JP2016511256A5 - - Google Patents
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- JP2016511256A5 JP2016511256A5 JP2015560296A JP2015560296A JP2016511256A5 JP 2016511256 A5 JP2016511256 A5 JP 2016511256A5 JP 2015560296 A JP2015560296 A JP 2015560296A JP 2015560296 A JP2015560296 A JP 2015560296A JP 2016511256 A5 JP2016511256 A5 JP 2016511256A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cancer
- epas1
- nucleotides
- antisense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
- 108091030071 RNAI Proteins 0.000 claims description 33
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- 108010018033 endothelial PAS domain-containing protein 1 Proteins 0.000 claims description 32
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770713P | 2013-02-28 | 2013-02-28 | |
| US61/770,713 | 2013-02-28 | ||
| PCT/US2014/018873 WO2014134255A2 (en) | 2013-02-28 | 2014-02-27 | Organic compositions to treat epas1-related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019028972A Division JP2019089836A (ja) | 2013-02-28 | 2019-02-21 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016511256A JP2016511256A (ja) | 2016-04-14 |
| JP2016511256A5 true JP2016511256A5 (enExample) | 2017-03-30 |
Family
ID=50483469
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560296A Withdrawn JP2016511256A (ja) | 2013-02-28 | 2014-02-27 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2019028972A Pending JP2019089836A (ja) | 2013-02-28 | 2019-02-21 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2021031732A Pending JP2021091710A (ja) | 2013-02-28 | 2021-03-01 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2023046940A Pending JP2023068147A (ja) | 2013-02-28 | 2023-03-23 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019028972A Pending JP2019089836A (ja) | 2013-02-28 | 2019-02-21 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2021031732A Pending JP2021091710A (ja) | 2013-02-28 | 2021-03-01 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2023046940A Pending JP2023068147A (ja) | 2013-02-28 | 2023-03-23 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9868949B2 (enExample) |
| EP (1) | EP2961843A2 (enExample) |
| JP (4) | JP2016511256A (enExample) |
| CN (1) | CN105247051A (enExample) |
| AU (3) | AU2014223432A1 (enExample) |
| CA (1) | CA2902393C (enExample) |
| HK (1) | HK1214301A1 (enExample) |
| SG (2) | SG10201706960TA (enExample) |
| WO (1) | WO2014134255A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1214301A1 (zh) * | 2013-02-28 | 2016-07-22 | 箭头研究公司 | 治療epas1相關疾病的有機組合物 |
| TWI761305B (zh) * | 2015-05-29 | 2022-04-21 | 美商愛羅海德製藥公司 | 抑制Ｈｉｆ２α基因表現之組合物及方法 |
| US20180193270A1 (en) | 2016-11-29 | 2018-07-12 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| IL309955A (en) * | 2018-04-27 | 2024-03-01 | Arrowhead Pharmaceuticals Inc | Integrin-targeting ligands and their uses |
| EP3784267B1 (en) | 2018-04-27 | 2025-11-12 | Arrowhead Pharmaceuticals, Inc. | Integrin targeting ligands and uses thereof |
| KR20210113273A (ko) * | 2019-01-09 | 2021-09-15 | 애로우헤드 파마슈티컬스 인코포레이티드 | HIF-2 알파 (EPAS1)의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법 |
| CN116916900A (zh) * | 2021-10-18 | 2023-10-20 | 尼坎治疗公司 | 用于治疗膀胱癌的低氧诱导因子-2（α）抑制剂 |
| WO2024102894A2 (en) * | 2022-11-11 | 2024-05-16 | The Regents Of The University Of California | Methods for treating monge's disease |
| CN119523991B (zh) * | 2024-12-06 | 2025-09-05 | 湖南师范大学 | 表木栓醇在制备抗肺癌物质中的用途和抗肺癌组合物 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5030453A (en) | 1983-03-24 | 1991-07-09 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US5891467A (en) | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| AU776150B2 (en) | 1999-01-28 | 2004-08-26 | Medical College Of Georgia Research Institute, Inc. | Composition and method for (in vivo) and (in vitro) attenuation of gene expression using double stranded RNA |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| WO2000053722A2 (en) | 1999-03-10 | 2000-09-14 | Phogen Limited | Delivery of nucleic acids and proteins to cells |
| US6309401B1 (en) | 1999-04-30 | 2001-10-30 | Vladimir Redko | Apparatus and method for percutaneous implant of a paddle style lead |
| JP2003526367A (ja) | 2000-03-16 | 2003-09-09 | ジェネティカ インコーポレイテッド | Ｒｎａ干渉の方法とｒｎａ干渉組成物 |
| AU2001250572A1 (en) * | 2000-04-07 | 2001-10-23 | Epigenomics Ag | Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations |
| US6680068B2 (en) | 2000-07-06 | 2004-01-20 | The General Hospital Corporation | Drug delivery formulations and targeting |
| US20080188430A1 (en) | 2001-05-18 | 2008-08-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
| WO2002100435A1 (en) | 2001-06-11 | 2002-12-19 | Centre Hospitalier Universitaire De Montreal | Compositions and methods for enhancing nucleic acid transfer into cells |
| WO2003015757A1 (en) | 2001-08-16 | 2003-02-27 | The Trustees Of The University Of Pennsylvania | Synthesis and use of reagents for improved dna lipofection and/or slow release prodrug and drug therapies |
| DE10230997A1 (de) | 2001-10-26 | 2003-07-17 | Ribopharma Ag | Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| EP1658304A4 (en) | 2002-09-28 | 2009-01-14 | Massachusetts Inst Technology | THERAPY ANTIGRIPPALE |
| US7655785B1 (en) * | 2002-11-14 | 2010-02-02 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
| EP2305813A3 (en) * | 2002-11-14 | 2012-03-28 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| WO2004048545A2 (en) | 2002-11-26 | 2004-06-10 | University Of Massachusetts | DELIVERY OF siRNAs______________________________________________ |
| US20040208921A1 (en) | 2003-01-14 | 2004-10-21 | Ho Rodney J. Y. | Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues |
| AU2004257373B2 (en) | 2003-07-16 | 2011-03-24 | Arbutus Biopharma Corporation | Lipid encapsulated interfering RNA |
| CN1845993B (zh) | 2003-08-28 | 2010-06-23 | 诺瓦提斯公司 | 具有平端和3＇修饰的干扰rna双链体 |
| CA2559955C (en) | 2004-03-15 | 2016-02-16 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
| CA2566286A1 (en) * | 2004-05-11 | 2005-12-08 | Rnai Co., Ltd. | Polynucleotide causing rna interfere and method of regulating gene expression with the use of the same |
| EP1948674A4 (en) | 2005-11-02 | 2009-02-04 | Protiva Biotherapeutics Inc | MODIFIED SIRNA MOLECULES AND APPLICATIONS THEREOF |
| ES2556128T3 (es) | 2006-03-23 | 2016-01-13 | Roche Innovation Center Copenhagen A/S | ARN interfiriente pequeño internamente segmentado |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| CN101500548A (zh) | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
| NZ580712A (en) | 2007-05-22 | 2011-12-22 | Marina Biotech Inc | Hydroxymethyl substituted rna oligonucleotides and rna complexes containing acyclic monomers |
| CN101868251B (zh) * | 2007-08-06 | 2012-10-10 | 千寿制药株式会社 | 含有HIF-1α和HIF-2α表达抑制物质的药物 |
| US9006191B2 (en) | 2007-12-27 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Silencing of polo-like kinase expression using interfering RNA |
| US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| US8067178B2 (en) | 2008-03-14 | 2011-11-29 | Genomic Health, Inc. | Gene expression markers for prediction of patient response to chemotherapy |
| WO2009117531A1 (en) | 2008-03-18 | 2009-09-24 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| JP2011516065A (ja) * | 2008-04-04 | 2011-05-26 | カランド ファーマシューティカルズ， インコーポレイテッド | Ｅｐａｓ１阻害剤の組成物および使用 |
| KR20110110776A (ko) | 2008-12-18 | 2011-10-07 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| WO2010093788A2 (en) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Multiplex dicer substrate rna interference molecules having joining sequences |
| WO2011076807A2 (en) | 2009-12-23 | 2011-06-30 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| PH12012501596A1 (en) | 2010-02-24 | 2017-02-03 | Arrowhead Res Corporation | Compositions for targeted delivery of sirna |
| KR101223660B1 (ko) * | 2010-05-20 | 2013-01-17 | 광주과학기술원 | ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물 |
| US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
| RU2013117288A (ru) | 2010-12-17 | 2015-01-27 | Эрроухэд Рисерч Корпорейшн | СОДЕРЖАЩАЯ ГАЛАКТОЗНЫЙ КЛАСТЕР НАЦЕЛИВАЮЩАЯ ГРУППА ДЛЯ миРНК, МОДУЛИРУЮЩАЯ ФОРМАКОКИНЕТИЧЕСКИЕ СВОЙСТВА |
| RU2582235C2 (ru) | 2010-12-29 | 2016-04-20 | Ф.Хоффманн-Ля Рош Аг | Низкомолекулярные конъюгаты для внутриклеточной доставки нуклеиновых кислот |
| WO2012174224A2 (en) * | 2011-06-17 | 2012-12-20 | Calando Pharmaceuticals, Inc. | Methods for administering nucleic acid-based therapeutics |
| CA2842039A1 (en) | 2011-08-26 | 2013-03-07 | Arrowhead Research Corporation | Poly(vinyl ester) polymers for in vivo nucleic acid delivery |
| MX2014001965A (es) | 2012-04-18 | 2014-03-31 | Arrowhead Res Corp | Polimeros de poli(acrilato) para suministro de acido nucleico in vivo. |
| HK1214301A1 (zh) * | 2013-02-28 | 2016-07-22 | 箭头研究公司 | 治療epas1相關疾病的有機組合物 |
| US9504747B2 (en) | 2013-03-08 | 2016-11-29 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
-
2014
- 2014-02-27 HK HK16102257.6A patent/HK1214301A1/zh unknown
- 2014-02-27 US US14/770,765 patent/US9868949B2/en active Active
- 2014-02-27 AU AU2014223432A patent/AU2014223432A1/en not_active Abandoned
- 2014-02-27 SG SG10201706960TA patent/SG10201706960TA/en unknown
- 2014-02-27 EP EP14717233.2A patent/EP2961843A2/en active Pending
- 2014-02-27 CN CN201480011225.5A patent/CN105247051A/zh active Pending
- 2014-02-27 WO PCT/US2014/018873 patent/WO2014134255A2/en not_active Ceased
- 2014-02-27 SG SG11201506805QA patent/SG11201506805QA/en unknown
- 2014-02-27 JP JP2015560296A patent/JP2016511256A/ja not_active Withdrawn
- 2014-02-27 CA CA2902393A patent/CA2902393C/en active Active
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2017
- 2017-12-07 US US15/834,323 patent/US10538765B2/en active Active
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2019
- 2019-02-21 JP JP2019028972A patent/JP2019089836A/ja active Pending
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2020
- 2020-01-21 US US16/747,729 patent/US11261444B2/en active Active
- 2020-03-04 AU AU2020201617A patent/AU2020201617A1/en not_active Abandoned
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2021
- 2021-03-01 JP JP2021031732A patent/JP2021091710A/ja active Pending
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2022
- 2022-05-23 AU AU2022203490A patent/AU2022203490A1/en not_active Abandoned
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2023
- 2023-03-23 JP JP2023046940A patent/JP2023068147A/ja active Pending
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