JP2016511262A5 - - Google Patents

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Publication number
JP2016511262A5
JP2016511262A5 JP2015560617A JP2015560617A JP2016511262A5 JP 2016511262 A5 JP2016511262 A5 JP 2016511262A5 JP 2015560617 A JP2015560617 A JP 2015560617A JP 2015560617 A JP2015560617 A JP 2015560617A JP 2016511262 A5 JP2016511262 A5 JP 2016511262A5
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JP
Japan
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alkyl
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substituents
cycloalkyl
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JP2015560617A
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English (en)
Japanese (ja)
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JP2016511262A (ja
JP6427506B2 (ja
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Priority claimed from PCT/EP2014/053718 external-priority patent/WO2014135414A1/en
Publication of JP2016511262A publication Critical patent/JP2016511262A/ja
Publication of JP2016511262A5 publication Critical patent/JP2016511262A5/ja
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JP2015560617A 2013-03-04 2014-02-26 置換二環式ジヒドロピリミジノン及び好中球エラスターゼ活性の阻害薬としてのそれらの使用 Active JP6427506B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13157640 2013-03-04
EP13157640.7 2013-03-04
PCT/EP2014/053718 WO2014135414A1 (en) 2013-03-04 2014-02-26 Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity

Publications (3)

Publication Number Publication Date
JP2016511262A JP2016511262A (ja) 2016-04-14
JP2016511262A5 true JP2016511262A5 (enExample) 2017-03-30
JP6427506B2 JP6427506B2 (ja) 2018-11-21

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ID=47754372

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015560617A Active JP6427506B2 (ja) 2013-03-04 2014-02-26 置換二環式ジヒドロピリミジノン及び好中球エラスターゼ活性の阻害薬としてのそれらの使用

Country Status (7)

Country Link
US (1) US9115093B2 (enExample)
EP (1) EP2964617B1 (enExample)
JP (1) JP6427506B2 (enExample)
AR (1) AR094975A1 (enExample)
TW (1) TW201446746A (enExample)
UY (1) UY35357A (enExample)
WO (1) WO2014135414A1 (enExample)

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US20140221335A1 (en) 2013-02-06 2014-08-07 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9440930B2 (en) * 2014-07-31 2016-09-13 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9657015B2 (en) * 2014-07-31 2017-05-23 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9458113B2 (en) * 2014-07-31 2016-10-04 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9475779B2 (en) * 2014-07-31 2016-10-25 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
JP6832918B2 (ja) * 2015-09-18 2021-02-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 立体選択的方法
US9856232B1 (en) 2017-06-20 2018-01-02 King Saud University Dihydropyrimidinone derivatives
US10047071B1 (en) 2018-01-15 2018-08-14 King Saud University Dihydropyrimidinone derivatives
US10111873B1 (en) 2018-01-17 2018-10-30 King Saud University Dihydropyrimidinone derivatives
CA3154761A1 (en) 2019-09-17 2021-03-25 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
SI4106757T1 (sl) 2020-04-16 2023-11-30 Mereo Biopharma 4 Limited Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1
WO2023067103A1 (en) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

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