JP2016504289A5 - - Google Patents
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- JP2016504289A5 JP2016504289A5 JP2015544036A JP2015544036A JP2016504289A5 JP 2016504289 A5 JP2016504289 A5 JP 2016504289A5 JP 2015544036 A JP2015544036 A JP 2015544036A JP 2015544036 A JP2015544036 A JP 2015544036A JP 2016504289 A5 JP2016504289 A5 JP 2016504289A5
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| JP6779867B2 (ja) * | 2014-06-13 | 2020-11-04 | ユマ セラピューティクス，インコーポレーテッド | ピリミジン化合物およびその使用方法 |
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| WO2016135139A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | 2,3-dihydrocyclopenta[b]quinoline derivatives as mth1 inhibitors for the therapy of cancer |
| WO2016135138A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Oxoquinoline derivatives as mth1 inhibitors for the therapy of cancer |
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| WO2016145383A1 (en) * | 2015-03-11 | 2016-09-15 | Board Of Regents, University Of Texas System | Mth1 inhibitors for treating disease |
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| CN106928192B (zh) * | 2015-12-29 | 2020-11-13 | 中国科学院广州生物医药与健康研究院 | 一种嘧啶类化合物及其制备方法和应用 |
| CN105732516A (zh) * | 2016-03-09 | 2016-07-06 | 哈尔滨医科大学 | 一种合成mth1蛋白抑制剂th287的方法 |
| US10981899B2 (en) | 2016-04-28 | 2021-04-20 | Cornell University | Inhibitors of soluble adenylyl cyclase |
| KR101876514B1 (ko) * | 2016-11-08 | 2018-07-10 | 한국화학연구원 | 신규한 피리미딘화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암 및 염증질환의 예방 또는 치료용 약학적 조성물 |
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| KR102612140B1 (ko) | 2017-05-18 | 2023-12-08 | 이도르시아 파마슈티컬스 리미티드 | 피리미딘 유도체 |
| TW201900179A (zh) | 2017-05-18 | 2019-01-01 | 瑞士商愛杜西亞製藥有限公司 | 作為pge2受體調節劑之苯并呋喃及苯并噻吩衍生物 |
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| JP7566775B2 (ja) * | 2019-04-12 | 2024-10-15 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 筋肉量及び酸化的代謝を増加させるための組成物及び方法 |
| JP2022550394A (ja) * | 2019-09-30 | 2022-12-01 | エフ．ホフマン－ラ ロシュ アーゲー | Ｂ型肝炎ウイルス感染症の処置および予防のための置換ピリミジン |
| TW202130618A (zh) * | 2019-11-13 | 2021-08-16 | 美商建南德克公司 | 治療性化合物及使用方法 |
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| CN111557940A (zh) * | 2020-05-28 | 2020-08-21 | 青岛大学附属医院 | Mth1抑制剂th588在制备治疗多发性骨髓瘤的药物中的应用 |
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| US2691655A (en) * | 1952-05-24 | 1954-10-12 | Burroughs Wellcome Co | 2-amino-4-substituted amino-6-aryl pyrimidines and process of preparing same |
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| US6169086B1 (en) | 1997-01-27 | 2001-01-02 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
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| ATE325608T1 (de) | 2001-08-13 | 2006-06-15 | Janssen Pharmaceutica Nv | 2,4,5-trisubstituted thiazolyl derivative und deren antiinflammatorische wirkung |
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| US8268846B2 (en) | 2008-07-11 | 2012-09-18 | Abbott Laboratories | Amino heterocyclic linked pyrimidine derivatives |
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| CN102753168A (zh) * | 2010-02-10 | 2012-10-24 | 莱西肯医药有限公司 | 用于治疗转移性骨病的色氨酸羟化酶抑制剂 |
| WO2012080729A2 (en) | 2010-12-14 | 2012-06-21 | Electrophoretics Limited | CASEIN KINASE 1δ (CK1δ) INHIBITORS |
| GB201215502D0 (en) | 2012-08-31 | 2012-10-17 | Chalkiadakis Spyridon | Medical use |
| EP2925744B1 (en) * | 2012-11-27 | 2020-12-30 | Thomas Helledays Stiftelse För Medicinsk Forskning | Pyrimidine-2,4-diamine derivatives for treatment of cancer |
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