JP5537556B2 - インターロイキン−1及びペプチドを含有する組成物 - Google Patents
インターロイキン−1及びペプチドを含有する組成物 Download PDFInfo
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- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- CWKLZLBVOJRSOM-UHFFFAOYSA-N methyl pyruvate Chemical compound COC(=O)C(C)=O CWKLZLBVOJRSOM-UHFFFAOYSA-N 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000036562 nail growth Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- HUGZTWBSBIZZOQ-UHFFFAOYSA-N octyl 2-methyl-3-phenylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C(C)=CC1=CC=CC=C1 HUGZTWBSBIZZOQ-UHFFFAOYSA-N 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 229940014662 pantothenate Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 108010011110 polyarginine Proteins 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- WUBJISGMPZWFKY-UHFFFAOYSA-N propan-2-yl 2-oxopropanoate Chemical compound CC(C)OC(=O)C(C)=O WUBJISGMPZWFKY-UHFFFAOYSA-N 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000008362 succinate buffer Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 238000011191 terminal modification Methods 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940084883 wheat amino acids Drugs 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Description
Tyr−X1−X2−Phe−X3−X4−Y
[式中:
X1は、Gly、L-Ala又はD-Alaであり;
X2は、Gly、L-Ala又はD-Alaであり;
X3は、存在しないか、あるいは独立してLeu、Met、Ile又はValであり;
X4は、存在しないか、あるいは独立してAla、Asp、Asn、Glu、Gln、Pro、Arg、Gly、Lys、Thr又はSerであり;
Yは、存在しないか、あるいはアミノ酸残基1〜5個の配列である]。
Tyr−X1−X2−Phe−X3−X4−Y
[式中:
X1は、Gly、L-Ala又はD-Alaであり;
X2は、Gly、L-Ala又はD-Alaであり;
X3は、存在しないか、あるいは独立してLeu、Met、Ile又はValであり;
X4は、存在しないか、あるいは独立してAla、Asp、Asn、Glu、Gln、Pro、Arg、Gly、Lys、Thr又はSerであり;
Yは、存在しないか、あるいはアミノ酸残基1〜5個の配列である];ならびに(c)医薬的に許容できる希釈剤又はキャリヤー。
(a)インターロイキン−1アルファ、インターロイキン−1ファミリーメンバー5(デルタ)、インターロイキン−1ファミリーメンバー6(イプシロン)、インターロイキン−1ファミリーメンバー7(ゼータ)、インターロイキン−1ファミリーメンバー8(イータ)、インターロイキン−1ファミリーメンバー9、インターロイキン−1ファミリーメンバー10(シータ)及びインターロイキン−18からなるインターロイキン−1ファミリーメンバーの群から選択されるポリペプチド;
(b)一般式(I)のペプチド:
Tyr−X1−X2−Phe−X3−X4−Y
[式中:
X1は、Gly、L-Ala又はD-Alaであり;
X2は、Gly、L-Ala又はD-Alaであり;
X3は、存在しないか、あるいは独立してLeu、Met、Ile又はValであり;
X4は、存在しないか、あるいは独立してAla、Asp、Asn、Glu、Gln、Pro、Arg、Gly、Lys、Thr又はSerであり;
Yは、存在しないか、あるいはアミノ酸残基1〜5個の配列である];ならびに
(c)皮膚医薬的に許容できる希釈剤又はキャリヤー。
(a)インターロイキン−1アルファ、インターロイキン−1ファミリーメンバー5(デルタ)、インターロイキン−1ファミリーメンバー6(イプシロン)、インターロイキン−1ファミリーメンバー7(ゼータ)、インターロイキン−1ファミリーメンバー8(イータ)、インターロイキン−1ファミリーメンバー9、インターロイキン−1ファミリーメンバー10(シータ)及びインターロイキン−18からなるインターロイキン−1ファミリーメンバーの群から選択されるポリペプチド;
(b)一般式(I)のペプチド:
Tyr−X1−X2−Phe−X3−X4−Y
[式中:
X1は、Gly、L-Ala又はD-Alaであり;
X2は、Gly、L-Ala又はD-Alaであり;
X3は、存在しないか、あるいは独立してLeu、Met、Ile又はValであり;
X4は、存在しないか、あるいは独立してAla、Asp、Asn、Glu、Gln、Pro、Arg、Gly、Lys、Thr又はSerであり;
Yは、存在しないか、あるいはアミノ酸残基1〜5個の配列である];ならびに
(c)皮膚医薬的に許容できる希釈剤又はキャリヤー。
[0046] この実施例は注射用医薬組成物を示す:
[0047] この実施例は、スキンケアのための美容又は美容医薬組成物を示す:
この溶液を用いて老化しつつある皮膚の徴候を処置する方法:1mlのゲルを顔の皮膚に局所適用し、好ましくは少なくとも約15分の期間、皮膚に残す。
[0048] この実施例は、老化しつつある皮膚の徴候を処置するための皮膚医薬組成物を示す:
皺を治療する方法:1mlの組成物を皺のある領域の顔の皮膚に局所適用し、好ましくは少なくとも約15分の期間、皮膚に残しておく。
Claims (16)
- 下記のものを含む組成物:
(a)インターロイキン−1アルファ;
(b)一般式(I)のペプチド:
Tyr−X1−Gly−Phe−Leu−X4
[式中:
X1は、Gly、L-Ala又はD-Alaであり;
X4は、独立してAla、Asp、Asn、Glu、Gln、Pro、Arg、Gly、Lys、Thr又はSerである]。 - 組成物中のインターロイキン−1アルファの含量が10−7重量%から10−4重量%までの範囲である、請求項1に記載の組成物。
- ペプチドが、
Tyr-Gly-Gly-Phe-Leu-Asp (SEQ ID NO: 1)
Tyr-L-Ala-Gly-Phe-Leu-Asp (SEQ ID NO: 2)
Tyr-D-Ala-Gly-Phe-Leu-Asp (SEQ ID NO: 3)
Tyr-Gly-Gly-Phe-Leu-Asn(SEQ ID NO: 13)
Tyr-L-Ala-Gly-Phe-Leu-Asn(SEQ ID NO: 14)
Tyr-D-Ala-Gly-Phe-Leu-Asn(SEQ ID NO: 15)
Tyr-Gly-Gly-Phe-Leu-Glu(SEQ ID NO: 25)
Tyr-L-Ala-Gly-Phe-Leu-Glu(SEQ ID NO: 26)
Tyr-D-Ala-Gly-Phe-Leu-Glu(SEQ ID NO: 27)
Tyr-Gly-Gly-Phe-Leu-Gln(SEQ ID NO: 37)
Tyr-L-Ala-Gly-Phe-Leu-Gln(SEQ ID NO: 38)
Tyr-D-Ala-Gly-Phe-Leu-Gln(SEQ ID NO: 39)
Tyr-D-Ala-Gly-Phe-Leu-Arg(SEQ ID NO: 49)
Tyr-D-Ala-Gly-Phe-Leu-Gly(SEQ ID NO: 50)
Tyr-D-Ala-Gly-Phe-Leu-Lys (SEQ ID NO: 51)
Tyr-D-Ala-Gly-Phe-Leu-Thr(SEQ ID NO: 52)
Tyr-D-Ala-Gly-Phe-Leu-Ser (SEQ ID NO: 53)
Tyr-D-Ala-Gly-Phe-Leu-Pro (SEQ ID NO: 54)
からなる群から選択される、請求項1に記載の組成物。 - 組成物中のペプチドの含量が10−4重量%から10−1重量%までの範囲である、請求項1に記載の組成物。
- 下記のものを含む医薬組成物:
(a)インターロイキン−1アルファ;
(b)一般式(I)のペプチド:
Tyr−X1−Gly−Phe−Leu−X4
[式中:
X1は、Gly、L-Ala又はD-Alaであり;
X4は、存在しないか、あるいは独立してAla、Asp、Asn、Glu、Gln、Pro、Arg、Gly、Lys、Thr又はSerである];
(c)医薬的に許容できる希釈剤又はキャリヤー。 - 組成物中のインターロイキン−1アルファの含量が10−7重量%から10−4重量%までの範囲である、請求項5に記載の組成物。
- ペプチドが、
Tyr-Gly-Gly-Phe-Leu-Asp (SEQ ID NO: 1)
Tyr-L-Ala-Gly-Phe-Leu-Asp (SEQ ID NO: 2)
Tyr-D-Ala-Gly-Phe-Leu-Asp (SEQ ID NO: 3)
Tyr-Gly-Gly-Phe-Leu-Asn(SEQ ID NO: 13)
Tyr-L-Ala-Gly-Phe-Leu-Asn(SEQ ID NO: 14)
Tyr-D-Ala-Gly-Phe-Leu-Asn(SEQ ID NO: 15)
Tyr-Gly-Gly-Phe-Leu-Glu(SEQ ID NO: 25)
Tyr-L-Ala-Gly-Phe-Leu-Glu(SEQ ID NO: 26)
Tyr-D-Ala-Gly-Phe-Leu-Glu(SEQ ID NO: 27)
Tyr-Gly-Gly-Phe-Leu-Gln(SEQ ID NO: 37)
Tyr-L-Ala-Gly-Phe-Leu-Gln(SEQ ID NO: 38)
Tyr-D-Ala-Gly-Phe-Leu-Gln(SEQ ID NO: 39)
Tyr-D-Ala-Gly-Phe-Leu-Arg(SEQ ID NO: 49)
Tyr-D-Ala-Gly-Phe-Leu-Gly(SEQ ID NO: 50)
Tyr-D-Ala-Gly-Phe-Leu-Lys (SEQ ID NO: 51)
Tyr-D-Ala-Gly-Phe-Leu-Thr(SEQ ID NO: 52)
Tyr-D-Ala-Gly-Phe-Leu-Ser (SEQ ID NO: 53)
Tyr-D-Ala-Gly-Phe-Leu-Pro (SEQ ID NO: 54)
からなる群から選択される、請求項5に記載の組成物。 - 組成物中のペプチドの含量が10−4重量%から10−1重量%までの範囲である、請求項5に記載の組成物。
- 下記のものを含む皮膚医薬組成物:
(a)インターロイキン−1アルファ;
(b)一般式(I)のペプチド:
Tyr−X1−Gly−Phe−Leu−X4
[式中:
X1は、Gly、L-Ala又はD-Alaであり;
X4は、存在しないか、あるいは独立してAla、Asp、Asn、Glu、Gln、Pro、Arg、Gly、Lys、Thr又はSerである];
(c)皮膚医薬的に許容できる希釈剤又はキャリヤー。 - 組成物中のインターロイキン−1アルファの含量が10−7重量%から10−4重量%までの範囲である、請求項9に記載の組成物。
- ペプチドが、
Tyr-Gly-Gly-Phe-Leu-Asp (SEQ ID NO: 1)
Tyr-L-Ala-Gly-Phe-Leu-Asp (SEQ ID NO: 2)
Tyr-D-Ala-Gly-Phe-Leu-Asp (SEQ ID NO: 3)
Tyr-Gly-Gly-Phe-Leu-Asn(SEQ ID NO: 13)
Tyr-L-Ala-Gly-Phe-Leu-Asn(SEQ ID NO: 14)
Tyr-D-Ala-Gly-Phe-Leu-Asn(SEQ ID NO: 15)
Tyr-Gly-Gly-Phe-Leu-Glu(SEQ ID NO: 25)
Tyr-L-Ala-Gly-Phe-Leu-Glu(SEQ ID NO: 26)
Tyr-D-Ala-Gly-Phe-Leu-Glu(SEQ ID NO: 27)
Tyr-Gly-Gly-Phe-Leu-Gln(SEQ ID NO: 37)
Tyr-L-Ala-Gly-Phe-Leu-Gln(SEQ ID NO: 38)
Tyr-D-Ala-Gly-Phe-Leu-Gln(SEQ ID NO: 39)
Tyr-D-Ala-Gly-Phe-Leu-Arg(SEQ ID NO: 49)
Tyr-D-Ala-Gly-Phe-Leu-Gly(SEQ ID NO: 50)
Tyr-D-Ala-Gly-Phe-Leu-Lys (SEQ ID NO: 51)
Tyr-D-Ala-Gly-Phe-Leu-Thr(SEQ ID NO: 52)
Tyr-D-Ala-Gly-Phe-Leu-Ser (SEQ ID NO: 53)
Tyr-D-Ala-Gly-Phe-Leu-Pro (SEQ ID NO: 54)
からなる群から選択される、請求項9に記載の組成物。 - 組成物中のペプチドの含量が10−4重量%から10−1重量%までの範囲である、請求項9に記載の組成物。
- 下記のものを含む美容組成物:
(a)インターロイキン−1アルファ;
(b)一般式(I)のペプチド:
Tyr−X1−Gly−Phe−Leu−X4
[式中:
X1は、Gly、L-Ala又はD-Alaであり;
X4は、存在しないか、あるいは独立してAla、Asp、Asn、Glu、Gln、Pro、Arg、Gly、Lys、Thr又はSerである];
(c)皮膚医薬的に許容できる希釈剤又はキャリヤー。 - 組成物中のインターロイキン−1アルファの含量が10−7重量%から10−4重量%までの範囲である、請求項13に記載の組成物。
- ペプチドが、
Tyr-Gly-Gly-Phe-Leu-Asp (SEQ ID NO: 1)
Tyr-L-Ala-Gly-Phe-Leu-Asp (SEQ ID NO: 2)
Tyr-D-Ala-Gly-Phe-Leu-Asp (SEQ ID NO: 3)
Tyr-Gly-Gly-Phe-Leu-Asn(SEQ ID NO: 13)
Tyr-L-Ala-Gly-Phe-Leu-Asn(SEQ ID NO: 14)
Tyr-D-Ala-Gly-Phe-Leu-Asn(SEQ ID NO: 15)
Tyr-Gly-Gly-Phe-Leu-Glu(SEQ ID NO: 25)
Tyr-L-Ala-Gly-Phe-Leu-Glu(SEQ ID NO: 26)
Tyr-D-Ala-Gly-Phe-Leu-Glu(SEQ ID NO: 27)
Tyr-Gly-Gly-Phe-Leu-Gln(SEQ ID NO: 37)
Tyr-L-Ala-Gly-Phe-Leu-Gln(SEQ ID NO: 38)
Tyr-D-Ala-Gly-Phe-Leu-Gln(SEQ ID NO: 39)
Tyr-D-Ala-Gly-Phe-Leu-Arg(SEQ ID NO: 49)
Tyr-D-Ala-Gly-Phe-Leu-Gly(SEQ ID NO: 50)
Tyr-D-Ala-Gly-Phe-Leu-Lys (SEQ ID NO: 51)
Tyr-D-Ala-Gly-Phe-Leu-Thr(SEQ ID NO: 52)
Tyr-D-Ala-Gly-Phe-Leu-Ser (SEQ ID NO: 53)
Tyr-D-Ala-Gly-Phe-Leu-Pro (SEQ ID NO: 54)
からなる群から選択される、請求項13に記載の組成物。 - 組成物中のペプチドの含量が10−4重量%から10−1重量%までの範囲である、請求項13に記載の組成物。
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EP3062804A4 (en) * | 2013-10-28 | 2017-05-31 | Atp Institute Pty Ltd. | Pain relief formulation and method of treatment |
RU2664702C1 (ru) * | 2017-03-10 | 2018-08-21 | Сергей Георгиевич Морозов | Способ профилактики несостоятельности межкишечного анастомоза при операциях на брюшной полости с помощью пептида |
JP6997222B2 (ja) | 2017-06-23 | 2022-01-17 | ザ プロクター アンド ギャンブル カンパニー | 皮膚の外観を改善するための組成物及び方法 |
JP2021530447A (ja) | 2018-07-03 | 2021-11-11 | ザ プロクター アンド ギャンブル カンパニーThe Procter & Gamble Company | 皮膚状態の治療方法 |
RU2718912C1 (ru) * | 2019-12-24 | 2020-04-15 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт общей патологии и физиологии" (ФГБНУ "НИИОПП") | Способ лечения и профилактики инфаркта миокарда с патологией легких |
JP2023528616A (ja) | 2020-06-01 | 2023-07-05 | ザ プロクター アンド ギャンブル カンパニー | ビタミンb3化合物の皮膚への浸透を改善する方法 |
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US4816436A (en) * | 1986-10-29 | 1989-03-28 | Immunex Corporation | Anti-arthritic use of interleukin-1 proteins |
AU630341B2 (en) * | 1987-12-18 | 1992-10-29 | Immunex Corporation | Topical wound-healing preparations comprising interleukin-1 proteins |
US5202118A (en) * | 1987-12-18 | 1993-04-13 | Immunex Corporation | Method for promoting wound healing using IL-1 |
DK172424B1 (da) * | 1988-07-29 | 1998-06-08 | Otsuka Pharma Co Ltd | IL-1alfa-Derivater, farmaceutisk præparat omfattende sådanne derivater, anvendelse af IL-1alfa-derivater, DNA sekvenser kod |
ZA902663B (en) | 1989-04-07 | 1991-12-24 | Syntex Inc | Interleukin-1 formulation |
US5035887A (en) * | 1989-09-07 | 1991-07-30 | Institute Of Moelcular Biology, Inc. | Wound healing composition of IL-1 and PDGF or IGF-1 |
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JP2818834B2 (ja) * | 1991-08-12 | 1998-10-30 | 大塚製薬株式会社 | IL−1α安定化医薬製剤 |
US5861483A (en) * | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
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JP4018033B2 (ja) | 2003-06-18 | 2007-12-05 | バンドー化学株式会社 | ブレード素材とその製造方法および製造装置 |
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ES2259928B1 (es) * | 2005-04-08 | 2007-11-01 | Lipotec, S.A. | Composicion cosmetica o dermofarmaceutica que comprende peptidos derivados de encefalinas para reducir y/o eliminar arrugas faciales. |
EA019154B1 (ru) * | 2008-04-24 | 2014-01-30 | Юнайтед Текнолоджис Ут Аг | Гексапептиды и композиции на их основе |
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KR20110092288A (ko) | 2011-08-17 |
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