JP2016507555A - 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法 - Google Patents

血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法 Download PDF

Info

Publication number
JP2016507555A
JP2016507555A JP2015556930A JP2015556930A JP2016507555A JP 2016507555 A JP2016507555 A JP 2016507555A JP 2015556930 A JP2015556930 A JP 2015556930A JP 2015556930 A JP2015556930 A JP 2015556930A JP 2016507555 A JP2016507555 A JP 2016507555A
Authority
JP
Japan
Prior art keywords
antibody
seq
antibodies
human
active fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015556930A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016507555A5 (enExample
Inventor
エッケルマン、ブレンダン
ティマー、ジョン
ラザイ、アミール
デヴロー、クイン
ジョーンズ、カイル
ラッペ、マーク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inhibrx Inc
Original Assignee
Inhibrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2013/024995 external-priority patent/WO2013119714A1/en
Application filed by Inhibrx Inc filed Critical Inhibrx Inc
Publication of JP2016507555A publication Critical patent/JP2016507555A/ja
Publication of JP2016507555A5 publication Critical patent/JP2016507555A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2015556930A 2013-02-06 2013-08-06 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法 Pending JP2016507555A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
PCT/US2013/024995 WO2013119714A1 (en) 2012-02-06 2013-02-06 Cd47 antibodies and methods of use thereof
USPCT/US2013/024995 2013-02-06
US13/761,087 2013-02-06
US13/761,087 US9045541B2 (en) 2012-02-06 2013-02-06 CD47 antibodies and methods of use thereof
US201361815219P 2013-04-23 2013-04-23
US61/815,219 2013-04-23
PCT/US2013/053818 WO2014123580A1 (en) 2013-02-06 2013-08-06 Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018146460A Division JP6726238B2 (ja) 2013-02-06 2018-08-03 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法

Publications (2)

Publication Number Publication Date
JP2016507555A true JP2016507555A (ja) 2016-03-10
JP2016507555A5 JP2016507555A5 (enExample) 2016-10-06

Family

ID=51300031

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015556930A Pending JP2016507555A (ja) 2013-02-06 2013-08-06 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法
JP2018146460A Active JP6726238B2 (ja) 2013-02-06 2018-08-03 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018146460A Active JP6726238B2 (ja) 2013-02-06 2018-08-03 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法

Country Status (19)

Country Link
EP (2) EP2953643B1 (enExample)
JP (2) JP2016507555A (enExample)
KR (2) KR102276974B1 (enExample)
CN (1) CN105101997B (enExample)
AU (2) AU2013377886B2 (enExample)
BR (1) BR112015018851A2 (enExample)
CA (1) CA2900468C (enExample)
CL (1) CL2015002203A1 (enExample)
EA (1) EA036963B1 (enExample)
ES (1) ES2944477T3 (enExample)
IL (2) IL240390B (enExample)
MX (2) MX2015010115A (enExample)
NI (1) NI201500103A (enExample)
NZ (1) NZ710695A (enExample)
PE (1) PE20151408A1 (enExample)
PH (1) PH12015501729A1 (enExample)
SG (2) SG11201506132PA (enExample)
WO (1) WO2014123580A1 (enExample)
ZA (2) ZA201505745B (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019515899A (ja) * 2016-04-15 2019-06-13 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー がん処置における抗ｃｄ４７薬の治療有効用量を決定及び達成する方法
JP2020511481A (ja) * 2017-03-22 2020-04-16 アーチ オンコロジー, インコーポレイテッドArch Oncology, Inc. 固形及び血液癌の治療のための併用療法
JP2020536488A (ja) * 2017-08-02 2020-12-17 フェインズ セラピューティクス，インコーポレーテッド 抗ｃｄ４７抗体及びその使用
JP2021502324A (ja) * 2017-11-10 2021-01-28 アイ−マブ バイオファーマ ユーエス リミテッド Ｃｄ４７抗体およびサイトカインを含む融合タンパク質
JP2021527110A (ja) * 2018-06-11 2021-10-11 康▲諾▼▲亞▼生物医葯科技（成都）有限公司Ｃｈｅｎｇｄｕ Ｃｏｎｍｅｄ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏ．， Ｌｔｄ ＣＤ４７とＳＩＲＰａの相互作用を遮断できる抗体及びその応用
JP2021535743A (ja) * 2018-08-31 2021-12-23 南京聖和薬業股▲ふん▼有限公司Nanjing Sanhome Pharmaceutical Co., Ltd. 抗ｃｄ４７抗体及びその応用
JP2023052145A (ja) * 2017-03-27 2023-04-11 セルジーン コーポレイション 免疫原性の低下のための方法及び組成物
JP2023083424A (ja) * 2017-06-21 2023-06-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 血液悪性腫瘍に対するｃｄ４７標的化治療のための投与パラメータ
US11692035B2 (en) 2016-10-21 2023-07-04 Arch Oncology, Inc. Therapeutic CD47 antibodies
US12091467B2 (en) 2016-10-20 2024-09-17 I-Mab Biopharma Us Limited CD47 monoclonal antibodies and uses thereof
JP7591917B2 (ja) 2015-08-07 2024-11-29 エーエルエックス オンコロジー インコーポレイテッド Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3578569A1 (en) 2012-02-06 2019-12-11 Inhibrx, Inc. Cd47 antibodies and methods of use thereof
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
MX2015007446A (es) 2012-12-12 2015-12-07 Vasculox Inc Anticuerpos terapeuticos para cd47.
JP6335189B2 (ja) 2012-12-17 2018-05-30 トリリアム・セラピューティクス・インコーポレイテッドＴｒｉｌｌｉｕｍ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． ＳＩＲＰアルファ−Ｆｃ融合体でのＣＤ４７＋疾患細胞の治療
JP6426693B2 (ja) 2013-03-15 2018-11-21 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 抗ｃｄ４７薬の処理上有効量を達成するための方法
EP3012271A1 (en) * 2014-10-24 2016-04-27 Effimune Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
AU2015350190B2 (en) * 2014-11-18 2021-08-05 Janssen Pharmaceutica Nv CD47 antibodies, methods, and uses
EP3240569A4 (en) 2014-12-30 2018-05-30 Celgene Corporation Anti-cd47 antibodies and uses thereof
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
AU2016225993B2 (en) * 2015-03-04 2020-09-24 Yuhan Corporation Antibody therapeutics that bind CD47
BR112018005322A2 (pt) * 2015-09-18 2018-12-11 Arch Oncology, Inc. anticorpo monoclonal ou seu fragmento de ligação a antígenos, composição farmacêutica, anticorpo monoclonal ou seu fragmento de ligação a antígenos para uso, método de tratamento de lesão de isquemia-reperfusão, método de tratamento de câncer em um paciente humano, método de avaliação da expressão de cd47 em células tumorais e/ou imunes usando um anticorpo monoclonal ou seu fragmento de ligação a antígenos
CN108290948B (zh) 2015-09-21 2021-10-29 伊拉兹马斯大学医疗中心 抗-cd47抗体及使用方法
EA038880B1 (ru) 2016-01-11 2021-11-01 Форти Севен, Инк. Гуманизированные моноклональные антитела, моноклональные антитела мыши или химерные моноклональные антитела против cd47
DK3443010T3 (da) 2016-04-14 2024-09-30 Ose Immunotherapeutics Nye anti-SIRPa-antistoffer og terapeutiske anvendelser deraf
US11649284B2 (en) 2016-04-18 2023-05-16 Baylor College Of Medicine Cancer gene therapy targeting CD47
CN106084052B (zh) * 2016-06-17 2019-12-27 长春金赛药业股份有限公司 抗cd47单克隆抗体及其应用
CN106117354B (zh) * 2016-06-24 2020-01-14 安徽未名细胞治疗有限公司 一种全人源抗CD47的全分子IgG抗体及其应用
CA3029977A1 (en) 2016-07-06 2018-01-11 Celgene Corporation Antibodies with low immunogenicity and uses thereof
US10277886B2 (en) 2016-07-19 2019-04-30 Gopro, Inc. Mapping of spherical image data into rectangular faces for transport and decoding across networks
CN107955071B (zh) * 2016-10-18 2021-03-26 上海赛远生物科技有限公司 人源抗人cd47抗体及其编码基因与应用
US10995152B2 (en) 2016-10-26 2021-05-04 The Board Of Trustees Of The Leland Stanford Junior University Modified immunoglobulin hinge regions to reduce hemagglutination
US11446315B2 (en) 2016-11-03 2022-09-20 Pf Argentum Ip Holdings Llc Enhancement of CD47 blockade therapy by proteasome inhibitors
CA3042583A1 (en) 2016-11-03 2018-05-11 Trillium Therapeutics Inc. Improvements in cd47 blockade therapy by hdac inhibitors
US11352425B2 (en) 2016-11-08 2022-06-07 Absos, Llc Anti-CD47 antibodies
CN108779179B (zh) * 2016-11-28 2022-02-08 江苏恒瑞医药股份有限公司 Cd47抗体、其抗原结合片段及其医药用途
JP7173971B2 (ja) 2016-12-09 2022-11-16 アレクトル エルエルシー 抗ＳＩＲＰ－α抗体及びその使用方法
JP7117311B2 (ja) * 2017-01-26 2022-08-12 ゼットリップ ホールディング リミテッド Ｃｄ４７抗原結合単位およびその使用
CN109422811A (zh) 2017-08-29 2019-03-05 信达生物制药(苏州)有限公司 抗cd47抗体及其用途
EA039662B1 (ru) 2017-10-03 2022-02-24 Закрытое Акционерное Общество "Биокад" Антитела, специфичные к cd47 и pd-l1
US11771764B2 (en) 2017-11-06 2023-10-03 Pfizer Inc. CD47 blockade with radiation therapy
CN110914304B (zh) * 2017-11-10 2022-07-26 江苏恒瑞医药股份有限公司 Cd96抗体、其抗原结合片段及医药用途
ES2927305T3 (es) 2018-02-12 2022-11-04 Forty Seven Inc Régimen contra el cáncer usando anticuerpos anti-CD47 y anti-CD20
CN110305212A (zh) 2018-03-27 2019-10-08 信达生物制药(苏州)有限公司 抗cd47抗体及其用途
PE20210342A1 (es) 2018-05-25 2021-02-23 Alector Llc Anticuerpos anti-sirpa y metodos de utilizacion de los mismos
WO2020047651A1 (en) 2018-09-04 2020-03-12 Trillium Therapeutics Inc. Cd47 blockade with parp inhibition for disease treatment
CN112105386A (zh) * 2018-10-31 2020-12-18 天境生物科技(上海)有限公司 新的cd47抗体及其使用方法
TW202104260A (zh) * 2019-04-05 2021-02-01 美商西建公司 腫瘤選擇性結合ｃｄ４７之抗體之工程
JP7561775B2 (ja) 2019-06-07 2024-10-04 エーエルエックス オンコロジー インコーポレイテッド 血清学的アッセイにおいてｃｄ４７に結合する薬物の干渉を低減するための方法及び試薬
US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
CN113461817B (zh) * 2020-03-31 2025-04-18 苏州泽璟生物制药股份有限公司 一种抗人cd47抗体及其抗原结合片段、制备方法和应用
TWI869582B (zh) * 2020-04-10 2025-01-11 大陸商和記黃埔醫藥（上海）有限公司 抗ｃｄ４７抗體及其用途
US20230159663A1 (en) * 2020-04-24 2023-05-25 Virtuoso Binco, Inc. Bispecific antibodies for treating cd47-associated diseases
CN114057876B (zh) * 2020-07-31 2025-03-21 百奥泰生物制药股份有限公司 Cd47抗体及其应用
MX2023005201A (es) 2020-11-04 2023-06-28 Myeloid Therapeutics Inc Composiciones de proteinas de fusion quimerica modificadas por ingenieria y metodos de uso de las mismas.
US20220196651A1 (en) 2020-12-06 2022-06-23 ALX Oncology Inc. Multimers for reducing the interference of drugs that bind cd47 in serological assays
TW202413428A (zh) * 2020-12-23 2024-04-01 大陸商廣東菲鵬製藥股份有限公司 桃園路1號10棟301室 郵編：523808 靶向cd47的抗體、編碼其的核酸、包含其的載體、細胞、藥物組合物、其應用及其試劑盒
WO2022148412A1 (zh) * 2021-01-08 2022-07-14 北京韩美药品有限公司 特异性结合cd47的抗体及其抗原结合片段
BR112023018832A2 (pt) 2021-03-17 2023-12-26 Myeloid Therapeutics Inc Composições de proteínas de fusão quiméricas modificadas e métodos de uso das mesmas
CA3217814A1 (en) 2021-04-27 2022-11-03 Pfizer Inc. Enhancement of cd47 blockade therapy with dhfr inhibitors
EP4337268A4 (en) 2021-05-11 2025-06-04 Myeloid Therapeutics, Inc. Methods and compositions for genomic integration
US20250235504A1 (en) 2021-10-29 2025-07-24 Pfizer Inc. Enhancement of cd47 blockade with taxanes for cd47+ cancer therapy
WO2023079438A1 (en) 2021-11-08 2023-05-11 Pfizer Inc. Enhancement of cd47 blockade therapy with anti-vegf agents
CN118221812A (zh) * 2022-12-14 2024-06-21 上海迈石生物技术有限公司 一种靶向cd47的单克隆抗体及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002512776A (ja) * 1998-04-28 2002-05-08 スミスクライン・ビーチャム・コーポレイション 免疫原性の低下したモノクローナル抗体
JPWO2001066737A1 (ja) * 2000-03-10 2003-07-02 中外製薬株式会社 アポトーシスを誘起するポリペプチド
JP4637749B2 (ja) * 2003-11-11 2011-02-23 中外製薬株式会社 ヒト化抗ｃｄ４７抗体
JP2015508072A (ja) * 2012-02-06 2015-03-16 インヒブルクス エルエルシーＩｎｈｉｂｒｘ Ｌｌｃ Ｃｄ４７抗体及びその使用方法

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4681581A (en) 1983-12-05 1987-07-21 Coates Fredrica V Adjustable size diaper and folding method therefor
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4735210A (en) 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5101827A (en) 1985-07-05 1992-04-07 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
WO1988001513A1 (fr) 1986-08-28 1988-03-10 Teijin Limited Complexe d'anticorps cytocide et procede de production
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5648471A (en) 1987-12-03 1997-07-15 Centocor, Inc. One vial method for labeling antibodies with Technetium-99m
US5057604A (en) 1988-08-03 1991-10-15 Washington University Novel monoclonal antibodies
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ATE144793T1 (de) 1989-06-29 1996-11-15 Medarex Inc Bispezifische reagenzien für die aids-therapie
WO1991001754A1 (en) 1989-08-09 1991-02-21 Rhodes Buck A Direct radiolabeling of antibodies and other proteins with technetium or rhenium
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
US5151510A (en) 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5165424A (en) 1990-08-09 1992-11-24 Silverman Harvey N Method and system for whitening teeth
JPH06506105A (ja) 1990-08-29 1994-07-14 ファーミング　ビーブイ 哺乳動物細胞における相同性組換え
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5194594A (en) 1990-09-07 1993-03-16 Techniclone, Inc. Modified antibodies
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
WO1992022670A1 (en) 1991-06-12 1992-12-23 Genpharm International, Inc. Early detection of transgenic embryos
WO1992022645A1 (en) 1991-06-14 1992-12-23 Genpharm International, Inc. Transgenic immunodeficient non-human animals
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
CA2124967C (en) 1991-12-17 2008-04-08 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
EP0592677B1 (en) 1992-02-18 2001-11-07 Otsuka Kagaku Kabushiki Kaisha Beta-LACTAM COMPOUND AND CEPHEM COMPOUND, AND PRODUCTION THEREOF
US5233409A (en) 1992-02-25 1993-08-03 Schwab Karl W Color analysis of organic constituents in sedimentary rocks for thermal maturity
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
JPH07508410A (ja) 1992-06-18 1995-09-21 ジェンファーム　インターナショナル　インコーポレイテッド 酵母人工染色体を有するトランスジェニック非ヒト動物の製造方法
WO1994002602A1 (en) 1992-07-24 1994-02-03 Cell Genesys, Inc. Generation of xenogeneic antibodies
ES2091684T3 (es) 1992-11-13 1996-11-01 Idec Pharma Corp Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b.
AU6819494A (en) 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DE69425890D1 (de) 1993-06-04 2000-10-19 Us Health Verfahren zur behandlung von kaposi-sarcoma mit antisense-oligonukleotide
US5625825A (en) 1993-10-21 1997-04-29 Lsi Logic Corporation Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
EP0745134A1 (en) 1994-02-22 1996-12-04 Danafarber Cancer Institute Nucleic acid delivery system, method of synthesis and uses thereof
US5643763A (en) 1994-11-04 1997-07-01 Genpharm International, Inc. Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5703057A (en) 1995-04-07 1997-12-30 Board Of Regents The University Of Texas System Expression library immunization
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
CA2230759C (en) 1995-08-29 2012-02-21 Kirin Beer Kabushiki Kaisha Chimeric animal and method for producing the same
US6025130A (en) 1996-04-04 2000-02-15 Mercator Genetics, Inc. Hereditary hemochromatosis gene
DE69738539T2 (de) 1996-12-03 2009-03-26 Amgen Fremont Inc. Vollkommen humane Antikörper die EGFR binden
US6833268B1 (en) 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
TWI242043B (en) * 2000-03-10 2005-10-21 Chugai Pharmaceutical Co Ltd Polypeptide inducing apoptosis
US7282556B2 (en) * 2001-05-15 2007-10-16 Emory University Polynucleotides and polypeptides relating to the modulation of SIRPα-CD47
EP1575509B1 (en) * 2002-05-10 2011-10-26 Purdue Research Foundation Epha2 agonistic monoclonal antibodies and methods of use thereof
DE112008003232T5 (de) * 2007-11-30 2011-02-24 Glaxo Group Limited, Greenford Antigen-Bindungskonstrukte
EP2293667A4 (en) 2008-05-27 2012-07-18 Kyowa Hakko Kirin Co Ltd INTERLEUKIN 10-RECEPTOR (IL-10R) ANTIBODY AND USE PROCESS
US8563697B2 (en) * 2008-08-14 2013-10-22 Cephalon Australia Pty. Ltd. Anti-IL-12/IL-23 antibodies
HRP20170254T1 (hr) * 2010-05-14 2017-04-21 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Humanizirana i kimerna monoklonska protutijela usmjerena na cd47
KR20160044598A (ko) * 2011-03-29 2016-04-25 로슈 글리카트 아게 항체 Fc 변이체
US9111624B2 (en) 2013-03-22 2015-08-18 Katsuyuki Fujita Semiconductor memory device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002512776A (ja) * 1998-04-28 2002-05-08 スミスクライン・ビーチャム・コーポレイション 免疫原性の低下したモノクローナル抗体
JPWO2001066737A1 (ja) * 2000-03-10 2003-07-02 中外製薬株式会社 アポトーシスを誘起するポリペプチド
JP4637749B2 (ja) * 2003-11-11 2011-02-23 中外製薬株式会社 ヒト化抗ｃｄ４７抗体
JP2015508072A (ja) * 2012-02-06 2015-03-16 インヒブルクス エルエルシーＩｎｈｉｂｒｘ Ｌｌｃ Ｃｄ４７抗体及びその使用方法

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7591917B2 (ja) 2015-08-07 2024-11-29 エーエルエックス オンコロジー インコーポレイテッド Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物
JP7532009B2 (ja) 2016-04-15 2024-08-13 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー がん処置における抗ｃｄ４７薬の治療有効用量を決定及び達成する方法
JP2019515899A (ja) * 2016-04-15 2019-06-13 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー がん処置における抗ｃｄ４７薬の治療有効用量を決定及び達成する方法
US11472878B2 (en) 2016-04-15 2022-10-18 The Board Of Trustees Of The Leland Stanford Junior University Methods for determining and achieving therapeutically effective doses of anti-CD47 agents in treatment of cancer
US12091467B2 (en) 2016-10-20 2024-09-17 I-Mab Biopharma Us Limited CD47 monoclonal antibodies and uses thereof
US11692035B2 (en) 2016-10-21 2023-07-04 Arch Oncology, Inc. Therapeutic CD47 antibodies
JP7170331B2 (ja) 2017-03-22 2022-11-14 アーチ オンコロジー，インコーポレイテッド 固形及び血液癌の治療のための併用療法
JP2020511481A (ja) * 2017-03-22 2020-04-16 アーチ オンコロジー, インコーポレイテッドArch Oncology, Inc. 固形及び血液癌の治療のための併用療法
JP2023052145A (ja) * 2017-03-27 2023-04-11 セルジーン コーポレイション 免疫原性の低下のための方法及び組成物
JP2023083424A (ja) * 2017-06-21 2023-06-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 血液悪性腫瘍に対するｃｄ４７標的化治療のための投与パラメータ
JP7262440B2 (ja) 2017-08-02 2023-04-21 フェインズ セラピューティクス，インコーポレーテッド 抗ｃｄ４７抗体及びその使用
JP2020536488A (ja) * 2017-08-02 2020-12-17 フェインズ セラピューティクス，インコーポレーテッド 抗ｃｄ４７抗体及びその使用
JP7084045B2 (ja) 2017-11-10 2022-06-14 アイ－マブ バイオファーマ ユーエス リミテッド Ｃｄ４７抗体およびサイトカインを含む融合タンパク質
JP2021502324A (ja) * 2017-11-10 2021-01-28 アイ−マブ バイオファーマ ユーエス リミテッド Ｃｄ４７抗体およびサイトカインを含む融合タンパク質
JP7143452B2 (ja) 2018-06-11 2022-09-28 康▲諾▼▲亞▼生物医葯科技（成都）有限公司 ＣＤ４７とＳＩＲＰａの相互作用を遮断できる抗体及びその応用
JP2021527110A (ja) * 2018-06-11 2021-10-11 康▲諾▼▲亞▼生物医葯科技（成都）有限公司Ｃｈｅｎｇｄｕ Ｃｏｎｍｅｄ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏ．， Ｌｔｄ ＣＤ４７とＳＩＲＰａの相互作用を遮断できる抗体及びその応用
US11820820B2 (en) 2018-06-11 2023-11-21 Chengdu Conmed Biosciences Co., Ltd. Antibody capable of blocking CD47-SIRPa interaction and application thereof
JP2021535743A (ja) * 2018-08-31 2021-12-23 南京聖和薬業股▲ふん▼有限公司Nanjing Sanhome Pharmaceutical Co., Ltd. 抗ｃｄ４７抗体及びその応用
JP7583707B2 (ja) 2018-08-31 2024-11-14 南京聖和薬業股▲ふん▼有限公司 抗ｃｄ４７抗体及びその応用
US11987627B2 (en) 2018-08-31 2024-05-21 Nanjing Sanhome Pharmaceutical Co., Ltd. Anti-CD47 antibody and application thereof

Also Published As

Publication number Publication date
KR20150123825A (ko) 2015-11-04
IL274566B (en) 2021-10-31
AU2019200942B2 (en) 2021-01-21
CL2015002203A1 (es) 2016-01-29
ZA201505745B (en) 2020-02-26
IL274566A (en) 2020-06-30
WO2014123580A8 (en) 2015-10-22
IL240390A0 (en) 2015-09-24
JP2018177813A (ja) 2018-11-15
CA2900468C (en) 2024-04-30
CA2900468A1 (en) 2014-08-14
KR20200123270A (ko) 2020-10-28
AU2019200942A1 (en) 2019-02-28
EP2953643A1 (en) 2015-12-16
ZA201905292B (en) 2022-09-28
NI201500103A (es) 2016-09-29
EP2953643B1 (en) 2023-02-22
PE20151408A1 (es) 2015-10-15
WO2014123580A1 (en) 2014-08-14
SG11201506132PA (en) 2015-09-29
IL240390B (en) 2020-05-31
MX2015010115A (es) 2016-05-31
PH12015501729B1 (en) 2015-10-19
CN105101997A (zh) 2015-11-25
EP2953643A4 (en) 2016-11-09
HK1218863A1 (en) 2017-03-17
AU2013377886A1 (en) 2015-09-03
BR112015018851A2 (pt) 2017-07-18
KR102276974B1 (ko) 2021-07-13
NZ710695A (en) 2020-05-29
KR102170196B1 (ko) 2020-10-26
ES2944477T3 (es) 2023-06-21
PH12015501729A1 (en) 2015-10-19
EP4137518A1 (en) 2023-02-22
EA036963B1 (ru) 2021-01-20
JP6726238B2 (ja) 2020-07-22
MX2021008851A (es) 2021-09-08
EA201500818A1 (ru) 2016-02-29
AU2013377886B2 (en) 2018-11-29
SG10201706383XA (en) 2017-09-28
CN105101997B (zh) 2018-11-09

Similar Documents

Publication Publication Date Title
JP6726238B2 (ja) 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法
US20240166744A1 (en) Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof
JP6273212B2 (ja) Ｃｄ４７抗体及びその使用方法
US20210371522A1 (en) Cd47 antibodies and methods of use thereof
HK40088423A (en) Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof
HK40018837A (en) Cd47 antibodies and methods of use thereof
HK1218863B (en) Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof
HK1205195B (en) Cd47 antibodies and methods of use thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151007

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160805

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160818

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161012

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20170614

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170620

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170919

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171220

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180316

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180403