JP2016511256A5 - - Google Patents
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- JP2016511256A5 JP2016511256A5 JP2015560296A JP2015560296A JP2016511256A5 JP 2016511256 A5 JP2016511256 A5 JP 2016511256A5 JP 2015560296 A JP2015560296 A JP 2015560296A JP 2015560296 A JP2015560296 A JP 2015560296A JP 2016511256 A5 JP2016511256 A5 JP 2016511256A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cancer
- epas1
- nucleotides
- antisense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 201000010099 disease Diseases 0.000 claims description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
- 108091030071 RNAI Proteins 0.000 claims description 33
- 230000009368 gene silencing by RNA Effects 0.000 claims description 33
- 102100036448 Endothelial PAS domain-containing protein 1 Human genes 0.000 claims description 32
- 108010018033 endothelial PAS domain-containing protein 1 Proteins 0.000 claims description 32
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- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 2
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- SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 claims description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770713P | 2013-02-28 | 2013-02-28 | |
| US61/770,713 | 2013-02-28 | ||
| PCT/US2014/018873 WO2014134255A2 (en) | 2013-02-28 | 2014-02-27 | Organic compositions to treat epas1-related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019028972A Division JP2019089836A (ja) | 2013-02-28 | 2019-02-21 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016511256A JP2016511256A (ja) | 2016-04-14 |
| JP2016511256A5 true JP2016511256A5 (enExample) | 2017-03-30 |
Family
ID=50483469
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560296A Withdrawn JP2016511256A (ja) | 2013-02-28 | 2014-02-27 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2019028972A Pending JP2019089836A (ja) | 2013-02-28 | 2019-02-21 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2021031732A Pending JP2021091710A (ja) | 2013-02-28 | 2021-03-01 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2023046940A Pending JP2023068147A (ja) | 2013-02-28 | 2023-03-23 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019028972A Pending JP2019089836A (ja) | 2013-02-28 | 2019-02-21 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2021031732A Pending JP2021091710A (ja) | 2013-02-28 | 2021-03-01 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
| JP2023046940A Pending JP2023068147A (ja) | 2013-02-28 | 2023-03-23 | Ｅｐａｓ１関連疾患を治療するための有機組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9868949B2 (enExample) |
| EP (1) | EP2961843A2 (enExample) |
| JP (4) | JP2016511256A (enExample) |
| CN (1) | CN105247051A (enExample) |
| AU (3) | AU2014223432A1 (enExample) |
| CA (1) | CA2902393C (enExample) |
| HK (1) | HK1214301A1 (enExample) |
| SG (2) | SG11201506805QA (enExample) |
| WO (1) | WO2014134255A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9868949B2 (en) * | 2013-02-28 | 2018-01-16 | Arrowhead Pharmaceuticals, Inc. | Organic compositions to treat EPAS1-related diseases |
| MX2017014641A (es) * | 2015-05-29 | 2018-01-23 | Arrowhead Pharmaceuticals Inc | Composiciones y metodos para inhibir la expresion del gen de factor inducible por hipoxia alfa (hif2alfa). |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| WO2019210308A1 (en) | 2018-04-27 | 2019-10-31 | Arrowhead Pharmaceuticals, Inc. | Integrin targeting ligands and uses thereof |
| SI3784269T1 (sl) * | 2018-04-27 | 2024-08-30 | Arrowhead Pharmaceuticals, Inc., | Integrinski ciljni ligandi in njihova uporaba |
| JP2022518384A (ja) * | 2019-01-09 | 2022-03-15 | アローヘッド ファーマシューティカルズ インコーポレイテッド | ＨＩＦ－２アルファ（ＥＰＡＳ１）の発現を阻害するためのＲＮＡｉ剤、その組成物及び使用方法 |
| CN116916900A (zh) * | 2021-10-18 | 2023-10-20 | 尼坎治疗公司 | 用于治疗膀胱癌的低氧诱导因子-2（α）抑制剂 |
| WO2024102894A2 (en) * | 2022-11-11 | 2024-05-16 | The Regents Of The University Of California | Methods for treating monge's disease |
| CN119523991B (zh) * | 2024-12-06 | 2025-09-05 | 湖南师范大学 | 表木栓醇在制备抗肺癌物质中的用途和抗肺癌组合物 |
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| US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US5891467A (en) | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| WO2000044914A1 (en) | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| EP1159441B8 (en) | 1999-03-10 | 2008-10-29 | Marie Curie Cancer Care | Delivery of nucleic acids and proteins to cells |
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| EP1268856A2 (de) * | 2000-04-07 | 2003-01-02 | Epigenomics AG | Detektion von snp's und cytosin-methylierungen |
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-
2014
- 2014-02-27 US US14/770,765 patent/US9868949B2/en active Active
- 2014-02-27 SG SG11201506805QA patent/SG11201506805QA/en unknown
- 2014-02-27 CN CN201480011225.5A patent/CN105247051A/zh active Pending
- 2014-02-27 EP EP14717233.2A patent/EP2961843A2/en active Pending
- 2014-02-27 WO PCT/US2014/018873 patent/WO2014134255A2/en not_active Ceased
- 2014-02-27 AU AU2014223432A patent/AU2014223432A1/en not_active Abandoned
- 2014-02-27 JP JP2015560296A patent/JP2016511256A/ja not_active Withdrawn
- 2014-02-27 SG SG10201706960TA patent/SG10201706960TA/en unknown
- 2014-02-27 CA CA2902393A patent/CA2902393C/en active Active
- 2014-02-27 HK HK16102257.6A patent/HK1214301A1/zh unknown
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2017
- 2017-12-07 US US15/834,323 patent/US10538765B2/en active Active
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2019
- 2019-02-21 JP JP2019028972A patent/JP2019089836A/ja active Pending
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2020
- 2020-01-21 US US16/747,729 patent/US11261444B2/en active Active
- 2020-03-04 AU AU2020201617A patent/AU2020201617A1/en not_active Abandoned
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2021
- 2021-03-01 JP JP2021031732A patent/JP2021091710A/ja active Pending
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2022
- 2022-05-23 AU AU2022203490A patent/AU2022203490A1/en not_active Abandoned
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2023
- 2023-03-23 JP JP2023046940A patent/JP2023068147A/ja active Pending
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