JP2016505044A5 - - Google Patents
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- Publication number
- JP2016505044A5 JP2016505044A5 JP2015553858A JP2015553858A JP2016505044A5 JP 2016505044 A5 JP2016505044 A5 JP 2016505044A5 JP 2015553858 A JP2015553858 A JP 2015553858A JP 2015553858 A JP2015553858 A JP 2015553858A JP 2016505044 A5 JP2016505044 A5 JP 2016505044A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- cyclodextrin
- compound
- nitroxyl donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 229920000858 Cyclodextrin Polymers 0.000 claims 16
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 14
- ZZRODMXZJNLQGD-UHFFFAOYSA-N ONS(=O)=O Chemical compound ONS(=O)=O ZZRODMXZJNLQGD-UHFFFAOYSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- NZAQRZWBQUIBSF-UHFFFAOYSA-N 4-(4-sulfobutoxy)butane-1-sulfonic acid Chemical class OS(=O)(=O)CCCCOCCCCS(O)(=O)=O NZAQRZWBQUIBSF-UHFFFAOYSA-N 0.000 claims 4
- 229960004853 betadex Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical group [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010007556 Cardiac failure acute Diseases 0.000 claims 2
- 239000001116 FEMA 4028 Substances 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 2
- 239000006172 buffering agent Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 235000011056 potassium acetate Nutrition 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 239000008057 potassium phosphate buffer Substances 0.000 claims 1
- 0 Cc1ccc(*)[o]1 Chemical compound Cc1ccc(*)[o]1 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361754237P | 2013-01-18 | 2013-01-18 | |
| US61/754,237 | 2013-01-18 | ||
| US201361782781P | 2013-03-14 | 2013-03-14 | |
| US61/782,781 | 2013-03-14 | ||
| PCT/US2014/012089 WO2014113700A1 (en) | 2013-01-18 | 2014-01-17 | Pharmaceutical compositions comprising nitroxyl donors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019096869A Division JP6801045B2 (ja) | 2013-01-18 | 2019-05-23 | ニトロキシル供与体を含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505044A JP2016505044A (ja) | 2016-02-18 |
| JP2016505044A5 true JP2016505044A5 (enExample) | 2017-02-23 |
| JP6533159B2 JP6533159B2 (ja) | 2019-06-19 |
Family
ID=50064795
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553858A Expired - Fee Related JP6533159B2 (ja) | 2013-01-18 | 2014-01-17 | ニトロキシル供与体を含む医薬組成物 |
| JP2015553856A Expired - Fee Related JP6449171B2 (ja) | 2013-01-18 | 2014-01-17 | 治療指数の改善されたニトロキシル供与体 |
| JP2017005276A Expired - Fee Related JP6311038B2 (ja) | 2013-01-18 | 2017-01-16 | 治療指数の改善されたニトロキシル供与体 |
| JP2018228317A Active JP6656345B2 (ja) | 2013-01-18 | 2018-12-05 | 治療指数の改善されたニトロキシル供与体 |
| JP2019096869A Expired - Fee Related JP6801045B2 (ja) | 2013-01-18 | 2019-05-23 | ニトロキシル供与体を含む医薬組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553856A Expired - Fee Related JP6449171B2 (ja) | 2013-01-18 | 2014-01-17 | 治療指数の改善されたニトロキシル供与体 |
| JP2017005276A Expired - Fee Related JP6311038B2 (ja) | 2013-01-18 | 2017-01-16 | 治療指数の改善されたニトロキシル供与体 |
| JP2018228317A Active JP6656345B2 (ja) | 2013-01-18 | 2018-12-05 | 治療指数の改善されたニトロキシル供与体 |
| JP2019096869A Expired - Fee Related JP6801045B2 (ja) | 2013-01-18 | 2019-05-23 | ニトロキシル供与体を含む医薬組成物 |
Country Status (29)
| Country | Link |
|---|---|
| US (13) | US8987326B2 (enExample) |
| EP (5) | EP3567031A1 (enExample) |
| JP (5) | JP6533159B2 (enExample) |
| KR (2) | KR102277165B1 (enExample) |
| CN (4) | CN110179777B (enExample) |
| AU (5) | AU2014207404B2 (enExample) |
| BR (2) | BR112015017251B1 (enExample) |
| CA (2) | CA2898443C (enExample) |
| CY (3) | CY1120535T1 (enExample) |
| DK (3) | DK2945620T3 (enExample) |
| ES (4) | ES2705240T3 (enExample) |
| HK (1) | HK1251170B (enExample) |
| HR (3) | HRP20180121T1 (enExample) |
| HU (3) | HUE041861T2 (enExample) |
| IL (4) | IL239906B (enExample) |
| LT (3) | LT2945621T (enExample) |
| MX (2) | MX373176B (enExample) |
| NZ (4) | NZ709986A (enExample) |
| PL (3) | PL3284463T3 (enExample) |
| PT (3) | PT2945621T (enExample) |
| RS (3) | RS59434B1 (enExample) |
| RU (3) | RU2676277C2 (enExample) |
| SG (6) | SG10201802862WA (enExample) |
| SI (3) | SI3284463T1 (enExample) |
| SM (3) | SMT201800088T1 (enExample) |
| TR (1) | TR201802211T4 (enExample) |
| TW (3) | TWI619491B (enExample) |
| WO (2) | WO2014113696A1 (enExample) |
| ZA (2) | ZA201505090B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0708804B8 (pt) | 2006-03-17 | 2021-05-25 | Cardioxyl Pharmaceuticals Inc | compostos derivados de n-hidroxilsulfonamida como doadores de nitroxil, composição farmacêutica e kit |
| AU2013201929B2 (en) | 2011-10-17 | 2015-07-23 | The Johns Hopkins University | N-substituted hydroxylamine derivatives with carbon-based leaving groups |
| TWI619491B (zh) | 2013-01-18 | 2018-04-01 | 卡爾迪奧克斯爾製藥公司 | 包含硝醯基予體的醫藥組合物 |
| EP3126329B1 (en) | 2014-01-17 | 2019-05-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxymethanesulfonamide nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| ES2749682T3 (es) | 2014-05-27 | 2020-03-23 | Cardioxyl Pharmaceuticals Inc | Derivados de pirazolona como donadores de nitroxilo |
| CN108349911B (zh) | 2015-09-07 | 2022-05-13 | 浙江华海药业股份有限公司 | 可释放一氧化氮的前药分子 |
| JP6957459B2 (ja) | 2015-10-19 | 2021-11-02 | カルディオキシル ファーマシューティカルズ，インク． | ニトロキシルドナーとしてのｎ−ヒドロキシルスルホンアミド誘導体 |
| US10723704B2 (en) | 2015-10-19 | 2020-07-28 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| US10913728B2 (en) | 2016-07-28 | 2021-02-09 | The Johns Hopkins University | O-substituted hydroxamic acids |
| WO2018128999A1 (en) * | 2017-01-03 | 2018-07-12 | Cardioxyl Pharmaceuticals, Inc. | Method of administering nitroxyl donating compounds |
| CN110536682B (zh) * | 2017-04-18 | 2023-01-06 | 基恩菲特公司 | 依拉非诺或其衍生物与抗nash、抗纤维化或抗胆汁淤积药剂的组合 |
| CN116283762B (zh) * | 2023-03-28 | 2025-08-12 | 昆山市第一人民医院 | 一种用于制备白鲜碱的中间体化合物及其制备方法、白鲜碱的制备方法 |
| WO2025043108A1 (en) | 2023-08-23 | 2025-02-27 | Bristol -Myers S Quibb Company | Co-crystals of nitroxyl donating compounds |
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| JP5654450B2 (ja) | 2008-05-07 | 2015-01-14 | カルディオキシル ファーマシューティカルズ，インク． | ニトロキシル供与体としての新規ニトロソ化合物およびその使用方法 |
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| CN105919987B (zh) | 2009-12-07 | 2020-04-03 | 约翰斯霍普金斯大学 | N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物及其用途 |
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| AU2013201929B2 (en) | 2011-10-17 | 2015-07-23 | The Johns Hopkins University | N-substituted hydroxylamine derivatives with carbon-based leaving groups |
| JP6306602B2 (ja) | 2012-11-01 | 2018-04-04 | ザ ジョンズ ホプキンス ユニバーシティ | 分子内環化−脱離による制御されたｈｎｏ放出 |
| TWI619491B (zh) * | 2013-01-18 | 2018-04-01 | 卡爾迪奧克斯爾製藥公司 | 包含硝醯基予體的醫藥組合物 |
| EP3126329B1 (en) | 2014-01-17 | 2019-05-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxymethanesulfonamide nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
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2014
- 2014-01-17 TW TW103101912A patent/TWI619491B/zh not_active IP Right Cessation
- 2014-01-17 ES ES14703010T patent/ES2705240T3/es active Active
- 2014-01-17 CN CN201910446030.8A patent/CN110179777B/zh active Active
- 2014-01-17 SG SG10201802862WA patent/SG10201802862WA/en unknown
- 2014-01-17 BR BR112015017251-2A patent/BR112015017251B1/pt active IP Right Grant
- 2014-01-17 JP JP2015553858A patent/JP6533159B2/ja not_active Expired - Fee Related
- 2014-01-17 PT PT14703010T patent/PT2945621T/pt unknown
- 2014-01-17 HR HRP20180121TT patent/HRP20180121T1/hr unknown
- 2014-01-17 HR HRP20182144TT patent/HRP20182144T1/hr unknown
- 2014-01-17 AU AU2014207404A patent/AU2014207404B2/en active Active
- 2014-01-17 RS RSP20191352 patent/RS59434B1/sr unknown
- 2014-01-17 JP JP2015553856A patent/JP6449171B2/ja not_active Expired - Fee Related
- 2014-01-17 SG SG10201913286PA patent/SG10201913286PA/en unknown
- 2014-01-17 LT LTEP14703010.0T patent/LT2945621T/lt unknown
- 2014-01-17 KR KR1020157022192A patent/KR102277165B1/ko active Active
- 2014-01-17 RU RU2015134581A patent/RU2676277C2/ru active
- 2014-01-17 SI SI201431361T patent/SI3284463T1/sl unknown
- 2014-01-17 NZ NZ709986A patent/NZ709986A/en unknown
- 2014-01-17 AU AU2014207408A patent/AU2014207408C1/en active Active
- 2014-01-17 SI SI201430983T patent/SI2945621T1/sl unknown
- 2014-01-17 SM SM20180088T patent/SMT201800088T1/it unknown
- 2014-01-17 RU RU2018143994A patent/RU2018143994A/ru unknown
- 2014-01-17 CN CN201480013223.XA patent/CN105142627B/zh active Active
- 2014-01-17 KR KR1020157022200A patent/KR102177899B1/ko not_active Expired - Fee Related
- 2014-01-17 PL PL17195759T patent/PL3284463T3/pl unknown
- 2014-01-17 EP EP19181338.5A patent/EP3567031A1/en not_active Withdrawn
- 2014-01-17 HU HUE14703010A patent/HUE041861T2/hu unknown
- 2014-01-17 SI SI201430507T patent/SI2945620T1/en unknown
- 2014-01-17 CN CN201480013565.1A patent/CN105073105B/zh active Active
- 2014-01-17 SG SG10201802855TA patent/SG10201802855TA/en unknown
- 2014-01-17 PT PT171957590T patent/PT3284463T/pt unknown
- 2014-01-17 TR TR2018/02211T patent/TR201802211T4/tr unknown
- 2014-01-17 TW TW103101913A patent/TWI686193B/zh active
- 2014-01-17 RS RS20180099A patent/RS56968B1/sr unknown
- 2014-01-17 LT LT17195759T patent/LT3284463T/lt unknown
- 2014-01-17 MX MX2015009276A patent/MX373176B/es active IP Right Grant
- 2014-01-17 NZ NZ748771A patent/NZ748771A/en unknown
- 2014-01-17 PL PL14703010T patent/PL2945621T3/pl unknown
- 2014-01-17 DK DK14703009.2T patent/DK2945620T3/en active
- 2014-01-17 HU HUE17195759A patent/HUE046722T2/hu unknown
- 2014-01-17 EP EP17195759.0A patent/EP3284463B1/en active Active
- 2014-01-17 SM SM20190027T patent/SMT201900027T1/it unknown
- 2014-01-17 PL PL14703009T patent/PL2945620T3/pl unknown
- 2014-01-17 HU HUE14703009A patent/HUE036589T2/hu unknown
- 2014-01-17 PT PT147030092T patent/PT2945620T/pt unknown
- 2014-01-17 ES ES17195759T patent/ES2751922T3/es active Active
- 2014-01-17 DK DK17195759T patent/DK3284463T3/da active
- 2014-01-17 RU RU2015134583A patent/RU2684916C2/ru active
- 2014-01-17 ES ES14703009.2T patent/ES2659969T3/es active Active
- 2014-01-17 ES ES18190818T patent/ES2882279T3/es active Active
- 2014-01-17 DK DK14703010.0T patent/DK2945621T3/en active
- 2014-01-17 US US14/158,456 patent/US8987326B2/en active Active
- 2014-01-17 TW TW107143952A patent/TWI712409B/zh not_active IP Right Cessation
- 2014-01-17 SG SG11201505568PA patent/SG11201505568PA/en unknown
- 2014-01-17 SM SM20190575T patent/SMT201900575T1/it unknown
- 2014-01-17 EP EP18190818.7A patent/EP3427728B1/en active Active
- 2014-01-17 RS RS20181599A patent/RS58174B1/sr unknown
- 2014-01-17 EP EP14703009.2A patent/EP2945620B1/en active Active
- 2014-01-17 WO PCT/US2014/012085 patent/WO2014113696A1/en not_active Ceased
- 2014-01-17 MX MX2015009269A patent/MX363843B/es active IP Right Grant
- 2014-01-17 SG SG11201505567RA patent/SG11201505567RA/en unknown
- 2014-01-17 EP EP14703010.0A patent/EP2945621B1/en active Active
- 2014-01-17 NZ NZ748769A patent/NZ748769A/en unknown
- 2014-01-17 WO PCT/US2014/012089 patent/WO2014113700A1/en not_active Ceased
- 2014-01-17 SG SG10201913441RA patent/SG10201913441RA/en unknown
- 2014-01-17 US US14/761,934 patent/US10245249B2/en active Active
- 2014-01-17 LT LTEP14703009.2T patent/LT2945620T/lt unknown
- 2014-01-17 CN CN201810074807.8A patent/CN108610312A/zh active Pending
- 2014-01-17 NZ NZ709985A patent/NZ709985A/en unknown
- 2014-01-17 CA CA2898443A patent/CA2898443C/en active Active
- 2014-01-17 BR BR112015017241-5A patent/BR112015017241B1/pt active IP Right Grant
- 2014-01-17 CA CA2898445A patent/CA2898445C/en active Active
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2015
- 2015-03-07 US US14/641,377 patent/US9156804B2/en active Active
- 2015-07-13 IL IL239906A patent/IL239906B/en active IP Right Grant
- 2015-07-15 ZA ZA2015/05090A patent/ZA201505090B/en unknown
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