JP2013525332A5 - - Google Patents
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- JP2013525332A5 JP2013525332A5 JP2013505469A JP2013505469A JP2013525332A5 JP 2013525332 A5 JP2013525332 A5 JP 2013525332A5 JP 2013505469 A JP2013505469 A JP 2013505469A JP 2013505469 A JP2013505469 A JP 2013505469A JP 2013525332 A5 JP2013525332 A5 JP 2013525332A5
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- JP
- Japan
- Prior art keywords
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- sequence
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- nucleotides
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32737910P | 2010-04-23 | 2010-04-23 | |
| US61/327,379 | 2010-04-23 | ||
| US33339810P | 2010-05-11 | 2010-05-11 | |
| US61/333,398 | 2010-05-11 | ||
| PCT/EP2011/056299 WO2011131707A1 (en) | 2010-04-23 | 2011-04-20 | ORGANIC COMPOSITIONS TO TREAT BETA-ENaC-RELATED DISEASES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085797A Division JP5976032B2 (ja) | 2010-04-23 | 2014-04-17 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525332A JP2013525332A (ja) | 2013-06-20 |
| JP2013525332A5 true JP2013525332A5 (enExample) | 2014-06-05 |
| JP5857378B2 JP5857378B2 (ja) | 2016-02-10 |
Family
ID=44227799
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505469A Expired - Fee Related JP5857378B2 (ja) | 2010-04-23 | 2011-04-20 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2014085797A Expired - Fee Related JP5976032B2 (ja) | 2010-04-23 | 2014-04-17 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2016141325A Expired - Fee Related JP6290316B2 (ja) | 2010-04-23 | 2016-07-19 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2018019887A Expired - Fee Related JP6577073B2 (ja) | 2010-04-23 | 2018-02-07 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2019150816A Pending JP2019214604A (ja) | 2010-04-23 | 2019-08-21 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2021165417A Pending JP2022003089A (ja) | 2010-04-23 | 2021-10-07 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085797A Expired - Fee Related JP5976032B2 (ja) | 2010-04-23 | 2014-04-17 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2016141325A Expired - Fee Related JP6290316B2 (ja) | 2010-04-23 | 2016-07-19 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2018019887A Expired - Fee Related JP6577073B2 (ja) | 2010-04-23 | 2018-02-07 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2019150816A Pending JP2019214604A (ja) | 2010-04-23 | 2019-08-21 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2021165417A Pending JP2022003089A (ja) | 2010-04-23 | 2021-10-07 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (10) | US8344127B2 (enExample) |
| EP (3) | EP3431604A1 (enExample) |
| JP (6) | JP5857378B2 (enExample) |
| KR (4) | KR20190122893A (enExample) |
| CN (2) | CN107929306B (enExample) |
| AR (1) | AR081082A1 (enExample) |
| AU (1) | AU2011244335B2 (enExample) |
| BR (1) | BR112012027080A2 (enExample) |
| CA (2) | CA2797051C (enExample) |
| DK (1) | DK2561077T3 (enExample) |
| EA (1) | EA034363B1 (enExample) |
| ES (1) | ES2574204T3 (enExample) |
| MX (2) | MX383583B (enExample) |
| TW (1) | TWI434692B (enExample) |
| WO (1) | WO2011131707A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2797051C (en) | 2010-04-23 | 2021-01-12 | Novartis Ag | Organic compositions to treat beta-enac-related diseases |
| CN102397279B (zh) * | 2011-11-18 | 2012-10-31 | 新乡医学院 | 无羁萜-3β-醇在制备抗血管性痴呆的药物中的应用 |
| US9605255B2 (en) * | 2012-07-12 | 2017-03-28 | Proqr Therapeutics Ii B.V. | Oligonucleotides for making a change in the sequence of a target RNA molecule present in a living cell |
| WO2015131161A2 (en) | 2014-02-28 | 2015-09-03 | Attends Healthcare Products, Inc. | Absorbent article with multi-layer folded absorbent core |
| CN109475552B (zh) * | 2016-08-09 | 2022-04-05 | 上海药苑生物科技有限公司 | 用于食欲控制和体重管理的方法和组合物 |
| WO2018112229A1 (en) | 2016-12-14 | 2018-06-21 | Eam Corporation | Absorbent laminates, absorbent cores and disposable articles utilizing the absorbent laminates, and related methods |
| EP3801424B1 (en) | 2018-05-28 | 2025-01-22 | Attends Healthcare Products, Inc. | Dryness layer laminate for absorbent articles |
| CN109364248B (zh) * | 2018-10-16 | 2021-05-18 | 哈尔滨医科大学 | ENaC及其抑制剂在预防、缓解和/或治疗动脉粥样硬化中的应用 |
| TW202130809A (zh) * | 2019-10-29 | 2021-08-16 | 美商愛羅海德製藥公司 | 用於抑制β-ENaC表現之RNAi藥劑、其組合物及使用方法 |
| US20230136960A1 (en) * | 2020-03-19 | 2023-05-04 | Nature's Toolbox, Inc. | Novel MRNA-Based COVID-19 Multi-Valent Vaccine and Methods of Scaled Production of the Same |
| CN114149492A (zh) * | 2020-08-21 | 2022-03-08 | 中国人民解放军军事科学院军事医学研究院 | 一种用于预防甲型流感病毒感染的HA-mRNA疫苗 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696561B1 (en) | 1909-07-09 | 2004-02-24 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US5030453A (en) | 1983-03-24 | 1991-07-09 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US5891467A (en) | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| EP2314700A1 (en) | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| EP1272630A2 (en) | 2000-03-16 | 2003-01-08 | Genetica, Inc. | Methods and compositions for rna interference |
| PT1309726E (pt) | 2000-03-30 | 2010-03-08 | Whitehead Biomedical Inst | Mediadores de interferência por rna específicos de sequência de rna |
| US6680068B2 (en) | 2000-07-06 | 2004-01-20 | The General Hospital Corporation | Drug delivery formulations and targeting |
| WO2003070910A2 (en) * | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2002100435A1 (en) | 2001-06-11 | 2002-12-19 | Centre Hospitalier Universitaire De Montreal | Compositions and methods for enhancing nucleic acid transfer into cells |
| EP1424998B1 (en) | 2001-08-16 | 2010-05-26 | The Trustees of The University of Pennsylvania | Synthesis and use of reagents for improved dna lipofection and/or slow release prodrug and drug therapies |
| EP1478655A4 (en) | 2001-12-31 | 2006-05-10 | Algos Therapeutics Inc | METHODS AND SUBSTANCES FOR ENAC-BETA MODULATION |
| DE60334618D1 (de) | 2002-06-28 | 2010-12-02 | Protiva Biotherapeutics Inc | Verfahren und vorrichtung zur herstellung von liposomen |
| KR20050084607A (ko) | 2002-09-28 | 2005-08-26 | 매사추세츠 인스티튜트 오브 테크놀로지 | 인플루엔자 치료제 |
| US8090542B2 (en) * | 2002-11-14 | 2012-01-03 | Dharmacon Inc. | Functional and hyperfunctional siRNA |
| CA2506714A1 (en) | 2002-11-26 | 2004-06-10 | University Of Massachusetts | Delivery of sirnas |
| WO2004064731A2 (en) | 2003-01-14 | 2004-08-05 | University Of Washington | Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymlplhoid tissues |
| MXPA06000266A (es) * | 2003-07-10 | 2006-03-30 | Senomyx Inc | Ensayos electrofisiologicos mejorados utilizando oocitos que expresan un enac humano y el uso de fenamilo para mejorar el efecto de intensificadores del enac en ensayos. |
| CN101291653B (zh) | 2003-07-16 | 2012-06-27 | 普洛体维生物治疗公司 | 脂质包封的干扰rna |
| NZ545360A (en) | 2003-08-28 | 2009-06-26 | Novartis Ag | Interfering RNA duplex having blunt-ends and 3'-modifications |
| AU2005248147A1 (en) * | 2004-05-11 | 2005-12-08 | Alphagen Co., Ltd. | Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| PT2270181E (pt) | 2005-09-16 | 2016-01-26 | Devgen Nv | Arncd como agente de controlo de insetos |
| CN101346393B (zh) | 2005-11-02 | 2015-07-22 | 普洛体维生物治疗公司 | 修饰的siRNA分子及其应用 |
| US7389426B2 (en) | 2005-11-29 | 2008-06-17 | Research In Motion Limited | Mobile software terminal identifier |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| US8314227B2 (en) | 2007-05-22 | 2012-11-20 | Marina Biotech, Inc. | Hydroxymethyl substituted RNA oligonucleotides and RNA complexes |
| AR066984A1 (es) | 2007-06-15 | 2009-09-23 | Novartis Ag | Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia) |
| EP2238251B1 (en) | 2007-12-27 | 2015-02-11 | Protiva Biotherapeutics Inc. | Silencing of polo-like kinase expression using interfering rna |
| CA2797051C (en) | 2010-04-23 | 2021-01-12 | Novartis Ag | Organic compositions to treat beta-enac-related diseases |
-
2011
- 2011-04-20 CA CA2797051A patent/CA2797051C/en active Active
- 2011-04-20 KR KR1020197031212A patent/KR20190122893A/ko not_active Ceased
- 2011-04-20 WO PCT/EP2011/056299 patent/WO2011131707A1/en not_active Ceased
- 2011-04-20 EP EP18190981.3A patent/EP3431604A1/en not_active Withdrawn
- 2011-04-20 MX MX2017011441A patent/MX383583B/es unknown
- 2011-04-20 JP JP2013505469A patent/JP5857378B2/ja not_active Expired - Fee Related
- 2011-04-20 CA CA3098080A patent/CA3098080A1/en active Pending
- 2011-04-20 BR BR112012027080A patent/BR112012027080A2/pt not_active Application Discontinuation
- 2011-04-20 CN CN201711213535.7A patent/CN107929306B/zh active Active
- 2011-04-20 US US13/090,580 patent/US8344127B2/en not_active Expired - Fee Related
- 2011-04-20 KR KR1020227000366A patent/KR20220008383A/ko not_active Ceased
- 2011-04-20 EP EP11715243.9A patent/EP2561077B1/en active Active
- 2011-04-20 MX MX2012012355A patent/MX350595B/es active IP Right Grant
- 2011-04-20 KR KR1020187008466A patent/KR20180033606A/ko not_active Ceased
- 2011-04-20 EA EA201201457A patent/EA034363B1/ru not_active IP Right Cessation
- 2011-04-20 CN CN201180030997XA patent/CN102985544A/zh active Pending
- 2011-04-20 AR ARP110101377A patent/AR081082A1/es unknown
- 2011-04-20 EP EP16163880.4A patent/EP3061824B1/en active Active
- 2011-04-20 DK DK11715243.9T patent/DK2561077T3/en active
- 2011-04-20 ES ES11715243.9T patent/ES2574204T3/es active Active
- 2011-04-20 AU AU2011244335A patent/AU2011244335B2/en not_active Ceased
- 2011-04-20 KR KR1020127030568A patent/KR20130051954A/ko not_active Ceased
- 2011-04-22 TW TW100114186A patent/TWI434692B/zh not_active IP Right Cessation
-
2012
- 2012-01-23 US US13/355,879 patent/US8344129B2/en not_active Expired - Fee Related
- 2012-01-23 US US13/355,930 patent/US8344131B2/en not_active Expired - Fee Related
- 2012-01-23 US US13/355,903 patent/US8344130B2/en not_active Expired - Fee Related
- 2012-09-13 US US13/614,836 patent/US8598335B2/en not_active Expired - Fee Related
-
2013
- 2013-10-01 US US14/042,924 patent/US9080175B2/en active Active
-
2014
- 2014-04-17 JP JP2014085797A patent/JP5976032B2/ja not_active Expired - Fee Related
-
2015
- 2015-05-28 US US14/723,555 patent/US9376683B2/en active Active
-
2016
- 2016-05-27 US US15/166,576 patent/US9752152B2/en not_active Expired - Fee Related
- 2016-07-19 JP JP2016141325A patent/JP6290316B2/ja not_active Expired - Fee Related
-
2017
- 2017-07-27 US US15/661,132 patent/US10081811B2/en active Active
-
2018
- 2018-02-07 JP JP2018019887A patent/JP6577073B2/ja not_active Expired - Fee Related
- 2018-08-20 US US16/105,522 patent/US10550391B2/en active Active
-
2019
- 2019-08-21 JP JP2019150816A patent/JP2019214604A/ja active Pending
-
2021
- 2021-10-07 JP JP2021165417A patent/JP2022003089A/ja active Pending
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