JP2016505044A5 - - Google Patents
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- Publication number
- JP2016505044A5 JP2016505044A5 JP2015553858A JP2015553858A JP2016505044A5 JP 2016505044 A5 JP2016505044 A5 JP 2016505044A5 JP 2015553858 A JP2015553858 A JP 2015553858A JP 2015553858 A JP2015553858 A JP 2015553858A JP 2016505044 A5 JP2016505044 A5 JP 2016505044A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- cyclodextrin
- compound
- nitroxyl donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 229920000858 Cyclodextrin Polymers 0.000 claims 16
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 14
- ZZRODMXZJNLQGD-UHFFFAOYSA-N ONS(=O)=O Chemical compound ONS(=O)=O ZZRODMXZJNLQGD-UHFFFAOYSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- NZAQRZWBQUIBSF-UHFFFAOYSA-N 4-(4-sulfobutoxy)butane-1-sulfonic acid Chemical class OS(=O)(=O)CCCCOCCCCS(O)(=O)=O NZAQRZWBQUIBSF-UHFFFAOYSA-N 0.000 claims 4
- 229960004853 betadex Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical group [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010007556 Cardiac failure acute Diseases 0.000 claims 2
- 239000001116 FEMA 4028 Substances 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 2
- 239000006172 buffering agent Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 235000011056 potassium acetate Nutrition 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 239000008057 potassium phosphate buffer Substances 0.000 claims 1
- 0 Cc1ccc(*)[o]1 Chemical compound Cc1ccc(*)[o]1 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361754237P | 2013-01-18 | 2013-01-18 | |
| US61/754,237 | 2013-01-18 | ||
| US201361782781P | 2013-03-14 | 2013-03-14 | |
| US61/782,781 | 2013-03-14 | ||
| PCT/US2014/012089 WO2014113700A1 (en) | 2013-01-18 | 2014-01-17 | Pharmaceutical compositions comprising nitroxyl donors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019096869A Division JP6801045B2 (ja) | 2013-01-18 | 2019-05-23 | ニトロキシル供与体を含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505044A JP2016505044A (ja) | 2016-02-18 |
| JP2016505044A5 true JP2016505044A5 (enExample) | 2017-02-23 |
| JP6533159B2 JP6533159B2 (ja) | 2019-06-19 |
Family
ID=50064795
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553858A Expired - Fee Related JP6533159B2 (ja) | 2013-01-18 | 2014-01-17 | ニトロキシル供与体を含む医薬組成物 |
| JP2015553856A Expired - Fee Related JP6449171B2 (ja) | 2013-01-18 | 2014-01-17 | 治療指数の改善されたニトロキシル供与体 |
| JP2017005276A Expired - Fee Related JP6311038B2 (ja) | 2013-01-18 | 2017-01-16 | 治療指数の改善されたニトロキシル供与体 |
| JP2018228317A Active JP6656345B2 (ja) | 2013-01-18 | 2018-12-05 | 治療指数の改善されたニトロキシル供与体 |
| JP2019096869A Expired - Fee Related JP6801045B2 (ja) | 2013-01-18 | 2019-05-23 | ニトロキシル供与体を含む医薬組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553856A Expired - Fee Related JP6449171B2 (ja) | 2013-01-18 | 2014-01-17 | 治療指数の改善されたニトロキシル供与体 |
| JP2017005276A Expired - Fee Related JP6311038B2 (ja) | 2013-01-18 | 2017-01-16 | 治療指数の改善されたニトロキシル供与体 |
| JP2018228317A Active JP6656345B2 (ja) | 2013-01-18 | 2018-12-05 | 治療指数の改善されたニトロキシル供与体 |
| JP2019096869A Expired - Fee Related JP6801045B2 (ja) | 2013-01-18 | 2019-05-23 | ニトロキシル供与体を含む医薬組成物 |
Country Status (29)
| Country | Link |
|---|---|
| US (13) | US8987326B2 (enExample) |
| EP (5) | EP3284463B1 (enExample) |
| JP (5) | JP6533159B2 (enExample) |
| KR (2) | KR102177899B1 (enExample) |
| CN (4) | CN110179777B (enExample) |
| AU (5) | AU2014207404B2 (enExample) |
| BR (2) | BR112015017251B1 (enExample) |
| CA (2) | CA2898445C (enExample) |
| CY (3) | CY1120535T1 (enExample) |
| DK (3) | DK3284463T3 (enExample) |
| ES (4) | ES2659969T3 (enExample) |
| HK (1) | HK1251170B (enExample) |
| HR (3) | HRP20180121T1 (enExample) |
| HU (3) | HUE036589T2 (enExample) |
| IL (4) | IL239906B (enExample) |
| LT (3) | LT3284463T (enExample) |
| MX (2) | MX363843B (enExample) |
| NZ (4) | NZ709986A (enExample) |
| PL (3) | PL2945621T3 (enExample) |
| PT (3) | PT2945620T (enExample) |
| RS (3) | RS59434B1 (enExample) |
| RU (3) | RU2684916C2 (enExample) |
| SG (6) | SG11201505568PA (enExample) |
| SI (3) | SI2945620T1 (enExample) |
| SM (3) | SMT201900575T1 (enExample) |
| TR (1) | TR201802211T4 (enExample) |
| TW (3) | TWI712409B (enExample) |
| WO (2) | WO2014113696A1 (enExample) |
| ZA (2) | ZA201505090B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE029309T2 (en) | 2006-03-17 | 2017-02-28 | Univ Johns Hopkins | N-hydroxylsulfonamide derivatives as novel physiologically useful nitroxyl donors |
| CA2852914C (en) | 2011-10-17 | 2019-11-26 | The Johns Hopkins University | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors |
| BR112015017251B1 (pt) | 2013-01-18 | 2021-10-26 | Cardioxyl Pharmaceuticals, Inc. | Composições farmacêuticas compreendendo doadores de nitroxil, misturas e usos das referidas composições farmacêuticas |
| ES2734060T3 (es) | 2014-01-17 | 2019-12-04 | Cardioxyl Pharmaceuticals Inc | Donadores de nitroxilo de N-hidroximetanosulfonamida |
| ES2749682T3 (es) | 2014-05-27 | 2020-03-23 | Cardioxyl Pharmaceuticals Inc | Derivados de pirazolona como donadores de nitroxilo |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| CN108349911B (zh) | 2015-09-07 | 2022-05-13 | 浙江华海药业股份有限公司 | 可释放一氧化氮的前药分子 |
| JP6889704B2 (ja) | 2015-10-19 | 2021-06-18 | カルディオキシル ファーマシューティカルズ，インク． | ニトロキシルドナーとしてのピラゾロン誘導体 |
| EP3365325A1 (en) | 2015-10-19 | 2018-08-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxylsulfonamide derivatives as nitroxyl donors |
| KR20190070912A (ko) | 2016-07-28 | 2019-06-21 | 더 존스 홉킨스 유니버시티 | O-치환된 히드록삼산 |
| AU2018205621B2 (en) * | 2017-01-03 | 2023-01-05 | Cardioxyl Pharmaceuticals, Inc. | Method of administering nitroxyl donating compounds |
| CN110536683A (zh) * | 2017-04-18 | 2019-12-03 | 基恩菲特公司 | 包含PPAR激动剂如伊拉非诺和乙酰CoA羧化酶ACC抑制剂的组合 |
| CN116283762B (zh) * | 2023-03-28 | 2025-08-12 | 昆山市第一人民医院 | 一种用于制备白鲜碱的中间体化合物及其制备方法、白鲜碱的制备方法 |
| WO2025043108A1 (en) | 2023-08-23 | 2025-02-27 | Bristol -Myers S Quibb Company | Co-crystals of nitroxyl donating compounds |
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| CA2852914C (en) | 2011-10-17 | 2019-11-26 | The Johns Hopkins University | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors |
| EP2914579A1 (en) | 2012-11-01 | 2015-09-09 | The Johns Hopkins University | Controlled hno release through intramolecular cyclization-elimination |
| BR112015017251B1 (pt) | 2013-01-18 | 2021-10-26 | Cardioxyl Pharmaceuticals, Inc. | Composições farmacêuticas compreendendo doadores de nitroxil, misturas e usos das referidas composições farmacêuticas |
| ES2734060T3 (es) | 2014-01-17 | 2019-12-04 | Cardioxyl Pharmaceuticals Inc | Donadores de nitroxilo de N-hidroximetanosulfonamida |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
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2014
- 2014-01-17 BR BR112015017251-2A patent/BR112015017251B1/pt active IP Right Grant
- 2014-01-17 NZ NZ709986A patent/NZ709986A/en unknown
- 2014-01-17 EP EP17195759.0A patent/EP3284463B1/en active Active
- 2014-01-17 TW TW107143952A patent/TWI712409B/zh not_active IP Right Cessation
- 2014-01-17 PL PL14703010T patent/PL2945621T3/pl unknown
- 2014-01-17 CN CN201910446030.8A patent/CN110179777B/zh active Active
- 2014-01-17 PT PT147030092T patent/PT2945620T/pt unknown
- 2014-01-17 RS RSP20191352 patent/RS59434B1/sr unknown
- 2014-01-17 SI SI201430507T patent/SI2945620T1/en unknown
- 2014-01-17 EP EP14703010.0A patent/EP2945621B1/en active Active
- 2014-01-17 LT LT17195759T patent/LT3284463T/lt unknown
- 2014-01-17 HU HUE14703009A patent/HUE036589T2/hu unknown
- 2014-01-17 US US14/158,456 patent/US8987326B2/en active Active
- 2014-01-17 TW TW103101912A patent/TWI619491B/zh not_active IP Right Cessation
- 2014-01-17 CN CN201480013565.1A patent/CN105073105B/zh active Active
- 2014-01-17 EP EP18190818.7A patent/EP3427728B1/en active Active
- 2014-01-17 KR KR1020157022200A patent/KR102177899B1/ko not_active Expired - Fee Related
- 2014-01-17 SG SG11201505568PA patent/SG11201505568PA/en unknown
- 2014-01-17 RU RU2015134583A patent/RU2684916C2/ru active
- 2014-01-17 DK DK17195759T patent/DK3284463T3/da active
- 2014-01-17 TR TR2018/02211T patent/TR201802211T4/tr unknown
- 2014-01-17 HU HUE14703010A patent/HUE041861T2/hu unknown
- 2014-01-17 SM SM20190575T patent/SMT201900575T1/it unknown
- 2014-01-17 HR HRP20180121TT patent/HRP20180121T1/hr unknown
- 2014-01-17 CA CA2898445A patent/CA2898445C/en active Active
- 2014-01-17 KR KR1020157022192A patent/KR102277165B1/ko active Active
- 2014-01-17 TW TW103101913A patent/TWI686193B/zh active
- 2014-01-17 SI SI201431361T patent/SI3284463T1/sl unknown
- 2014-01-17 WO PCT/US2014/012085 patent/WO2014113696A1/en not_active Ceased
- 2014-01-17 CN CN201480013223.XA patent/CN105142627B/zh active Active
- 2014-01-17 PT PT171957590T patent/PT3284463T/pt unknown
- 2014-01-17 EP EP14703009.2A patent/EP2945620B1/en active Active
- 2014-01-17 NZ NZ748771A patent/NZ748771A/en unknown
- 2014-01-17 JP JP2015553858A patent/JP6533159B2/ja not_active Expired - Fee Related
- 2014-01-17 AU AU2014207404A patent/AU2014207404B2/en active Active
- 2014-01-17 LT LTEP14703010.0T patent/LT2945621T/lt unknown
- 2014-01-17 RU RU2018143994A patent/RU2018143994A/ru unknown
- 2014-01-17 RS RS20180099A patent/RS56968B1/sr unknown
- 2014-01-17 NZ NZ748769A patent/NZ748769A/en unknown
- 2014-01-17 EP EP19181338.5A patent/EP3567031A1/en not_active Withdrawn
- 2014-01-17 PL PL17195759T patent/PL3284463T3/pl unknown
- 2014-01-17 ES ES14703009.2T patent/ES2659969T3/es active Active
- 2014-01-17 DK DK14703010.0T patent/DK2945621T3/en active
- 2014-01-17 SM SM20180088T patent/SMT201800088T1/it unknown
- 2014-01-17 SM SM20190027T patent/SMT201900027T1/it unknown
- 2014-01-17 NZ NZ709985A patent/NZ709985A/en unknown
- 2014-01-17 SG SG10201913286PA patent/SG10201913286PA/en unknown
- 2014-01-17 ES ES18190818T patent/ES2882279T3/es active Active
- 2014-01-17 PL PL14703009T patent/PL2945620T3/pl unknown
- 2014-01-17 HU HUE17195759A patent/HUE046722T2/hu unknown
- 2014-01-17 LT LTEP14703009.2T patent/LT2945620T/lt unknown
- 2014-01-17 BR BR112015017241-5A patent/BR112015017241B1/pt active IP Right Grant
- 2014-01-17 SG SG11201505567RA patent/SG11201505567RA/en unknown
- 2014-01-17 SI SI201430983T patent/SI2945621T1/sl unknown
- 2014-01-17 RS RS20181599A patent/RS58174B1/sr unknown
- 2014-01-17 HR HRP20182144TT patent/HRP20182144T1/hr unknown
- 2014-01-17 CN CN201810074807.8A patent/CN108610312A/zh active Pending
- 2014-01-17 RU RU2015134581A patent/RU2676277C2/ru active
- 2014-01-17 SG SG10201802862WA patent/SG10201802862WA/en unknown
- 2014-01-17 SG SG10201802855TA patent/SG10201802855TA/en unknown
- 2014-01-17 PT PT14703010T patent/PT2945621T/pt unknown
- 2014-01-17 CA CA2898443A patent/CA2898443C/en active Active
- 2014-01-17 DK DK14703009.2T patent/DK2945620T3/en active
- 2014-01-17 WO PCT/US2014/012089 patent/WO2014113700A1/en not_active Ceased
- 2014-01-17 ES ES14703010T patent/ES2705240T3/es active Active
- 2014-01-17 MX MX2015009269A patent/MX363843B/es active IP Right Grant
- 2014-01-17 MX MX2015009276A patent/MX373176B/es active IP Right Grant
- 2014-01-17 AU AU2014207408A patent/AU2014207408C1/en active Active
- 2014-01-17 ES ES17195759T patent/ES2751922T3/es active Active
- 2014-01-17 SG SG10201913441RA patent/SG10201913441RA/en unknown
- 2014-01-17 US US14/761,934 patent/US10245249B2/en active Active
- 2014-01-17 JP JP2015553856A patent/JP6449171B2/ja not_active Expired - Fee Related
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2015
- 2015-03-07 US US14/641,377 patent/US9156804B2/en active Active
- 2015-07-13 IL IL239906A patent/IL239906B/en active IP Right Grant
- 2015-07-15 IL IL239952A patent/IL239952B/en active IP Right Grant
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