)=O WHBMMWSBFZVSSR-GSVOUGTGSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 6
- 239000002243 precursor Substances 0.000 description 4
- AOWPVIWVMWUSBD-COBSHVIPSA-N 3-hydroxybutyl (3r)-3-hydroxybutanoate Chemical compound CC(O)CCOC(=O)C[C@@H](C)O AOWPVIWVMWUSBD-COBSHVIPSA-N 0.000 description 2
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical group CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 210000001626 skin fibroblast Anatomy 0.000 description 2
- AFENDNXGAFYKQO-UHFFFAOYSA-N 2-hydroxybutyric acid Chemical group CCC(O)C(O)=O AFENDNXGAFYKQO-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 150000004729 acetoacetic acid derivatives Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1304467.2 | 2013-03-12 | ||
| GBGB1304467.2A GB201304467D0 (en) | 2013-03-12 | 2013-03-12 | Compound for use in protecting skin |
| PCT/EP2013/069189 WO2014139599A1 (en) | 2013-03-12 | 2013-09-16 | Compound for use in protecting skin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018060110A Division JP6789263B2 (ja) | 2013-03-12 | 2018-03-27 | 皮膚の保護に使用するための化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512207A JP2016512207A (ja) | 2016-04-25 |
| JP2016512207A5 true JP2016512207A5 (https=) | 2016-06-09 |
| JP6375315B2 JP6375315B2 (ja) | 2018-08-15 |
Family
ID=48189804
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561958A Active JP6375315B2 (ja) | 2013-03-12 | 2013-09-16 | 皮膚の保護に使用するための化合物 |
| JP2018060110A Active JP6789263B2 (ja) | 2013-03-12 | 2018-03-27 | 皮膚の保護に使用するための化合物 |
| JP2020114922A Active JP7267244B2 (ja) | 2013-03-12 | 2020-07-02 | 皮膚の保護に使用するための化合物 |
| JP2022194392A Pending JP2023029344A (ja) | 2013-03-12 | 2022-12-05 | 皮膚の保護に使用するための化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018060110A Active JP6789263B2 (ja) | 2013-03-12 | 2018-03-27 | 皮膚の保護に使用するための化合物 |
| JP2020114922A Active JP7267244B2 (ja) | 2013-03-12 | 2020-07-02 | 皮膚の保護に使用するための化合物 |
| JP2022194392A Pending JP2023029344A (ja) | 2013-03-12 | 2022-12-05 | 皮膚の保護に使用するための化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10821062B2 (https=) |
| EP (2) | EP4714505A2 (https=) |
| JP (4) | JP6375315B2 (https=) |
| AU (1) | AU2013382361B2 (https=) |
| CA (1) | CA2905545C (https=) |
| DK (1) | DK2968091T3 (https=) |
| ES (1) | ES3059181T3 (https=) |
| GB (2) | GB201304467D0 (https=) |
| HK (1) | HK1220382A1 (https=) |
| WO (1) | WO2014139599A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1648952B1 (en) | 2003-06-03 | 2018-03-07 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives |
| DK2240017T3 (da) | 2008-01-04 | 2019-06-17 | Univ Oxford Innovation Ltd | Ketonlegemer og ketonlegemsestere som blodlipid-sænkende midler |
| US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| GB201002983D0 (en) | 2010-02-22 | 2010-04-07 | Tdeltas Ltd | Nutritinal composition |
| EP2914251B1 (en) | 2012-11-05 | 2019-08-21 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Ketone bodies to protect tissues from damage by ionizing radiation |
| GB201304467D0 (en) * | 2013-03-12 | 2013-04-24 | Tdeltas Ltd | Compound for use in protecting skin |
| SG11201507685UA (en) * | 2013-03-14 | 2015-10-29 | Isis Innovation | Process for producing (r)-3-hydroxybutyl (r)-3-hydroxybutyrate |
| US9163202B2 (en) | 2013-08-02 | 2015-10-20 | Eastman Chemical Company | Aqueous cleaning compositions including an alkyl 3-hydroxybutyrate |
| US9388114B2 (en) | 2013-08-02 | 2016-07-12 | Eastman Chemical Company | Compositions including an alkyl 3-hydroxybutyrate |
| US9255059B2 (en) | 2013-08-02 | 2016-02-09 | Eastman Chemical Company | Method for producing an alkyl 3-hydroxybutyrate |
| US9249378B2 (en) | 2013-08-02 | 2016-02-02 | Eastman Chemical Company | Aqueous cleaning compositions having enhanced properties |
| US20180057846A1 (en) | 2016-08-30 | 2018-03-01 | KetoneAid Inc. | Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy |
| JP2018158898A (ja) * | 2017-03-22 | 2018-10-11 | 大阪瓦斯株式会社 | トロポエラスチン発現促進剤 |
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| JP6804352B2 (ja) * | 2017-03-22 | 2020-12-23 | 大阪瓦斯株式会社 | コラゲナーゼｍｍｐ１及び３の産生抑制剤 |
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| BR112020018030A2 (pt) * | 2018-04-05 | 2020-12-22 | Beiersdorf Ag | Composição cosmética para uma rápida evaporação de suor |
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| US20240173219A1 (en) * | 2022-11-29 | 2024-05-30 | Latif Jackson | Lotion Composition |
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| CN104487066B (zh) | 2012-07-23 | 2020-06-09 | 国立大学法人东京大学 | 放射线损害的预防和/或治疗剂 |
| EP2914251B1 (en) | 2012-11-05 | 2019-08-21 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Ketone bodies to protect tissues from damage by ionizing radiation |
| GB201304467D0 (en) | 2013-03-12 | 2013-04-24 | Tdeltas Ltd | Compound for use in protecting skin |
| SG11201507685UA (en) | 2013-03-14 | 2015-10-29 | Isis Innovation | Process for producing (r)-3-hydroxybutyl (r)-3-hydroxybutyrate |
| KR102499654B1 (ko) | 2013-03-19 | 2023-02-13 | 유니버시티 오브 사우스 플로리다 | 상승되고 지속되는 케톤증을 생성하기 위한 조성물 및 방법 |
| GB201314127D0 (en) | 2013-08-07 | 2013-09-18 | Tdeltas Ltd | Ketone body and ketone body ester for reducing muscle breakdown |
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2013
- 2013-03-12 GB GBGB1304467.2A patent/GB201304467D0/en not_active Ceased
- 2013-09-16 JP JP2015561958A patent/JP6375315B2/ja active Active
- 2013-09-16 EP EP25216792.9A patent/EP4714505A2/en active Pending
- 2013-09-16 EP EP13762832.7A patent/EP2968091B1/en active Active
- 2013-09-16 HK HK16108511.5A patent/HK1220382A1/zh unknown
- 2013-09-16 US US14/774,856 patent/US10821062B2/en active Active
- 2013-09-16 DK DK13762832.7T patent/DK2968091T3/da active
- 2013-09-16 CA CA2905545A patent/CA2905545C/en active Active
- 2013-09-16 WO PCT/EP2013/069189 patent/WO2014139599A1/en not_active Ceased
- 2013-09-16 ES ES13762832T patent/ES3059181T3/es active Active
- 2013-09-16 AU AU2013382361A patent/AU2013382361B2/en active Active
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2014
- 2014-03-12 GB GB1404400.2A patent/GB2511941B/en active Active
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2018
- 2018-03-27 JP JP2018060110A patent/JP6789263B2/ja active Active
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2020
- 2020-07-02 JP JP2020114922A patent/JP7267244B2/ja active Active
- 2020-09-25 US US17/032,616 patent/US12377032B2/en active Active
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2022
- 2022-12-05 JP JP2022194392A patent/JP2023029344A/ja active Pending
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2025
- 2025-08-04 US US19/289,781 patent/US20260108442A1/en active Pending
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