JP2016501866A5 - - Google Patents
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- JP2016501866A5 JP2016501866A5 JP2015544173A JP2015544173A JP2016501866A5 JP 2016501866 A5 JP2016501866 A5 JP 2016501866A5 JP 2015544173 A JP2015544173 A JP 2015544173A JP 2015544173 A JP2015544173 A JP 2015544173A JP 2016501866 A5 JP2016501866 A5 JP 2016501866A5
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- alanine
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- 239000000203 mixture Substances 0.000 claims description 113
- 150000001413 amino acids Chemical class 0.000 claims description 105
- 229940024606 amino acid Drugs 0.000 claims description 78
- 235000001014 amino acid Nutrition 0.000 claims description 78
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 70
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 41
- 235000004279 alanine Nutrition 0.000 claims description 41
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 39
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 30
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 26
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 26
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 25
- 239000004473 Threonine Substances 0.000 claims description 25
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 24
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 21
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 21
- 235000009582 asparagine Nutrition 0.000 claims description 21
- 229960001230 asparagine Drugs 0.000 claims description 21
- 239000004475 Arginine Substances 0.000 claims description 18
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 18
- 239000004472 Lysine Substances 0.000 claims description 18
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 18
- 238000006467 substitution reaction Methods 0.000 claims description 17
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 14
- 235000003704 aspartic acid Nutrition 0.000 claims description 14
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 14
- 231100000241 scar Toxicity 0.000 claims description 14
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 13
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 13
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 13
- 229960000310 isoleucine Drugs 0.000 claims description 13
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 12
- 239000004471 Glycine Substances 0.000 claims description 12
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 12
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 12
- 239000002537 cosmetic Substances 0.000 claims description 12
- 235000013922 glutamic acid Nutrition 0.000 claims description 12
- 239000004220 glutamic acid Substances 0.000 claims description 12
- 239000004474 valine Substances 0.000 claims description 12
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 11
- 229930182817 methionine Natural products 0.000 claims description 11
- 238000007920 subcutaneous administration Methods 0.000 claims description 10
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 8
- 235000018417 cysteine Nutrition 0.000 claims description 7
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 7
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 6
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 5
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 206010039580 Scar Diseases 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 3
- 206010000496 acne Diseases 0.000 claims description 3
- 150000008574 D-amino acids Chemical class 0.000 claims description 2
- 150000008575 L-amino acids Chemical class 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 125000006239 protecting group Chemical group 0.000 claims 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 208000032544 Cicatrix Diseases 0.000 claims 1
- 230000037387 scars Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 19
- 230000002209 hydrophobic effect Effects 0.000 description 9
- 230000011759 adipose tissue development Effects 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 102000008186 Collagen Human genes 0.000 description 7
- 108010035532 Collagen Proteins 0.000 description 7
- 229920001436 collagen Polymers 0.000 description 7
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- -1 aromatic amino acid Chemical class 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 208000002881 Colic Diseases 0.000 description 2
- 230000003444 anaesthetic effect Effects 0.000 description 2
- 239000002884 skin cream Substances 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 210000004003 subcutaneous fat Anatomy 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 208000035484 Cellulite Diseases 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 206010049752 Peau d'orange Diseases 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 230000036232 cellulite Effects 0.000 description 1
- 210000003467 cheek Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 210000000088 lip Anatomy 0.000 description 1
- 230000001483 mobilizing effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261729626P | 2012-11-25 | 2012-11-25 | |
| US61/729,626 | 2012-11-25 | ||
| US201361778084P | 2013-03-12 | 2013-03-12 | |
| US61/778,084 | 2013-03-12 | ||
| PCT/US2013/071719 WO2014082042A2 (en) | 2012-11-25 | 2013-11-25 | Peptides that stimulate subcutaneous adipogenesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016501866A JP2016501866A (ja) | 2016-01-21 |
| JP2016501866A5 true JP2016501866A5 (enExample) | 2017-01-12 |
Family
ID=49753509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544173A Pending JP2016501866A (ja) | 2012-11-25 | 2013-11-25 | 皮下脂肪生成を刺激するペプチド |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10494402B2 (enExample) |
| EP (1) | EP2922869B1 (enExample) |
| JP (1) | JP2016501866A (enExample) |
| KR (1) | KR20150088841A (enExample) |
| CN (1) | CN105008396A (enExample) |
| AU (1) | AU2013347797A1 (enExample) |
| CA (1) | CA2930117A1 (enExample) |
| HK (1) | HK1216895A1 (enExample) |
| IL (1) | IL239008A0 (enExample) |
| RU (1) | RU2015123315A (enExample) |
| WO (1) | WO2014082042A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2922869B1 (en) | 2012-11-25 | 2017-09-27 | The Regents of The University of California | Peptides that stimulate subcutaneous adipogenesis |
| US10844102B2 (en) | 2014-05-28 | 2020-11-24 | The Regents Of The University Of California | Peptides, compositions, and methods for stimulating subcutaneous adipogenesis |
| US10562935B2 (en) | 2015-03-20 | 2020-02-18 | London Health Sciences Centre Research Inc. | Stapled peptides and uses thereof |
| ES2984980T3 (es) * | 2015-04-17 | 2024-10-31 | Symic Holdings Usa Inc | Bioconjugados y usos de los mismos |
| KR102208853B1 (ko) * | 2018-05-08 | 2021-01-28 | 오션펩 주식회사 | 주름개선 효능을 갖는 펩티드 |
| CN113164512A (zh) * | 2018-11-26 | 2021-07-23 | 韩国海洋科学技术院 | 刺激脂肪生成的肽、组合物和方法 |
| CN114081861B (zh) * | 2021-11-19 | 2023-10-31 | 和泓尚医(成都)生物科技有限公司 | 一种干细胞外泌体与复合肽抗衰制剂及其制备方法和应用 |
| GB202211043D0 (en) * | 2022-07-28 | 2022-09-14 | Univ Birmingham | Peptide agonist |
| WO2025059165A1 (en) * | 2023-09-14 | 2025-03-20 | University Of Florida Research Foundation, Incorporated | Methods of use for rhamm-derived peptides and rhamm-derived peptide mimetics |
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| EP2922869B1 (en) | 2012-11-25 | 2017-09-27 | The Regents of The University of California | Peptides that stimulate subcutaneous adipogenesis |
| US10844102B2 (en) | 2014-05-28 | 2020-11-24 | The Regents Of The University Of California | Peptides, compositions, and methods for stimulating subcutaneous adipogenesis |
-
2013
- 2013-11-25 EP EP13802811.3A patent/EP2922869B1/en not_active Not-in-force
- 2013-11-25 JP JP2015544173A patent/JP2016501866A/ja active Pending
- 2013-11-25 US US14/646,298 patent/US10494402B2/en active Active
- 2013-11-25 CA CA2930117A patent/CA2930117A1/en not_active Abandoned
- 2013-11-25 HK HK16104706.9A patent/HK1216895A1/zh unknown
- 2013-11-25 KR KR1020157016698A patent/KR20150088841A/ko not_active Withdrawn
- 2013-11-25 RU RU2015123315A patent/RU2015123315A/ru not_active Application Discontinuation
- 2013-11-25 CN CN201380061413.4A patent/CN105008396A/zh active Pending
- 2013-11-25 WO PCT/US2013/071719 patent/WO2014082042A2/en not_active Ceased
- 2013-11-25 US US14/089,445 patent/US10766927B2/en not_active Expired - Fee Related
- 2013-11-25 AU AU2013347797A patent/AU2013347797A1/en not_active Abandoned
-
2015
- 2015-05-25 IL IL239008A patent/IL239008A0/en unknown
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