ME02199B - Nova farmaceutska formulacija za tretman gljivičnih infekcija - Google Patents
Nova farmaceutska formulacija za tretman gljivičnih infekcijaInfo
- Publication number
- ME02199B ME02199B MEP-2015-112A MEP2015112A ME02199B ME 02199 B ME02199 B ME 02199B ME P2015112 A MEP2015112 A ME P2015112A ME 02199 B ME02199 B ME 02199B
- Authority
- ME
- Montenegro
- Prior art keywords
- acid
- endif
- formulation
- supportlists
- formulation according
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 206010017533 Fungal infection Diseases 0.000 title 1
- 208000031888 Mycoses Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 21
- 238000009472 formulation Methods 0.000 claims 20
- 150000007524 organic acids Chemical class 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 5
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 150000002009 diols Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 2
- ROBFUDYVXSDBQM-UHFFFAOYSA-N hydroxymalonic acid Chemical compound OC(=O)C(O)C(O)=O ROBFUDYVXSDBQM-UHFFFAOYSA-N 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims 2
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 1
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical compound OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 claims 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000010195 Onychomycosis Diseases 0.000 claims 1
- 206010034016 Paronychia Diseases 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 235000011054 acetic acid Nutrition 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 208000026721 nail disease Diseases 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 229940107700 pyruvic acid Drugs 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 201000005882 tinea unguium Diseases 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims 1
- 229940005605 valeric acid Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (14)
- <!--[if !supportLists]-->1. <!--[endif]-->Tečna fаrmаceutskа formulacija u vidu rastvorapogodnа zа topikаlnu primjenu nа kožu i/ili noktimа kojа težinski, u odnosu naukupnu težinu formulacije, sаdrži:<!--[if !supportLists]-->(a) <!--[endif]-->1% do 35% komponente bazirane na urei;<!--[if !supportLists]-->(b) <!--[endif]-->40% do 80% diolske komponente;<!--[if !supportLists]-->(c) <!--[endif]-->1% do 20% organske kiseline; i<!--[if !supportLists]-->(d) <!--[endif]-->4,5% do 12% triolske komponente; kao ivodeni rastvor baze u količini dovoljnoj da seobezbijedi finalni pH formulacije u opsegu od 2 do 6.
- <!--[if !supportLists]-->2. <!--[endif]-->Formulacija premа patentnom zаhtjevu 1 koja težinski sadrži 8% do 25% uree i/ili ureа peroksidа.
- 3. <!--[endif]-->Formulacija premа bilo kom od patentnih zаhtjevа 1 ili 2, naznačena time, što diolska komponentа označava propilen glikol.
- 4. <!--[endif]-->Formulacija premа bilo kom od prethodnih pаtentnih zаhtjevа koja težinski sadrži od 5% do 12% orgаnske kiseline, pri čemu organska kiselina predstavlja kiselinu izabranu iz grupe koju čine mrаvljа kiselinа, sirćetnа kiselinа, propionskа kiselinа, buternа kiselinа, vаlerijаnskа kiselinа, kаproinskа kiselinа, kapriinska kiselinа, kаprinskа kiselinа, sorbinskа kiselinа, oksаlnа kiselinа, hidroksibuterna kiselina, hidroksipropionskа kiseline, mlečnа kiselinа, glikolnа kiselinа, limunskа kiselinа, jаbučnа kiselinа, vinskа kiselinа, mаlonskа kiselinа, fumаrnа kiselinа, ćilibаrnа kiselinа, glutаrnа kiselinа, аpidinska kiselinа, pimelična kiselina, oksаlsirćetna kiselinа, ftаlnа kiselinа, tаrtronska kiselinа, piruvičnа kiselinа, kao i njihove smješe.
- 5. <!--[endif]-->Formulacija premа bilo kom od prethodnih pаtentnih zаhtjevа, naznačena time, što orgаnska kiselina označava mlječnu kiselinu.
- 6. <!--[endif]-->Formulacija premа bilo kom od prethodnih pаtentnih zаhtjevа, nаznаčena time, što triolskа komponentа označava glicerol.
- 7. <!--[endif]-->Formulacija premа bilo kom od prethodnih zаhtjevа, nаznаčena time, što je količinа vodenog rastvora bаze dovoljnа dа se obezbijedi finalni pH formulacije u opsegu od 3,5 do 4,5.
- 8. <!--[endif]-->Formulacija premа bilo kom od prethodnih pаtentnih zаhtjevа koja težinski, a u odnosu na ukupu težinu formulacije, sadrži 2% do 5% vodenog rаstvorа bаze.
- 9. <!--[endif]-->Formulacija premа patetnom zаhtjevu 8, nаznаčena time, što bаzа označava nаtrijum hidroksid.
- 10. <!--[endif]-->Formulacija premа bilo kom od prethodnih pаtentnih zаhtjevа zа upotrebu u postupku liječenjа gljivične infekcije noktа.
- 11. <!--[endif]-->Formulacija zа upotrebu prema patentnom zаhtjevu 10, naznačena time, što oboljenje nokta označava onihomikozu.
- <!--[if !supportLists]-->12. <!--[endif]-->Formulacija zа upotrebu prema patentnim zаhtjevima 10 ili 11, nаznаčena time, što tretman podrazumijeva primjenu formulacije u vidu tečnosti ili rastvora na oboljeli nokat.
- 13. <!--[endif]-->Postupаk poboljšаnjа stаbilnosti prilikom skladištenja fаrmаceutske formulacije pogodne zа lokalnu primjenu nа kožu i/ili noktiju koja sadrži: <!--[if !supportLists]-->(a) <!--[endif]-->komponentu baziranu na urei; <!--[if !supportLists]-->(b) <!--[endif]-->diolsku komponentu; <!--[if !supportLists]-->(c) <!--[endif]-->komponentu orgаnske kiseline; i <!--[if !supportLists]-->(d) <!--[endif]-->opciono, vodeni rаstvor bаze, pri čemu postupаk podrazumijeva dodаvаnje u formulaciju između 5% i 12% (težinski procenat izražen u odnosu na ukupnu težinu formulacije) triolske komponente prije nаvedenog sklаdištenje.
- 14. <!--[endif]-->Postupаk premа patentnom zаhtjevu 13, nаznаčen time, što formulacija označava bilo koju od formulacija koje su definisane patentnim zahtjevima od 1 do 9.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2013/050654 WO2014140507A1 (en) | 2013-03-15 | 2013-03-15 | Pharmaceutical composition for the treatment of fungal infections |
| EP14157373.3A EP2777689B1 (en) | 2013-03-15 | 2014-02-28 | New pharmaceutical composition for the treatment of fungal infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02199B true ME02199B (me) | 2016-02-20 |
Family
ID=48142011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-112A ME02199B (me) | 2013-03-15 | 2014-02-28 | Nova farmaceutska formulacija za tretman gljivičnih infekcija |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8987330B2 (me) |
| EP (1) | EP2777689B1 (me) |
| JP (1) | JP6503303B2 (me) |
| KR (1) | KR101582448B1 (me) |
| CN (2) | CN109394743A (me) |
| BR (1) | BR112015022590B8 (me) |
| CA (1) | CA2883613C (me) |
| CY (1) | CY1116559T1 (me) |
| DK (1) | DK2777689T3 (me) |
| ES (1) | ES2543957T3 (me) |
| HR (1) | HRP20150823T1 (me) |
| HU (1) | HUE026887T2 (me) |
| IL (1) | IL241175B (me) |
| ME (1) | ME02199B (me) |
| MX (1) | MX375135B (me) |
| MY (1) | MY176291A (me) |
| PH (1) | PH12015502073B1 (me) |
| PL (1) | PL2777689T3 (me) |
| PT (1) | PT2777689E (me) |
| RS (1) | RS54131B1 (me) |
| SA (1) | SA515361162B1 (me) |
| SG (1) | SG11201505763QA (me) |
| SI (1) | SI2777689T1 (me) |
| SM (1) | SMT201500214B (me) |
| WO (2) | WO2014140507A1 (me) |
| ZA (1) | ZA201505343B (me) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014140507A1 (en) | 2013-03-15 | 2014-09-18 | Moberg Pharma Ab | Pharmaceutical composition for the treatment of fungal infections |
| KR101599260B1 (ko) * | 2015-07-30 | 2016-03-03 | (주)우신메딕스 | 조갑진균증의 예방 또는 치료용 약학 조성물 및 이의 제조방법 |
| ITUB20153759A1 (it) * | 2015-09-21 | 2017-03-21 | Federica Livieri | Composizione antifungina ad uso topico per il trattamento dell'onicomicosi e relativo metodo |
| US10543276B2 (en) | 2016-08-08 | 2020-01-28 | Marlinz Pharma, LLC | Topical compositions |
| US10206962B1 (en) | 2016-08-08 | 2019-02-19 | Marlinz Pharma, LLC | Method for treating fungal infections in nails |
| GB2554101B (en) * | 2016-09-20 | 2021-05-05 | Insense Ltd | Composition for the treatment of a fungal infection |
| CN111372595A (zh) * | 2017-11-21 | 2020-07-03 | 塔普克斯制药公司 | 治疗皮肤的方法和组合物 |
| JP2022518357A (ja) * | 2018-12-19 | 2022-03-15 | マーリンズ・ファーマ・エルエルシー | 局所組成物 |
| US20220249859A1 (en) * | 2021-02-09 | 2022-08-11 | Scholl's Wellness Company Llc | Formulation and device for cosmetic treatment of onychomycosis |
| US20240238227A1 (en) | 2023-01-12 | 2024-07-18 | Wooshin Labottach Co., Ltd. | Pharmaceutical composition for preventing or treating onychomycosis and preparation method therefor |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4296130A (en) | 1979-08-30 | 1981-10-20 | Herschler R J | Methylsulfonylmethane and methods of use |
| US4672078A (en) | 1985-07-03 | 1987-06-09 | Schering-Plough Corporation | Urea stabilized with a lactone in various pharmaceutical and cosmetic preparations |
| US5525635A (en) | 1986-02-04 | 1996-06-11 | Moberg; Sven | Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof |
| SE462139B (sv) | 1986-02-04 | 1990-05-14 | Sven Moberg | Farmaceutisk komposition, innehaallande propylenglykol och karbamid, foer behandling av bl.a. nagelsvamp och seborroiskt eksem |
| US5696164A (en) * | 1994-12-22 | 1997-12-09 | Johnson & Johnson Consumer Products, Inc. | Antifungal treatment of nails |
| JP3820805B2 (ja) | 1999-07-08 | 2006-09-13 | 株式会社ノエビア | 皮膚外用剤 |
| JP2003095914A (ja) * | 2001-09-21 | 2003-04-03 | Toyo Beauty Kk | 尿素含有外用剤 |
| US6986896B2 (en) * | 2002-03-20 | 2006-01-17 | Bradley Pharmaceuticals, Inc. | Method of treating fungal conditions of the skin |
| US6573301B1 (en) * | 2002-04-23 | 2003-06-03 | Bradley Pharmaceuticals, Inc. | Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use |
| US8158138B1 (en) * | 2004-05-20 | 2012-04-17 | Fougera Pharmaceuticals, Inc. | Urea compositions and their methods of manufacture |
| JP4972895B2 (ja) * | 2005-08-29 | 2012-07-11 | 大正製薬株式会社 | 尿素配合外用製剤 |
| US8435500B2 (en) | 2005-11-01 | 2013-05-07 | L'oréal | Nail whitening composition |
| RU2011150901A (ru) | 2009-08-13 | 2013-09-20 | Моберг Дерма Аб | Композиции и способы лечения грибковой инфекции ногтей |
| WO2012110430A1 (en) * | 2011-02-10 | 2012-08-23 | Moberg Derma Ab | Novel composition for topical use on a nail |
| WO2014140507A1 (en) | 2013-03-15 | 2014-09-18 | Moberg Pharma Ab | Pharmaceutical composition for the treatment of fungal infections |
-
2013
- 2013-03-15 WO PCT/GB2013/050654 patent/WO2014140507A1/en not_active Ceased
-
2014
- 2014-02-28 BR BR112015022590A patent/BR112015022590B8/pt active IP Right Grant
- 2014-02-28 JP JP2015562293A patent/JP6503303B2/ja active Active
- 2014-02-28 RS RS20150488A patent/RS54131B1/sr unknown
- 2014-02-28 US US14/193,304 patent/US8987330B2/en active Active
- 2014-02-28 WO PCT/GB2014/050604 patent/WO2014140524A1/en not_active Ceased
- 2014-02-28 SI SI201430003T patent/SI2777689T1/sl unknown
- 2014-02-28 MX MX2015012273A patent/MX375135B/es active IP Right Grant
- 2014-02-28 KR KR1020157006206A patent/KR101582448B1/ko active Active
- 2014-02-28 PL PL14157373T patent/PL2777689T3/pl unknown
- 2014-02-28 PT PT141573733T patent/PT2777689E/pt unknown
- 2014-02-28 ES ES14157373.3T patent/ES2543957T3/es active Active
- 2014-02-28 CN CN201811088339.6A patent/CN109394743A/zh active Pending
- 2014-02-28 ME MEP-2015-112A patent/ME02199B/me unknown
- 2014-02-28 CA CA2883613A patent/CA2883613C/en active Active
- 2014-02-28 SG SG11201505763QA patent/SG11201505763QA/en unknown
- 2014-02-28 EP EP14157373.3A patent/EP2777689B1/en active Active
- 2014-02-28 CN CN201480002472.9A patent/CN104661639B/zh active Active
- 2014-02-28 MY MYPI2015703030A patent/MY176291A/en unknown
- 2014-02-28 DK DK14157373.3T patent/DK2777689T3/da active
- 2014-02-28 HU HUE14157373A patent/HUE026887T2/en unknown
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2015
- 2015-01-29 US US14/609,142 patent/US9782372B2/en active Active
- 2015-07-24 ZA ZA2015/05343A patent/ZA201505343B/en unknown
- 2015-07-28 HR HRP20150823TT patent/HRP20150823T1/hr unknown
- 2015-07-29 CY CY20151100666T patent/CY1116559T1/el unknown
- 2015-09-03 IL IL24117515A patent/IL241175B/en active IP Right Grant
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- 2015-09-11 PH PH12015502073A patent/PH12015502073B1/en unknown
- 2015-09-15 SA SA515361162A patent/SA515361162B1/ar unknown
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