RU2015123315A - Пептиды, стимулирующие подкожный адипогенез - Google Patents
Пептиды, стимулирующие подкожный адипогенез Download PDFInfo
- Publication number
- RU2015123315A RU2015123315A RU2015123315A RU2015123315A RU2015123315A RU 2015123315 A RU2015123315 A RU 2015123315A RU 2015123315 A RU2015123315 A RU 2015123315A RU 2015123315 A RU2015123315 A RU 2015123315A RU 2015123315 A RU2015123315 A RU 2015123315A
- Authority
- RU
- Russia
- Prior art keywords
- amino acid
- composition according
- peptide
- alanine
- serine
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 30
- 238000007920 subcutaneous administration Methods 0.000 title claims 10
- 230000011759 adipose tissue development Effects 0.000 title claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 claims 68
- 229940024606 amino acid Drugs 0.000 claims 53
- 235000001014 amino acid Nutrition 0.000 claims 53
- 239000000203 mixture Substances 0.000 claims 49
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 23
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 23
- 235000004279 alanine Nutrition 0.000 claims 23
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 18
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 16
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 16
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 16
- 239000004473 Threonine Substances 0.000 claims 16
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 15
- 238000000034 method Methods 0.000 claims 13
- 238000006467 substitution reaction Methods 0.000 claims 13
- 239000004475 Arginine Substances 0.000 claims 12
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 12
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 12
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 12
- 239000004472 Lysine Substances 0.000 claims 12
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 12
- 229960001230 asparagine Drugs 0.000 claims 12
- 235000009582 asparagine Nutrition 0.000 claims 12
- 239000004471 Glycine Substances 0.000 claims 9
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 9
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 9
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 9
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 9
- 230000002209 hydrophobic effect Effects 0.000 claims 9
- 229930182817 methionine Natural products 0.000 claims 9
- 239000004474 valine Substances 0.000 claims 9
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 8
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 8
- 229940009098 aspartate Drugs 0.000 claims 8
- 229960000310 isoleucine Drugs 0.000 claims 8
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 8
- 230000004936 stimulating effect Effects 0.000 claims 8
- 102000008186 Collagen Human genes 0.000 claims 7
- 108010035532 Collagen Proteins 0.000 claims 7
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 7
- 229920001436 collagen Polymers 0.000 claims 7
- 229930195712 glutamate Natural products 0.000 claims 7
- 235000018417 cysteine Nutrition 0.000 claims 5
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 5
- 239000002537 cosmetic Substances 0.000 claims 4
- 231100000241 scar Toxicity 0.000 claims 4
- 230000037390 scarring Effects 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 3
- -1 aromatic amino acid Chemical class 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 2
- 206010039580 Scar Diseases 0.000 claims 2
- 230000003444 anaesthetic effect Effects 0.000 claims 2
- 230000037303 wrinkles Effects 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 208000035484 Cellulite Diseases 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- 206010049752 Peau d'orange Diseases 0.000 claims 1
- 206010040925 Skin striae Diseases 0.000 claims 1
- 208000031439 Striae Distensae Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000001217 buttock Anatomy 0.000 claims 1
- 230000036232 cellulite Effects 0.000 claims 1
- 210000003467 cheek Anatomy 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 210000000744 eyelid Anatomy 0.000 claims 1
- 210000001061 forehead Anatomy 0.000 claims 1
- 238000009499 grossing Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 210000000088 lip Anatomy 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 238000007665 sagging Methods 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Birds (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261729626P | 2012-11-25 | 2012-11-25 | |
| US61/729,626 | 2012-11-25 | ||
| US201361778084P | 2013-03-12 | 2013-03-12 | |
| US61/778,084 | 2013-03-12 | ||
| PCT/US2013/071719 WO2014082042A2 (en) | 2012-11-25 | 2013-11-25 | Peptides that stimulate subcutaneous adipogenesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015123315A true RU2015123315A (ru) | 2017-01-10 |
Family
ID=49753509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015123315A RU2015123315A (ru) | 2012-11-25 | 2013-11-25 | Пептиды, стимулирующие подкожный адипогенез |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10766927B2 (enExample) |
| EP (1) | EP2922869B1 (enExample) |
| JP (1) | JP2016501866A (enExample) |
| KR (1) | KR20150088841A (enExample) |
| CN (1) | CN105008396A (enExample) |
| AU (1) | AU2013347797A1 (enExample) |
| CA (1) | CA2930117A1 (enExample) |
| HK (1) | HK1216895A1 (enExample) |
| IL (1) | IL239008A0 (enExample) |
| RU (1) | RU2015123315A (enExample) |
| WO (1) | WO2014082042A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1216895A1 (zh) | 2012-11-25 | 2016-12-09 | The Regents Of The University Of California | 刺激皮下脂肪形成的肽 |
| WO2015184125A1 (en) | 2014-05-28 | 2015-12-03 | The Regents Of The University Of California | Peptides, compositions, and methods for stimulating subcutaneous adipogenesis |
| US10562935B2 (en) | 2015-03-20 | 2020-02-18 | London Health Sciences Centre Research Inc. | Stapled peptides and uses thereof |
| CN107771085B (zh) * | 2015-04-17 | 2024-09-03 | 斯米克控股(美国)有限公司 | 生物缀合物及其用途 |
| KR102208853B1 (ko) * | 2018-05-08 | 2021-01-28 | 오션펩 주식회사 | 주름개선 효능을 갖는 펩티드 |
| CN113164512A (zh) * | 2018-11-26 | 2021-07-23 | 韩国海洋科学技术院 | 刺激脂肪生成的肽、组合物和方法 |
| CN114081861B (zh) * | 2021-11-19 | 2023-10-31 | 和泓尚医(成都)生物科技有限公司 | 一种干细胞外泌体与复合肽抗衰制剂及其制备方法和应用 |
| GB202211043D0 (en) * | 2022-07-28 | 2022-09-14 | Univ Birmingham | Peptide agonist |
| WO2025059165A1 (en) * | 2023-09-14 | 2025-03-20 | University Of Florida Research Foundation, Incorporated | Methods of use for rhamm-derived peptides and rhamm-derived peptide mimetics |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA175473A (en) * | 1917-01-08 | 1917-03-06 | Clarence G. Cashman | Reamer head |
| GB9207949D0 (en) | 1992-04-09 | 1992-05-27 | Univ Manitoba | Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility |
| WO1994016328A1 (en) | 1992-12-30 | 1994-07-21 | Matthias Rath | Synthetic oligopeptides analogous to protein signal sequences methods of identification and methods of use |
| GB9420740D0 (en) | 1994-10-14 | 1994-11-30 | Univ Manitoba | Sequence of the hyaluronan receptor gene |
| US6127525A (en) | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| CA2166155C (en) | 1995-12-27 | 2008-02-05 | Eva Anne Turley | Agents binding to hyaluronic acid binding domains and the use thereof |
| GB9607441D0 (en) | 1996-04-10 | 1996-06-12 | Univ Manitoba | Human hyaluronan receptor |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| CA2237051A1 (en) | 1997-12-19 | 1999-06-19 | Eva A. Turley | Enhanced affinity hyaluronan binding peptides |
| US6211149B1 (en) | 1998-08-03 | 2001-04-03 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors of formation of protease resistant prion protein |
| GB9811962D0 (en) | 1998-06-03 | 1998-07-29 | Janssen Pharmaceutica Nv | Vertebrate homologue of UNC-53 protein of C.elegans |
| EP1151012A4 (en) | 1998-11-19 | 2003-01-08 | Smithkline Beecham Corp | ANTAGONIST ANTIBODIES OF RHAMM |
| US6153432A (en) | 1999-01-29 | 2000-11-28 | Zen-Bio, Inc | Methods for the differentiation of human preadipocytes into adipocytes |
| JP2000217576A (ja) | 1999-02-02 | 2000-08-08 | Herikkusu Kenkyusho:Kk | 脂肪細胞への分化を誘導する方法、並びに脂肪細胞への分化を制御する化合物およびそのスクリーニング方法 |
| US6864235B1 (en) | 1999-04-01 | 2005-03-08 | Eva A. Turley | Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans |
| US6911429B2 (en) | 1999-04-01 | 2005-06-28 | Transition Therapeutics Inc. | Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans |
| US20070116669A1 (en) * | 2002-09-13 | 2007-05-24 | Chemokine Therapeutics Corporation | Interferon-inducible protein-10 (IP-10 or CXCL10) chemokine analogs for the treatment of human diseases |
| WO2001080899A2 (en) | 2000-04-20 | 2001-11-01 | Cangene Corporation | Rhamm peptide conjugates |
| US7601825B2 (en) | 2001-03-05 | 2009-10-13 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer |
| EP1401483A1 (en) | 2001-06-11 | 2004-03-31 | Transition Therapeutics Inc. | Combination therapies using vitamin b12 and therapeutic agents for treatment of viral, proliferative and inflammatory diseases |
| EP1407039A4 (en) * | 2001-06-19 | 2005-12-21 | Us Gov Health & Human Serv | ANTI-ARTHROPODE VECTOR VACCINES, SELECTION METHOD AND USES THEREOF |
| US7387800B2 (en) | 2001-08-15 | 2008-06-17 | Meiji Dairies Corporation | Sesquiterpenoid derivatives having adipocyte differentiation inhibitory effect |
| US20030170755A1 (en) | 2001-09-26 | 2003-09-11 | Ludwig Institute For Cancer Research | Tumor-associated antigen RHAMM |
| AU2002332028A1 (en) | 2001-10-06 | 2003-04-22 | Boston Medical Center Corporation | Preadipocyte cell strains and uses therefore |
| WO2003043998A1 (en) | 2001-11-15 | 2003-05-30 | Incyte San Diego Incorporated | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases |
| WO2003048358A1 (fr) | 2001-12-07 | 2003-06-12 | Nissui Pharmaceutical Co., Ltd. | Gene et proteine associes a la differenciation adipocytaire |
| FR2834996B1 (fr) | 2002-01-18 | 2004-12-03 | Genfit S A | Methode d'identification de substances capables de moduler la differenciation adipocytaire |
| US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| SE0201863D0 (en) * | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| WO2004003545A1 (en) | 2002-07-01 | 2004-01-08 | Tufts University | Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers |
| AU2003259285A1 (en) | 2002-07-29 | 2004-02-16 | Hmgene, Inc. | Methods of identifying adipocyte specific genes, the genes identified, and their uses |
| EP1620061B1 (en) * | 2003-04-28 | 2010-02-24 | Sequoia Pharmaceuticals, Inc. | Antiviral agents for the treatment, control and prevention of infections by coronaviruses |
| US20040229219A1 (en) * | 2003-04-30 | 2004-11-18 | Gallaher William R. | Method of inhibiting human metapneumovirus and human coronavirus in the prevention and treatment of severe acute respiratory syndrome (SARS) |
| AU2004266642A1 (en) | 2003-08-12 | 2005-03-03 | University Of Utah Research Foundation | Heparin binding proteins: sensors for heparin detection |
| EP1677735B1 (en) | 2003-10-17 | 2014-07-23 | Joslin Diabetes Center, Inc. | Methods and compositions for modulating adipocyte function |
| US7544661B2 (en) | 2003-12-05 | 2009-06-09 | Northwestern University | Self-assembling peptide amphiphiles and related methods for growth factor delivery |
| CA2610791C (en) | 2005-06-08 | 2015-12-01 | Cangene Corporation | Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria |
| US20090176306A1 (en) | 2005-06-10 | 2009-07-09 | Toshio Taira | Method of inducing differentiation from visceral preadipocyte to visceral adipocyte |
| US20070179085A1 (en) | 2005-07-20 | 2007-08-02 | Savani Rashmin C | Modulation of rhamm-caveolin/lipid raft interactions to affect development, responses to tissue injury, angiogenesis, tumorigenesis, metastasis and growth factor/cytokine responses |
| US20070292869A1 (en) | 2006-03-02 | 2007-12-20 | Ppd Biomarker Discovery Sciences, Llc | Compositions and Methods for Analyzing Renal Cancer |
| US8066691B2 (en) | 2006-04-21 | 2011-11-29 | Khouri Roger K | Method and system for preparing soft tissue for grafting, enhancing grafting results, and grafting autologous fat to soft tissue such as the breast |
| WO2008047061A2 (fr) | 2006-10-20 | 2008-04-24 | Laboratoires Inneov | Utilisation cosmetique par voie orale et/ou parenterale de la glucosamine eventuellement associee a au moins un compose polyphenol et composition correspondante |
| CA2670320A1 (en) | 2006-11-21 | 2008-11-20 | The Regents Of The University Of California | Modulation of rhamm (cd168) for selective adipose tissue development |
| US20100062000A1 (en) | 2006-11-21 | 2010-03-11 | The Regents Of The University Of California | Rhamm, a Co-Receptor and Its Interactions with Other Receptors in Cancer Cell Motility and the Identification of Cancer Prognitor Cell Populations |
| EP1967524A1 (en) * | 2007-03-06 | 2008-09-10 | Friesland Brands B.V. | Methods for producing ACE-inhibitory peptides from whey and peptides obtained thereby |
| WO2009036246A2 (en) | 2007-09-14 | 2009-03-19 | Immunotope, Inc. | Immunogens that induce cytotoxic t-lymphocytes and their use in prevention, treatment, and diagnosis of cancer |
| EP2197908A2 (en) | 2007-09-27 | 2010-06-23 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
| US20100290989A1 (en) | 2007-10-12 | 2010-11-18 | London Health Sciences Centre Research Inc. | Compositions affecting hyaluronic acid mediated activity |
| WO2009061130A2 (en) | 2007-11-06 | 2009-05-14 | Procell Therapeutics Inc. | Cell permeable runx3 recombinant proteins, polynucleotides encoding the same, and anticancer compositions including the same |
| US8216828B2 (en) | 2008-05-30 | 2012-07-10 | Corning Incorporated | Assembly of cell culture vessels |
| EP2576597A4 (en) | 2010-05-31 | 2013-11-06 | London Health Sci Ct Res Inc | HYALURONIC ACID MEDIATED MOTILITY RECEPTOR BINDING PEPTIDES (RHAMM) |
| US20120076810A1 (en) | 2010-09-01 | 2012-03-29 | Poland Gregory A | Vaccinia virus polypeptides |
| CA2809847A1 (en) | 2010-09-01 | 2012-03-08 | The Regents Of The University Of California | Cell culture screen for agents that control adipogenesis and myofibroblast differentiation |
| MX2013002303A (es) * | 2010-09-07 | 2013-10-28 | Oncotherapy Science Inc | Peptidos hjurp y vacunas que incluyen los mismos. |
| HK1216895A1 (zh) | 2012-11-25 | 2016-12-09 | The Regents Of The University Of California | 刺激皮下脂肪形成的肽 |
| WO2015184125A1 (en) | 2014-05-28 | 2015-12-03 | The Regents Of The University Of California | Peptides, compositions, and methods for stimulating subcutaneous adipogenesis |
-
2013
- 2013-11-25 HK HK16104706.9A patent/HK1216895A1/zh unknown
- 2013-11-25 KR KR1020157016698A patent/KR20150088841A/ko not_active Withdrawn
- 2013-11-25 WO PCT/US2013/071719 patent/WO2014082042A2/en not_active Ceased
- 2013-11-25 CN CN201380061413.4A patent/CN105008396A/zh active Pending
- 2013-11-25 EP EP13802811.3A patent/EP2922869B1/en not_active Not-in-force
- 2013-11-25 US US14/089,445 patent/US10766927B2/en not_active Expired - Fee Related
- 2013-11-25 AU AU2013347797A patent/AU2013347797A1/en not_active Abandoned
- 2013-11-25 JP JP2015544173A patent/JP2016501866A/ja active Pending
- 2013-11-25 RU RU2015123315A patent/RU2015123315A/ru not_active Application Discontinuation
- 2013-11-25 US US14/646,298 patent/US10494402B2/en active Active
- 2013-11-25 CA CA2930117A patent/CA2930117A1/en not_active Abandoned
-
2015
- 2015-05-25 IL IL239008A patent/IL239008A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014082042A2 (en) | 2014-05-30 |
| EP2922869B1 (en) | 2017-09-27 |
| AU2013347797A1 (en) | 2015-07-02 |
| KR20150088841A (ko) | 2015-08-03 |
| IL239008A0 (en) | 2015-07-30 |
| US20140179616A1 (en) | 2014-06-26 |
| US10494402B2 (en) | 2019-12-03 |
| US20150284433A1 (en) | 2015-10-08 |
| CA2930117A1 (en) | 2014-05-30 |
| CN105008396A (zh) | 2015-10-28 |
| JP2016501866A (ja) | 2016-01-21 |
| US10766927B2 (en) | 2020-09-08 |
| EP2922869A2 (en) | 2015-09-30 |
| WO2014082042A3 (en) | 2014-07-24 |
| HK1216895A1 (zh) | 2016-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015123315A (ru) | Пептиды, стимулирующие подкожный адипогенез | |
| JP2016501866A5 (enExample) | ||
| CN103096980B (zh) | 皮肤抗衰老治疗 | |
| US20120148649A1 (en) | Composition for restoration of age related tissue in the face or selected areas of the body | |
| CN105616184B (zh) | 一种透明质酸多肽键合物面膜及其制备方法 | |
| JP2017105790A5 (enExample) | ||
| Thareja et al. | En coup de sabre morphea treated with hyaluronic acid filler. Report of a case and review of the literature. | |
| CA2596597A1 (en) | Method for stimulation collagen synthesis and/or kgf expression | |
| CN105233270A (zh) | 用于水光治疗的药物组合物及其应用 | |
| WO1991018614A1 (en) | Method for the treatment of aging or photo-damaged skin | |
| JP5537556B2 (ja) | インターロイキン−１及びペプチドを含有する組成物 | |
| RU2016144971A (ru) | Композиции, содержащие производные остеопонтина для ингибирования роста волос | |
| KR102324076B1 (ko) | 엘라스틴 및 콜라겐 유도를 이용한 피부 주름 및 탄력 개선 효과 조성물 | |
| AU2006290251B2 (en) | Agonist peptides of basic fibroblast growth factor (BFGF) and the method of reduction of wrinkle on skin, darkening of hair and acceleration of wound healing | |
| JP2008502624A5 (enExample) | ||
| CN107029219B (zh) | 一种促进皮肤组织再生的药膏 | |
| RU2281082C1 (ru) | Способ коррекции эстетических и возрастных проблем кожи | |
| ES2660023T3 (es) | Formulación de ácido hialurónico que contiene piruvato | |
| CN111419780A (zh) | 一种面部用组合物及其应用 | |
| KR101917026B1 (ko) | 피부 주름 개선 또는 예방용 화장료 조성물 | |
| CN114746436B (zh) | 改善温度稳定性和蛋白酶抗性的fgf2多肽及其用途 | |
| CN110063936A (zh) | 一种重组人酸性成纤维细胞生长因子液体制剂 | |
| Park et al. | Hyaluronic acid filler combined with antioxidants for infraorbital rejuvenation: Report of two cases. | |
| RU2524610C1 (ru) | Косметологический набор для лифтинга мягких тканей с использованием мезонитей и его применение (варианты) | |
| CN101077889A (zh) | 类生长因子多肽及其保养品 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20161128 |