JP2013525332A5 - - Google Patents
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- JP2013525332A5 JP2013525332A5 JP2013505469A JP2013505469A JP2013525332A5 JP 2013525332 A5 JP2013525332 A5 JP 2013525332A5 JP 2013505469 A JP2013505469 A JP 2013505469A JP 2013505469 A JP2013505469 A JP 2013505469A JP 2013525332 A5 JP2013525332 A5 JP 2013525332A5
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- JP
- Japan
- Prior art keywords
- strand
- sequence
- composition
- nucleotides
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32737910P | 2010-04-23 | 2010-04-23 | |
| US61/327,379 | 2010-04-23 | ||
| US33339810P | 2010-05-11 | 2010-05-11 | |
| US61/333,398 | 2010-05-11 | ||
| PCT/EP2011/056299 WO2011131707A1 (en) | 2010-04-23 | 2011-04-20 | ORGANIC COMPOSITIONS TO TREAT BETA-ENaC-RELATED DISEASES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085797A Division JP5976032B2 (ja) | 2010-04-23 | 2014-04-17 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525332A JP2013525332A (ja) | 2013-06-20 |
| JP2013525332A5 true JP2013525332A5 (enExample) | 2014-06-05 |
| JP5857378B2 JP5857378B2 (ja) | 2016-02-10 |
Family
ID=44227799
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505469A Expired - Fee Related JP5857378B2 (ja) | 2010-04-23 | 2011-04-20 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2014085797A Expired - Fee Related JP5976032B2 (ja) | 2010-04-23 | 2014-04-17 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2016141325A Expired - Fee Related JP6290316B2 (ja) | 2010-04-23 | 2016-07-19 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2018019887A Expired - Fee Related JP6577073B2 (ja) | 2010-04-23 | 2018-02-07 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2019150816A Pending JP2019214604A (ja) | 2010-04-23 | 2019-08-21 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2021165417A Pending JP2022003089A (ja) | 2010-04-23 | 2021-10-07 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085797A Expired - Fee Related JP5976032B2 (ja) | 2010-04-23 | 2014-04-17 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2016141325A Expired - Fee Related JP6290316B2 (ja) | 2010-04-23 | 2016-07-19 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2018019887A Expired - Fee Related JP6577073B2 (ja) | 2010-04-23 | 2018-02-07 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2019150816A Pending JP2019214604A (ja) | 2010-04-23 | 2019-08-21 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| JP2021165417A Pending JP2022003089A (ja) | 2010-04-23 | 2021-10-07 | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (10) | US8344127B2 (enExample) |
| EP (3) | EP3061824B1 (enExample) |
| JP (6) | JP5857378B2 (enExample) |
| KR (4) | KR20130051954A (enExample) |
| CN (2) | CN102985544A (enExample) |
| AR (1) | AR081082A1 (enExample) |
| AU (1) | AU2011244335B2 (enExample) |
| BR (1) | BR112012027080A2 (enExample) |
| CA (2) | CA3098080A1 (enExample) |
| DK (1) | DK2561077T3 (enExample) |
| EA (1) | EA034363B1 (enExample) |
| ES (1) | ES2574204T3 (enExample) |
| MX (2) | MX350595B (enExample) |
| TW (1) | TWI434692B (enExample) |
| WO (1) | WO2011131707A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5857378B2 (ja) | 2010-04-23 | 2016-02-10 | アローヘッド リサーチ コーポレイション | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
| CN102397279B (zh) * | 2011-11-18 | 2012-10-31 | 新乡医学院 | 无羁萜-3β-醇在制备抗血管性痴呆的药物中的应用 |
| WO2014011053A1 (en) * | 2012-07-12 | 2014-01-16 | Proqr Therapeutics B.V. | Oligonucleotides for making a change in the sequence of a target rna molecule present in a living cell |
| EP3110381B1 (en) | 2014-02-28 | 2020-07-15 | Attends Healthcare Products, Inc. | Absorbent article with multi-layer folded absorbent core |
| US20190167675A1 (en) * | 2016-08-09 | 2019-06-06 | Shanghai Yao Yuan Biotechnology Co., Ltd. | Methods and compositions for appetite control and weight management |
| CN110573122A (zh) | 2016-12-14 | 2019-12-13 | 阿坦斯医疗保健产品公司 | 吸收层压件、吸收芯和利用该吸收层压件的一次性制品及相关方法 |
| WO2019231926A1 (en) | 2018-05-28 | 2019-12-05 | Attends Healthcare Products, Inc. | Dryness layer laminate for absorbent articles |
| CN109364248B (zh) * | 2018-10-16 | 2021-05-18 | 哈尔滨医科大学 | ENaC及其抑制剂在预防、缓解和/或治疗动脉粥样硬化中的应用 |
| TW202130809A (zh) * | 2019-10-29 | 2021-08-16 | 美商愛羅海德製藥公司 | 用於抑制β-ENaC表現之RNAi藥劑、其組合物及使用方法 |
| US20230136960A1 (en) * | 2020-03-19 | 2023-05-04 | Nature's Toolbox, Inc. | Novel MRNA-Based COVID-19 Multi-Valent Vaccine and Methods of Scaled Production of the Same |
| CN114149492A (zh) * | 2020-08-21 | 2022-03-08 | 中国人民解放军军事科学院军事医学研究院 | 一种用于预防甲型流感病毒感染的HA-mRNA疫苗 |
Family Cites Families (48)
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| US6696561B1 (en) | 1909-07-09 | 2004-02-24 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US5030453A (en) | 1983-03-24 | 1991-07-09 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US5891467A (en) | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| WO2000044914A1 (en) | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| AU2001245793A1 (en) | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
| EP1309726B2 (en) | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
| US6680068B2 (en) | 2000-07-06 | 2004-01-20 | The General Hospital Corporation | Drug delivery formulations and targeting |
| WO2003070910A2 (en) * | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP1399189A1 (en) | 2001-06-11 | 2004-03-24 | Universite De Montreal | Compositions and methods for enhancing nucleic acid transfer into cells |
| AU2002324723B2 (en) | 2001-08-16 | 2007-10-25 | The Trustees Of The University Of Pennsylvania | Synthesis and use of reagents for improved DNA lipofection and/or slow release pro-drug and drug therapies |
| AU2002364612A1 (en) | 2001-12-31 | 2003-07-24 | Algos Therapeutics, Inc. | METHODS AND MATERIALS FOR MODULATING ENaC-BETA |
| US7901708B2 (en) | 2002-06-28 | 2011-03-08 | Protiva Biotherapeutics, Inc. | Liposomal apparatus and manufacturing methods |
| AU2003279004B2 (en) | 2002-09-28 | 2009-10-08 | Massachusetts Institute Of Technology | Influenza therapeutic |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| US20040204377A1 (en) | 2002-11-26 | 2004-10-14 | University Of Massachusetts | Delivery of siRNAs |
| US20040208921A1 (en) | 2003-01-14 | 2004-10-21 | Ho Rodney J. Y. | Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues |
| CA2530497A1 (en) * | 2003-07-10 | 2005-02-17 | Senomyx, Inc. | Improved electrophysiological assays using oocytes that express human enac and the use of phenamil to improve the effect of enac enhancers in assays using membrane potential reporting dyes |
| SG190613A1 (en) | 2003-07-16 | 2013-06-28 | Protiva Biotherapeutics Inc | Lipid encapsulated interfering rna |
| CN1845993B (zh) | 2003-08-28 | 2010-06-23 | 诺瓦提斯公司 | 具有平端和3＇修饰的干扰rna双链体 |
| AU2005248147A1 (en) | 2004-05-11 | 2005-12-08 | Alphagen Co., Ltd. | Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| EP2270182B1 (en) | 2005-09-16 | 2016-02-10 | deVGen N.V. | DSRNA as insect control agent |
| US8101741B2 (en) | 2005-11-02 | 2012-01-24 | Protiva Biotherapeutics, Inc. | Modified siRNA molecules and uses thereof |
| US7389426B2 (en) | 2005-11-29 | 2008-06-17 | Research In Motion Limited | Mobile software terminal identifier |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| BRPI0811170B8 (pt) | 2007-05-22 | 2021-05-25 | Arcturus Therapeutics Inc | oligonucleotídeos de rna e complexos de rna substituídos por hidroximetila |
| AR066984A1 (es) * | 2007-06-15 | 2009-09-23 | Novartis Ag | Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia) |
| CA2710713C (en) | 2007-12-27 | 2017-09-19 | Protiva Biotherapeutics, Inc. | Silencing of polo-like kinase expression using interfering rna |
| JP5857378B2 (ja) | 2010-04-23 | 2016-02-10 | アローヘッド リサーチ コーポレイション | ベータ−ＥＮａＣ−関連疾患を処置するための有機組成物 |
-
2011
- 2011-04-20 JP JP2013505469A patent/JP5857378B2/ja not_active Expired - Fee Related
- 2011-04-20 BR BR112012027080A patent/BR112012027080A2/pt not_active Application Discontinuation
- 2011-04-20 CN CN201180030997XA patent/CN102985544A/zh active Pending
- 2011-04-20 WO PCT/EP2011/056299 patent/WO2011131707A1/en not_active Ceased
- 2011-04-20 KR KR1020127030568A patent/KR20130051954A/ko not_active Ceased
- 2011-04-20 CA CA3098080A patent/CA3098080A1/en active Pending
- 2011-04-20 EP EP16163880.4A patent/EP3061824B1/en active Active
- 2011-04-20 CN CN201711213535.7A patent/CN107929306B/zh active Active
- 2011-04-20 DK DK11715243.9T patent/DK2561077T3/en active
- 2011-04-20 EP EP18190981.3A patent/EP3431604A1/en active Pending
- 2011-04-20 ES ES11715243.9T patent/ES2574204T3/es active Active
- 2011-04-20 EA EA201201457A patent/EA034363B1/ru not_active IP Right Cessation
- 2011-04-20 US US13/090,580 patent/US8344127B2/en not_active Expired - Fee Related
- 2011-04-20 MX MX2012012355A patent/MX350595B/es active IP Right Grant
- 2011-04-20 KR KR1020197031212A patent/KR20190122893A/ko not_active Ceased
- 2011-04-20 MX MX2017011441A patent/MX383583B/es unknown
- 2011-04-20 CA CA2797051A patent/CA2797051C/en active Active
- 2011-04-20 EP EP11715243.9A patent/EP2561077B1/en active Active
- 2011-04-20 AU AU2011244335A patent/AU2011244335B2/en not_active Ceased
- 2011-04-20 KR KR1020187008466A patent/KR20180033606A/ko not_active Ceased
- 2011-04-20 AR ARP110101377A patent/AR081082A1/es unknown
- 2011-04-20 KR KR1020227000366A patent/KR20220008383A/ko not_active Ceased
- 2011-04-22 TW TW100114186A patent/TWI434692B/zh not_active IP Right Cessation
-
2012
- 2012-01-23 US US13/355,879 patent/US8344129B2/en not_active Expired - Fee Related
- 2012-01-23 US US13/355,930 patent/US8344131B2/en not_active Expired - Fee Related
- 2012-01-23 US US13/355,903 patent/US8344130B2/en not_active Expired - Fee Related
- 2012-09-13 US US13/614,836 patent/US8598335B2/en active Active
-
2013
- 2013-10-01 US US14/042,924 patent/US9080175B2/en active Active
-
2014
- 2014-04-17 JP JP2014085797A patent/JP5976032B2/ja not_active Expired - Fee Related
-
2015
- 2015-05-28 US US14/723,555 patent/US9376683B2/en active Active
-
2016
- 2016-05-27 US US15/166,576 patent/US9752152B2/en not_active Expired - Fee Related
- 2016-07-19 JP JP2016141325A patent/JP6290316B2/ja not_active Expired - Fee Related
-
2017
- 2017-07-27 US US15/661,132 patent/US10081811B2/en active Active
-
2018
- 2018-02-07 JP JP2018019887A patent/JP6577073B2/ja not_active Expired - Fee Related
- 2018-08-20 US US16/105,522 patent/US10550391B2/en active Active
-
2019
- 2019-08-21 JP JP2019150816A patent/JP2019214604A/ja active Pending
-
2021
- 2021-10-07 JP JP2021165417A patent/JP2022003089A/ja active Pending
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