CL2015002203A1 - Anticuerpos cd47 que no agotan plaquetas ni glóbulos rojos y métodos de uso de los mismos - Google Patents

Anticuerpos cd47 que no agotan plaquetas ni glóbulos rojos y métodos de uso de los mismos

Info

Publication number
CL2015002203A1
CL2015002203A1 CL2015002203A CL2015002203A CL2015002203A1 CL 2015002203 A1 CL2015002203 A1 CL 2015002203A1 CL 2015002203 A CL2015002203 A CL 2015002203A CL 2015002203 A CL2015002203 A CL 2015002203A CL 2015002203 A1 CL2015002203 A1 CL 2015002203A1
Authority
CL
Chile
Prior art keywords
antibodies
methods
blood cells
red blood
deplete platelets
Prior art date
Application number
CL2015002203A
Other languages
English (en)
Inventor
Brendan Eckelman
John Timmer
Amir Razai
Quinn Deveraux
Kyle Jones
Mark Lappe
Original Assignee
Inhibrx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/761,087 external-priority patent/US9045541B2/en
Application filed by Inhibrx Llc filed Critical Inhibrx Llc
Publication of CL2015002203A1 publication Critical patent/CL2015002203A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

ANTICUERPO DE UNIÓN A CD47 QUE NO PROVOCA AGOTAMIENTO DE PLAQUETAS NI GLÓBULOS ROJOS; COMPOSICIÓN FARMACÉUTICA QUE LO COMPRENDE; Y USO PARA TRATAR CÁNCER U OTRA AFECCIÓN NEOPLÁSICA.
CL2015002203A 2013-02-06 2015-08-06 Anticuerpos cd47 que no agotan plaquetas ni glóbulos rojos y métodos de uso de los mismos CL2015002203A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/761,087 US9045541B2 (en) 2012-02-06 2013-02-06 CD47 antibodies and methods of use thereof
PCT/US2013/024995 WO2013119714A1 (en) 2012-02-06 2013-02-06 Cd47 antibodies and methods of use thereof
US201361815219P 2013-04-23 2013-04-23

Publications (1)

Publication Number Publication Date
CL2015002203A1 true CL2015002203A1 (es) 2016-01-29

Family

ID=51300031

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002203A CL2015002203A1 (es) 2013-02-06 2015-08-06 Anticuerpos cd47 que no agotan plaquetas ni glóbulos rojos y métodos de uso de los mismos

Country Status (20)

Country Link
EP (2) EP4137518A1 (es)
JP (2) JP2016507555A (es)
KR (2) KR102170196B1 (es)
CN (1) CN105101997B (es)
AU (2) AU2013377886B2 (es)
BR (1) BR112015018851A2 (es)
CA (1) CA2900468C (es)
CL (1) CL2015002203A1 (es)
EA (1) EA036963B1 (es)
ES (1) ES2944477T3 (es)
HK (1) HK1218863A1 (es)
IL (2) IL240390B (es)
MX (2) MX2015010115A (es)
NI (1) NI201500103A (es)
NZ (1) NZ710695A (es)
PE (1) PE20151408A1 (es)
PH (1) PH12015501729B1 (es)
SG (2) SG11201506132PA (es)
WO (1) WO2014123580A1 (es)
ZA (2) ZA201505745B (es)

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