JP2016507555A - 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法 - Google Patents

血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法 Download PDF

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JP2016507555A
JP2016507555A JP2015556930A JP2015556930A JP2016507555A JP 2016507555 A JP2016507555 A JP 2016507555A JP 2015556930 A JP2015556930 A JP 2015556930A JP 2015556930 A JP2015556930 A JP 2015556930A JP 2016507555 A JP2016507555 A JP 2016507555A
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antibody
seq
antibodies
human
active fragment
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JP2016507555A5 (enExample
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エッケルマン、ブレンダン
ティマー、ジョン
ラザイ、アミール
デヴロー、クイン
ジョーンズ、カイル
ラッペ、マーク
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Sanofi Aatd Inc
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Inhibrx Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2015556930A 2013-02-06 2013-08-06 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法 Pending JP2016507555A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US13/761,087 2013-02-06
USPCT/US2013/024995 2013-02-06
PCT/US2013/024995 WO2013119714A1 (en) 2012-02-06 2013-02-06 Cd47 antibodies and methods of use thereof
US13/761,087 US9045541B2 (en) 2012-02-06 2013-02-06 CD47 antibodies and methods of use thereof
US201361815219P 2013-04-23 2013-04-23
US61/815,219 2013-04-23
PCT/US2013/053818 WO2014123580A1 (en) 2013-02-06 2013-08-06 Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof

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JP2018146460A Active JP6726238B2 (ja) 2013-02-06 2018-08-03 血小板非減少性かつ赤血球非減少性ｃｄ４７抗体及びその使用方法

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JP (2) JP2016507555A (enExample)
KR (2) KR102276974B1 (enExample)
CN (1) CN105101997B (enExample)
AU (2) AU2013377886B2 (enExample)
BR (1) BR112015018851A2 (enExample)
CA (1) CA2900468C (enExample)
CL (1) CL2015002203A1 (enExample)
EA (1) EA036963B1 (enExample)
ES (1) ES2944477T3 (enExample)
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NI (1) NI201500103A (enExample)
NZ (1) NZ710695A (enExample)
PE (1) PE20151408A1 (enExample)
PH (1) PH12015501729B1 (enExample)
SG (2) SG10201706383XA (enExample)
WO (1) WO2014123580A1 (enExample)
ZA (2) ZA201505745B (enExample)

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JP2019515899A (ja) * 2016-04-15 2019-06-13 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー がん処置における抗ｃｄ４７薬の治療有効用量を決定及び達成する方法
JP2020511481A (ja) * 2017-03-22 2020-04-16 アーチ オンコロジー, インコーポレイテッドArch Oncology, Inc. 固形及び血液癌の治療のための併用療法
JP2020536488A (ja) * 2017-08-02 2020-12-17 フェインズ セラピューティクス，インコーポレーテッド 抗ｃｄ４７抗体及びその使用
JP2021502324A (ja) * 2017-11-10 2021-01-28 アイ−マブ バイオファーマ ユーエス リミテッド Ｃｄ４７抗体およびサイトカインを含む融合タンパク質
JP2021527110A (ja) * 2018-06-11 2021-10-11 康▲諾▼▲亞▼生物医葯科技（成都）有限公司Ｃｈｅｎｇｄｕ Ｃｏｎｍｅｄ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏ．， Ｌｔｄ ＣＤ４７とＳＩＲＰａの相互作用を遮断できる抗体及びその応用
JP2021535743A (ja) * 2018-08-31 2021-12-23 南京聖和薬業股▲ふん▼有限公司Nanjing Sanhome Pharmaceutical Co., Ltd. 抗ｃｄ４７抗体及びその応用
JP2023052145A (ja) * 2017-03-27 2023-04-11 セルジーン コーポレイション 免疫原性の低下のための方法及び組成物
JP2023083424A (ja) * 2017-06-21 2023-06-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 血液悪性腫瘍に対するｃｄ４７標的化治療のための投与パラメータ
US11692035B2 (en) 2016-10-21 2023-07-04 Arch Oncology, Inc. Therapeutic CD47 antibodies
US12091467B2 (en) 2016-10-20 2024-09-17 I-Mab Biopharma Us Limited CD47 monoclonal antibodies and uses thereof
JP7591917B2 (ja) 2015-08-07 2024-11-29 エーエルエックス オンコロジー インコーポレイテッド Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物

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KR102338833B1 (ko) 2012-02-06 2021-12-13 인히브릭스, 인크. Cd47 항체 및 그 사용 방법
HK1216647A1 (zh) 2012-12-12 2016-11-25 Vasculox Inc. 治疗性cd47抗体
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
US9969789B2 (en) 2012-12-17 2018-05-15 Trillium Therapeutics Inc. Treatment of CD47+ disease cells with SIRP alpha-Fc fusions
JP6426693B2 (ja) 2013-03-15 2018-11-21 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 抗ｃｄ４７薬の処理上有効量を達成するための方法
EP3012271A1 (en) * 2014-10-24 2016-04-27 Effimune Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
CA2967379A1 (en) * 2014-11-18 2016-05-26 Janssen Pharmaceutica Nv Cd47 antibodies, methods, and uses
EA037654B1 (ru) 2014-12-30 2021-04-27 Селджин Корпорейшн Анти-cd47-антитела и их применения
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
WO2016141328A2 (en) * 2015-03-04 2016-09-09 Sorrento Therapeutics, Inc. Antibody therapeutics that bind cd47
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WO2017100462A2 (en) * 2015-12-11 2017-06-15 The Board Of Trustees Of The Leland Stanford Junior University Treatment of cancer with dual targeting of cd47 and egfr
KR20220163516A (ko) * 2016-01-11 2022-12-09 포티 세븐, 인코포레이티드 인간화된, 마우스 또는 키메라 항-cd47 단클론 항체
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WO2017184553A1 (en) * 2016-04-18 2017-10-26 Baylor College Of Medicine Cancer gene therapy targeting cd47
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CN106117354B (zh) * 2016-06-24 2020-01-14 安徽未名细胞治疗有限公司 一种全人源抗CD47的全分子IgG抗体及其应用
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CN107955071B (zh) * 2016-10-18 2021-03-26 上海赛远生物科技有限公司 人源抗人cd47抗体及其编码基因与应用
EP3532497B1 (en) * 2016-10-26 2024-07-24 The Board of Trustees of the Leland Stanford Junior University Modified immunoglobulin hinge regions to reduce hemagglutination
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EP3538557A4 (en) * 2016-11-08 2020-11-18 Ablexis, LLC ANTI-CD47 ANTIBODY
WO2018095428A1 (zh) * 2016-11-28 2018-05-31 江苏恒瑞医药股份有限公司 Cd47抗体、其抗原结合片段及其医药用途
JP7173971B2 (ja) 2016-12-09 2022-11-16 アレクトル エルエルシー 抗ＳＩＲＰ－α抗体及びその使用方法
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TW202448946A (zh) 2018-05-25 2024-12-16 美商阿列克特有限責任公司 抗-sirpa 抗體及其使用方法
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