JP2016510797A5 - - Google Patents
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- Publication number
- JP2016510797A5 JP2016510797A5 JP2015562215A JP2015562215A JP2016510797A5 JP 2016510797 A5 JP2016510797 A5 JP 2016510797A5 JP 2015562215 A JP2015562215 A JP 2015562215A JP 2015562215 A JP2015562215 A JP 2015562215A JP 2016510797 A5 JP2016510797 A5 JP 2016510797A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- het
- independently
- cycloalkyl
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000000217 alkyl group Chemical group 0.000 claims 333
- 125000001475 halogen functional group Chemical group 0.000 claims 69
- 125000001424 substituent group Chemical group 0.000 claims 48
- -1 R 2 is -H Chemical group 0.000 claims 17
- 229910052757 nitrogen Inorganic materials 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 9
- 125000005842 heteroatom Chemical group 0.000 claims 9
- 239000002207 metabolite Substances 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 239000000651 prodrug Substances 0.000 claims 9
- 229940002612 prodrug Drugs 0.000 claims 9
- 230000000069 prophylactic effect Effects 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 229940124597 therapeutic agent Drugs 0.000 claims 9
- 239000000032 diagnostic agent Substances 0.000 claims 8
- 229940039227 diagnostic agent Drugs 0.000 claims 8
- 108091000080 Phosphotransferase Proteins 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 102000020233 phosphotransferase Human genes 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 150000001204 N-oxides Chemical class 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- MJQSRSOTRPMVKB-UHFFFAOYSA-N 5h-imidazo[4,5-c]pyridazine Chemical group C1=NNC2=NC=NC2=C1 MJQSRSOTRPMVKB-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical group C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000019612 pigmentation Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2013055389 | 2013-03-15 | ||
| EPPCT/EP2013/055389 | 2013-03-15 | ||
| PCT/EP2014/055168 WO2014140313A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic salt-inducible kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016510797A JP2016510797A (ja) | 2016-04-11 |
| JP2016510797A5 true JP2016510797A5 (https=) | 2017-03-30 |
Family
ID=50588637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562215A Ceased JP2016510797A (ja) | 2013-03-15 | 2014-03-14 | 大環状塩誘導性キナーゼ阻害剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9586975B2 (https=) |
| JP (1) | JP2016510797A (https=) |
| KR (1) | KR20150133767A (https=) |
| CN (1) | CN105209040A (https=) |
| AU (1) | AU2014230125A1 (https=) |
| BR (1) | BR112015022650A8 (https=) |
| CA (1) | CA2906262A1 (https=) |
| EA (1) | EA201591794A1 (https=) |
| HK (1) | HK1219057A1 (https=) |
| IL (1) | IL241325A0 (https=) |
| MX (1) | MX2015012528A (https=) |
| SG (1) | SG11201507493SA (https=) |
| WO (1) | WO2014140313A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201591773A1 (ru) * | 2013-03-15 | 2016-01-29 | Онкодизайн С.А. | Макроциклические ингибиторы rip2-киназы |
| AU2015292818B2 (en) | 2014-07-21 | 2020-01-16 | Dana-Farber Cancer Institute, Inc. | Imidazolyl kinase inhibitors and uses thereof |
| WO2018009544A1 (en) | 2016-07-05 | 2018-01-11 | The Broad Institute, Inc. | Bicyclic urea kinase inhibitors and uses thereof |
| US11241435B2 (en) | 2016-09-16 | 2022-02-08 | The General Hospital Corporation | Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis |
| AU2018226771B2 (en) | 2017-02-28 | 2023-11-23 | Dana-Farber Cancer Institute, Inc. | Uses of pyrimidopyrimidinones as SIK inhibitors |
| EP3391907B8 (en) | 2017-04-20 | 2020-03-04 | iOmx Therapeutics AG | Intracellular kinase sik3 associated with resistance against anti-tumour immune responses, and uses thereof |
| CN109956957B (zh) * | 2017-12-22 | 2021-11-09 | 广州白云山医药集团股份有限公司白云山制药总厂 | 一种咪唑并[1,2-b]哒嗪大环类激酶抑制剂 |
| JPWO2020027200A1 (ja) | 2018-08-01 | 2021-08-19 | 小野薬品工業株式会社 | 軟骨関連疾患治療剤 |
| US11690897B2 (en) | 2019-02-04 | 2023-07-04 | The Board Of Trustees Of The University Of Illinois | Salt inducible kinase inhibitors for enhancing fertility |
| US20230126352A1 (en) * | 2020-01-31 | 2023-04-27 | Oncodesign Sa | Macrocyclic rip2-kinase inhibitors |
| WO2024051631A1 (zh) * | 2022-09-07 | 2024-03-14 | 苏州朗睿生物医药有限公司 | 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
| WO2025252075A1 (en) * | 2024-06-04 | 2025-12-11 | Insilico Medicine Ip Limited | Novel compounds as salt-inducible kinases inhibitors and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| PT721331E (pt) | 1993-10-01 | 2002-05-31 | Astrazeneca Ab | Processo i |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US7517882B2 (en) * | 2006-09-18 | 2009-04-14 | Polaris Group | Protein kinase inhibitors |
| WO2008058126A2 (en) * | 2006-11-06 | 2008-05-15 | Supergen, Inc. | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| WO2008060248A1 (en) * | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
| KR101324804B1 (ko) * | 2008-05-13 | 2013-11-01 | 아이알엠 엘엘씨 | 키나제 억제제로서의 질소 함유 융합 헤테로사이클 및 그의 조성물 |
| BR112014007622A2 (pt) | 2011-09-30 | 2017-04-04 | Oncodesign Sa | inibidores de flt3 cinase macrocíclicos |
| HUE029728T2 (en) * | 2011-09-30 | 2017-03-28 | Ipsen Pharma Sas | Macrocyclic LRRK2 kinase inhibitors |
-
2014
- 2014-03-14 AU AU2014230125A patent/AU2014230125A1/en not_active Abandoned
- 2014-03-14 US US14/776,798 patent/US9586975B2/en not_active Expired - Fee Related
- 2014-03-14 JP JP2015562215A patent/JP2016510797A/ja not_active Ceased
- 2014-03-14 MX MX2015012528A patent/MX2015012528A/es unknown
- 2014-03-14 CA CA2906262A patent/CA2906262A1/en not_active Abandoned
- 2014-03-14 CN CN201480023832.3A patent/CN105209040A/zh active Pending
- 2014-03-14 SG SG11201507493SA patent/SG11201507493SA/en unknown
- 2014-03-14 BR BR112015022650A patent/BR112015022650A8/pt not_active IP Right Cessation
- 2014-03-14 EA EA201591794A patent/EA201591794A1/ru unknown
- 2014-03-14 HK HK16107168.3A patent/HK1219057A1/zh unknown
- 2014-03-14 WO PCT/EP2014/055168 patent/WO2014140313A1/en not_active Ceased
- 2014-03-14 KR KR1020157029486A patent/KR20150133767A/ko not_active Withdrawn
-
2015
- 2015-09-08 IL IL241325A patent/IL241325A0/en unknown
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